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1. 发明申请

US20190233322A1 GLASSES, CEMENTS AND USES THEREOF 审中-公开
公开(公告)号：US20190233322A1
公开(公告)日：2019-08-01
申请号：US16318064
申请日：2017-07-14
申请人： Mark Robert Towler , Adel Moh'd Fawzi A.R. Alhalawani
发明人： Mark Robert Towler , Adel Moh'd Fawzi A.R. Alhalawani
IPC分类号： C03C3/062 , C03C3/097 , C03C3/078 , C03C4/00 , A61L24/12 , A61K6/083
摘要： Various embodiments of tantalum- and/or niobium-containing glasses and cements as well as uses thereof are described herein. For example, in an embodiment, the glasses comprise a transition metal pentoxide such as tantalum pentoxide and/or niobium pentoxide present in the glass in an amount of less than 2.0 mol %, based on the total composition of the glass, glass polyalkenoate cements prepared from such glasses and uses of such cements, for example, for sternal closure or fixation, stabilization and/or repair of a fracture in a bone in the wrist, elbow, knee, shoulder, spine and/or hip.

2. 发明申请

US20080208340A1 Synthetic bone graft 审中-公开
标题翻译：合成骨移植
公开(公告)号：US20080208340A1
公开(公告)日：2008-08-28
申请号：US12071756
申请日：2008-02-26
申请人： Daniel Boyd , Mark Robert Towler
发明人： Daniel Boyd , Mark Robert Towler
IPC分类号： A61F2/28 , A61Q11/00 , A61K8/27 , A61K8/18 , C03C3/00 , C03C3/04 , A61K33/30 , A61P19/10 , A61P19/08
CPC分类号： A61L24/12 , A61L27/10 , A61L2430/02 , C03C3/062 , C03C4/0007
摘要： A particulate glass for a synthetic bone (including dental) graft includes ZnO, SrO, and may include NaO. The glass promotes cellular metabolism, and upon implantation in living bone tissue induces bone growth at their surface. The ZnO and SrO respectively degrade to provide Zn2+ and Sr2+ ions respectively. The ions released by the glass provide anti-bacterial effects; improved bone formation in place of diseased tissue; inhibition of bone resorption; and radiopacity. There is excellent synergy between the SrO, ZnO, and NaO. The Sr2+ ions have better bone formation effects than the Zn2+ ions, but an anti-bacterial effect which is not as good. Choice of relative proportions of ZnO and SrO combined with the choice of NaO concentration to set the resorption rate allow optimisation. NaO there is control of the degradation rate of the graft; a feature which is advantageous in tailoring the grafts to specific patients and applications. Additionally the sodium (Na) in the glass imparts water solubility, allowing glasses to degrade to their ionic components.
摘要翻译：用于合成骨（包括牙科）移植物的颗粒状玻璃包括ZnO，SrO，并且可以包括NaO。玻璃促进细胞代谢，并且植入活体骨组织后，在其表面诱导骨生长。 ZnO和SrO分别降解以分别提供Zn 2+和Sr 2+ 2+。由玻璃释放的离子提供抗菌作用; 改善骨形成代替病变组织; 抑制骨吸收; 和不透射线。 SrO，ZnO和NaO之间具有良好的协同作用。 Sr 2+离子具有比Zn 2+ 2+离子更好的骨形成效果，但是抗菌效果不如那么好。选择ZnO和SrO的相对比例结合选择NaO浓度来设定吸收速率允许优化。 NaO有控制移植物的降解速率; 这有利于将移植物定制到特定患者和应用中。此外，玻璃中的钠（Na）赋予水溶解性，允许玻璃降解成其离子组分。

3. 发明申请

US20080182920A1 Bone cement 审中-公开
标题翻译：骨水泥
公开(公告)号：US20080182920A1
公开(公告)日：2008-07-31
申请号：US12010480
申请日：2008-01-25
申请人： Mark Robert Towler , Daniel Boyd , Owen Clarkin
发明人： Mark Robert Towler , Daniel Boyd , Owen Clarkin
IPC分类号： A61K6/06 , A61L24/00
CPC分类号： A61L27/50 , A61L27/10 , A61L2430/02 , C03C3/078 , C03C4/0007 , C03C14/004 , C03C2214/12 , C03C2214/30
摘要： A bone cement comprises a zinc-based glass and polyalkenoate acid. In addition, the cement comprises a controlled amount of tri-sodium citrate (Na3C6H5O7) (“TSC”). The cement has enhanced rheology without negatively impacting on the mechanical properties. Controlled addition of TSC significantly improves the rheology of the bone cements, increasing working and setting times (illustrated in FIG. 1). For three formulations of the working time can be adjusted from less than 50 seconds to almost 120 seconds; concomitantly working times improve from 58 seconds to duration in excess of 300 s.
摘要翻译：骨水泥包括锌基玻璃和聚烯丙酸。此外，水泥包含受控量的柠檬酸三钠（Na 3 N 3 H 5 O 7 O 3） >）（“TSC”）。该水泥具有增强的流变性，而不会对机械性能产生负面影响。 TSC的控制添加显着改善骨水泥的流变性，增加工作和凝固时间（如图1所示）。对于三种配方的工作时间可以从小于50秒调整到近120秒; 伴随的工作时间从58秒提高到持续时间超过300秒。

4. 发明授权

US10815144B2 Glasses, cements and uses thereof 有权
公开(公告)号：US10815144B2
公开(公告)日：2020-10-27
申请号：US16318064
申请日：2017-07-14
申请人： Mark Robert Towler , Adel Moh'd Fawzi A. R. Alhalawani
发明人： Mark Robert Towler , Adel Moh'd Fawzi A. R. Alhalawani
IPC分类号： C03C3/062 , A61L24/12 , C03C4/00 , A61K6/864 , A61K6/889 , C03C3/078 , C03C3/097 , C08L33/08
摘要： Various embodiments of tantalum- and/or niobium-containing glasses and cements as well as uses thereof are described herein. For example, in an embodiment, the glasses comprise a transition metal pentoxide such as tantalum pentoxide and/or niobium pentoxide present in the glass in an amount of less than 2.0 mol %, based on the total composition of the glass, glass polyalkenoate cements prepared from such glasses and uses of such cements, for example, for sternal closure or fixation, stabilization and/or repair of a fracture in a bone in the wrist, elbow, knee, shoulder, spine and/or hip.

5. 发明申请

US20160310063A1 DEVICE AND METHOD FOR DETECTING MONOSODIUM URATE DEPOSITIONS 审中-公开
标题翻译：用于检测单一酸性沉积物的装置和方法
公开(公告)号：US20160310063A1
公开(公告)日：2016-10-27
申请号：US15106224
申请日：2014-12-19
申请人： Declan Joseph CURRAN , Mark Robert TOWLER
发明人： Declan Joseph CURRAN , Mark Robert TOWLER
IPC分类号： A61B5/00
CPC分类号： A61B5/4538 , A61B5/0059 , A61B5/0075 , A61B5/4528 , A61B5/4869
摘要： Various embodiments are described herein for a method and a use of a device for detecting gout. The method can include irradiating a portion of the anatomical region through a skin surface using a light source and receiving scattered light from the portion of the anatomical region. The portion of the anatomical region may be subcutaneous. The method further includes determining Raman spectral data from the received scattered light and identifying a plurality of peaks associated with monosodium urate in the Raman spectral data. The method further comprises determining that a monosodium urate deposition is present in the anatomical region when the number of identified peaks associated with monosodium urate is greater than a detection threshold. The method may be performed using a device that includes a light source, an optical detection component and a spectral selection component.
摘要翻译：本文中描述了用于检测痛风的装置的方法和用途的各种实施例。该方法可以包括使用光源照射解剖区域的一部分通过皮肤表面并且接收来自解剖区域的部分的散射光。解剖区域的部分可以是皮下的。该方法还包括从所接收的散射光中确定拉曼光谱数据，并在拉曼光谱数据中识别与尿酸单钠相关联的多个峰。该方法进一步包括当与尿酸单钠相关联的已鉴定峰的数目大于检测阈值时，确定在解剖区域中存在的单酸钠沉积物。该方法可以使用包括光源，光学检测部件和光谱选择部件的装置来执行。

6. 发明授权

US08535238B2 Diagnostic methods for osteoporosis 有权
公开(公告)号：US08535238B2
公开(公告)日：2013-09-17
申请号：US11570669
申请日：2005-06-20
申请人： Mark Robert Towler , Declan Lyons
发明人： Mark Robert Towler , Declan Lyons
IPC分类号： A61B10/00
CPC分类号： A61B5/0075 , A61B5/0059 , A61B5/441 , A61B5/4504 , A61B5/4509 , G01J3/44
摘要： Methods of diagnosing bone disease such as osteoporosis are provided. The methods comprise detecting changes in the physical or chemical structure of a keratinized tissue as correlates of disease. The methods include detecting changes in the hardness, modulus, or level of sulfur bonding, particularly the level of disulfide bonding, in a keratinized tissue sample such as nail, hair, or skin. Changes in these variables serve as diagnostic markers of bone diseases that are associated with changes in bone elasticity and bone density.

7. 发明申请

US20200164324A1 A STORAGE, MIXING AND DISPENSING DEVICE 审中-公开
公开(公告)号：US20200164324A1
公开(公告)日：2020-05-28
申请号：US16636369
申请日：2018-08-02
申请人： Mark Robert Towler
发明人： Mark Robert Towler
IPC分类号： B01F15/02 , B01F5/06 , C08K3/40 , B05C17/005 , B01F11/00 , A61L24/06 , A61L24/12 , B01F15/00 , A61B17/88 , B01F13/00
摘要： A device for storing first and second ingredient materials, mixing the ingredient materials to form an adhesive material and dispensing the adhesive material. The device comprises: a nozzle for dispensing the third material; a first container adapted to store a first ingredient material and mix the first ingredient material with a second ingredient material; a second container disposed within the first container, and moveable between a storage position in which a second ingredient material is stored in the second container and a mixing position in which the second ingredient material is moved to the first container; a mixer that longitudinally extends into the first and second containers; a handle alternatively coupled to the mixer to mix the first and second ingredient materials or to the second container to move the second container to a dispensing position to dispense the third material. During use, the first container is rotated causing the second container to move relative to the first container and the second material to flow into the first container for mixing. After mixing, the handle is uncoupled from the mixer and coupled to the second container to dispense the third material from the nozzle. Embodiments are also described herein for a method of making the device and a method of using the device.

8. 发明申请

US20090093571A1 Synthetic graft having a glass network 有权
标题翻译：具有玻璃网络的合成移植物
公开(公告)号：US20090093571A1
公开(公告)日：2009-04-09
申请号：US11990336
申请日：2006-07-31
申请人： Mark Robert Towler , Daniel Boyd
发明人： Mark Robert Towler , Daniel Boyd
IPC分类号： C04B24/04 , C03C3/076 , C03C3/078
CPC分类号： C04B28/28 , A61L24/0089 , A61L24/12 , C03C3/078 , C03C4/0007 , C03C12/00 , C04B2111/00836 , C04B14/06 , C04B14/30 , C04B2103/001 , C08L33/02
摘要： A synthetic graft has a glass composition comprises silicon as a network former and Sr as a stable isotope acting as a network modifier. The composition contains calcium as a network modifier and Zn acting as a as either a network modifier or as a network former. The glass composition may be mixed with a solution of polyalkenoic acid to provide advantageous glass polyalkenoate cements (GPCs). These cements are particularly effective for use as bone cements and fillers in the human skeleton as they set at room temperature, have similar strengths to bone, chemically bond to both bone and surgical metal, and release therapeutic ions, which can assist in wound healing and bone re-growth.
摘要翻译：合成移植物具有玻璃组合物，其包含作为网络形成剂的硅和Sr作为稳定同位素作为网络改性剂。该组合物含有钙作为网络改性剂，Zn作为网络改性剂或作为网络前体。玻璃组合物可以与聚烯酸溶液混合以提供有利的玻璃聚烯丙酸酯粘结剂（GPC）。这些粘固剂在人体骨架中用作骨水泥和填料时特别有效，因为它们在室温下固化，具有与骨相似的强度，与骨和手术金属化学键合，以及释放治疗离子，其可以帮助伤口愈合和骨再生长。

9. 发明授权

US07981972B2 Synthetic graft having a glass network 有权
标题翻译：具有玻璃网络的合成移植物
公开(公告)号：US07981972B2
公开(公告)日：2011-07-19
申请号：US11990336
申请日：2006-07-31
申请人： Mark Robert Towler , Daniel Boyd
发明人： Mark Robert Towler , Daniel Boyd
IPC分类号： C08F8/42 , A61K6/08
CPC分类号： C04B28/28 , A61L24/0089 , A61L24/12 , C03C3/078 , C03C4/0007 , C03C12/00 , C04B2111/00836 , C04B14/06 , C04B14/30 , C04B2103/001 , C08L33/02
摘要： A synthetic graft has a glass composition comprises silicon as a network former and Sr as a stable isotope acting as a network modifier. The composition contains calcium as a network modifier and Zn acting as a as either a network modifier or as a network former. The glass composition may be mixed with a solution of polyalkenoic acid to provide advantageous glass polyalkenoate cements (GPCs). These cements are particularly effective for use as bone cements and fillers in the human skeleton as they set at room temperature, have similar strengths to bone, chemically bond to both bone and surgical metal, and release therapeutic ions, which can assist in wound healing and bone re-growth.
摘要翻译：合成移植物具有玻璃组合物，其包含作为网络形成剂的硅和Sr作为稳定同位素作为网络改性剂。该组合物含有钙作为网络改性剂，Zn作为网络改性剂或作为网络前体。玻璃组合物可以与聚烯酸溶液混合以提供有利的玻璃聚烯丙酸酯粘结剂（GPC）。这些粘固剂在人体骨架中用作骨水泥和填料时特别有效，因为它们在室温下固化，具有与骨相似的强度，与骨和手术金属化学键合，以及释放治疗离子，其可以帮助伤口愈合和骨再生长。

10. 发明授权

US11358109B2 Storage, mixing and dispensing device 有权
公开(公告)号：US11358109B2
公开(公告)日：2022-06-14
申请号：US16636369
申请日：2018-08-02
申请人： Mark Robert Towler
发明人： Mark Robert Towler
IPC分类号： B01F35/71 , B01F25/451 , B01F25/452 , B01F31/40 , B01F33/501 , B01F35/50 , B01F35/75 , B01F21/00 , A61B17/88 , A61L24/06 , A61L24/12 , B05C17/005 , C08K3/40 , B01F101/20
摘要： Various embodiments are described herein for a device for storing first and second ingredient materials, mixing the ingredient materials to form an adhesive material and dispensing the adhesive material. Various embodiments are also described herein for a method of making the device and a method of using the device.

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