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1. 发明申请

US20080071085A1 Chemical process 审中-公开
标题翻译：化学工艺
公开(公告)号：US20080071085A1
公开(公告)日：2008-03-20
申请号：US11897996
申请日：2007-08-31
申请人： Mark Maybury , Ian Patel , Simon Nicholas Tyler
发明人： Mark Maybury , Ian Patel , Simon Nicholas Tyler
IPC分类号： C07D403/14
CPC分类号： C07D401/12
摘要： A process for preparing an optically active compound of formula (II) or a salt thereof where * indicates a stereogenic centre; and R1 and R7 are as defined in the specification, which process comprises the acid hydrolysis of an optically active compound of formula (IV) where R5 and R6 are as defined in the specification, recovering the resultant optically active compound of formula (II) as a salt, and thereafter if desired, converting the salt to a compound of formula (II). The process is suitable for the preparation of; for instance, intermediates for pharmaceutical compounds. Certain novel intermediates are also disclosed and claimed.
摘要翻译：制备式（II）的光学活性化合物或其盐的方法，其中*表示立体中心; 和R 1和R 7如说明书中所定义，该方法包括酸式水解式（IV）的光学活性化合物，其中R 5， R 6和R 6如说明书中所定义，作为盐回收得到的式（II）的光学活性化合物，然后如果需要，将盐转化为式（II）的化合物）。该方法适用于制备; 例如药物化合物的中间体。还公开并要求保护某些新颖的中间体。

2. 发明申请

US20100075942A1 N-PHENYL-4-PYRIDIN-2-YL-BENZAMIDE DERIVATIVES AS HISTONE DEACYLASE (HDAC) INHIBITORS FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：作为治疗癌症的HISTONE DEACYLASE（HDAC）抑制剂的N-苯基-4-吡啶-2-基-L-苯甲酰胺衍生物
公开(公告)号：US20100075942A1
公开(公告)日：2010-03-25
申请号：US11813838
申请日：2006-01-12
申请人： Keith Hopkinson Gibson , Elaine Sophie, Elizabeth Stokes , Michael James Waring , David Michael Andrews , Zbigniew Stanley Matusiak , Mark Maybury , Craig Anthony Roberts
发明人： Keith Hopkinson Gibson , Elaine Sophie, Elizabeth Stokes , Michael James Waring , David Michael Andrews , Zbigniew Stanley Matusiak , Mark Maybury , Craig Anthony Roberts
IPC分类号： A61K31/4418 , C07D213/61 , C07D401/12 , C07D213/82 , C07D401/06 , A61K31/496 , A61K31/4523
CPC分类号： C07D213/82 , C07D213/61 , C07D213/65
摘要： The invention concerns benzamide derivatives of Formula (I) wherein R1a, R1b, R1c, R2, R3, R4, W, m and n have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions which are sensitive to the inhibition of histone deacetylase (HDAC).
摘要翻译：本发明涉及式（I）的苯甲酰胺衍生物，其中R1a，R1b，R1c，R2，R3，R4，W，m和n具有本说明书中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用于预防或治疗对组蛋白脱乙酰酶（HDAC）的抑制敏感的肿瘤或其它增殖病症中的抗增殖剂的药物中的用途。

3. 发明申请

US20060047701A1 Personalized broadcast news navigator 有权
标题翻译：个性化广播新闻导航仪
公开(公告)号：US20060047701A1
公开(公告)日：2006-03-02
申请号：US10928372
申请日：2004-08-30
申请人： Mark Maybury , Warren Greiff , Stanley Boykin , Chadwick McHenry , Lisa Ferro
发明人： Mark Maybury , Warren Greiff , Stanley Boykin , Chadwick McHenry , Lisa Ferro
IPC分类号： G06F17/00 , G06F7/00
CPC分类号： G06F17/30828 , G06F17/30867 , G06F17/3097 , Y10S707/914 , Y10S707/943 , Y10S707/99933
摘要： A system and method are provided that use explicitly and implicitly derived models of user information needs and content and presentation preferences together with relevancy feedback to expand a user's original query to the most related terms in a corpus and/or to allow the user to provide interactive feedback to enhance the relevance of selected news stories and display profile of the selected news stories. By personalizing both the selection of stories and the form in which they are delivered, users are provided with tailored broadcast news.
摘要翻译：提供了一种系统和方法，其使用显式和隐式导出的用户信息需求模型和内容和呈现偏好以及相关性反馈来将用户的原始查询扩展到语料库中的最相关术语和/或允许用户提供交互式反馈意见，以提高所选新闻报道的相关性，并显示所选新闻报道的简介。通过个性化故事的选择和交付形式，向用户提供定制的广播新闻。

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