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1. 发明授权

US07630838B2 Method for identifying agents that interact with beta-site APP cleaving enzyme (BACE) 失效
标题翻译：用于鉴定与β位点APP切割酶（BACE）相互作用的试剂的方法
公开(公告)号：US07630838B2
公开(公告)日：2009-12-08
申请号：US09955737
申请日：2001-09-19
申请人： Rajiv Chopra , Kristine Svenson , Bethany Annis Freeman , Tatos N. Akopian , Jonathan Bard , Mark Lloyd Stahl , William S. Somers
发明人： Rajiv Chopra , Kristine Svenson , Bethany Annis Freeman , Tatos N. Akopian , Jonathan Bard , Mark Lloyd Stahl , William S. Somers
IPC分类号： G01N31/00 , C12Q1/37 , C30B29/58
CPC分类号： C12N9/6421 , C07K14/4711 , C07K2299/00 , C07K2319/02
摘要： This invention is directed to the three dimensional crystal structure of Beta-site APP Cleaving Enzyme (BACE), and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of BACE. Such agents may represent new therapeutics in the treatment and/or prevention of Alzheimer's Disease.
摘要翻译：本发明涉及β位点APP裂解酶（BACE）的三维晶体结构，以及在合理药物设计方法中使用该结构来鉴定可能与BACE的活性位点相互作用的试剂。这样的药剂可代表治疗和/或预防阿尔茨海默病的新疗法。

2. 发明申请

US20090214513A1 MAMMALIAN EXPRESSION SYSTEMS 审中-公开
标题翻译： MAMMALIAN表达系统
公开(公告)号：US20090214513A1
公开(公告)日：2009-08-27
申请号：US11911908
申请日：2006-04-20
申请人： Xiaotian Zhong , Ronald William Kriz , Mark Lloyd Stahl
发明人： Xiaotian Zhong , Ronald William Kriz , Mark Lloyd Stahl
IPC分类号： A61K38/46 , C12N5/06 , C12N15/87 , C12N5/08 , C12P21/00 , A61K38/02
CPC分类号： C12P21/02
摘要： The present invention features mammalian expression systems with improved production yields, and method of using these systems to produce desired proteins. In one embodiment, the expression systems of the present invention comprise genetically-engineered mammalian host cells cultured in a medium that contains an effective amount of heparin or heparin-like molecules. The presence of heparin or heparin-like molecules significantly increases protein production by the cultured cells. The present invention also features the use of constitutively-active components of FGFR-I-mediated signal transduction pathways to improve protein production by cultured mammalian cells. Co-expression of such a component with a protein of interest markedly increases the production yield of the protein of interest.
摘要翻译：本发明具有提高生产产量的哺乳动物表达系统以及使用这些系统产生所需蛋白质的方法。在一个实施方案中，本发明的表达系统包含在含有有效量的肝素或类肝素分子的培养基中培养的遗传工程化的哺乳动物宿主细胞。肝素或肝素样分子的存在显着增加培养细胞的蛋白质产生。本发明还特征在于使用FGFR-1介导的信号转导途径的组成型活性成分来改善培养的哺乳动物细胞的蛋白质产生。这种与感兴趣的蛋白质的组分的共表达显着增加了目的蛋白质的产量。

3. 发明授权

US07135319B2 Crystals of an acyl carrier protein synthase/acyl carrier protein complex 失效
标题翻译：酰基载体蛋白合成酶/酰基载体蛋白复合物的晶体
公开(公告)号：US07135319B2
公开(公告)日：2006-11-14
申请号：US10717138
申请日：2003-11-19
申请人： Kevin Delos Parris , William Stuart Somers , Amy Szepui Tam , Laura Long Lin , Mark Lloyd Stahl
发明人： Kevin Delos Parris , William Stuart Somers , Amy Szepui Tam , Laura Long Lin , Mark Lloyd Stahl
IPC分类号： C12N9/10
CPC分类号： C12N9/1288 , G06F19/16
摘要： This invention is directed to the crystal structure of Acyl Carrier Protein Synthase (ACPS) complexed with Acyl Carrier Protein (ACP), the solution structure of B. subtilis ACP, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of ACPS and ACP, and to the testing of these agents to identify agents that may represent novel antibiotics.
摘要翻译：本发明涉及与酰基载体蛋白（ACP）络合的酰基载体蛋白质合成酶（ACPS），枯草芽孢杆菌ACP的溶液结构的晶体结构，以及在合理的药物设计方法中使用这些结构来鉴定可能与ACPS和ACP的活性位点相互作用，以及这些试剂的测试以鉴定可能代表新型抗生素的药剂。

4. 发明授权

US06684162B2 Methods for identifying agents that interact with an active site of acyl carrier protein synthase-acyl carrier protein complex 失效
标题翻译：用于鉴定与酰基载体蛋白合酶 - 酰基载体蛋白复合物的活性位点相互作用的试剂的方法
公开(公告)号：US06684162B2
公开(公告)日：2004-01-27
申请号：US09770834
申请日：2001-01-25
申请人： Kevin Delos Parris , William Stuart Somers , Amy Szepui Tam , Laura Long Lin , Mark Lloyd Stahl , Robert Powers , Guang-Yi Xu
发明人： Kevin Delos Parris , William Stuart Somers , Amy Szepui Tam , Laura Long Lin , Mark Lloyd Stahl , Robert Powers , Guang-Yi Xu
IPC分类号： G06F1900
CPC分类号： C12N9/1288 , G06F19/16
摘要： This invention is directed to the crystal structure of Acyl Carrier Protein Synthase (ACPS) complexed with Acyl Carrier Protein (ACP), the solution structure of B. subtilis ACP, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of ACPS and ACP, and to the testing of these agents to identify agents that may represent novel antibiotics.
摘要翻译：本发明涉及与酰基载体蛋白（ACP）络合的酰基载体蛋白质合成酶（ACPS），枯草芽孢杆菌ACP的溶液结构的晶体结构，以及在合理的药物设计方法中使用这些结构来鉴定可能与ACPS和ACP的活性位点相互作用，以及这些试剂的测试以鉴定可能代表新型抗生素的药剂。

5. 发明授权

US06957150B2 Methods for identifying an agent that interacts with an active site of acyl carrier protein synthase or acyl carrier protein synthase complex 失效
标题翻译：用于鉴定与酰基载体蛋白质合成酶或酰基载体蛋白质合酶复合物的活性位点相互作用的试剂的方法
公开(公告)号：US06957150B2
公开(公告)日：2005-10-18
申请号：US09771383
申请日：2001-01-25
申请人： Kevin Delos Parris , William Stuart Somers , Amy Szepui Tam , Laura Long Lin , Mark Lloyd Stahl
发明人： Kevin Delos Parris , William Stuart Somers , Amy Szepui Tam , Laura Long Lin , Mark Lloyd Stahl
IPC分类号： C12N9/12 , G06F19/00 , G01N31/00 , G01N33/48
CPC分类号： C12N9/1288
摘要： This invention is directed to Acyl Carrier Protein Synthase (ACPS) crystals and crystals of Acyl Carrier Protein Synthase-Coenzyme A (ACPS-CoA) complex, and to the use of these crystals to determine the three dimensional structure of ACPS. This invention is further directed to the use of rational drug design methods to identify agents that may interact with active sites of ACPS and ACPS-CoA complex, and to the testing of these agents to identify agents that may inhibit ACPS and/or ACPS-CoA complex activity.
摘要翻译：本发明涉及酰基载体蛋白合成酶（ACPS）晶体和酰基载体蛋白合成酶辅酶A（ACPS-CoA）复合物的晶体，以及这些晶体的用途来确定ACPS的三维结构。本发明进一步涉及使用合理的药物设计方法来鉴定可与ACPS和ACPS-CoA复合物的活性位点相互作用的试剂，以及这些试剂的测试以鉴定可抑制ACPS和/或ACPS-CoA的药剂复杂的活动。

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