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1. 发明授权

US08573898B2 Form milling cutter for the machining of titanium alloys etc 有权
标题翻译：用于钛合金加工的铣刀
公开(公告)号：US08573898B2
公开(公告)日：2013-11-05
申请号：US13496209
申请日：2010-09-21
申请人： Christopher Peter Ralph Hill , Mark Kirby
发明人： Christopher Peter Ralph Hill , Mark Kirby
IPC分类号： B23C5/12 , B23C3/34
CPC分类号： B24B3/08 , B23C5/10 , B23C5/14 , B23C2210/084 , B23C2215/44 , B23C2220/366 , B23C2222/88 , B24B1/00 , B24B19/009 , B24B19/02 , Y10T407/1946 , Y10T407/1952 , Y10T407/1954 , Y10T407/196 , Y10T407/1964
摘要： A method of manufacturing a multi-tooth fir-tree or bulbous form milling cutter, by the grinding of a blank with a grinding wheel, wherein, a flat clearance angle Θ of between 0° and 20° is generated on each tooth (13) by the path (14) of the grinding wheel (10), with each tooth (13) having a width (X) from tip to point of maximum clearance (see FIG. 5), calculated as follows: —X={[(R tan Θ)cos Θ] cos Θ}±0.25% (being calculation (A)) where R=radius of cutter, and where Θ=clearance angle measured from a tangent to the tooth tip, and furthermore, wherein, each tooth (13) has a variable depth (Y) around the cutter, calculated as follows: —Y={[πD]/[180/Θ]}0.5±0.2. (being calculation (B)) where D=maximum diameter of the form at any given point along the form. The invention also includes fir tree and bulbous milling cutters produced by the above defined method.
摘要翻译：通过用砂轮研磨坯料来制造多齿枞树或球形铣刀的方法，其中在每个齿（13）上产生0°和20°之间的平坦间隙角度θta，通过砂轮（10）的路径（14），每个齿（13）具有从顶端到最大间隙（见图5）的宽度（X），如下计算：-X = {[（其中R =切割器的半径，其中Theta =从齿尖的切线测量的间隙角，此外，其中，每个齿（（R） 13）具有围绕刀具的可变深度（Y），其计算如下：-Y = {[piD] / [180 /θ] 0.5±0.2。（计算（B））其中D =在形式的任何给定点处的形式的最大直径。本发明还包括通过上述方法制造的枞树和球根铣刀。

2. 发明申请

US20090324347A1 MILLING CUTTER MANUFACTURING METHOD 有权
标题翻译：铣削切割机制造方法
公开(公告)号：US20090324347A1
公开(公告)日：2009-12-31
申请号：US12448696
申请日：2007-11-12
申请人： Mark Kirby , Christopher P.R. Hill
发明人： Mark Kirby , Christopher P.R. Hill
IPC分类号： B26D1/12 , B21K5/04
CPC分类号： B24B3/065 , B23C5/10 , B24B19/04 , Y10T82/10 , Y10T407/1946 , Y10T407/1958
摘要： A method of manufacturing a milling cutter having a cutting head and a coaxial integral shank comprising the steps of grinding, in a first grinding operation, a plurality of helical flutes (5) into the outer periphery of a cutter blank from a lead end (24) using a peripheral area (16) of a first grinding wheel (15) generally of frusto-conical profile and rotatable about an axis (18) generally transversely of the milling cutter axis (1), which peripheral area (16) produces, simultaneously, the following three features: a leading face (9) of a trailing tooth; a rear face (10) on an adjacent preceding tooth; and a swarf removal gullet (13) having divergent sides, grinding, in a second grinding operation, and using a peripheral edge (19) of a second grinding wheel (20), a relief face (11), which extends rearwardly from a leading end of a tooth tip, resulting in a minimum tooth wedge angle of approximately 60°, and grinding, in a third grinding operation, a radius (23) on the end of each flute. The invention also includes a milling cutter (1).
摘要翻译：一种制造具有切割头和同轴整体柄的铣刀的方法，包括以下步骤：在第一研磨操作中，将多个螺旋槽（5）从引导端（24）研磨到切割坯料的外周），其使用大致为截头圆锥形轮廓的第一砂轮（15）的周边区域（16），并且可围绕所述铣刀轴线（1）大致横向于所述铣刀轴线（1）的轴线（18）旋转，该周边区域（16）同时产生，以下三个特征：后齿的前导面（9）; 在相邻的前牙上的后表面（10）; 和具有发散侧面的切屑移除齿槽（13），在第二研磨操作中研磨，并且使用第二砂轮（20）的周边边缘（19），从第一研磨操作中向后延伸的浮雕面（11）齿尖的端部，产生大约60°的最小齿楔角度，并且在第三研磨操作中，研磨在每个凹槽的端部上的半径（23）。本发明还包括铣刀（1）。

3. 发明申请

US20080085528A1 GLUCOKINASE ACTIVITY ASSAYS FOR MEASURING KINETIC AND ACTIVATION PARAMETERS 审中-公开
标题翻译：用于测量动力学和激活参数的GLUCOKINASE活性测定
公开(公告)号：US20080085528A1
公开(公告)日：2008-04-10
申请号：US11869778
申请日：2007-10-10
申请人： Jovita Marcinkeviciene , Kevin O'Malley , Mark Kirby , Aiying Wang , Lisa Kopcho , Ramakrishna Seethala
发明人： Jovita Marcinkeviciene , Kevin O'Malley , Mark Kirby , Aiying Wang , Lisa Kopcho , Ramakrishna Seethala
IPC分类号： C12Q1/48 , C12Q1/54
CPC分类号： C12Q1/485 , C12Q1/54 , G01N33/60 , G01N2500/00
摘要： The subject matter disclosed and claimed herein relates to novel in vitro assays for measuring glucokinase activity and use of these assays for identifying modulators of glucokinase.
摘要翻译：本文公开和要求保护的主题涉及用于测量葡萄糖激酶活性的新型体外测定法和这些测定用于鉴别葡糖激酶的调节剂的用途。

4. 发明申请

US20050228021A1 Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods 审中-公开
标题翻译：基于金刚烷基甘氨酸的二肽基肽酶IV抑制剂及方法
公开(公告)号：US20050228021A1
公开(公告)日：2005-10-13
申请号：US11149414
申请日：2005-06-09
申请人： Lawrence Hamann , Ashish Khanna , Mark Kirby , David Magnin , Ligaya Simpkins , James Sutton , Jeffrey Robl
发明人： Lawrence Hamann , Ashish Khanna , Mark Kirby , David Magnin , Ligaya Simpkins , James Sutton , Jeffrey Robl
IPC分类号： C07C255/46 , C07C255/47 , C07D207/16 , C07D209/52 , C07D277/04 , C07D295/185 , A61K31/445 , A61K31/275 , A61K31/401 , A61K31/403 , A61K31/426
CPC分类号： C07C255/46 , C07C255/47 , C07C2601/08 , C07C2602/18 , C07C2603/74 , C07D207/16 , C07D209/52 , C07D277/04 , C07D295/185
摘要： Compounds are provided having the formula (I) wherein: n is 0, 1 or 2; m is 0, 1 or 2; the sum of n+m less then or equal to 2; the dashed bonds forming a cyclopropyl ring can only be present when Y is CH; X is H or CN; Y is CH, CH2, CHF, CF2, O, S, SO, or SO2; and A is adamantyl. Further provided are methods of using such compounds for the treatment of diabetes and related diseases, and to pharmaceutical compositions containing such compounds.
摘要翻译：提供具有式（I）的化合物，其中：n为0,1或2; m为0,1或2; n + m的和小于等于2; 当Y是CH时，形成环丙基环的虚线键只能存在; X是H或CN; Y是CH，CH 2 CH 2，CHF，CF 2 O，O，S，SO或SO 2。而A是金刚烷基。还提供了使用这些化合物治疗糖尿病和相关疾病的方法，以及含有这些化合物的药物组合物。

5. 发明申请

US20120170985A1 FORM MILLING CUTTER FOR THE MACHINING OF TITANIUM ALLOYS ETC 有权
标题翻译：用于加工钛合金的成型切割机等
公开(公告)号：US20120170985A1
公开(公告)日：2012-07-05
申请号：US13496209
申请日：2010-09-21
申请人： Christopher Peter Ralph Hill , Mark Kirby
发明人： Christopher Peter Ralph Hill , Mark Kirby
IPC分类号： B23C5/12 , B24B1/00 , B24B3/08 , B23C5/10
CPC分类号： B24B3/08 , B23C5/10 , B23C5/14 , B23C2210/084 , B23C2215/44 , B23C2220/366 , B23C2222/88 , B24B1/00 , B24B19/009 , B24B19/02 , Y10T407/1946 , Y10T407/1952 , Y10T407/1954 , Y10T407/196 , Y10T407/1964
摘要： A method of manufacturing a multi-tooth fir-tree or bulbous form milling cutter, by the grinding of a blank with a grinding wheel, wherein, a flat clearance angle Θ of between 0° and 20° is generated on each tooth (13) by the path (14) of the grinding wheel (10), with each tooth (13) having a width (X) from tip to point of maximum clearance (see FIG. 5), calculated as follows: X={[(RtanΘ)cosΘ]cosΘ}±0.25% (being calculation (A)) where R=radius of cutter, and where Θ=clearance angle measured from a tangent to the tooth tip, and furthermore, wherein, each tooth (13) has a variable depth (Y) around the cutter, calculated as follows: Y={[πD]/[180/Θ]} 0.5±0.2. (being calculation (B)) where D=maximum diameter of the form at any given point along the form. The invention also includes fir tree and bulbous milling cutters produced by the above defined method.
摘要翻译：通过用砂轮研磨坯料来制造多齿枞树或球形铣刀的方法，其中在每个齿（13）上产生0°和20°之间的平坦间隙角θ，通过磨轮（10）的路径（14），每个齿（13）具有从顶端到最大间隙（参见图5）的宽度（X），如下计算：X = {[（RtanΘ ）cosθ]cosθ}±0.25％（计算（A））其中R =切割器的半径，并且其中Θ=从与齿尖的切线测量的间隙角，此外，其中，每个齿（13）具有变量深度（Y），如下计算：Y = {[＆pgr; D] / [180 /Θ]} 0.5±0.2。（计算（B））其中D =在形式的任何给定点处的形式的最大直径。本发明还包括通过上述方法制造的枞树和球根铣刀。

6. 发明授权

US08286536B2 Milling cutter manufacturing method 有权
标题翻译：铣刀制造方法
公开(公告)号：US08286536B2
公开(公告)日：2012-10-16
申请号：US12448696
申请日：2007-11-12
申请人： Mark Kirby , Christopher P R Hill
发明人： Mark Kirby , Christopher P R Hill
IPC分类号： B23B1/00 , B23C5/00
CPC分类号： B24B3/065 , B23C5/10 , B24B19/04 , Y10T82/10 , Y10T407/1946 , Y10T407/1958
摘要： A method of manufacturing a milling cutter having a cutting head and a coaxial integral shank including grinding, in a first grinding operation, a plurality of helical flutes into the outer periphery of a cutter blank from a lead end using a peripheral area of a first grinding wheel generally of frusto-conical profile and rotatable about an axis generally transversely of the milling cutter axis, which peripheral area produces, simultaneously, the following three features: a leading face of a trailing tooth; a rear face on an adjacent preceding tooth; and a swarf removal gullet having divergent sides, grinding, in a second grinding operation, and using a peripheral edge of a second grinding wheel, a relief face, which extends rearwardly from a leading end of a tooth tip, resulting in a minimum tooth wedge angle of approximately 60°, and grinding, in a third grinding operation, a radius on the end of each flute.
摘要翻译：一种制造具有切割头和同轴整体柄的铣刀的方法，包括：在第一研磨操作中，使用第一研磨的周边区域，从多个螺旋槽从引线端磨削多个螺旋槽轮通常具有截头圆锥形轮廓，并且可围绕铣刀轴线大致横向的轴线旋转，该外围区域同时产生以下三个特征：后齿的前表面; 相邻前齿的后表面; 以及在第二研磨操作中具有发散侧，研磨的切屑齿槽，并且使用第二砂轮的周边边缘，其从齿尖的前端向后延伸，从而形成最小齿楔大约60°的角度，并且在第三研磨操作中研磨在每个凹槽的端部上的半径。

7. 外观设计

USD662529S1 Cutter 有权
公开(公告)号：USD662529S1
公开(公告)日：2012-06-26
申请号：US29389642
申请日：2011-04-14
申请人： Mark Kirby , Christopher Peter Ralph Hill
设计人： Mark Kirby , Christopher Peter Ralph Hill

8. 发明申请

US20050239839A1 Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods 审中-公开
公开(公告)号：US20050239839A1
公开(公告)日：2005-10-27
申请号：US11149408
申请日：2005-06-09
申请人： Lawrence Hamann , Ashish Khanna , Mark Kirby , David Magnin , Ligaya Simpkins , James Sutton , Jeffrey Robl
发明人： Lawrence Hamann , Ashish Khanna , Mark Kirby , David Magnin , Ligaya Simpkins , James Sutton , Jeffrey Robl
IPC分类号： C07C255/46 , C07C255/47 , C07D207/16 , C07D209/52 , C07D277/04 , C07D295/185 , A61K31/445 , A61K31/275 , A61K31/401 , A61K31/403 , A61K31/426
CPC分类号： C07C255/46 , C07C255/47 , C07C2601/08 , C07C2602/18 , C07C2603/74 , C07D207/16 , C07D209/52 , C07D277/04 , C07D295/185
摘要： Compounds are provided having the formula (I) wherein: n is 0, 1 or 2; m is 0, 1 or 2; the sum of n+m less then or equal to 2; the dashed bonds forming a cyclopropyl ring can only be present when Y is CH; X is H or CN; Y is CH, CH2, CHF, CF2, O, S, SO, or SO2; and A is adamantyl. Further provided are methods of using such compounds for the treatment of diabetes and related diseases, and to pharmaceutical compositions containing such compounds.

9. 外观设计

USD662115S1 Cutter 有权
公开(公告)号：USD662115S1
公开(公告)日：2012-06-19
申请号：US29402310
申请日：2011-09-22
申请人： Mark Kirby , Christopher Peter Ralph Hill
设计人： Mark Kirby , Christopher Peter Ralph Hill

10. 发明申请

US20080090113A1 ENHANCED SOLID OXIDE FUEL CELL SYSTEMS 审中-公开
标题翻译：增强固体氧化物燃料电池系统
公开(公告)号：US20080090113A1
公开(公告)日：2008-04-17
申请号：US11869555
申请日：2007-10-09
申请人： Bowie Keefer , Matthew Babicki , Mark Kirby
发明人： Bowie Keefer , Matthew Babicki , Mark Kirby
IPC分类号： H01M8/06
CPC分类号： H01M8/04007 , H01M8/0637 , H01M8/1231 , H01M8/2428 , H01M8/243 , H01M8/244 , Y02E60/566
摘要： Enhanced high temperature fuel cell systems, such as solid oxide fuel cell systems and molten carbonate fuel cell systems are disclosed. Embodiments of the disclosure include solid oxide and molten carbonate fuel cell systems incorporating gas separation apparati facilitating the recycle of hydrogen fuel from fuel cell anode exhaust for supply to the fuel cell anode inlet. Further embodiments of the disclosure include solid oxide and molten carbonate fuel cell systems incorporating inventive combinations of anode materials conducive to combination with enriched hydrogen fuel. Other embodiments of the disclosure include gas separation apparati for providing enriched oxygen feed to the cathode inlet of solid oxide and molten carbonate fuel cells.
摘要翻译：公开了增强的高温燃料电池系统，例如固体氧化物燃料电池系统和熔融碳酸盐燃料电池系统。本公开的实施方案包括固体氧化物和熔融碳酸盐燃料电池系统，其包括气体分离装置，其有助于将燃料电池阳极排气中的氢燃料循环供应到燃料电池阳极入口。本公开的另外的实施方案包括固体氧化物和熔融碳酸盐燃料电池系统，其结合有助于与富集氢燃料组合的阳极材料的本发明组合。本公开的其它实施方案包括气体分离装置，用于向固体氧化物和熔融碳酸盐燃料电池的阴极入口提供富集的氧气进料。

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