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1. 发明申请

US20060099709A1 Targeted tumor therapy by use of recombinant adenovirus vectors that selectively replicate in hypoxic regions of tumors 审中-公开
标题翻译：通过使用在肿瘤缺氧区选择性复制的重组腺病毒载体进行靶向肿瘤治疗
公开(公告)号：US20060099709A1
公开(公告)日：2006-05-11
申请号：US10529071
申请日：2003-10-01
申请人： Chuan-Yuan Li , Qian Huang , Mark Dewhirst
发明人： Chuan-Yuan Li , Qian Huang , Mark Dewhirst
IPC分类号： C12N15/861 , A61K48/00
CPC分类号： C12N15/86 , A61K35/761 , A61K38/2013 , A61K38/208 , A61K48/00 , A61K48/0058 , C07K14/4702 , C07K14/52 , C07K14/525 , C12N15/85 , C12N2710/10332 , C12N2710/10343 , C12N2710/10345 , C12N2830/002 , C12N2830/008 , C12N2830/15 , C12N2830/60 , C12N2830/85 , C12N2840/20
摘要： The presently claimed subject matter provides conditionally replication competent adenoviral vectors that confer selective cytotoxicity on cells expressing HIF-1 by infecting cells that allow HIF-1 inducible promoters present within the vectors to function. Also provided are compositions and host cells based upon the vectors, as well as methods of propagating and using the vectors. The presently claimed subject matter further provides a method of inhibiting tumor growth by co-infecting cells in a tumor with a conditionally replication competent adenovirus vector in conjunction with a replication deficient adenovirus vector.
摘要翻译：目前要求保护的主题提供了条件复制的腺病毒载体，其通过感染允许存在于载体内的HIF-1诱导型启动子起作用的细胞赋予表达HIF-1的细胞的选择性细胞毒性。还提供了基于载体的组合物和宿主细胞，以及传播和使用载体的方法。目前要求保护的主题还提供了通过与复制缺陷型腺病毒载体结合的条件复制型腺病毒载体共同感染肿瘤中的细胞来抑制肿瘤生长的方法。

2. 发明授权

US08946289B2 Manassatin compounds and methods of making and using the same 有权
标题翻译：马尼他化合物及其制备和使用方法
公开(公告)号：US08946289B2
公开(公告)日：2015-02-03
申请号：US13130237
申请日：2009-11-19
申请人： Jiyong Hong , Mark Dewhirst , Hyoungsu Kim , Amanda C. Kasper , Eui Jung Moon , Yongho Park , Ceshea M. Wooten
发明人： Jiyong Hong , Mark Dewhirst , Hyoungsu Kim , Amanda C. Kasper , Eui Jung Moon , Yongho Park , Ceshea M. Wooten
IPC分类号： C07D307/12 , A61K31/341 , A61K31/40 , C07D407/12
CPC分类号： A61K31/341 , A61K31/40 , C07D307/12 , C07D407/12
摘要： Provided are manassantin compounds and methods of using the compounds. Provided are methods of treating a disease, the method comprising administering a compound according to Formula I. Further provided are pharmaceutical compositions comprising compounds according to Formula I. Also provided are methods of inhibiting HIF-1 in a cell, the methods comprising administering to the cell a compound according to Formula I.
摘要翻译：提供芒那他啶化合物和使用该化合物的方法。本发明提供了治疗疾病的方法，所述方法包括给予式I化合物。还提供包含根据式I的化合物的药物组合物。还提供了抑制细胞中HIF-1的方法，所述方法包括向细胞根据式I的化合物。

3. 发明申请

US20130039929A1 METHOD TREATING BREAST CANCER 审中-公开
标题翻译：方法治疗乳腺癌
公开(公告)号：US20130039929A1
公开(公告)日：2013-02-14
申请号：US13642324
申请日：2011-04-19
申请人： Sudha Shenoy , Mark Dewhirst , Sang-Oh Han
发明人： Sudha Shenoy , Mark Dewhirst , Sang-Oh Han
IPC分类号： A61K31/713 , C07D401/04 , C07H21/02 , A61K39/395 , A61P35/00
CPC分类号： A61K31/70 , C07K16/18
摘要： The present invention relates, in general, to breast cancer and, in particular, to methods of treating breast cancer comprising administering to a subject in need thereof an agent that modulates signal transduction regulated by β-arrestin (e.g., β-arrestin 1). The invention further relates to methods of identifying compounds suitable for use in such methods.
摘要翻译：本发明一般涉及乳腺癌，特别涉及治疗乳腺癌的方法，其包括向有需要的受试者施用调节由α-淀粉蛋白调节的信号转导的药剂（例如，）。本发明还涉及鉴定适用于这些方法的化合物的方法。

4. 发明申请

US20110230540A1 MANASSATIN COMPOUNDS AND METHODS OF MAKING AND USING THE SAME 有权
标题翻译：麻黄碱化合物及其制备和使用方法
公开(公告)号：US20110230540A1
公开(公告)日：2011-09-22
申请号：US13130237
申请日：2009-11-19
申请人： Jiyong Hong , Mark Dewhirst , Hyoungsu Kim , Amanda C. Kasper , Eui Jung Moon , Yongho Park , Ceshea M. Wooten
发明人： Jiyong Hong , Mark Dewhirst , Hyoungsu Kim , Amanda C. Kasper , Eui Jung Moon , Yongho Park , Ceshea M. Wooten
IPC分类号： A61K31/40 , A61P35/00 , A61P35/02 , A61P9/10 , A61K31/341 , C07D307/12 , C12N5/00 , C12Q1/02 , C07D207/08
CPC分类号： A61K31/341 , A61K31/40 , C07D307/12 , C07D407/12
摘要： Provided are manassantin compounds and methods of using the compounds. Provided are methods of treating a disease, the method comprising administering a compound according to Formula I. Further provided are pharmaceutical compositions comprising compounds according to Formula I. Also provided are methods of inhibiting HIF-1 in a cell, the methods comprising administering to the cell a compound according to Formula I.
摘要翻译：提供芒那他啶化合物和使用该化合物的方法。本发明提供了治疗疾病的方法，所述方法包括给予式I化合物。还提供包含根据式I的化合物的药物组合物。还提供了抑制细胞中HIF-1的方法，所述方法包括向细胞根据式I的化合物。

5. 发明申请

US20080107637A1 Use of an agent that restores tissue perfusion and oxygenation 有权
公开(公告)号：US20080107637A1
公开(公告)日：2008-05-08
申请号：US12006842
申请日：2008-01-07
申请人： Mark Dewhirst , Jonathan Stamler , Timothy McMahon , Pierre Sonveaux
发明人： Mark Dewhirst , Jonathan Stamler , Timothy McMahon , Pierre Sonveaux
IPC分类号： A61K35/18 , A61K38/16 , A61K33/00 , A61P43/00 , A61K31/04
CPC分类号： A61K38/1709 , A61K31/21 , A61K33/00 , A61K35/18 , A61K38/00 , A61K38/42 , A61K45/06 , A61K47/08 , A61K47/16 , A61K47/6445 , A61K2300/00
摘要： The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects. In some embodiments, the presently disclosed methods involve administering to subjects in need thereof a first composition selected from the group consisting of a nitrosylated hemoglobin and an agent that induces nitrosylation of endogenous hemoglobin in the subject and a second composition comprising a hyperoxic gas. In some embodiments, the presently disclosed methods also include treating a tumor with radiation therapy, chemotherapy, photodynamic therapy, immunotherapy, or combinations thereof. Also provided are inhalable gases that can be employed in the presently disclosed methods.

6. 发明申请

US20070135373A1 Method for selective expression of therapeutic genes by hyperthermia 审中-公开
标题翻译：通过热疗选择性表达治疗性基因的方法
公开(公告)号：US20070135373A1
公开(公告)日：2007-06-14
申请号：US11602476
申请日：2006-11-20
申请人： Chuan-Yuan Li , Qian Huang , Mark Dewhirst
发明人： Chuan-Yuan Li , Qian Huang , Mark Dewhirst
IPC分类号： A61K48/00 , A61N1/39
CPC分类号： A61K38/191 , A61K38/208 , A61K48/00 , A61K48/0058 , C12N15/86 , C12N2710/10343 , C12N2830/002 , C12N2830/85 , C12N2840/203
摘要： A method for controlling in vivo heat-inducible gene expression for provision of therapeutic polypeptide. The method includes the steps of: (a) providing a construct comprising a polynucleotide encoding a therapeutic polypeptide, wherein the polynucleotide is operatively linked to a heat-inducible promoter; (b) administering the construct to a warm-blooded vertebrate at a site at or near the tumor; and (c) applying heat to the site at or near the tumor to express the therapeutic polypeptide, whereby anti-tumor activity is observed.
摘要翻译：用于控制体内热诱导基因表达以提供治疗性多肽的方法。该方法包括以下步骤：（a）提供包含编码治疗性多肽的多核苷酸的构建体，其中所述多核苷酸可操作地连接于热诱导型启动子; （b）将该构建体施用于在肿瘤处或其附近的部位的温血脊椎动物; 和（c）向肿瘤处或附近的部位施加热量以表达治疗性多肽，由此观察到抗肿瘤活性。

7. 发明申请

US20070197904A1 MRI imageable liposomes for the evaluation of treatment efficacy, thermal distribution, and demonstration of dose painting 失效
标题翻译： MRI可成像的脂质体用于评估治疗效果，热分布和剂量绘画的演示
公开(公告)号：US20070197904A1
公开(公告)日：2007-08-23
申请号：US11648148
申请日：2006-12-29
申请人： Benjamin Viglianti , Mark Dewhirst , Ana Ponce
发明人： Benjamin Viglianti , Mark Dewhirst , Ana Ponce
IPC分类号： A61B5/05
CPC分类号： G01R33/5601 , A61B5/055 , A61K9/1271 , A61K31/704 , A61K41/0028 , A61K49/1812 , A61K51/1234
摘要： Methods and compositions useful for detecting an in vivo blood pool, monitoring the distribution of a compound of interest to a desired site in an organism by magnetic resonance imaging, monitoring the accumulation of a compound of interest at a desired site in vivo by magnetic resonance imaging, and monitoring the release of liposomal contents to an external stimulus at a desired site in vivo by magnetic resonance imaging are disclosed. Some compositions comprise envirosensitive or non-sensitive liposomes. Contrast agents, such as manganese-based compounds, are also disclosed.
摘要翻译：用于检测体内血液池的方法和组合物，通过磁共振成像监测感兴趣的化合物到生物体中的所需位点的分布，通过磁共振成像在体内监测所需位点的目标化合物的积累并且通过磁共振成像来监测脂质体含量在体内所需位点处的外部刺激的释放。一些组合物包含环境敏感或非敏感脂质体。还公开了对比剂，例如锰基化合物。

8. 发明授权

US09023249B2 Adhesive bonding composition and method of use 有权
标题翻译：粘合剂组合物及其使用方法
公开(公告)号：US09023249B2
公开(公告)日：2015-05-05
申请号：US13102277
申请日：2011-05-06
申请人： Zakaryae Fathi , James Clayton , Harold Walder , Frederic A. Bourke, Jr. , Ian Stanton , Jennifer Ayres , Joshua T. Stecher , Michael Therien , Eric Toone , Dave Gooden , Mark Dewhirst , Joseph A. Herbert , Diane Fels , Katherine S. Hansen
发明人： Zakaryae Fathi , James Clayton , Harold Walder , Frederic A. Bourke, Jr. , Ian Stanton , Jennifer Ayres , Joshua T. Stecher , Michael Therien , Eric Toone , Dave Gooden , Mark Dewhirst , Joseph A. Herbert , Diane Fels , Katherine S. Hansen
IPC分类号： C09J4/00 , B41J2/175
CPC分类号： H01L24/83 , A61B17/0057 , A61L24/06 , B32B3/266 , B32B7/14 , B32B9/04 , B32B37/1284 , B32B37/18 , B32B38/0008 , B32B2037/1253 , B32B2457/00 , B32B2457/08 , B32B2457/14 , B41J2/17559 , C08K3/00 , C09J4/00 , C09J9/02 , C09J11/04 , C09J11/06 , C09J133/08 , C09K11/02 , C09K11/7769 , C09K11/777 , H01L23/5226 , H01L24/32 , H01L25/0657 , H01L25/50 , H01L2224/16225 , H01L2224/32225 , H01L2224/48091 , H01L2224/48227 , H01L2224/73204 , H01L2224/73253 , H01L2224/73265 , H01L2224/83192 , H01L2224/83855 , H01L2224/92125 , H01L2225/06524 , H01L2225/06589 , H01L2924/07811 , H01L2924/1461 , H01L2924/15311 , Y10T428/2852 , H01L2924/00014 , H01L2924/00
摘要： A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.
摘要翻译：可聚合组合物包括至少一种单体，当暴露于光时能够引发单体聚合的光引发剂和当暴露于辐射（通常为X射线）时能产生光的荧光体）。该材料特别适用于在外部光源不能接合接合点的情况下在环境温度下结合部件。相关方法包括：将可聚合粘合剂组合物，包括光引发剂和能量转换材料（例如下变换磷光体）与要结合的至少两种组分接触以形成组件; 并且能够将第一波长的辐射照射到组件上，该辐射能够转换（由荧光体进行下变频）到能够激活光引发剂的第二波长，以制备诸如喷墨墨盒，晶片到晶片组件，半导体，集成电路等。

9. 发明申请

US20120089180A1 ADHESIVE BONDING COMPOSITION AND METHOD OF USE 有权
标题翻译：胶粘剂组合物及其使用方法
公开(公告)号：US20120089180A1
公开(公告)日：2012-04-12
申请号：US13102277
申请日：2011-05-06
申请人： Zakaryae Fathi , James Clayton , Harold Walder , Frederic A. Bourke, JR. , Ian Stanton , Jennifer Ayres , Joshua T. Stecher , Michael Therien , Eric Toone , Dave Gooden , Mark Dewhirst , Joseph A. Herbert , Diane Fels , Katherine S. Hansen
发明人： Zakaryae Fathi , James Clayton , Harold Walder , Frederic A. Bourke, JR. , Ian Stanton , Jennifer Ayres , Joshua T. Stecher , Michael Therien , Eric Toone , Dave Gooden , Mark Dewhirst , Joseph A. Herbert , Diane Fels , Katherine S. Hansen
IPC分类号： A61B17/03 , G03F7/038 , C09D163/10 , H01B1/12 , C09D167/07 , G21K5/00 , B41J2/175 , H01L23/28 , B32B37/12 , B32B38/14 , B32B7/12 , C09D7/12 , C09D4/02 , B82Y30/00
CPC分类号： H01L24/83 , A61B17/0057 , A61L24/06 , B32B3/266 , B32B7/14 , B32B9/04 , B32B37/1284 , B32B37/18 , B32B38/0008 , B32B2037/1253 , B32B2457/00 , B32B2457/08 , B32B2457/14 , B41J2/17559 , C08K3/00 , C09J4/00 , C09J9/02 , C09J11/04 , C09J11/06 , C09J133/08 , C09K11/02 , C09K11/7769 , C09K11/777 , H01L23/5226 , H01L24/32 , H01L25/0657 , H01L25/50 , H01L2224/16225 , H01L2224/32225 , H01L2224/48091 , H01L2224/48227 , H01L2224/73204 , H01L2224/73253 , H01L2224/73265 , H01L2224/83192 , H01L2224/83855 , H01L2224/92125 , H01L2225/06524 , H01L2225/06589 , H01L2924/07811 , H01L2924/1461 , H01L2924/15311 , Y10T428/2852 , H01L2924/00014 , H01L2924/00
摘要： A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.
摘要翻译：可聚合组合物包括至少一种单体，当暴露于光时能够引发单体聚合的光引发剂和当暴露于辐射（通常为X射线）时能产生光的荧光体）。该材料特别适用于在外部光源不能接合接合点的情况下在环境温度下结合部件。相关方法包括：将可聚合粘合剂组合物，包括光引发剂和能量转换材料（例如下变换磷光体）与要结合的至少两种组分接触以形成组件; 并且能够将第一波长的辐射照射到组件上，该辐射能够转换（由荧光体进行下变频）到能够激活光引发剂的第二波长，以制备诸如喷墨墨盒，晶片到晶片组件，半导体，集成电路等。

10. 发明申请

US20080113901A1 Use of an agent that restores tissue perfusion and oxygenation 有权
标题翻译：使用恢复组织灌注和氧合的药物
公开(公告)号：US20080113901A1
公开(公告)日：2008-05-15
申请号：US12006849
申请日：2008-01-07
申请人： Mark Dewhirst , Jonathan Stamler , Timothy McMahon , Pierre Sonveaux
发明人： Mark Dewhirst , Jonathan Stamler , Timothy McMahon , Pierre Sonveaux
IPC分类号： A61K38/42 , A61P35/00
CPC分类号： A61K38/1709 , A61K31/21 , A61K33/00 , A61K35/18 , A61K38/00 , A61K38/42 , A61K45/06 , A61K47/08 , A61K47/16 , A61K47/6445 , A61K2300/00
摘要： The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects. In some embodiments, the presently disclosed methods involve administering to subjects in need thereof a first composition selected from the group consisting of a nitrosylated hemoglobin and an agent that induces nitrosylation of endogenous hemoglobin in the subject and a second composition comprising a hyperoxic gas. In some embodiments, the presently disclosed methods also include treating a tumor with radiation therapy, chemotherapy, photodynamic therapy, immunotherapy, or combinations thereof. Also provided are inhalable gases that can be employed in the presently disclosed methods.
摘要翻译：目前公开的主题提供了在受试者的组织的缺氧区域中增加灌注的方法。还提供了用于治疗受试者与缺氧相关的疾病和/或病症的方法，用于增加肿瘤对放射和/或化疗治疗的敏感性的方法，用于延迟受试者的肿瘤生长的方法，以及用于抑制受试者的肿瘤血管生长的方法。在一些实施方案中，本发明公开的方法包括向有需要的受试者施用选自亚硝基化血红蛋白和诱导受试者内源性血红蛋白亚硝基化的试剂的第一组合物和包含高氧气体的第二组合物。在一些实施方案中，本发明公开的方法还包括用放射治疗，化疗，光动力疗法，免疫治疗或其组合治疗肿瘤。还提供了可在本公开的方法中使用的可吸入气体。

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