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1. 发明申请

US20110306919A1 Selective Photostimulation to Induce Cell Proliferation 审中-公开
标题翻译：选择性光刺激诱导细胞增殖
公开(公告)号：US20110306919A1
公开(公告)日：2011-12-15
申请号：US12863281
申请日：2009-01-21
申请人： Mark A. Latina , Martin L. Yarmush
发明人： Mark A. Latina , Martin L. Yarmush
IPC分类号： A61M37/00 , A61N5/067 , A61N5/06
CPC分类号： A61N5/0613 , A61N2005/0659 , A61N2005/0662
摘要： The invention is based, at least in part, on the discovery that if a tissue is irradiated with a sublethal dose of radiation, e.g., from a laser, that pigmented cells in the tissue are selectively stimulated to proliferate and to produce higher levels of certain mitogenic factors and growth factors such as platelet derived growth factor (PDGF). In particular, the various parameters of a pulsed laser beam, such as power, pulse duration, total radiation energy (‘fluence’), wavelength, and if multiple pulses are used, the pulse rate and total number of pulses, are carefully selected and controlled to minimize killing the irradiated pigmented cells.
摘要翻译：本发明至少部分地基于以下发现：如果组织被照射来自激光的亚致死剂量的辐射，组织中的着色细胞被选择性刺激以增殖并产生更高水平的某些促有丝分裂因子和生长因子如血小板衍生生长因子（PDGF）。特别地，精确地选择脉冲激光束的各种参数，例如功率，脉冲持续时间，总辐射能量（“注量”），波长以及如果使用多个脉冲，则脉冲速率和总脉冲数被精心选择，控制以最小化杀死被照射的色素细胞。

2. 发明申请

US20110098692A1 SURGICAL LASER DEVICE UTILIZING A VISIBLE LASER DIODE 有权
标题翻译：使用可见激光二极管的外科激光器件
公开(公告)号：US20110098692A1
公开(公告)日：2011-04-28
申请号：US12906372
申请日：2010-10-18
申请人： Tarek A. Shazly , Mark A. Latina
发明人： Tarek A. Shazly , Mark A. Latina
IPC分类号： A61B18/20
CPC分类号： A61F9/008 , A61B2018/2025 , A61F9/00781
摘要： Systems, apparatuses, and methods for a compact surgical device include a laser unit and one or more laser outlet assemblies. The laser unit has a power regulator, one or more diode laser assemblies, each having a single diode laser source, and a laser trigger mechanism. The laser unit can emit an aiming light beam and a treatment laser beam either both from the same single diode laser or from two separate single diode lasers. The beam can pass through the one or more laser outlet assemblies. The aiming light beam can have a first energy level. The treatment laser beam can have a second energy level that is substantially greater than the first energy level of the aiming light beam.
摘要翻译：用于紧凑型手术装置的系统，装置和方法包括激光单元和一个或多个激光出口组件。激光单元具有功率调节器，一个或多个二极管激光器组件，每个具有单个二极管激光源和激光触发机构。激光单元可以从相同的单个二极管激光器或两个单独的单个二极管激光器发射瞄准光束和处理激光束。光束可以穿过一个或多个激光出口组件。瞄准光束可以具有第一能级。处理激光束可以具有基本上大于瞄准光束的第一能级的第二能级。

3. 发明授权

US08394076B2 Laser assisted therapeutic agent delivery into a targeted tissue 有权
标题翻译：激光辅助治疗剂递送到靶组织
公开(公告)号：US08394076B2
公开(公告)日：2013-03-12
申请号：US12436511
申请日：2009-05-06
申请人： Mark A. Latina
发明人： Mark A. Latina
IPC分类号： A61M31/00
CPC分类号： A61F9/008 , A61F9/0008 , A61F9/00821 , A61F2009/00863
摘要： The present invention involves selectively breaking down or altering a blocking tissue by irradiating the blocking tissue with a laser irradiation. Breaking down the blocking tissue allows the delivery of therapeutic agents through the blocking tissue to a target tissue. An area of the blocking tissue is selected for treatment. The selected area is irradiated with a laser to induce an alteration or breakdown of the blocking tissue. Areas not irradiated are not affected. Once the selected area of the blocking tissue is treated, a therapeutic agent can be delivered to the selected area and passed through the altered or broken down blocking tissue to the target tissue. The blocking tissue will then undergo a healing response after a period of time. The present invention may be used to treat the retina or subretinal space of a patient's eye through the blocking tissue of the Retinal Pigment Epithelium (RPE).
摘要翻译：本发明涉及通过用激光照射照射阻挡组织来选择性地分解或改变阻塞组织。打破阻断组织允许治疗剂通过阻断组织递送至靶组织。选择阻断组织的区域进行治疗。用激光照射所选择的区域以引起阻塞组织的改变或破坏。不照射的区域不受影响。一旦处理了阻断组织的选定区域，治疗剂可以被递送到所选择的区域并且通过改变或破坏的阻断组织到达目标组织。然后，一段时间后，阻塞性组织将经历愈合反应。本发明可用于通过视网膜色素上皮（RPE）的阻断组织治疗患者眼睛的视网膜或视网膜下腔。

4. 发明申请

US20090287138A1 LASER ASSISTED THERAPEUTIC AGENT DELIVERY INTO A TARGETED TISSUE 有权
标题翻译：激光辅助治疗药物分配到一个有针对性的组织
公开(公告)号：US20090287138A1
公开(公告)日：2009-11-19
申请号：US12436511
申请日：2009-05-06
申请人： Mark A. Latina
发明人： Mark A. Latina
IPC分类号： A61M37/00
CPC分类号： A61F9/008 , A61F9/0008 , A61F9/00821 , A61F2009/00863
摘要： The present invention involves selectively breaking down or altering a blocking tissue by irradiating the blocking tissue with a laser irradiation. Breaking down the blocking tissue allows the delivery of therapeutic agents through the blocking tissue to a target tissue. An area of the blocking tissue is selected for treatment. The selected area is irradiated with a laser to induce an alteration or breakdown of the blocking tissue. Areas not irradiated are not affected. Once the selected area of the blocking tissue is treated, a therapeutic agent can be delivered to the selected area and passed through the altered or broken down blocking tissue to the target tissue. The blocking tissue will then undergo a healing response after a period of time. The present invention may be used to treat the retina or subretinal space of a patient's eye through the blocking tissue of the Retinal Pigment Epithelium (RPE).
摘要翻译：本发明涉及通过用激光照射照射阻挡组织来选择性地分解或改变阻塞组织。打破阻断组织允许治疗剂通过阻断组织递送至靶组织。选择阻断组织的区域进行治疗。用激光照射所选择的区域以引起阻塞组织的改变或破坏。不照射的区域不受影响。一旦处理了阻断组织的选定区域，治疗剂可以被递送到所选择的区域并且通过改变或破坏的阻断组织到达目标组织。然后，一段时间后，阻塞性组织将经历愈合反应。本发明可用于通过视网膜色素上皮（RPE）的阻断组织治疗患者眼睛的视网膜或视网膜下腔。

5. 发明授权

US5549596A Selective laser targeting of pigmented ocular cells 失效
标题翻译：色素性眼细胞的选择性激光靶向
公开(公告)号：US5549596A
公开(公告)日：1996-08-27
申请号：US545887
申请日：1995-10-20
申请人： Mark A. Latina
发明人： Mark A. Latina
IPC分类号： A61B18/20 , A61F9/008 , A61F9/009 , A61B17/36
CPC分类号： A61F9/00821 , A61F9/008 , A61B2018/2075 , A61F2009/00868 , A61F2009/00891 , A61F9/009
摘要： A method of damaging pigmented intraocular cells, a patient with a disease, which involves selectively damaging pigmented cells in an intraocular area by irradiating the area with laser radiation of radiant exposure between about 0.01 and about 5 Joules/cm.sup.2, while sparing nonpigmented cells and collagenous structures within the irradiated area. The method is useful for the treatment of glaucoma, intraocular melanoma, and macular edema.
摘要翻译：一种损害色素性眼内细胞的方法，一种患有疾病的患者，其涉及通过以约0.01至约5焦耳/平方厘米的辐射暴露的激光辐射照射该区域来选择性地损伤眼内区域中的着色细胞，同时保留未着色的细胞和胶原照射区域内的结构。该方法可用于治疗青光眼，眼内黑素瘤和黄斑水肿。

6. 发明授权

US5025811A Method for focal destruction of eye tissue by electroablation 失效
标题翻译：通过电解消融对眼组织进行局灶性破坏的方法
公开(公告)号：US5025811A
公开(公告)日：1991-06-25
申请号：US480742
申请日：1990-02-16
申请人： Michael J. Dobrogowski , Mark A. Latina
发明人： Michael J. Dobrogowski , Mark A. Latina
IPC分类号： A61B18/12 , A61B18/14 , A61F9/007 , A61M3/02
CPC分类号： A61F9/00781 , A61B18/14 , A61B2018/1266 , A61F9/0079 , A61M3/0279
摘要： A non-invasive method for focal transcleral destruction of living human eye tissue. The method includes providing a conical-shaped probe, filled with a neutral saline solution and having inserted therein an electrode connected to the positive terminal of a constant current supply. The narrow aperture ends of the probe is lowered onto the conjunctiva overlying the target tissue, in about 20-30 locations with a current in the range from about 3.0-4.0 milliamps for about 30 seconds to 5 minutes at each location.
摘要翻译：一种用于活的人眼组织的聚焦超声破坏的非侵入性方法。该方法包括提供填充有中性盐溶液的锥形探针，并且在其中插入连接到恒定电流源的正端子的电极。在大约20-30个位置，探针的窄孔径端部被覆盖在覆盖目标组织的结膜上，电流范围为约3.0-4.0毫安，每个位置约30秒至5分钟。

7. 发明授权

US08574224B2 Surgical laser device utilizing a visible laser diode 有权
标题翻译：使用可见激光二极管的手术激光装置
公开(公告)号：US08574224B2
公开(公告)日：2013-11-05
申请号：US12906372
申请日：2010-10-18
申请人： Tarek A. Shazly , Mark A. Latina
发明人： Tarek A. Shazly , Mark A. Latina
IPC分类号： A61B18/20
CPC分类号： A61F9/008 , A61B2018/2025 , A61F9/00781
摘要： Systems, apparatuses, and methods for a compact surgical device include a laser unit and one or more laser outlet assemblies. The laser unit has a power regulator, one or more diode laser assemblies, each having a single diode laser source, and a laser trigger mechanism. The laser unit can emit an aiming light beam and a treatment laser beam either both from the same single diode laser or from two separate single diode lasers. The beam can pass through the one or more laser outlet assemblies. The aiming light beam can have a first energy level. The treatment laser beam can have a second energy level that is substantially greater than the first energy level of the aiming light beam.
摘要翻译：用于紧凑型手术装置的系统，装置和方法包括激光单元和一个或多个激光出口组件。激光单元具有功率调节器，一个或多个二极管激光器组件，每个具有单个二极管激光源和激光触发机构。激光单元可以从相同的单个二极管激光器或两个单独的单个二极管激光器发射瞄准光束和处理激光束。光束可以穿过一个或多个激光出口组件。瞄准光束可以具有第一能级。处理激光束可以具有基本上大于瞄准光束的第一能级的第二能级。

8. 发明授权

US5174304A Electrocycloablation apparatus and method 失效
标题翻译：电环化装置及方法
公开(公告)号：US5174304A
公开(公告)日：1992-12-29
申请号：US699157
申请日：1991-05-13
申请人： Mark A. Latina , Robert I. Park
发明人： Mark A. Latina , Robert I. Park
IPC分类号： A61B18/12 , A61B18/14 , A61F9/007 , A61M3/02
CPC分类号： A61F9/00781 , A61B18/14 , A61B2018/1266 , A61F9/0079 , A61M3/0279
摘要： Apparatus and non-invasive method for focal transcleral destruction of living human eye tissue. The apparatus includes a pair of conical-shaped probes, each probe filled with an ionic probe solution and having therein an electrode connected to a constant current supply. The method includes lowering the narrow aperture end of the probes onto the conjunctiva overlying the target tissue, each probe being approximately 90.degree. apart from the other about the eye surface. The probes of the invention have opposite polarity to enable transfer of ions between the probes. Electrodes are of appropriate conductive materials.
摘要翻译：用于聚焦超声破坏活体眼组织的装置和非侵入性方法。该装置包括一对锥形探针，每个探针填充有离子探针溶液，并且其中具有连接到恒流源的电极。该方法包括将探针的窄孔径端部降低到覆盖目标组织的结膜上，每个探针距眼睛表面大约90度。本发明的探针具有相反的极性，使得能够在探针之间传递离子。电极是适当的导电材料。

9. 发明授权

US07766480B1 Gonio lens with geometric reference 有权
标题翻译： Gonio镜头具有几何参考
公开(公告)号：US07766480B1
公开(公告)日：2010-08-03
申请号：US12505346
申请日：2009-07-17
申请人： Raymond D. Graham , Sungjun J. Hwang , Mark A. Latina
发明人： Raymond D. Graham , Sungjun J. Hwang , Mark A. Latina
IPC分类号： A61B3/00 , A61B3/10
CPC分类号： A61B3/117
摘要： A gonio lens is provided including a contact lens element and a geometric reference member. The contact lens element has an optical axis, a concave posterior contact surface to be placed in optical contact with the cornea of a patient's eye, and an anterior surface. The geometric reference member, such as a scale, is provided near the concave posterior contact surface of the contact lens element. The configuration and location of the geometric reference member are chosen to provide an image of the geometric reference member adjacent to an image of the periphery of the anterior chamber of the eye of a patient within a field of view of the contact lens element when the contact lens element is placed on the eye of a patient. The two images are formed relative to each other such that they are simultaneously in focus to permit visual comparison between the two.
摘要翻译：提供了包括接触透镜元件和几何参考构件的gonio透镜。隐形眼镜元件具有光轴，与眼睛的角膜光学接触的凹后接触面和前表面。在接触透镜元件的凹后接触表面附近提供诸如刻度的几何参考构件。选择几何参考构件的构造和位置，以在接触透镜元件的视场内提供与患者眼睛的前房的周边的图像相邻的几何参考构件的图像，当接触透镜元件放置在患者的眼睛上。这两个图像相对于彼此形成，使得它们同时聚焦以允许两者之间的视觉比较。

10. 发明授权

US5522837A Nasolacrimal duct occlusion device and method 失效
标题翻译：鼻泪管闭塞装置及方法
公开(公告)号：US5522837A
公开(公告)日：1996-06-04
申请号：US262002
申请日：1994-06-17
申请人： Mark A. Latina
发明人： Mark A. Latina
IPC分类号： A61B17/122 , A61F5/08 , A61F9/00 , A61F9/007
CPC分类号： A61B17/1227 , A61B17/122 , A61F5/08 , A61F9/0017 , A61F9/007 , A61F9/00772
摘要： A method and device for nasolacrimal duct occlusion during eye medication provides a device having a pair of joined legs terminating in angled elements for fitting into the medial canthal area and compressing the nasolacrimal ducts. The device is placed over the nasal bridge during, and for a short time after, eye medication.
摘要翻译：用于眼药物期间鼻泪管阻塞的方法和装置提供了一种装置，其具有终止于倾斜元件的一对连接的腿，用于装配到内侧手术区域并压缩鼻泪管。在此期间，在短时间内，将该装置置于鼻梁上，进行眼药物治疗。

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