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    • 1. 发明授权
    • System and method for independent control of for-hire vehicles
    • 租用车辆独立控制系统和方法
    • US09037852B2
    • 2015-05-19
    • US13225360
    • 2011-09-02
    • Michael Collins PinkusMark A. JamesJames Alan Wisniewski
    • Michael Collins PinkusMark A. JamesJames Alan Wisniewski
    • G06F21/00G07B13/00H04L29/08G07B15/00G07C5/08
    • G07B13/00G07B15/00G07C5/08G07C5/085H04L67/12
    • A computer system storing parameters pertaining to the regulatory restrictions placed on a for-hire vehicle compares the parameters to a current operating environment of the for-hire vehicle. In some embodiments, the computer system acts as the meter (such as a taximeter) of the for-hire vehicle. The operating parameters may include expiration or exclusion parameters that define the scope of operation of the for-hire vehicle stemming from the for-hire vehicle's medallion or certificate of public convenience and necessity. The expiration or exclusion parameters may also correspond to a driver's permit or any general regulation enacted by the regulatory agency. If the current operating environment does not comply with the expiration or exclusion parameters, the computer system shuts down, or enters a standby mode, and may not accept additional passenger fares until the current operating environment complies with the expiration and exclusion parameters.
    • 存储与放置在租用车辆上的监管限制有关的参数的计算机系统将参数与租用车辆的当前操作环境进行比较。 在一些实施例中,计算机系统用作租用车辆的计量器(例如计程表)。 操作参数可以包括到期或排除参数,其限定出租汽车徽章的出租车辆的操作范围或公共便利和必要性的证书。 过期或排除参数也可能对应于驾驶执照或监管机构制定的任何一般规定。 如果当前操作环境不符合到期或排除参数,则计算机系统将关闭或进入待机模式,并且在当前操作环境符合到期和排除参数之前可能不接受额外的乘客车费。
    • 2. 发明授权
    • Synthetic malarial antigens and uses thereof
    • 合成疟疾抗原及其用途
    • US5456911A
    • 1995-10-10
    • US3966
    • 1993-01-15
    • Mark A. JamesSonia Montenegro-James
    • Mark A. JamesSonia Montenegro-James
    • A61K39/00C07K14/445A61K39/015A61K38/08A61K38/16
    • C07K14/445A61K39/00
    • The present invention includes novel peptides GQDEGEENEG, SEQ. ID NO:1 GRNGLGANTDQDDQLEDE, SEQ. ID NO:2 DQFFDANPNLFQLLEPVEFDED, SEQ. ID NO:3 and LVFLVQQPFLFVLWDQNEKFPVFMGVYDP SEQ. ID NO:3. Such peptides are useful for detecting antibodies against circulating malarial antigens. In one aspect, these peptides may be copolymerized or crosslinked to form immunogens presenting epitopes of the malarial Plasmodium falciparum antigen Pf70. Preferably at least two of the above peptides are so crosslinked. Most preferably, all four peptides are copolymerized. The crosslinking agent preferred is glutaraldehyde although, of course, other crosslinking agents such as dialdehydes of various lengths, for example, or even possibly the carbodiimides may be used. Compositions of matter comprising such peptides in crosslinked or copolymerized forms are an important part of the present invention, particularly when used as immunogens. Rabbits have been immunized with a composition of the four crosslinked peptides at a dose of 2.5 mg (administered three times). An analogous dose for larger animals should, of course, produce the same response to induce immunity to malaria. The present invention also, of course, includes a method of producing an antigen usable to generate antibodies reacting with malarial organisms, Plasmodium falciparum and Plasmodium vivax. The above copolymerizing methodology utilizing crosslinking agents with the peptides of choice is the method of production.
    • 本发明包括新型肽GQDEGEENEG,SEQ。 ID NO:1 GRNGLGANTDQDDQLEDE,SEQ。 ID NO:2 DQFFDANPNLFQLLEPVEFDED,SEQ。 ID NO:3和LVFLVQQPFLFVLWDQNEKFPVFMGVYDP SEQ。 编号:3。 这样的肽可用于检测针对循环疟疾抗原的抗体。 一方面,这些肽可以共聚或交联以形成呈现疟原虫恶性疟原虫抗原Pf70的表位的免疫原。 优选地,至少两种上述肽是如此交联的。 最优选地,所有四种肽都是共聚的。 优选的交联剂是戊二醛,但是当然也可以使用其它交联剂,例如各种长度的二醛,甚至可能的碳二亚胺。 包含交联或共聚形式的这些肽的物质组合物是本发明的重要部分,特别是当用作免疫原时。 已经用2.5mg的剂量的四种交联肽的组合物(施用三次)免疫兔子。 对于较大的动物,类似的剂量当然应该产生相同的反应来诱导对疟疾的免疫。 本发明当然还包括产生可用于产生与疟疾生物,恶性疟原虫和间日疟原虫反应的抗原的抗原的方法。 使用交联剂与所选择的肽的上述共聚方法是生产方法。
    • 3. 发明申请
    • SYSTEM AND METHOD FOR INDEPENDENT CONTROL OF FOR-HIRE VEHICLES
    • 用于独立控制汽车的系统和方法
    • US20130061044A1
    • 2013-03-07
    • US13225360
    • 2011-09-02
    • Michael Collins PinkusMark A. JamesJames Alan Wisniewski
    • Michael Collins PinkusMark A. JamesJames Alan Wisniewski
    • G06F12/14H04L29/06G08B21/00
    • G07B13/00G07B15/00G07C5/08G07C5/085H04L67/12
    • A computer system storing parameters pertaining to the regulatory restrictions placed on a for-hire vehicle compares the parameters to a current operating environment of the for-hire vehicle. In some embodiments, the computer system acts as the meter (such as a taximeter) of the for-hire vehicle. The operating parameters may include expiration or exclusion parameters that define the scope of operation of the for-hire vehicle stemming from the for-hire vehicle's medallion or certificate of public convenience and necessity. The expiration or exclusion parameters may also correspond to a driver's permit or any general regulation enacted by the regulatory agency. If the current operating environment does not comply with the expiration or exclusion parameters, the computer system shuts down, or enters a standby mode, and may not accept additional passenger fares until the current operating environment complies with the expiration and exclusion parameters.
    • 存储与放置在租用车辆上的监管限制有关的参数的计算机系统将参数与租用车辆的当前操作环境进行比较。 在一些实施例中,计算机系统用作租用车辆的计量器(例如计程表)。 操作参数可以包括到期或排除参数,其限定出租汽车徽章的出租车辆的操作范围或公共便利和必要性的证书。 过期或排除参数也可能对应于驾驶执照或监管机构制定的任何一般规定。 如果当前操作环境不符合到期或排除参数,则计算机系统将关闭或进入待机模式,并且在当前操作环境符合到期和排除参数之前可能不接受额外的乘客车费。
    • 4. 发明申请
    • SYSTEMS AND METHODS FOR PAIRING OF FOR-HIRE VEHICLE METERS AND MEDALLIONS
    • 用于配对乘用车表和仪表的系统和方法
    • US20130060721A1
    • 2013-03-07
    • US13225352
    • 2011-09-02
    • Michael Collins PinkusMark A. James
    • Michael Collins PinkusMark A. James
    • G07B13/00G06F17/30G06F17/00
    • G07B13/00G07C5/008G07C5/08
    • For-hire vehicles, such as taxis, may operate with a for-hire vehicle meter (taximeter) and may be required to have a regulatory agency assigned medallion to accept passenger fares. The meter may determine if it is connected with its assigned medallion and may shut down if it is not connected to the proper medallion. In some embodiments, medallions may place conditions on the operation of the for-hire vehicle including, for example, time and location of passenger pick-up restrictions. Before engaging a passenger fare, the meter may check the conditions associated with the medallion and may not engage if the conditions are not satisfied. A central server may track the meters that have become disconnected from their medallions, or it may track the medallions that are not connected to a meter.
    • 出租车等租用车辆可以使用租用车辆表(计程车)进行操作,并可能需要有管理机构指定大奖章接受乘客票价。 仪表可以确定是否与其指定的大奖章相连,如果没有连接到适当的大奖章,则可能会关闭。 在一些实施例中,纪念章可以对租用车辆的操作设置条件,包括例如乘客接送限制的时间和位置。 在乘坐乘客车费之前,仪表可以检查与大奖章有关的条件,如果条件不满足,可能不会参与。 中央服务器可以跟踪已经与其纪念章断开连接的仪表,或者可以跟踪未连接到仪表的纪念章。