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1. 发明授权

US08470822B2 Folate mimetics and folate-receptor binding conjugates thereof 有权
标题翻译：叶酸模拟物和叶酸受体结合结合物
公开(公告)号：US08470822B2
公开(公告)日：2013-06-25
申请号：US12775824
申请日：2010-05-07
申请人： Mark A Green , Chun-Yen Ke , Christopher P Leamon
发明人： Mark A Green , Chun-Yen Ke , Christopher P Leamon
IPC分类号： A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495 , C07D475/00
CPC分类号： C07D475/04 , A61K31/519 , A61K51/0497
摘要： This present disclosure relates to folate mimetics and their use in therapeutic and diagnostic applications. More particularly, the disclosure relates to using des-glutamyl folic acid analogs recognized by and selectively bound by folate receptors and other folate binding proteins and the use of such analogs for targeted delivery of diagnostic or therapeutic agents to folate-receptor bearing cell populations.
摘要翻译：本公开内容涉及叶酸盐模拟物及其在治疗和诊断应用中的用途。更具体地，本公开涉及使用由叶酸受体和其他叶酸结合蛋白识别并选择性结合的去谷氨酰叶酸类似物，以及使用这种类似物用于将有依赖性的递送诊断或治疗剂用于携带叶酸受体的细胞群体。

2. 发明授权

US07875612B2 Folate mimetics and folate-receptor binding conjugates thereof 有权
标题翻译：叶酸模拟物和叶酸受体结合结合物
公开(公告)号：US07875612B2
公开(公告)日：2011-01-25
申请号：US10475876
申请日：2002-04-24
申请人： Mark A. Green , Chun-Yen Ke , Christopher P. Leamon
发明人： Mark A. Green , Chun-Yen Ke , Christopher P. Leamon
IPC分类号： A01N43/64 , A01N43/58 , A01N43/60 , A01N43/90 , A61K31/53 , A61K31/50 , A61K31/495 , A61K31/519 , C07D253/08 , C07D487/00 , C07D475/00
CPC分类号： C07D475/04 , A61K31/519 , A61K51/0497
摘要： A cell population expressing folate receptors is selectively targeted with a non-peptide folic acid analogue. The non-peptide folic acid analogue is conjugated to a diagnostic or therapeutic agent to enable selective delivery of the agent to the targeted cell population.
摘要翻译：表达叶酸受体的细胞群体选择性地用非肽叶酸类似物靶向。非肽叶酸类似物与诊断或治疗剂缀合以使得药剂能够选择性递送至靶细胞群体。

3. 发明授权

US07114028B1 Method of automatically formatting and pseudo-mounting a removable media 有权
标题翻译：自动格式化和伪装可移动媒体的方法
公开(公告)号：US07114028B1
公开(公告)日：2006-09-26
申请号：US10340175
申请日：2003-01-09
申请人： Mark A. Green , Dennis M. Summers , Gregory P. Fry , David A. Coleman , Carl Fry
发明人： Mark A. Green , Dennis M. Summers , Gregory P. Fry , David A. Coleman , Carl Fry
IPC分类号： G06F12/00 , G11B27/36
CPC分类号： G11B20/1217 , G06F3/0605 , G06F3/0632 , G06F3/0644 , G06F3/0677 , G11B20/10 , G11B2220/2537
摘要： An invention is disclosed for automatically formatting removable media. A default media image is generated in computer memory in response to detecting unformatted media in a computer drive. The media image includes default file system structures for the media. In response to receiving a request to read the media, data is returned based on the default file system structures. However, the removable media is automatically prepared for content in response to receiving a request to write information to the media, wherein the default media image in memory is committed to the media.
摘要翻译：公开了一种用于自动格式化可移除介质的发明。响应于在计算机驱动器中检测到未格式化的介质，在计算机存储器中生成默认媒体图像。媒体图像包括媒体的默认文件系统结构。响应于接收到读取媒体的请求，基于默认文件系统结构返回数据。然而，响应于接收到向介质写入信息的请求，可移动介质被自动准备用于内容，其中存储器中的默认媒体图像被提交给媒体。

4. 发明授权

US5517494A Method and system of multicast routing for groups with a single transmitter 失效
标题翻译：具有单个发射机的组播组播路由方法和系统
公开(公告)号：US5517494A
公开(公告)日：1996-05-14
申请号：US316081
申请日：1994-09-30
申请人： Mark A. Green
发明人： Mark A. Green
IPC分类号： H04L12/18 , H04L12/46 , H04L12/56
CPC分类号： H04L12/185
摘要： A method of implementing a multicast routing protocol in routers is provided to manage the assignment of multicast transport addresses and to forward data from a single transmitting endpoint to multiple receiving endpoints. This method in conjunction with a method for implementing the multicast routing protocol as a transport protocol layer service for endpoints provides an internet wide multicast transport service. The multicast transport service provides the capability of transmitting data from a single source to multiple receivers on interconnected networks efficiently and without having to send duplicate copies of the data on any single network. Routers and endpoints transmit and receive multicast packets in a manner which is independent of the network layer datagram protocols used by the multicast transport service. Multicast control packets are exchanged using a multicast transaction protocol which allows routers and endpoints to execute transactions in a manner that does not require either routers to know the state of specific endpoints or endpoints to know the state of specific routers.
摘要翻译：提供了一种在路由器中实现多播路由协议的方法，用于管理组播传输地址的分配，并将数据从单个发送端点转发到多个接收端点。该方法结合用于实现作为端点的传输协议层服务的多播路由协议的方法提供了一种互联网广播组播传输服务。多播传输服务提供了将数据从单个源传输到互连网络上的多个接收器的能力，而无需在任何单个网络上发送数据的重复副本。路由器和端点以独立于组播传输服务使用的网络层数据报协议的方式发送和接收组播数据包。组播控制分组使用多播交易协议进行交换，该协议允许路由器和端点以不要求路由器知道特定端点或端点的状态以知道特定路由器的状态的方式执行事务。

5. 发明授权

US5561670A Method and apparatus for operating a multicast system on an unreliable network 失效
公开(公告)号：US5561670A
公开(公告)日：1996-10-01
申请号：US242138
申请日：1994-05-13
申请人： Eric M. Hoffert , Mark A. Green
发明人： Eric M. Hoffert , Mark A. Green
IPC分类号： H04L12/18 , H04L29/06 , H04N21/236 , H04N21/434 , H04J3/12 , H04L12/56 , H04N7/08
CPC分类号： H04L65/4076 , H04L12/1868 , H04L29/06 , H04L65/604 , H04N21/236 , H04N21/434 , H04L29/06027
摘要： A multicast network system comprises a data network which provides a medium for data transfer. A media source having a control packet and media packets coupled to the data network broadcasts the control packet and the media packets to the data network and rebroadcasts the control packet in conjunction with the media packets to the data network. A media receiver is coupled to the network and receives the control packet and the media packets from the data network to process the control packet and the media packets to produce a media output.

6. 发明授权

US07117230B1 Method and apparatus for formatting and initialization of re-writable optical media using multiple tracks 有权
标题翻译：用于使用多个轨道格式化和初始化可重写光学介质的方法和装置
公开(公告)号：US07117230B1
公开(公告)日：2006-10-03
申请号：US10193422
申请日：2002-07-10
申请人： Mark A. Green , Chris M. Bellman
发明人： Mark A. Green , Chris M. Bellman
IPC分类号： G06F12/00
CPC分类号： G11B27/034 , G11B20/1217 , G11B27/322 , G11B2020/1235 , G11B2020/1267 , G11B2020/1277 , G11B2020/1288 , G11B2220/216 , G11B2220/2537 , Y10S707/99943
摘要： A software-driven method for the initialization of re-writable optical media is provided. Embodiments include a software-driven method for the formatting of re-writable optical media to include defining a file system and writing a UDF reader to the optical media to enable implementation on a plurality of optical media devices in a plurality of operating system environments. The re-writable optical media is initialized using either user data or initialization patterns in a background operation to allow user interaction with the optical media during initialization. Methods are provided for multi-track capabilities of the optical media. Prior to initialization of the entire media space of an optical media, a session can be closed to enable compatibility of a partially initialized media in a ROM device. Further methods are provided to re-open a closed session to complete initialization of the media space.
摘要翻译：提供了一种用于初始化可重写光学介质的软件驱动方法。实施例包括用于格式化可重写光学介质的软件驱动方法，以包括定义文件系统并将UDF读取器写入光学介质以使得能够在多个操作系统环境中的多个光学介质设备上实现。可重写光学介质在背景操作中使用用户数据或初始化模式进行初始化，以允许用户在初始化期间与光学介质进行交互。提供了用于光学介质的多轨能力的方法。在光学介质的整个媒体空间的初始化之前，可以关闭会话以实现ROM设备中部分初始化的媒体的兼容性。提供了进一步的方法来重新打开封闭的会话以完成媒体空间的初始化。

7. 发明授权

US5894480A Method and apparatus for operating a multicast system on an unreliable network 失效
标题翻译：用于在不可靠网络上操作多播系统的方法和装置
公开(公告)号：US5894480A
公开(公告)日：1999-04-13
申请号：US946892
申请日：1997-10-08
申请人： Eric M. Hoffert , Mark A. Green
发明人： Eric M. Hoffert , Mark A. Green
IPC分类号： H04L12/56 , H04Q11/04 , H04J3/12 , H04N7/08
CPC分类号： H04Q11/0478 , H04L2012/5627 , H04L2012/5638 , H04L2012/5642
摘要： A multicast network system comprises a data network which provides a medium for data transfer. A media source having a control packet and media packets coupled to the data network broadcasts the control packet and the media packets to the data network and rebroadcasts the control packet in conjunction with the media packets to the data network. A media receiver is coupled to the network and receives the control packet and the media packets from the data network to process the control packet and the media packets to produce a media output.
摘要翻译：组播网络系统包括提供用于数据传输的介质的数据网络。具有控制分组和耦合到数据网络的媒体分组的媒体源将控制分组和媒体分组广播到数据网络，并将控制分组与媒体分组重新广播到数据网络。媒体接收器耦合到网络并且从数据网络接收控制分组和媒体分组以处理控制分组和媒体分组以产生媒体输出。

8. 外观设计

USD366171S Toothbrush holding device for a toothpaste canister 失效
公开(公告)号：USD366171S
公开(公告)日：1996-01-16
申请号：US34208
申请日：1995-01-30
申请人： Mark A. Green
设计人： Mark A. Green

9. 发明授权

US5324502A Radiopharmaceuticals for imaging the heart 失效
标题翻译：用于成像心脏的放射性药物
公开(公告)号：US5324502A
公开(公告)日：1994-06-28
申请号：US861778
申请日：1992-04-02
申请人： Mark A. Green , Brenda W. Tsang
发明人： Mark A. Green , Brenda W. Tsang
IPC分类号： A61K51/04 , C07B59/00 , C07C251/24 , C07D233/02 , C07D295/13 , A61K49/02 , A61K43/00
CPC分类号： C07D295/13 , A61K51/0478 , C07B59/001 , C07B59/002 , C07C251/24 , C07D233/02 , A61K2123/00
摘要： Radiopharmaceuticals for imaging myocardial tissues are prepared by forming lipophilic, cationic complexes of radioactive metal ions with metal chelating ligands comprising the Schiff base adducts of triamines and tetraamines with optionally substituted salicylaldehydes. The lipophilic, cationic, radioactive complexes of the invention exhibit high uptake and retention in myocardial tissues. Preferred gallium-68(III) complexes in accordance with this invention can be used to image the heart using positron emission tomography.
摘要翻译：用于成像心肌组织的放射性药物通过形成放射性金属离子的亲脂性阳离子配合物与金属螯合配体来制备，金属螯合配体包含三胺和四胺的席夫碱加成物与任选取代的水杨醛。本发明的亲脂性，阳离子，放射性复合物在心肌组织中表现出高吸收和保留。可以使用根据本发明的优选镓-68（III）复合物来使用正电子发射断层摄影来对心脏进行成像。

10. 发明申请

US20110028714A1 FOLATE MIMETICS AND FOLATE-RECEPTOR BINDING CONJUGATES THEREOF 有权
标题翻译： FOLATE与其结合的物质和功能受体结合
公开(公告)号：US20110028714A1
公开(公告)日：2011-02-03
申请号：US12775824
申请日：2010-05-07
申请人： Mark A. Green , Chun-Yen Ko , Christopher P. Leamon
发明人： Mark A. Green , Chun-Yen Ko , Christopher P. Leamon
IPC分类号： C07D475/04
CPC分类号： C07D475/04 , A61K31/519 , A61K51/0497
摘要： A cell population expressing folate receptors is selectively targeted with a folate mimetic. The folate mimetic is conjugated to a diagnostic or therapeutic agent to enable selective delivery of the agent to the targeted cell population.
摘要翻译：表达叶酸受体的细胞群体选择性地用叶酸盐模拟物靶向。叶酸酯模拟物与诊断或治疗剂缀合以使得药剂能够选择性递送至靶细胞群体。

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