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1. 发明授权

US06878749B2 Method of treating metabolic disorders, especially diabetes, or a disease or condition associated with diabetes 失效
标题翻译：治疗代谢紊乱，特别是糖尿病或与糖尿病有关的疾病或病症的方法
公开(公告)号：US06878749B2
公开(公告)日：2005-04-12
申请号：US10345908
申请日：2003-01-16
申请人： Marjorie Regan Gatlin , Michele Ann Ball , Richard Owen Mannion , Anees Abdulquadar Karnachi , Christiane Guitard , Malcolm Allison
发明人： Marjorie Regan Gatlin , Michele Ann Ball , Richard Owen Mannion , Anees Abdulquadar Karnachi , Christiane Guitard , Malcolm Allison
IPC分类号： A61K9/20 , A61K31/195 , A61K31/198 , A61K31/425 , A61K31/44 , A61K31/64 , A61K31/13 , A61K31/70 , A61K31/715
CPC分类号： A61K31/425 , A61K9/2054 , A61K9/2077 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/44 , A61K31/64 , A61K31/717 , A61K2300/00
摘要： The invention relates to a combination, such as a combined preparation or pharmaceutical composition, respectively, which comprises nateglinide (1) stet or repaglinide and at least one other antidiabetic compound selected from the group consisting of thiazolidinedione derivatives (glitazones), sulfonyl urea derivatives and metformin for simultaneous, separate or sequential use in the prevention, delay of progression or treatment of diseases, especially metabolic disorders and in particular type 2 diabetes and diseases and conditions associated with diabetes; to a composition, respectively, which comprises nateglinide and a pharmaceutically acceptable carrier and to a process of making such composition; the use of such combination or composition for the preparation of a medicament for the prevention, delay of progression or treatment of metabolic disorders; a method of prevention, delay of progression or treatment of diseases in warm-blooded animals; the use of such combination or composition for the cosmetic treatment of a mammal in order to effect a cosmetically beneficial loss of body weight; and to a method of improving the bodily appearance of a warm-blooded animal.
摘要翻译：本发明涉及一种组合，例如组合制剂或药物组合物，其分别包含那格列奈（1）脊髓瑞格列奈和至少一种选自噻唑烷二酮衍生物（格列酮），磺酰脲衍生物和二甲双胍的其他抗糖尿病化合物用于预防，延迟进展或治疗疾病，特别是代谢紊乱，特别是2型糖尿病和与糖尿病相关的疾病和病症的同时，单独或顺序使用; 涉及包含那格列奈和药学上可接受的载体的组合物和制备该组合物的方法; 使用这种组合或组合物来制备用于预防，延缓进展或治疗代谢紊乱的药物; 一种预防，延缓进展或治疗温血动物疾病的方法; 使用这样的组合或组合物来进行化妆品处理哺乳动物以实现美容上有益的体重损失; 以及改善温血动物的身体外观的方法。

2. 发明授权

US06559188B1 Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes 失效
标题翻译：治疗代谢障碍，特别是糖尿病或与糖尿病有关的疾病或病症的方法
公开(公告)号：US06559188B1
公开(公告)日：2003-05-06
申请号：US09663264
申请日：2000-09-15
申请人： Marjorie Regan Gatlin , Michele Ann Ball , Richard Owen Mannion , Anees Abdulquadar Karnachi , Christiane Guitard , Malcolm Allison
发明人： Marjorie Regan Gatlin , Michele Ann Ball , Richard Owen Mannion , Anees Abdulquadar Karnachi , Christiane Guitard , Malcolm Allison
IPC分类号： A61K3113
CPC分类号： A61K31/198 , Y10S514/866
摘要： The invention relates to a combination, such as a combined preparation or pharmaceutical composition, respectively, which comprises nateglinide (I) or repaglinide and at least one other antidiabetic compound selected from the group consisting of thiazolidinedione derivatives (glitazones), sulfonyl urea derivatives and metformin for simultaneous, separate or sequential use in the prevention, delay of progression or treatment of diseases, especially metabolic disorders and in particular type 2 diabetes and diseases and conditions associated with diabetes; to a composition, respectively, which comprises nateglinide and a pharmaceutically acceptable carrier and to a process of making such composition; the use of such combination or composition for the preparation of a medicament for the prevention, delay of progression or treatment of metabolic disorders; a method of prevention, delay of progression or treatment of diseases in warm-blooded animals; the use of such combination or composition for the cosmetic treatment of a mammal in order to effect a cosmetically beneficial loss of body weight; and to a method of improving the bodily appearance of a warm-blooded animal.
摘要翻译：本发明涉及分别包含那格列奈（I）或瑞格列奈和至少一种选自噻唑烷二酮衍生物（格列酮），磺酰脲衍生物和二甲双胍的其他抗糖尿病化合物的组合，例如组合制剂或药物组合物用于预防，延迟进展或治疗疾病，特别是代谢紊乱，特别是2型糖尿病和与糖尿病相关的疾病和病症的同时，单独或顺序使用; 涉及包含那格列奈和药学上可接受的载体的组合物和制备该组合物的方法; 使用这种组合或组合物来制备用于预防，延缓进展或治疗代谢紊乱的药物; 一种预防，延缓进展或治疗温血动物疾病的方法; 使用这样的组合或组合物来进行化妆品处理哺乳动物以实现美容上有益的体重损失; 以及改善温血动物的身体外观的方法。

3. 发明申请

US20100076084A1 Method of Treating Metabolic Disorders, Especially Diabetes, or a Disease or Condition Associated with Diabetes 审中-公开
标题翻译：治疗代谢紊乱，特别是糖尿病或与糖尿病有关的疾病或病症的方法
公开(公告)号：US20100076084A1
公开(公告)日：2010-03-25
申请号：US12624976
申请日：2009-11-24
申请人： Marjorie Regan Gatlin , Michele Ann Ball , Richard Owen Mannion , Anees Abdulquadar Karnachi , Christiane Guitard , Malcolm Allison
发明人： Marjorie Regan Gatlin , Michele Ann Ball , Richard Owen Mannion , Anees Abdulquadar Karnachi , Christiane Guitard , Malcolm Allison
IPC分类号： A61K31/165 , A61P3/10
CPC分类号： A61K31/425 , A61K9/2054 , A61K9/2077 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/44 , A61K31/64 , A61K31/717 , A61K2300/00
摘要： The invention relates to a combination, such as a combined preparation or pharmaceutical composition, respectively, which comprises nateglinide (I) or repaglinide and at least one other antidiabetic compound selected from the group consisting of thiazolidinedione derivatives (glitazones), sulfonyl urea derivatives and metformin for simultaneous, separate or sequential use in the prevention, delay of progression or treatment of diseases, especially metabolic disorders and in particular type 2 diabetes and diseases and conditions associated with diabetes; to a composition, respectively, which comprises nateglinide and a pharmaceutically acceptable carrier and to a process of making such composition; the use of such combination or composition for the preparation of a medicament for the prevention, delay of progression or treatment of metabolic disorders; a method of prevention, delay of progression or treatment of diseases in warm-blooded animals; the use of such combination or composition for the cosmetic treatment of a mammal in order to effect a cosmetically beneficial loss of body weight; and to a method of improving the bodily appearance of a warm-blooded animal.
摘要翻译：本发明涉及分别包含那格列奈（I）或瑞格列奈和至少一种选自噻唑烷二酮衍生物（格列酮），磺酰脲衍生物和二甲双胍的其他抗糖尿病化合物的组合，例如组合制剂或药物组合物用于预防，延迟进展或治疗疾病，特别是代谢紊乱，特别是2型糖尿病和与糖尿病相关的疾病和病症的同时，单独或顺序使用; 涉及包含那格列奈和药学上可接受的载体的组合物和制备该组合物的方法; 使用这种组合或组合物来制备用于预防，延缓进展或治疗代谢紊乱的药物; 一种预防，延缓进展或治疗温血动物疾病的方法; 使用这样的组合或组合物来进行化妆品处理哺乳动物以实现美容上有益的体重损失; 以及改善温血动物的身体外观的方法。

4. 发明申请

US20090131404A1 Combinations 审中-公开
标题翻译：组合
公开(公告)号：US20090131404A1
公开(公告)日：2009-05-21
申请号：US12290106
申请日：2008-10-27
申请人： Malcolm Allison , Marjorie Regan Gatlin
发明人： Malcolm Allison , Marjorie Regan Gatlin
IPC分类号： A61K31/55 , A61K31/165 , A61P3/04 , A61K31/404
CPC分类号： A61K45/06
摘要： The present invention relates to a combination, especially a pharmaceutical composition, comprising (a) an insulin secretion enhancer or a pharmaceutically acceptable salt thereof and (b) at least one of the active ingredients selected from the group consisting of (i) HMG-Co-A reductase inhibitors or a pharmaceutically acceptable salt thereof; and (ii) ACE inhibitors or a pharmaceutically acceptable salt thereof; and, in case of a pharmaceutical composition, a pharmaceutically acceptable carrier.
摘要翻译：本发明涉及一种组合，特别是药物组合物，其包含（a）胰岛素分泌增强剂或其药学上可接受的盐和（b）至少一种选自（i）HMG-Co -A还原酶抑制剂或其药学上可接受的盐; 和（ii）ACE抑制剂或其药学上可接受的盐; 并且在药物组合物的情况下，为药学上可接受的载体。

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