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1. 发明申请

US20090062375A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF VIRAL DISEASES 审中-公开
标题翻译：用于治疗病毒性疾病的方法和组合
公开(公告)号：US20090062375A1
公开(公告)日：2009-03-05
申请号：US11914941
申请日：2006-05-19
申请人： Francisco Veas , Dorothee Misse , Dorothy Bray , Mario Clerici
发明人： Francisco Veas , Dorothee Misse , Dorothy Bray , Mario Clerici
IPC分类号： A61K31/38 , A61P43/00
CPC分类号： A61K31/00 , Y02A50/385
摘要： The invention provides a method of treating viral haemorrhagic fevers, such as that caused by Dengue virus, which comprises administering a composition comprising a pharmaceutically active amount of a matrix metalloproteinase inhibitor.
摘要翻译：本发明提供了一种治疗由登革热病毒引起的病毒性出血热的方法，其包括施用包含药物活性量的基质金属蛋白酶抑制剂的组合物。

2. 发明授权

US5344755A Method for detecting immune system dysfunction in asymptomatic, HIV-scropositive individuals 失效
标题翻译：检测无症状HIV阳性个体的免疫系统功能障碍的方法
公开(公告)号：US5344755A
公开(公告)日：1994-09-06
申请号：US535407
申请日：1990-06-08
申请人： Gene M. Shearer , Ronald E. Gress , Mario Clerici , Philip J. Lucas , Charles S. Via
发明人： Gene M. Shearer , Ronald E. Gress , Mario Clerici , Philip J. Lucas , Charles S. Via
IPC分类号： A61K39/00 , G01N33/53 , G01N33/569 , G01N33/68
CPC分类号： G01N33/56988 , G01N33/56977 , G01N33/6869 , Y10S435/81 , Y10S435/974 , Y10S435/975
摘要： A sensitive and accurate tissue culture system and kit for detecting subtle changes in immune function is provided. The system is based on the comparison of IL-2 production by T helper cells in response to recall antigens including influenza A virus, tatanus toxoid, alloantigens, mouse xenogeneic antigens and the like or combinations thereof. Different stages of immune dysfunction can be differentiated and organ graft rejection can be predicted by the method of the present invention.
摘要翻译：提供了一种灵敏准确的组织培养系统和用于检测免疫功能微小变化的试剂盒。该系统是基于T辅助细胞对回归抗原（包括甲型流感病毒，tat类毒素，同种异体抗原，小鼠异种抗原等）或其组合的响应抗原的IL-2产生的比较。可以分化不同阶段的免疫功能障碍，并且可以通过本发明的方法预测器官移植排斥反应。

3. 发明授权

US4701428A Catalyst of silicon and titanium having high mechanical strength and a process for its preparation. 失效
标题翻译：具有高机械强度的硅和钛催化剂及其制备方法。
公开(公告)号：US4701428A
公开(公告)日：1987-10-20
申请号：US854890
申请日：1986-04-23
申请人： Giuseppe Bellussi , Franco Buonomo , Antonio Esposito , Mario Clerici , Ugo Romano , Bruno Notari
发明人： Giuseppe Bellussi , Franco Buonomo , Antonio Esposito , Mario Clerici , Ugo Romano , Bruno Notari
IPC分类号： B01J29/89 , C07C37/60 , C07D301/12 , C07D303/04 , B01J21/06 , B01J35/08
CPC分类号： C07D303/04 , B01J29/89 , C07C37/60 , C07C41/26 , C07D301/12
摘要： The invention discloses a catalyst on the basis of silicon and titanium having the form of microspheres and constituted by oligomeric silica and by titanium-silicalite crystals having an oligomeric silica/titanium-silicalite molar ratio comprised within the range of from 0.05 to 0.11, wherein the crystals of titanium-silicalite are encaged by means of Si-O-Si bridges.
摘要翻译：本发明公开了一种基于硅和钛的催化剂，其具有微球的形式，由低聚二氧化硅和钛 - 硅沸石晶体组成，其中低硅石/钛 - 硅沸石摩尔比在0.05至0.11的范围内，其中钛硅质岩的晶体通过Si-O-Si桥结合。

4. 发明授权

US4833211A Process for the preparation of solid polymeric stabilizer compounds 失效
标题翻译：固体高分子稳定剂化合物的制备方法
公开(公告)号：US4833211A
公开(公告)日：1989-05-23
申请号：US19881
申请日：1987-02-27
申请人： Arnaldo Roggero , Mario Clerici , Guglielmo Bertolini
发明人： Arnaldo Roggero , Mario Clerici , Guglielmo Bertolini
IPC分类号： C08L101/00 , C08F8/10 , C08F212/08 , C09K3/00
CPC分类号： C08F8/10
摘要： Solid polymeric stabilizer compound containing the hydroxybenzophenone function, having the general formula (I): ##STR1## wherein: m=from 0.01 to 0.99 (preferably from 0.1 to 0.6);l=from 0.99 to 0.01 (preferably from 0.9 to 0.4):m+l=1;R=H, --OH, --OR" (R"+(C.sub.1 -C.sub.20)-alkyl; aryl, alkylaryl cycloalkyl). halogen, (C.sub.1 -C.sub.20)-alkyl, cycloalkyl;R'=H, (C.sub.1 -C.sub.20)-alkyl, cycloalkyl.Also the process for preparing said solid polymeric stabilizers and the stabilized polymeric compositions comprising at least an organic polymer and a stabilizing amount of said solid polymeric stabilizers are disclosed.
摘要翻译：具有通式（I）的羟基二苯甲酮功能的固体高分子稳定剂化合物：其中：m = 0.01〜0.99（优选为0.1〜0.6）。 l = 0.99至0.01（优选0.9至0.4）：m + 1 = 1; R = H，-OH，-OR“（R”+（C 1 -C 20） - 烷基;芳基，烷基芳基环烷基）。卤素，（C 1 -C 20） - 烷基，环烷基; R'= H，（C 1 -C 20） - 烷基，环烷基。还公开了制备所述固体聚合物稳定剂和包含至少一种有机聚合物和稳定量的所述固体聚合物稳定剂的稳定化聚合物组合物的方法。

5. 发明申请

US20120214866A1 TREATMENT WITH CYTOKINES 审中-公开
标题翻译：用细胞因子治疗
公开(公告)号：US20120214866A1
公开(公告)日：2012-08-23
申请号：US13356374
申请日：2012-01-23
申请人： Mario Clerici , Giorgio Annoni
发明人： Mario Clerici , Giorgio Annoni
IPC分类号： C12Q1/68 , C07H21/04 , C07K14/52 , C07K14/54 , A61P25/28 , C07K14/55 , C07K14/56 , C07K14/565 , C07K14/57 , A61K48/00 , C07K14/545
CPC分类号： C12Q1/6883 , A61K38/19 , C12Q2600/156 , C12Q2600/172
摘要： An inflammatory process is suggested to be involved in the pathogenesis of Alzheimer's disease (AD), a neurodegenerative disorder characterized by the presence of neuritic plaques within the cerebral cortex that are mainly composed of a small insoluble protein of 40-42 aminoacids (amyloid protein). Amyloid-specific Interleukin-10 (IL-10) generation is found to be selectively and significantly reduced in AD patients (p=0.023). The genotype associated with high IL-10 production is extremely infrequent in AD individuals (2% vs. 28%). The presence of low/intermediate-IL-10-producing genotypes (GCC/ATA; ATA/ATA) was associated with an earlier age at disease onset and (ACC/ACC; ACC/ATA) with an accelerated rate of disease progression/severity and with amyloid-specific impairment of IL-10 production. This relationship is independent of ApoE gene polymorphism. These results support the use of anti-inflammatory compounds in the therapy of this disease.
摘要翻译：建议炎症过程参与阿尔茨海默病（AD）的发病机制，阿尔茨海默氏病（AD）是一种以大脑皮层内存在神经突斑为特征的神经变性疾病，主要由40-42个氨基酸（淀粉样蛋白）的小不溶性蛋白质组成，。发现AD患者淀粉样蛋白特异性白细胞介素-10（IL-10）代被选择性地显着降低（p = 0.023）。与高IL-10产生相关的基因型在AD个体中极少（2％vs. 28％）。低/中等IL-10产生基因型（GCC / ATA; ATA / ATA）的存在与疾病发病的早期年龄和（ACC / ACC; ACC / ATA）相关，具有加速的疾病进展/严重程度并具有IL-10产生的淀粉样蛋白特异性损伤。这种关系与ApoE基因多态性无关。这些结果支持在治疗这种疾病中使用抗炎化合物。

6. 发明申请

US20070009926A1 Biomarkers of resistance to infections in humans and biological applications thereof 审中-公开
标题翻译：抗人感染的生物标志物及其生物应用
公开(公告)号：US20070009926A1
公开(公告)日：2007-01-11
申请号：US11381811
申请日：2006-05-05
申请人： Francisco VEAS , Dorothee Misse , Mario Clerici , Daria Trabatoni
发明人： Francisco VEAS , Dorothee Misse , Mario Clerici , Daria Trabatoni
IPC分类号： C12Q1/70 , C12Q1/68 , C12P21/06
CPC分类号： C12Q1/6883 , A61K38/08 , A61K38/164 , A61K38/1709 , A61K38/1716 , A61K38/1729 , A61K38/195 , A61K38/20 , C12Q2600/156 , C12Q2600/158 , G01N33/56988 , G01N33/6863 , G01N33/6869 , G01N2800/52
摘要： The invention relates to the use of IL-22 alone or in combination as biomarker of resistance to infections in humans when added to of one or several agonists of the formyl peptide receptors (FPR) receptors family and formyl peptide receptors-like 1 (FPRL 1). Said biomarker is useful in diagnostics, prophylaxis and therapeutics.
摘要翻译：本发明涉及当加入到甲酰基肽受体（FPR）受体家族和甲酰肽受体样1（FPRL 1）的一种或几种激动剂时，单独或组合使用IL-22作为人类感染的抗性的生物标志物）。所述生物标志物可用于诊断，预防和治疗。

7. 发明申请

US20050266015A1 Enhanced activity of HIV vaccine using a second generation immunomodulatory oligonucleotide 审中-公开
标题翻译：使用第二代免疫调节寡核苷酸增强HIV疫苗的活性
公开(公告)号：US20050266015A1
公开(公告)日：2005-12-01
申请号：US11078654
申请日：2005-03-11
申请人： Mario Clerici , Richard Bartholomew , Dorothy Bray , Ekambar Kandimalla , Sudhir Agrawal
发明人： Mario Clerici , Richard Bartholomew , Dorothy Bray , Ekambar Kandimalla , Sudhir Agrawal
IPC分类号： A61K39/21 , A61K48/00
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5252 , A61K2039/545 , A61K2039/55561 , C12N2740/16134
摘要： The invention relates to the therapeutic use of a second generation immunomodulatory oligonucleotide in combination with HIV-1 antigen or immunogen to enhance the ability to reduce the risk HIV infection and to control the progression of HIV infection to prevent AIDS Related Complex (ARC) and AIDS.
摘要翻译：本发明涉及第二代免疫调节性寡核苷酸与HIV-1抗原或免疫原组合的治疗用途，以增强降低HIV感染风险并控制HIV感染进展以防止AIDS相关复合物（ARC）和艾滋病。

8. 发明授权

US4042609A .sigma. AND .pi. ORGANIC COMPLEXES OF TRANSITION METALS AND PROCESS FOR THE PREPARATION THEREOF 失效
标题翻译： {94 {0和{90 {0有机金属过渡复合物及其制备方法
公开(公告)号：US4042609A
公开(公告)日：1977-08-16
申请号：US654350
申请日：1976-02-02
申请人： Emilio Perrotti , Mario Clerici
发明人： Emilio Perrotti , Mario Clerici
IPC分类号： B01J31/22 , B01J31/24 , C07C5/03 , C07F9/00 , C07F15/00 , C07F13/00
CPC分类号： B01J31/2291 , B01J31/2295 , B01J31/24 , B01J31/2404 , C07C5/03 , C07F15/0033 , C07F9/00 , B01J2231/641 , B01J2231/70 , B01J2531/74 , B01J2531/827 , C07C2531/22
摘要： A compound having catalytic properties which is a .sigma. or .pi. organic complex of a transition metal represented by the general formula: M (A).sub.n (L-C) (L).sub.m, wherein M is Ir or Re; L is a member of the group consisting of alkyl and aryl phosphines; (L-C) is (a) an alkyl or aryl phosphine ligand wherein a C-H bond is reacted with the central M atom to which the ligand is coordinated, and a metal-carbon bond is formed, or (b) a .pi.-allyl radical; A is a linear monoolefin having from 2 to 5 carbon atoms or a cyclic monoolefin having from 6 to 8 carbon atoms; n is a number in the range of 0 to 2 and is always zero when L-C is a .pi.-allyl radical; and m is a number from 1 to 3 which satisfies the valence of M, is prepared by reacting a hydride complex represented by the general formula: MHLn.sub.1 wherein M and L have the meaning given above, x is in the range from 5 to 7 and n.sub.1 is a number from 2 to 3 which satisfies the valence of M, with a linear monoolefin having from 2 to 5 carbon atoms or a cyclic monoolefin having from 6 to 8 carbon atoms.
摘要翻译：具有催化性质的化合物，其为由通式M（A）n（L-C）（L）m表示的过渡金属的σ或π有机络合物，其中M为Ir或Re; L是由烷基和芳基膦组成的组的成员; （L-C）是（a）烷基或芳基膦配体，其中C-H键与配位体配位的中心M原子反应，形成金属 - 碳键，或（b）吡咯烷基; A是具有2至5个碳原子的直链单烯烃或具有6至8个碳原子的环状单烯烃; n为0〜2的数，当L-C为吡啶基时，该数为0。 m为1〜3的数，其满足M的化合价，通过使由通式MHLn1表示的氢化物配合物反应制备，其中M和L具有上述含义，x在5至7的范围内， n1是2至3的数，其满足M的价数，具有2至5个碳原子的直链单烯烃或具有6至8个碳原子的环状单烯烃。

9. 发明申请

US20060134607A1 Marker gene 审中-公开
标题翻译：标记基因
公开(公告)号：US20060134607A1
公开(公告)日：2006-06-22
申请号：US10531193
申请日：2003-10-16
申请人： Masaaki Miyazawa , Mario Clerici
发明人： Masaaki Miyazawa , Mario Clerici
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/703 , C12Q2600/156 , C12Q2600/172
摘要： A method of determining a predisposition to infection, especially infection with HIV, together with therapy for the infection is described.
摘要翻译：描述了确定感染易感性，特别是感染HIV的方法以及感染的治疗。

10. 发明申请

US20050260767A1 Treatment with cytokines 审中-公开
标题翻译：用细胞因子治疗
公开(公告)号：US20050260767A1
公开(公告)日：2005-11-24
申请号：US10516421
申请日：2003-05-30
申请人： Mario Clerici , Giorgio Annoni
发明人： Mario Clerici , Giorgio Annoni
IPC分类号： C12N15/09 , A61K38/00 , A61K38/19 , A61K38/20 , A61K45/00 , A61K48/00 , A61P3/10 , A61P11/06 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/18 , A61P37/02 , A61P43/00 , C12N15/24 , C12Q1/68 , C12Q1/6883 , G01N33/543
CPC分类号： C12Q1/6883 , A61K38/19 , C12Q2600/156 , C12Q2600/172
摘要： An inflammatory process is suggested to be involved in the pathogenesis of Alzheimer's disease (AD), a neurodegenerative disorder characterized by the presence of neuritic plaques within the cerebral cortex that are mainly composed of a small insoluble protein of 40-42 amino acids (amyloid protein). The biological correlates of this process are nevertheless not clear. Interleukin-10 (IL-10) is a cytokine that suppresses T lymphocytes and cell-mediated immunity in humans and mice and has potent anti-inflammatory properties. To verify if IL-10 production would be impaired in AD patients we stimulated PBMC of 47 patients and 25 age-matched healthy controls (HC) with a mitogen, a recall antigen or with amyloid peptides. IL-2 production was measured as well in the same cultural conditions. Results showed that amyloid-specific IL-10 generation is selectively and significantly reduced in AD patients (p=0.023). Analyses on the alleles of the IL-10 gene revealed that the genotype associated with high IL-10 production is extremely infrequent in AD individuals (2% vs. 28%). The presence of low/intermediate IL-10-producing genotypes (GCC/ATA; ATA/ATA) was associated with an earlier age at disease onset and (ACC/ACC; ACC/ATA) with an accelerated rate of disease progression. These data shed light on the biology of the inflammatory process involved in the pathogenesis of AD by showing that the presence of low-IL-10-allelic isoforms results in an amyloid-specific impairment of IL-10 production and is associated with the clinical severity of AD. These results lend support to the use of anti-inflammatory compounds in the therapy of this disease.
摘要翻译：建议炎症过程参与阿尔茨海默病（AD）的发病机制，阿尔茨海默病（AD）是一种以大脑皮层内存在神经突斑为特征的神经变性疾病，主要由40-42个氨基酸的小不溶性蛋白质（淀粉样蛋白）。然而，这一过程的生物相关性尚不清楚。白细胞介素-10（IL-10）是抑制人类和小鼠中T淋巴细胞和细胞介导的免疫的细胞因子，具有强大的抗炎特性。为了验证AD患者IL-10的产生是否受损，我们用有丝分裂原，召回抗原或淀粉样蛋白肽刺激47例患者和25例年龄匹配的健康对照（HC）的PBMC。在相同的文化条件下也测量了IL-2的产生。结果显示，AD患者淀粉样蛋白特异性IL-10的产生有明显的降低（p = 0.023）。对IL-10基因等位基因的分析显示，AD患者与高IL-10产生相关的基因型极少（2％vs. 28％）。低/中间IL-10产生基因型（GCC / ATA; ATA / ATA）的存在与疾病发病年龄和ACC（ACC / ACC）/ ACC（ACC / ATA）的发病率相关。通过显示低IL-10等位基因异构体的存在导致IL-10产生的淀粉样蛋白特异性损伤，并且与临床严重程度相关联，这些数据揭示了涉及AD发病机制的炎症过程的生物学特征的AD。这些结果支持在治疗这种疾病中使用抗炎化合物。

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