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1. 发明申请

US20090177107A1 DETECTION OF CORONARY ARTERY DISEASE USING AN ELECTRONIC STETHOSCOPE 审中-公开
标题翻译：使用电子硬脑膜检查冠状动脉疾病
公开(公告)号：US20090177107A1
公开(公告)日：2009-07-09
申请号：US12406849
申请日：2009-03-18
申请人： Marie A. Guion-Johnson
发明人： Marie A. Guion-Johnson
IPC分类号： A61B7/04
CPC分类号： A61B7/04
摘要： The disclosure describes an electronic stethoscope system that automatically detects coronary artery disease in patients. The system uses an electronic stethoscope to record acoustic data from the fourth left intercostal space of a patient. A processing technique is then applied in order to filter the data and produce Fast Fourier Transform (FFT) data of magnitude versus frequency. If a bell curve is identified in the data between a predefined frequency range (e.g., 50 and 80 Hz) with a peak magnitude of greater than a predefined threshold (e.g., 2.5 units), the system automatically provides an output indicating that the patient is likely to have 50 to 99 percent stenosis of the coronary artery. If no bell curve is present, the patient may have artery stenosis of less than 50 percent. An interface module may be used to transfer diagnosis information to the stethoscope and data to a general purpose computer. This inexpensive and quick system may improve the chances for early detection and patient survival of coronary artery disease.
摘要翻译：本公开描述了一种自动检测患者冠状动脉疾病的电子听诊器系统。该系统使用电子听诊器来记录来自患者的第四左肋间隙的声学数据。然后应用处理技术来过滤数据并产生幅度对频率的快速傅里叶变换（FFT）数据。如果在预定频率范围（例如，50和80Hz）之间的数据中识别出具有大于预定义阈值（例如，2.5单位）的峰值幅度的钟形曲线，则系统自动提供指示患者是可能有冠状动脉狭窄50〜99％。如果没有钟形曲线，患者可能有小于50％的动脉狭窄。接口模块可用于将诊断信息传送到听诊器和数据到通用计算机。这种廉价且快速的系统可以提高冠状动脉疾病的早期检测和患者存活的机会。

2. 发明授权

US07520860B2 Detection of coronary artery disease using an electronic stethoscope 有权
标题翻译：使用电子听诊器检测冠状动脉疾病
公开(公告)号：US07520860B2
公开(公告)日：2009-04-21
申请号：US11402654
申请日：2006-04-12
申请人： Marie A. Guion-Johnson , Kozhuvattasseril P. Madhusoodanan
发明人： Marie A. Guion-Johnson , Kozhuvattasseril P. Madhusoodanan
IPC分类号： A61B7/04 , A61B5/02
CPC分类号： A61B7/04
摘要： The disclosure describes an electronic stethoscope system that automatically detects coronary artery disease in patients. The system uses an electronic stethoscope to record acoustic data from the fourth left intercostal space of a patient. A processing technique is then applied in order to filter the data and produce Fast Fourier Transform (FFT) data of magnitude versus frequency. If a bell curve is identified in the data between a predefined frequency range (e.g., 50 and 80 Hz) with a peak magnitude of greater than a predefined threshold (e.g., 2.5 units), the system automatically provides an output indicating that the patient is likely to have 50 to 99 percent stenosis of the coronary artery. If no bell curve is present, the patient may have artery stenosis of less than 50 percent. An interface module may be used to transfer diagnosis information to the stethoscope and data to a general purpose computer. This inexpensive and quick system may improve the chances for early detection and patient survival of coronary artery disease.
摘要翻译：本公开描述了一种自动检测患者冠状动脉疾病的电子听诊器系统。该系统使用电子听诊器来记录来自患者的第四左肋间隙的声学数据。然后应用处理技术来过滤数据并产生幅度对频率的快速傅里叶变换（FFT）数据。如果在预定频率范围（例如，50和80Hz）之间的数据中识别出具有大于预定义阈值（例如，2.5单位）的峰值幅度的钟形曲线，则系统自动提供指示患者是可能有冠状动脉狭窄50〜99％。如果没有钟形曲线，患者可能有小于50％的动脉狭窄。接口模块可用于将诊断信息传送到听诊器和数据到通用计算机。这种廉价且快速的系统可以提高冠状动脉疾病的早期检测和患者存活的机会。

3. 发明申请

US20090143650A1 MINIATURIZED, DERMAL-ADHESIVE-BASED DEVICE FOR POSITION-INDEPENDENT, NON-INVASIVE FETAL MONITORING 审中-公开
标题翻译：微型化，用于位置独立的非侵入式监视器的基于粘合剂的设备
公开(公告)号：US20090143650A1
公开(公告)日：2009-06-04
申请号：US12274889
申请日：2008-11-20
申请人： Marie A. Guion-Johnson , David Boudreault , Beverly Tang , Shivinand Lad , Brian Fahey , Jeremy Collins , Elizabeth Langen
发明人： Marie A. Guion-Johnson , David Boudreault , Beverly Tang , Shivinand Lad , Brian Fahey , Jeremy Collins , Elizabeth Langen
IPC分类号： A61B5/00 , A61B5/02
CPC分类号： A61B5/6833 , A61B5/0011 , A61B5/02411 , A61B5/4356 , A61B8/02 , A61B8/0866 , A61B8/4472 , A61B8/56 , A61B2560/0412
摘要： A system for fetal position-independent, non-invasive fetal monitoring includes a plurality of disposable adhesive patches for placement on an expectant mother's upper and lower abdomen. Each of the patches includes one or more miniature electronic devices embedded within the adhesive patches to detect: (i) heart sounds of a fetus within the mother, (ii) heart sounds of the mother, and (iii) signals indicative of uterine contractions of the mother. A processing hub having a receiver to receive signals from the plurality of patches, wherein the processing hub receives and processes primary signal from the primary patch and the secondary signals from the secondary patches to triangulate the location of the fetus, cancel noise in the primary signal and increase the amplitude of the primary signal for more reliable reporting.
摘要翻译：用于胎儿位置无关，非侵入性胎儿监测的系统包括用于放置在预期母亲的上腹部和下腹部上的多个一次性贴剂。每个贴片包括一个或多个微型电子装置，其嵌入粘合贴片内以检测：（i）母体内的胎儿的心脏声音，（ii）母亲的心脏声音，以及（iii）指示子宫收缩的信号母亲一种处理集线器，具有接收器，用于接收来自所述多个补丁的信号，其中所述处理集线器接收并处理来自所述主要补丁的主要信号和来自所述次级补丁的辅助信号，以对所述胎儿的位置进行三角测量，消除所述主要信号中的噪声并增加主要信号的幅度以获得更可靠的报告。

4. 发明授权

US07300405B2 Analysis of auscultatory sounds using single value decomposition 有权
标题翻译：使用单值分解分析听诊声
公开(公告)号：US07300405B2
公开(公告)日：2007-11-27
申请号：US10781118
申请日：2004-02-18
申请人： Marie A. Guion , Arthur G. Erdman , George Sommerfeld , Ahmed H. Tewfik , Craig D. Oster
发明人： Marie A. Guion , Arthur G. Erdman , George Sommerfeld , Ahmed H. Tewfik , Craig D. Oster
IPC分类号： A61B5/02 , A61B7/02 , A61B7/04
CPC分类号： A61B7/00 , A61B7/003 , A61B7/04 , G06F19/00
摘要： Techniques are described for analyzing auscultatory sounds to aid a medical professional in diagnosing physiological conditions of a patient. A data analysis system, for example, applies singular value decomposition to auscultatory sounds associated known physiological conditions to define a set of one or more disease regions within a multidimensional space. A diagnostic device, such as an electronic stethoscope or personal digital assistant, applies configuration data from the data analysis system to generate a set of one or more vectors within the multidimensional space representative of auscultatory sounds associated with a patient. The diagnostic device outputs a diagnostic message associated with a physiological condition of the patient based on the orientation of the vectors relative to the disease regions within the multidimensional space.
摘要翻译：描述了用于分析听诊声音的技术，以帮助医学专业人员诊断患者的生理状况。例如，数据分析系统将奇异值分解应用于与已知生理条件相关联的听诊声音，以在多维空间内定义一组或多个疾病区域。诊断装置，例如电子听诊器或个人数字助理，应用来自数据分析系统的配置数据，以产生代表与患者相关联的听诊声音的多维空间内的一组或多个向量集合。诊断装置基于向量相对于多维空间内的疾病区域的取向输出与患者的生理状况相关联的诊断消息。

5. 发明授权

US06799467B2 Pressure indicator 失效
标题翻译：压力指示器
公开(公告)号：US06799467B2
公开(公告)日：2004-10-05
申请号：US10361809
申请日：2003-02-07
申请人： Phillip L. Minerich , Marie A. Guion , Andrew D. Bicek , Thomas B. Priebe , Daniel T. Wolters , Paul C. Luna
发明人： Phillip L. Minerich , Marie A. Guion , Andrew D. Bicek , Thomas B. Priebe , Daniel T. Wolters , Paul C. Luna
IPC分类号： G01L700
CPC分类号： G01L11/00 , A23L5/30
摘要： Pressure is measured inside of a high pressure vehicle. A substance is compressed at a first pressure to create a preform having a first density. The preform is placed inside of a high pressure vessel and subjected to a second pressure, greater than the first pressure. The preform therefore changes in density to a second density, greater than the first density, whereby the second pressure can be determined. The method may also be used in determining the pressure inside of a food product during food processing and a high pressure vessel.
摘要翻译：在高压车辆内部测量压力。物质在第一压力下被压缩以产生具有第一密度的预制件。将预成型件放置在高压容器的内部并经受大于第一压力的第二压力。因此，预制件因此将密度改变为大于第一密度的第二密度，从而可以确定第二压力。该方法还可用于确定食品加工期间食品中的压力和高压容器。

6. 发明授权

US10039520B2 Detection of coronary artery disease using an electronic stethoscope 有权
公开(公告)号：US10039520B2
公开(公告)日：2018-08-07
申请号：US12406849
申请日：2009-03-18
申请人： Marie A. Guion-Johnson
发明人： Marie A. Guion-Johnson
IPC分类号： A61B5/02 , A61B7/04
摘要： The disclosure describes an electronic stethoscope system that automatically detects coronary artery disease in patients. The system uses an electronic stethoscope to record acoustic data from the fourth left intercostal space of a patient. A processing technique is then applied in order to filter the data and produce Fast Fourier Transform (FFT) data of magnitude versus frequency. If a bell curve is identified in the data between a predefined frequency range (e.g., 50 and 80 Hz) with a peak magnitude of greater than a predefined threshold (e.g., 2.5 units), the system automatically provides an output indicating that the patient is likely to have 50 to 99 percent stenosis of the coronary artery. If no bell curve is present, the patient may have artery stenosis of less than 50 percent. An interface module may be used to transfer diagnosis information to the stethoscope and data to a general purpose computer. This inexpensive and quick system may improve the chances for early detection and patient survival of coronary artery disease.

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