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1. 发明授权

US08673313B2 Cell penetrating peptides and its use fused to biomolecules with therapeutic action 有权
标题翻译：细胞穿透肽及其使用与具有治疗作用的生物分子融合
公开(公告)号：US08673313B2
公开(公告)日：2014-03-18
申请号：US12671335
申请日：2008-07-31
申请人： Isis del Carmen Torrens Madrazo , Maribel Guerra Vallespi , Milaid Granadillo Rodriguez , Osvaldo Reyes Acosta , Boris Ernesto Acevedo Castro
发明人： Isis del Carmen Torrens Madrazo , Maribel Guerra Vallespi , Milaid Granadillo Rodriguez , Osvaldo Reyes Acosta , Boris Ernesto Acevedo Castro
IPC分类号： A61K39/12 , A61K39/02
CPC分类号： A61K39/12 , A61K2039/585 , A61K2039/6031 , C12N2710/20034
摘要： The present invention relates to use of a new cell penetrating peptides (CPP) and in particular to the region 32-51 of protein Limulus antilipopolisacárido (LALF) and its analogous. This invention refers to compositions containing these peptides associated to biomolecules with therapeutics properties. This invention consist of compositions comprise the covalent fusion of biomolecules, between this human papillomavirus antigens (HPV) to these CPP for induce a potent immune cellular responses against HPV and HPV protein antigen-exhibiting cells including HPV-associated tumors. The referred compositions are applicable in the pharmaceutical industry as vaccine for therapeutic use in human.
摘要翻译：本发明涉及使用新的细胞穿透肽（CPP），特别涉及蛋白鲎抗脂蛋白（LALF）的区域32-51及其类似物。本发明涉及包含与具有治疗学性质的生物分子相关联的这些肽的组合物。本发明由组合物组成，包括生物分子的共价融合，在该人乳头状瘤病毒抗原（HPV）与这些CPP之间，用于诱导对HPV和HPV蛋白抗原呈递细胞（包括HPV相关肿瘤）的有效免疫细胞应答。所提及的组合物可用作制药工业中用于人类治疗用途的疫苗。

2. 发明申请

US20140206621A1 Cancer Therapy Method 有权
标题翻译：癌症治疗方法
公开(公告)号：US20140206621A1
公开(公告)日：2014-07-24
申请号：US14075276
申请日：2013-11-08
申请人： Maribel Guerra Vallespi , Julio Raúl Fernández Massó , Alexis Musacchio Lasa , Jeovanis Gil Valdés , Osvaldo Reyes Acosta , Brizaida Maylin Oliva Argüelles
发明人： Maribel Guerra Vallespi , Julio Raúl Fernández Massó , Alexis Musacchio Lasa , Jeovanis Gil Valdés , Osvaldo Reyes Acosta , Brizaida Maylin Oliva Argüelles
IPC分类号： C12N15/11 , C07K7/08
CPC分类号： C12N15/11 , A61K31/505 , A61K31/513 , A61K33/24 , A61K38/10 , A61K38/1767 , A61K45/06 , A61K48/00 , C07K7/08 , G01N33/574 , A61K2300/00
摘要： This invention describes a method for treating cancer by increasing the nuclear localization of the COMMD1 protein, which is associated with decreasing or blocking the proliferation of the cancer cell. The invention is also related to the use of agents that increase nuclear localization of the COMMD1 protein, in the manufacture of a medicament for cancer therapy. These agents can be peptides or proteins, among other compounds. The invention is also related to the optimization of a peptide, coming from the sequence HARIKPTFRRLKWKKYKGKFW, to increase the nuclear localization of the protein COMMD, and thus, to increase the antitumor effect of this peptide.
摘要翻译：本发明描述了通过增加与降低或阻断癌细胞增殖相关的COMMD1蛋白的核定位来治疗癌症的方法。本发明还涉及在制造用于癌症治疗的药物中增加COMMD1蛋白的核定位的试剂的用途。这些试剂可以是其他化合物中的肽或蛋白质。本发明还涉及来自序列HARIKPTFRRLKWKKYKGKFW的肽的优化，以增加蛋白质COMMD的核定位，从而提高该肽的抗肿瘤效果。

3. 发明申请

US20090221508A1 IMMUNOMODULATORY AND ANTI-TUMOUR PEPTIDES 有权
标题翻译：免疫组织化学和抗肿瘤肽
公开(公告)号：US20090221508A1
公开(公告)日：2009-09-03
申请号：US12278990
申请日：2007-02-23
申请人： Maribel Guerra Vallespi , Isis del Carmen Torrrens Madrazo , Osvaldo Reyes Acosta , Hilda Elisa Garay Perez , Gerardo Enrique Guillen Nieto , Boris Ernesto Acevedo Castro , Raimundo Ubieta Gomez
发明人： Maribel Guerra Vallespi , Isis del Carmen Torrrens Madrazo , Osvaldo Reyes Acosta , Hilda Elisa Garay Perez , Gerardo Enrique Guillen Nieto , Boris Ernesto Acevedo Castro , Raimundo Ubieta Gomez
IPC分类号： A61K38/10 , C07K14/00 , A61P35/04
CPC分类号： C07K14/43509 , A61K38/00
摘要： The present invention is related to the development of peptides derived from the sequence HYRIKPTFRRLKWKKYKGKFW, showing aminoacids substitutions, these peptides unable to bind to the lipopolysaccharide and bearing anti-tumoral and immunomodulatory capacities. These peptides alone or in combination are useful to treat cancer, and also in synergy with conventional therapies.
摘要翻译：本发明涉及来自序列HYRIKPTFRRLKWKKYKGKFW的肽的开发，显示出氨基酸取代，这些肽不能结合脂多糖并具有抗肿瘤和免疫调节能力。单独或组合的这些肽可用于治疗癌症，并且与常规疗法协同作用。

4. 发明授权

US07012127B1 Analogues of lipopolysaccharide-binding protein (LBP)-derived peptides that efficiently neutralize lipopolysaccharides (LPS) 失效
标题翻译：类脂多糖结合蛋白（LBP）衍生的肽，有效中和脂多糖（LPS）
公开(公告)号：US07012127B1
公开(公告)日：2006-03-14
申请号：US09588525
申请日：2000-06-06
申请人： Manuel de Jesús Araña Rosainz , Glay Chinea Santiago , Maribel Guerra Vallespi , Osvaldo Reyes Acosta
发明人： Manuel de Jesús Araña Rosainz , Glay Chinea Santiago , Maribel Guerra Vallespi , Osvaldo Reyes Acosta
IPC分类号： C07K14/00 , C07K16/00 , C07K17/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to analogues of peptides from lipopolysaccharide-binding protein (LBP) region whose primary sequence have been substituted at particular amino acid sites to obtain effective binding to, and neutralization of, lipopolysaccharide (LPS).
摘要翻译：本发明涉及来自脂多糖结合蛋白（LBP）区域的肽类似物，其一级序列已在特定氨基酸位点被取代，以获得对脂多糖（LPS）的有效结合和中和。

5. 发明授权

US06191114B1 Immunological activity for a peptide of the limulus anti-LPS factor 失效
标题翻译：鲎抗LPS因子的肽的免疫活性
公开(公告)号：US06191114B1
公开(公告)日：2001-02-20
申请号：US09160309
申请日：1998-09-25
申请人： Maribel Guerra Vallespi , Manuel de Jesus Arana Rosainz
发明人： Maribel Guerra Vallespi , Manuel de Jesus Arana Rosainz
IPC分类号： A61K3816
CPC分类号： C07K14/43509 , A61K38/00
摘要： The present invention relates a novel immunological effect of one peptide from Limulus anti-LPS factor protein. The immunological effect are, (1) induce an antiviral state in both the Hep-2 and MDBK cell lines, (2) Supernatant from human mononuclear cells stimulated with peptide Limulus anti-LPS factor (LALF) is able to induce antiviral effect on Hep-2 cell line by mean of IFN-&ggr; (3) LALF peptide is able to modulate the immune response in vitro and in vivo. The present invention can be used in therapeutic and/or prophylactic treatment regimens of humans and animals to enhance their immune responses, without stimulating the production of certain biochemical mediators (e.g., TNF-&agr;,) that can cause detrimental effects, such as fever and inflammation.
摘要翻译：本发明涉及鲎抗LPS因子蛋白的一种新型免疫学效应。免疫学效应是：（1）在Hep-2和MDBK细胞系中诱导抗病毒状态，（2）用肽鲎抗LPS因子（LALF）刺激的人单核细胞的上清液能够诱导抗Hep病毒的抗病毒作用 -2细胞系的IFN-γ（3）LALF肽能够在体外和体内调节免疫反应。本发明可用于人和动物的治疗和/或预防性治疗方案以增强其免疫应答，而不刺激可能引起有害作用的某些生物化学介质（例如TNF-α）的产生，例如发烧和炎。

6. 发明申请

US20130224313A1 CANCER THERAPY METHOD 有权
标题翻译：癌症治疗方法
公开(公告)号：US20130224313A1
公开(公告)日：2013-08-29
申请号：US13700286
申请日：2011-05-31
申请人： Maribel Guerra Vallespi , Julio Raúl Fernández Massó , Alexis Musacchio Lasa , Jeovanis Gil Valdés , Osvaldo Reyes Acosta , Brizaida Maylin Oliva Argüelles
发明人： Maribel Guerra Vallespi , Julio Raúl Fernández Massó , Alexis Musacchio Lasa , Jeovanis Gil Valdés , Osvaldo Reyes Acosta , Brizaida Maylin Oliva Argüelles
IPC分类号： A61K38/10 , A61K31/513 , A61K33/24 , G01N33/574 , A61K48/00 , C07K7/08
CPC分类号： C12N15/11 , A61K31/505 , A61K31/513 , A61K33/24 , A61K38/10 , A61K38/1767 , A61K45/06 , A61K48/00 , C07K7/08 , G01N33/574 , A61K2300/00
摘要： This invention describes a method for treating cancer by increasing the nuclear localization of the COMMD1 protein, which is associated with decreasing or blocking the proliferation of the cancer cell. The invention is also related to the use of agents that increase nuclear localization of the COMMD1 protein, in the manufacture of a medicament for cancer therapy. These agents can be peptides or proteins, among other compounds. The invention is also related to the optimization of a peptide, coming from the sequence HARIKPTFRRLKWKKYKGKFW, to increase the nuclear localization of the protein COMMD, and thus, to increase the antitumor effect of this peptide.
摘要翻译：本发明描述了通过增加与降低或阻断癌细胞增殖相关的COMMD1蛋白的核定位来治疗癌症的方法。本发明还涉及在制造用于癌症治疗的药物中增加COMMD1蛋白的核定位的试剂的用途。这些试剂可以是其他化合物中的肽或蛋白质。本发明还涉及来自序列HARIKPTFRRLKWKKYKGKFW的肽的优化，以增加蛋白质COMMD的核定位，从而提高该肽的抗肿瘤效果。

7. 发明申请

US20120135021A1 CELL PENETRATING PEPTIDES AND ITS USE FUSED TO BIOMOLECULES WITH THERAPEUTIC ACTION 有权
标题翻译：细胞穿刺肽及其用于治疗生物分子的用途
公开(公告)号：US20120135021A1
公开(公告)日：2012-05-31
申请号：US12671335
申请日：2008-07-31
申请人： Isis del Carmen Torens Madrazo , Maribel Guerra Vallespi , Milaid Granadillo Rodriguez , Osvaldo Reyes Acosta , Boris Ernesto Acevedo Castro
发明人： Isis del Carmen Torens Madrazo , Maribel Guerra Vallespi , Milaid Granadillo Rodriguez , Osvaldo Reyes Acosta , Boris Ernesto Acevedo Castro
IPC分类号： A61K39/12 , C07K19/00 , A61P35/00 , C07K7/08
CPC分类号： A61K39/12 , A61K2039/585 , A61K2039/6031 , C12N2710/20034
摘要： The present invention relates to use of a new cell penetrating peptides (CPP) and in particular to the region 32-51 of protein Limulus antilipopolisacárido (LALF) and its analogous. This invention refers to compositions containing these peptides associated to biomolecules with therapeutics properties. This invention consist of compositions comprise the covalent fusion of biomolecules, between this human papillomavirus antigens (HPV) to these CPP for induce a potent immune cellular responses against HPV and HPV protein antigen-exhibiting cells including HPV-associated tumors. The referred compositions are applicable in the pharmaceutical industry as vaccine for therapeutic use in human.
摘要翻译：本发明涉及使用新的细胞穿透肽（CPP），特别涉及蛋白鲎抗脂蛋白（LALF）的区域32-51及其类似物。本发明涉及包含与具有治疗学性质的生物分子相关联的这些肽的组合物。本发明由组合物组成，包括生物分子的共价融合，在该人乳头状瘤病毒抗原（HPV）与这些CPP之间，用于诱导对HPV和HPV蛋白抗原呈递细胞（包括HPV相关肿瘤）的有效免疫细胞应答。所提及的组合物可用作制药工业中用于人类治疗用途的疫苗。

8. 发明授权

US08729226B2 Cancer therapy method 有权
标题翻译：癌症治疗方法
公开(公告)号：US08729226B2
公开(公告)日：2014-05-20
申请号：US13700286
申请日：2011-05-31
申请人： Maribel Guerra Vallespi , Julio Raúl Fernández Massó , Alexis Musacchio Lasa , Jeovanis Gil Valdés , Osvaldo Reyes Acosta , Brizaida Maylin Oliva Argüelles
发明人： Maribel Guerra Vallespi , Julio Raúl Fernández Massó , Alexis Musacchio Lasa , Jeovanis Gil Valdés , Osvaldo Reyes Acosta , Brizaida Maylin Oliva Argüelles
IPC分类号： A61K38/00
CPC分类号： C12N15/11 , A61K31/505 , A61K31/513 , A61K33/24 , A61K38/10 , A61K38/1767 , A61K45/06 , A61K48/00 , C07K7/08 , G01N33/574 , A61K2300/00
摘要： This invention describes a method for treating cancer by increasing the nuclear localization of the COMMD1 protein, which is associated with decreasing or blocking the proliferation of the cancer cell. The invention is also related to the use of agents that increase nuclear localization of the COMMD1 protein, in the manufacture of a medicament for cancer therapy. These agents can be peptides or proteins, among other compounds. The invention is also related to the optimization of a peptide, coming from the sequence HARIKPTFRRLKWKKYKGKFW, to increase the nuclear localization of the protein COMMD, and thus, to increase the antitumor effect of this peptide.
摘要翻译：本发明描述了通过增加与降低或阻断癌细胞增殖相关的COMMD1蛋白的核定位来治疗癌症的方法。本发明还涉及在制造用于癌症治疗的药物中增加COMMD1蛋白的核定位的试剂的用途。这些试剂可以是其他化合物中的肽或蛋白质。本发明还涉及来自序列HARIKPTFRRLKWKKYKGKFW的肽的优化，以增加蛋白质COMMD的核定位，从而提高该肽的抗肿瘤效果。

9. 发明授权

US08283324B2 Immunomodulatory and anti-tumour peptides 有权
标题翻译：免疫调节和抗肿瘤肽
公开(公告)号：US08283324B2
公开(公告)日：2012-10-09
申请号：US12278990
申请日：2007-02-23
申请人： Maribel Guerra Vallespi , Isis del Carmen Torréns Madrazo , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Gerardo Enrique Guillén Nieto , Boris Ernesto Acevedo Castro , Raimundo Ubieta Gómez
发明人： Maribel Guerra Vallespi , Isis del Carmen Torréns Madrazo , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Gerardo Enrique Guillén Nieto , Boris Ernesto Acevedo Castro , Raimundo Ubieta Gómez
IPC分类号： A61K38/16 , C07K14/00
CPC分类号： C07K14/43509 , A61K38/00
摘要： The present invention is related to the development of peptides derived from the sequence HYRIKPTFRRLKWKYKGKFW (SEQ ID NO.: 13), showing amino acid substitutions, these peptides unable to bind to the lipopolysaccharides and bearing anti-tumoral and immunomodulatory capacities. These peptides alone or in combination are useful to treat cancer, and also in synergy with conventional therapies.
摘要翻译：本发明涉及来自序列HYRIKPTFRRLKWKYKGKFW（SEQ ID NO：13）的肽的开发，显示氨基酸取代，这些肽不能结合脂多糖并具有抗肿瘤和免疫调节能力。单独或组合的这些肽可用于治疗癌症，并且与常规疗法协同作用。

10. 发明授权

US06632793B1 Immunological activity for a peptide of the limulus anti-LPS factor 失效
标题翻译：鲎抗LPS因子的肽的免疫活性
公开(公告)号：US06632793B1
公开(公告)日：2003-10-14
申请号：US09691500
申请日：2000-10-18
申请人： Maribel Guerra Vallespi , Manuel de Jesus Arana Rosianz
发明人： Maribel Guerra Vallespi , Manuel de Jesus Arana Rosianz
IPC分类号： A61K3939
CPC分类号： C07K14/43509 , A61K38/00
摘要： The present invention relates a novel immunological effect of one peptide from Limulus anti-LPS factor protein. The immunological effect are, (1) Induce an antiviral state in both the Hep-2 and MDBK cell lines, (2) Supernatant from human mononuclear cells stimulated with peptide Limulus anti-LPS factor (LALF) is able to induce antiviral effect on Hep-2 cell line by mean of IFN-&ggr; (3) LALF peptide is able to modulate the immune response in vitro and in vivo. The present invention can be used in therapeutic and/or prophylactic treatment regimens of humans and animals to enhance their immune responses, without stimulating the production of certain biochemical mediators (e.g., TNF-&agr;) that can cause detrimental effects, such as fever and inflammation.
摘要翻译：本发明涉及鲎抗LPS因子蛋白的一种新型免疫学效应。免疫学效应是：（1）在Hep-2和MDBK细胞系中诱导抗病毒状态，（2）用肽刺激的人单核细胞的上清液鲎抗LPS因子（LALF）能够诱导抗Hep病毒的抗病毒作用 -2细胞系的IFN-γ（3）LALF肽能够在体外和体内调节免疫反应。本发明可用于人和动物的治疗和/或预防性治疗方案以增强其免疫应答，而不刺激可引起有害作用的某些生物化学介质（例如，TNF-α）的产生，例如发烧和炎症。

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