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1. 发明授权

US4132732A Process for preparing alpha-formyl acids 失效
标题翻译： α-甲酰基酸的制备方法
公开(公告)号：US4132732A
公开(公告)日：1979-01-02
申请号：US882867
申请日：1978-03-02
申请人： Giorgio Bottaccio , Stefano Campolmi , Maria G. Felicioli
发明人： Giorgio Bottaccio , Stefano Campolmi , Maria G. Felicioli
IPC分类号： C07C69/14 , C07C51/00 , C07C51/15 , C07C59/147 , C07C59/74 , C07C67/00 , C07C65/02
CPC分类号： C07C51/15
摘要： Alpha-formyl acids are prepared by carboxylation of aldehydes in the presence of unsubstituted or substituted alkaline phenates, and of aprotic organic solvents.
摘要翻译：在未取代或取代的碱性酚盐和非质子有机溶剂的存在下，通过羧基化醛制备α-甲酰基酸。

2. 发明授权

US4511718A Preparation of pyrazine derivatives 失效
标题翻译：吡嗪衍生物的制备
公开(公告)号：US4511718A
公开(公告)日：1985-04-16
申请号：US471691
申请日：1983-03-03
申请人： Giuseppe Ribaldone , Maria G. Felicioli , Claudio Santini , Giovanni Agnes
发明人： Giuseppe Ribaldone , Maria G. Felicioli , Claudio Santini , Giovanni Agnes
IPC分类号： C07D241/14 , C07D241/12 , C07D241/24 , C07D401/02 , C07D413/02 , C07D417/02
CPC分类号： C07D241/12 , C07D241/24
摘要： A process for the preparation of a pyrazine derivative of the formula ##STR1## wherein R.sub.1 represents hydroxy, C.sub.1 -C.sub.6 alkoxy, or a group of the formula NR.sub.2 R.sub.3 in which R.sub.2 and R.sub.3 are independently a hydrogen atom or C.sub.1 -C.sub.6 alkyl or, together with the nitrogen atom to which they are linked, form a saturated ring having five or six atoms which may contain one or more additional heteroatoms; which process comprises reacting a compound of the formula: ##STR2## wherein R represents a hydrogen atom, C.sub.1 -C.sub.6 alkyl, or C.sub.1 -C.sub.6 alkoxy, Y represents a hydrogen atom or a sodium, lithium, or potassium ion, and A is a nitrile group or a substituent of the formula COR.sub.1 where R.sub.1 is as defined above either with pyruvic aldehyde oxime of the formula: ##STR3## or with a pyruvic aldehyde oxime acetal derivative of the formula: ##STR4## wherein R.sub.4 and R.sub.5 are independently a hydrogen atom or C.sub.1 -C.sub.6 alkyl or may be linked together so that the compound of formula IV is a cyclic acetal; and, when A is a nitrile group, hydrolyzing the reaction product.
摘要翻译：制备式I的吡嗪衍生物的方法，其中R 1表示羟基，C 1 -C 6烷氧基或式NR 2 R 3基团，其中R 2和R 3独立地为氢原子或C 1 -C 6烷基，与它们所连接的氮原子一起形成具有五个或六个原子的饱和环，其可以含有一个或多个另外的杂原子; 该方法包括使下式化合物：其中R表示氢原子，C1-C6烷基或C1-C6烷氧基，Y表示氢原子或钠，锂或钾离子，A为腈基或式COR1的取代基，其中R 1如上所定义，与下式的丙酮酸肟或与下式的其中R 4和R 5为的丙酮酸肟缩醛衍生物独立地是氢原子或C 1 -C 6烷基或可以连接在一起，使得式Ⅳ化合物是环状缩醛; 并且当A为腈基时，水解反应产物。

3. 发明授权

US4239914A Process for preparing 2-(6'-methoxy-2'-naphthyl)-propionic acid 失效
标题翻译：制备2-（6'-甲氧基-2'-萘基） - 丙酸的方法
公开(公告)号：US4239914A
公开(公告)日：1980-12-16
申请号：US40955
申请日：1979-05-21
申请人： Stefano Campolmi , Maria G. Felicioli , Vittorio Carletti , Roberto Santi
发明人： Stefano Campolmi , Maria G. Felicioli , Vittorio Carletti , Roberto Santi
IPC分类号： C07C51/00 , C07C51/36 , C07C59/64 , C07C67/00 , C07C65/00 , C07C65/11
CPC分类号： C07C59/64 , C07C51/36
摘要： There is disclosed an improved process for selectively preparing 2-(6'-methoxy-2'-naphthyl)-propionic acid in the active antipode (+) form by reacting 2-acetyl-6-methoxynaphthalene, in an organic solvent, with a system consisting of(a) a haloform selected from CHCl.sub.3 and CHBr.sub.3 ;(b) an aqueous solution of an inorganic base selected from NaOH and KOH; and(c) a crown-ether or hydrocarbyl salt of quaternary ammonium, or of phosphonium;and hydrogenating the 2-(6'-methoxy-2'-naphthyl)-acrylic acid thus formed to obtain 2-(6'-methoxy-2'-naphthyl)-propionic acid.
摘要翻译：公开了一种通过使有机溶剂中的2-乙酰基-6-甲氧基萘与有机溶剂中的2-（6'-甲氧基-2'-萘基）丙酸与有机溶剂反应来选择性地制备活性对映体（+）形式的2-（6'-甲氧基-2'-萘基）系统由（a）选自CHCl 3和CHBr 3的卤代基组成; （b）选自NaOH和KOH的无机碱的水溶液; 和（c）季铵或鏻的冠醚或烃基盐; 并氢化由此形成的2-（6'-甲氧基-2'-萘基） - 丙烯酸，得到2-（6'-甲氧基-2'-萘基） - 丙酸。

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