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1. 发明申请

US20040244714A1 Methods for growing and imprinting fish using an odorant 失效
标题翻译：使用气味剂生长和印迹鱼的方法
公开(公告)号：US20040244714A1
公开(公告)日：2004-12-09
申请号：US10851047
申请日：2004-05-21
申请人： MariCal, Inc.
发明人： H. William Harris JR. , Steven Jury , David R. Russell , Jacqueline Nearing , Marlies Betka , Timothy Linley , Edward M. Brown
IPC分类号： A01K061/00
CPC分类号： C07K14/461 , A01K79/00 , A01K79/02 , A23K50/80
摘要： The present invention relates to methods of imprinting fish in freshwater with at least one odorant for the fish and causing the imprinted fish to react to the odorant in seawater, wherein the fish are maintained in freshwater prior to transfer to seawater, The method includes: adding at least one Polyvalent Cation Sensing Receptor (PVCR) modulator to the freshwater in an amount sufficient to modulate expression and/or sensitivity of at least one PVCR, the PVCR modulator being one which alters olfactory sensing of the fish to the odorant; adding feed for fish consumption to the freshwater, the feed containing the odorant and an amount of NaCl sufficient to contribute to a significantly increased level of the PVCR modulator in serum of the fish upon consumption of the feed, whereby the fish are imprinted with the odorant; transferring the imprinted fish to seawater; and providing a source of said odorant in the seawater to which the imprinted fish are transferred, thereby causing the imprinted fish to react to said odorant. The present invention also includes methods of homing or attracting fish, as well as methods for repelling fish by modulating the expression and/or sensitivity of the PVCR in the olfactory apparatus of the fish.
摘要翻译：本发明涉及将淡水中的鱼印在鱼上的至少一种气味剂，并使印迹鱼与海水中的加味剂反应的方法，其中鱼在转移到海水之前保持在淡水中。该方法包括：加入至少一种多价阳离子感应受体（PVCR）调节剂，其量足以调节至少一个PVCR的表达和/或敏感性，PVCR调节剂是将鱼的嗅觉感测改变为加臭剂的PVCR调节剂; 向淡水添加饲料，含有气味剂的饲料和一定量的NaCl足以有助于在饲料消耗时鱼血清中PVCR调节剂的水平显着提高，由此将鱼加上加味剂 ; 将印迹鱼转移到海水中; 并在所述海水中提供所述加臭剂的来源，所述海水中转印有所述印迹鱼，从而使所述印迹鱼与所述加臭剂反应。本发明还包括归巢或吸引鱼的方法，以及通过调节鱼的嗅觉装置中PVCR的表达和/或敏感性来排斥鱼的方法。

2. 发明申请

US20030084855A1 Methods for raising pre-adult anadromous fish 有权
公开(公告)号：US20030084855A1
公开(公告)日：2003-05-08
申请号：US10270795
申请日：2002-10-11
申请人： MariCal, Inc.
发明人： H. William Harris JR. , David R. Russell , Jacqueline Nearing , Marlies Betka
IPC分类号： A01K061/00
CPC分类号： A01K61/10 , A23K50/80 , Y02A40/81
摘要： The invention relates to methods, compositions and kits for improving the raising of pre-adult anadromous fish, or preparing pre-adult anadromous fish for transfer to seawater. The methods involve adding PVCR modulators (e.g., calcium and/or magnesium) to the freshwater in an amount sufficient to increase expression and/or sensitivity of at least one PVCR; and adding feed for fish consumption to the freshwater, wherein the feed contains an amount of NaCl sufficient to contribute to a significantly increased level of the PVCR modulator in serum of the pre-adult anadromous fish.

3. 发明申请

US20030230247A1 Methods for raising pre-adult anadromous fish 有权
公开(公告)号：US20030230247A1
公开(公告)日：2003-12-18
申请号：US10410872
申请日：2003-04-09
申请人： MariCal, Inc.
发明人： H. William Harris JR. , David R. Russell , Jacqueline Nearing , Marlies Betka
IPC分类号： A01K061/00 , C12N005/00
CPC分类号： A01K61/10 , A23K50/80 , Y02A40/81
摘要： The invention relates to methods, compositions and kits for improving the raising of pre-adult anadromous fish, or preparing pre-adult anadromous fish for transfer to seawater. The methods involve adding at least one Polyvalent Cation Sensing Receptor (PVCR) modulator to the freshwater in an amount sufficient to increase expression and/or sensitivity of at least one PVCR; and adding feed for fish consumption to the freshwater, wherein the feed comprises an amount of NaCl sufficient to contribute to a significantly increased level of the PVCR modulator in serum of the pre-adult anadromous fish.

4. 发明授权

US09351998B2 Methods of nourishing animals 有权
标题翻译：滋养动物的方法
公开(公告)号：US09351998B2
公开(公告)日：2016-05-31
申请号：US14148242
申请日：2014-01-06
申请人： MariCal, Inc.
发明人： H. William Harris, Jr. , Marlies Betka , Chris Frederick Holm , Steven Harold Jury
IPC分类号： A61K31/315 , A61K31/20 , A61K38/00 , A61K33/34 , A23K1/16 , A23K1/175 , A23K1/18 , A61K31/137 , A61K31/19 , A61K31/198 , A61K31/28 , A61K31/593 , A61K33/06 , A61K33/30 , A61K33/32 , A61K45/06 , A61K31/59 , A61K31/138
CPC分类号： A61K33/34 , A23K10/18 , A23K20/10 , A23K20/111 , A23K20/142 , A23K20/147 , A23K20/174 , A23K20/24 , A23K20/30 , A23K50/30 , A23K50/70 , A23K50/75 , A61K31/137 , A61K31/138 , A61K31/19 , A61K31/198 , A61K31/28 , A61K31/315 , A61K31/59 , A61K31/593 , A61K33/06 , A61K33/30 , A61K33/32 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of maintaining, and methods of restoring, a desired calcium homeostasis in a non-human terrestrial animal by administering an effective amount of one or more Calcium-Sensing Receptor modulators (CaSRs) to the animal. The invention further provides methods of reducing foot lesions in chickens. The invention also relates to food compositions useful in the methods of the invention.
摘要翻译：本发明涉及通过向动物施用有效量的一种或多种钙感受器调节剂（CaSR）来维持和恢复非人类陆地动物中期望的钙稳态的方法和方法。本发明还提供了减少鸡中足部损伤的方法。本发明还涉及可用于本发明方法的食品组合物。

5. 发明申请

US20140370120A1 Methods of Nourishing Animals 有权
标题翻译：滋养动物的方法
公开(公告)号：US20140370120A1
公开(公告)日：2014-12-18
申请号：US14148242
申请日：2014-01-06
申请人： MariCal, Inc.
发明人： H. William Harris, JR. , Marlies Betka , Chris Frederick Holm , Steven Harold Jury
IPC分类号： A61K33/34 , A61K33/06 , A23K1/18 , A61K33/30 , A61K33/32 , A23K1/175 , A61K31/138 , A61K31/593
CPC分类号： A61K33/34 , A23K10/18 , A23K20/10 , A23K20/111 , A23K20/142 , A23K20/147 , A23K20/174 , A23K20/24 , A23K20/30 , A23K50/30 , A23K50/70 , A23K50/75 , A61K31/137 , A61K31/138 , A61K31/19 , A61K31/198 , A61K31/28 , A61K31/315 , A61K31/59 , A61K31/593 , A61K33/06 , A61K33/30 , A61K33/32 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of maintaining, and methods of restoring, a desired calcium homeostasis in a non-human terrestrial animal by administering an effective amount of one or more Calcium-Sensing Receptor modulators (CaSRs) to the animal. The invention further provides methods of reducing foot lesions in chickens. The invention also relates to food compositions useful in the methods of the invention.
摘要翻译：本发明涉及通过向动物施用有效量的一种或多种钙感受器调节剂（CaSR）来维持和恢复非人类陆地动物中期望的钙稳态的方法和方法。本发明还提供了减少鸡中足部损伤的方法。本发明还涉及可用于本发明方法的食品组合物。

6. 发明申请

US20030226516A1 Growing marine fish in fresh water 失效
标题翻译：在淡水中种植海鱼
公开(公告)号：US20030226516A1
公开(公告)日：2003-12-11
申请号：US10411076
申请日：2003-04-09
申请人： MariCal, Inc.
发明人： H. William Harris JR. , David R. Russell , Jacqueline Nearing , Marlies Betka
IPC分类号： A01K061/00 , C12N005/02
CPC分类号： A01K63/04 , A01K61/10 , A01K61/80 , A01K61/85 , A23K20/142 , A23K20/147 , A23K20/20 , A23K20/22 , A23K50/80 , Y02A40/81 , Y02A40/845
摘要： The invention relates to methods, compositions and kits for raising marine fish in freshwater. The methods involve adding at least one Polyvalent Cation Sensing Receptor (PVCR) modulator to the freshwater in an amount sufficient to increase expression and/or sensitivity of at least one PVCR; and adding feed for fish consumption to the freshwater, wherein the feed comprises an amount of NaCl sufficient to contribute to a significant increased level of the PVCR modulator in serum of the marine fish.
摘要翻译：本发明涉及用于在淡水中养殖海鱼的方法，组合物和试剂盒。所述方法包括以足以增加至少一个PVCR的表达和/或敏感性的量向淡水中加入至少一种多价阳离子感应受体（PVCR）调节剂; 并向淡水添加鱼类消费的饲料，其中饲料包含一定量的NaCl，足以有助于海鱼血清中PVCR调节剂的显着提高。

7. 发明申请

US20030124090A1 Methods for growing and imprinting fish using an odorant 有权
标题翻译：使用气味剂生长和印迹鱼的方法
公开(公告)号：US20030124090A1
公开(公告)日：2003-07-03
申请号：US10268051
申请日：2002-10-08
申请人： MariCal, Inc.
发明人： H. William Harris JR. , Steven Jury , David R. Russell , Jacqueline Nearing , Marlies Betka , Timothy Linley , Edward M. Brown
IPC分类号： A61K038/19 , A61K038/17 , A23K001/165 , A61K031/13
CPC分类号： C07K14/461 , A01K79/00 , A01K79/02 , A23K50/80
摘要： The present invention relates to methods of imprinting fish to be sensitized to an odorant so that modulation of the PVCR in the olfactory apparatus occurs, and then exposing the fish with the same odorant after transfer to seawater or freshwater. The present invention also includes methods of homing or attracting fish, as well as methods for repelling fish by modulating the expression and/or sensitivity of the PVCR in the olfactory apparatus of the fish.
摘要翻译：本发明涉及将臭味感光的鱼的印迹方法，以便调节嗅觉装置中的PVCR，然后在转移到海水或淡水之后用相同的气味剂将鱼暴露。本发明还包括归巢或吸引鱼的方法，以及通过调节鱼的嗅觉装置中PVCR的表达和/或敏感性来排斥鱼的方法。

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