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1. 发明授权

US08143420B2 Bifunctional and trifunctional nitrone spin trapping compounds and uses thereof 失效
标题翻译：双官能和三官能硝酮自旋捕获化合物及其用途
公开(公告)号：US08143420B2
公开(公告)日：2012-03-27
申请号：US12343975
申请日：2008-12-24
申请人： Micael Joel Hardy , Marcos Lopez , Balaraman Kalyanaraman , Neil Hogg , Olivier Ouari , Paul Tordo
发明人： Micael Joel Hardy , Marcos Lopez , Balaraman Kalyanaraman , Neil Hogg , Olivier Ouari , Paul Tordo
IPC分类号： C07D403/00
CPC分类号： G01N33/5308 , G01N33/84 , Y10T436/141111
摘要： Methods and compositions for detecting free radicals, the compositions being spin trapping compounds comprising a nitrone having a detecting moiety and optionally having a targeting moiety for targeting the nitrone to an organ, a cell, an organelle or a molecule of interest for directly detecting free radicals, especially free radicals in biological samples.
摘要翻译：用于检测自由基的方法和组合物，所述组合物是包含具有检测部分的硝酮的旋转捕获化合物，并且任选地具有靶向部分，用于将硝酮靶向用于直接检测自由基的器官，细胞，细胞器或目标分子，特别是生物样品中的自由基。

2. 发明授权

US06375529B1 Reversible life raft and method therefor 失效
标题翻译：可逆救生筏及其方法
公开(公告)号：US06375529B1
公开(公告)日：2002-04-23
申请号：US09898637
申请日：2001-07-03
申请人： Marisa Infante , Daniel Alvarez , Alain Sosa , Marcos Lopez
发明人： Marisa Infante , Daniel Alvarez , Alain Sosa , Marcos Lopez
IPC分类号： B63B3558
CPC分类号： B63C9/04 , B63C2009/042 , B63C2009/046
摘要： The present invention is an inflatable, reversible life raft with a raft body including upper and lower inflatable, peripherally disposed bladders defining a closed geometric shape. The raft body also includes upper and lower inflatable masts in pneumatic communication with the upper and lower bladders, respectively. A floor closes the geometric shape between the upper and lower bladders. The upper and lower masts support upper and lower canopies, respectively. The upper canopy forms an upright, above-water enclosure to protect survivors from the elements. The lower canopy forms an underwater ballast beneath the floor of the raft, stabilizing the life raft. The reversible life raft is equipped with a reversible, collapsible ladder attached to an exterior portion of the two stacked bladders, and is equipped with two reversible ballast pouches mounted to an exterior portion of the two stacked bladders opposite the ladder. A method for establishing a reversible life raft for survivors in a body of water is also included.
摘要翻译：本发明是一种具有筏体的可充气，可逆的救生筏，其包括限定封闭几何形状的上部和下部可充气的外围设置的气囊。筏体还包括分别与上下气囊气动连通的上下可充气桅杆。地板封闭上下囊之间的几何形状。上下桅分别支撑上下檐。上冠层形成一个直立的水上围栏，以保护幸存者免受元素的伤害。下层冠层在木筏底部形成水下压载物，稳定了救生筏。可逆式救生筏配备有可拆卸的可折叠的梯子，其附接到两个堆叠的气囊的外部部分，并且配备有两个可逆的压载气囊，其安装到与梯子相对的两个堆叠的气囊的外部部分。还包括为身体的幸存者建立可逆救生筏的方法。

3. 发明授权

US08388936B2 In vivo mitochondrial labeling using positively-charged nitroxide enhanced and gadolinium chelate enhanced magnetic resonance imaging 有权
标题翻译：体内线粒体标记使用正电荷氮氧自由基增强和钆螯合增强磁共振成像
公开(公告)号：US08388936B2
公开(公告)日：2013-03-05
申请号：US12390929
申请日：2009-02-23
申请人： Balaraman Kalyanaraman , Joy Joseph , Kathleen Marie Schmainda , Douglas Edward Prah , Marcos Lopez , Micael J. Hardy
发明人： Balaraman Kalyanaraman , Joy Joseph , Kathleen Marie Schmainda , Douglas Edward Prah , Marcos Lopez , Micael J. Hardy
IPC分类号： A61B5/055
CPC分类号： A61K49/108 , A61K49/103 , A61K49/105 , A61K49/106 , A61K49/20 , C07F9/572 , C07F9/59 , C07F9/6524 , C07F9/6561
摘要： A system and method for acquiring MR imaging data from a subject includes administering positively-charged nitroxides or gadolinium chelates for in vivo mitochondrial labeling, acquiring MR imaging data from the subject, and reconstructing an image of the subject having enhanced contrast in areas including metabolic and/or mitotic activity.
摘要翻译：用于从受试者获取MR成像数据的系统和方法包括给体内线粒体标记施用带正电的硝基氧化物或钆螯合物，从受试者获取MR成像数据，以及重建具有增强对比度的对象的图像，所述对象在包括代谢和 /或有丝分裂活性。

4. 发明申请

US20090069449A1 ETHAMBUTOL BASED NITRIC OXIDE DONORS 有权
标题翻译：基于陶瓷基的氧化氮助剂
公开(公告)号：US20090069449A1
公开(公告)日：2009-03-12
申请号：US11817377
申请日：2006-03-03
申请人： Daniel J. Smith , Marcos Lopez
发明人： Daniel J. Smith , Marcos Lopez
IPC分类号： A61K47/32 , C07C245/24 , D01D5/00 , C08F8/30
CPC分类号： C07C291/04 , D01D5/0007 , D01F6/76
摘要： The present invention relates generally to nitric oxide releasing pharmaceutical compounds. More particularly, the present invention relates to pharmaceutical compositions that release nitric oxide under physiological conditions. In one embodiment, the present invention relates to new chemical compounds—diazeniumdiolates nitric oxide donors—that are based on ethambutol possessing physiological and biomedical activity.
摘要翻译：本发明一般涉及一氧化氮释放药物化合物。更具体地说，本发明涉及在生理条件下释放一氧化氮的药物组合物。在一个实施方案中，本发明涉及基于具有生理和生物医学活性的乙胺丁醇的新的化学化合物 - 二氮烯二硫化物一氧化氮供体。

5. 发明申请

US20090214437A1 In Vivo Mitochondrial Labeling Using Positively-Charged Nitroxide Enhanced and Gadolinium Chelate Enhanced Magnetic Resonance Imaging 有权
标题翻译：体内线粒体标记使用正电荷硝酸氧化增强和钆增强磁共振成像
公开(公告)号：US20090214437A1
公开(公告)日：2009-08-27
申请号：US12390929
申请日：2009-02-23
申请人： Balaraman Kalyanaraman , Joy Joseph , Kathleen Marie Schmainda , Douglas Edward Prah , Marcos Lopez , Micael J. Hardy
发明人： Balaraman Kalyanaraman , Joy Joseph , Kathleen Marie Schmainda , Douglas Edward Prah , Marcos Lopez , Micael J. Hardy
IPC分类号： A61K49/06 , C07F9/28
CPC分类号： A61K49/108 , A61K49/103 , A61K49/105 , A61K49/106 , A61K49/20 , C07F9/572 , C07F9/59 , C07F9/6524 , C07F9/6561
摘要： A system and method for acquiring MR imaging data from a subject includes administering positively-charged nitroxides or gadolinium chelates for in vivo mitochondrial labeling, acquiring MR imaging data from the subject, and reconstructing an image of the subject having enhanced contrast in areas including metabolic and/or mitotic activity.
摘要翻译：用于从受试者获取MR成像数据的系统和方法包括给体内线粒体标记施用带正电的硝基氧化物或钆螯合物，从受试者获取MR成像数据，以及重建具有增强对比度的对象的图像，所述对象在包括代谢和 /或有丝分裂活性。

6. 发明申请

US20190294990A1 DETECTING FALSE POSITIVES IN STATISTICAL MODELS 审中-公开
公开(公告)号：US20190294990A1
公开(公告)日：2019-09-26
申请号：US16358937
申请日：2019-03-20
申请人： Marcos LOPEZ DE PRADO
发明人： Marcos LOPEZ DE PRADO
IPC分类号： G06N7/00 , G06F17/18 , G06F17/15 , G06N20/00
摘要： A method of estimating whether a statistical model is a false positive, comprising receiving a plurality of predicted outcomes computed by a plurality of statistical models for a historical dataset, computing a correlation matrix for the plurality of predicted outcomes, clustering the plurality of predicted outcomes in a plurality of clusters according to a plurality of clustering schemes based on the correlation matrix, selecting a clustering scheme having a highest quality score among a plurality of clustering schemes, computing, for each of the clusters of the selected clustering scheme, an aggregated predicted outcome aggregating the predicted outcomes clustered in the respective cluster, computing an estimated variance across the clusters, and computing a false positive probability of a selected one of the plurality of statistical models based on the aggregated predicted outcome of the cluster comprising the selected statistical model, the number of clusters, and the estimated variance across all clusters.

7. 发明申请

US20130142735A1 In Vivo Mitochondrial Labeling Using Positively-CHarged Nitroxide Enhanced and Gadolinum Chelate Enhanced Magnetic Resonance Imaging 审中-公开
标题翻译：体内线粒体标记使用积极的硝酸氧化增强和加钆螯合强化磁共振成像
公开(公告)号：US20130142735A1
公开(公告)日：2013-06-06
申请号：US13755506
申请日：2013-01-31
申请人： Balaraman Kalyanaraman , Joy Joseph , Kathleen Marie Schmainda , Douglas Edward Prah , Marcos Lopez , Micael Joel Hardy
发明人： Balaraman Kalyanaraman , Joy Joseph , Kathleen Marie Schmainda , Douglas Edward Prah , Marcos Lopez , Micael Joel Hardy
IPC分类号： A61K49/10 , C07F15/00
CPC分类号： A61K49/108 , A61K49/103 , A61K49/105 , A61K49/106 , A61K49/20 , C07F9/572 , C07F9/59 , C07F9/6524 , C07F9/6561
摘要： A system and method for acquiring MR imaging data from a subject includes administering positively-charged nitroxides or gadolinium chelates for in vivo mitochondrial labeling, acquiring MR imaging data from the subject, and reconstructing an image of the subject having enhanced contrast in areas including metabolic and/or mitotic activity.
摘要翻译：用于从受试者获取MR成像数据的系统和方法包括给体内线粒体标记施用带正电的硝基氧化物或钆螯合物，从受试者获取MR成像数据，以及重建具有增强对比度的对象的图像，所述对象在包括代谢和 /或有丝分裂活性。

8. 发明授权

US08119840B2 Ethambutol based nitric oxide donors 有权
标题翻译：乙胺丁醇一氧化氮供体
公开(公告)号：US08119840B2
公开(公告)日：2012-02-21
申请号：US11817377
申请日：2006-03-03
申请人： Daniel J. Smith , Marcos Lopez
发明人： Daniel J. Smith , Marcos Lopez
IPC分类号： C07C243/02 , B05D1/00 , A61F13/00
CPC分类号： C07C291/04 , D01D5/0007 , D01F6/76
摘要： The present invention relates generally to nitric oxide releasing pharmaceutical compounds. More particularly, the present invention relates to pharmaceutical compositions that release nitric oxide under physiological conditions. In one embodiment, the present invention relates to new chemical compounds—diazeniumdiolates nitric oxide donors—that are based on ethambutol possessing physiological and biomedical activity.
摘要翻译：本发明一般涉及一氧化氮释放药物化合物。更具体地说，本发明涉及在生理条件下释放一氧化氮的药物组合物。在一个实施方案中，本发明涉及基于具有生理和生物医学活性的乙胺丁醇的新的化学化合物 - 二氮烯二硫化物一氧化氮供体。

9. 发明申请

US20090170134A1 BIFUNCTIONAL AND TRIFUNCTIONAL NITRONE SPIN TRAPPING COMPOUNDS AND USES THEREOF 失效
标题翻译：双功能和功能性硝基螺旋捕获化合物及其用途
公开(公告)号：US20090170134A1
公开(公告)日：2009-07-02
申请号：US12343975
申请日：2008-12-24
申请人： Micael Joel Hardy , Marcos Lopez , Balaraman Kalyanaraman , Neil Hogg , Olivier Ouari , Paul Tordo
发明人： Micael Joel Hardy , Marcos Lopez , Balaraman Kalyanaraman , Neil Hogg , Olivier Ouari , Paul Tordo
IPC分类号： G01N33/573 , C07D495/04 , G01N33/68 , G01N33/543 , G01N33/00
CPC分类号： G01N33/5308 , G01N33/84 , Y10T436/141111
摘要： Methods and compositions for detecting free radicals, the compositions being spin trapping compounds comprising a nitrone having a detecting moiety and optionally having a targeting moiety for targeting the nitrone to an organ, a cell, an organelle or a molecule of interest for directly detecting free radicals, especially free radicals in biological samples.
摘要翻译：用于检测自由基的方法和组合物，所述组合物是包含具有检测部分的硝酮的旋转捕获化合物，并且任选地具有靶向部分，用于将硝酮靶向用于直接检测自由基的器官，细胞，细胞器或目标分子，特别是生物样品中的自由基。

10. 发明申请

US20130149240A1 99mTc-LABELED TRIPHENYLPHOSPHONIUM DERIVATIVE CONTRASTING AGENTS AND MOLECULAR PROBES FOR EARLY DETECTION AND IMAGING OF BREAST TUMORS 审中-公开
公开(公告)号：US20130149240A1
公开(公告)日：2013-06-13
申请号：US13753703
申请日：2013-01-30
申请人： Marcos Lopez , Micael Joel Hardy , Balaraman Kalyanaraman , Ming Zhao
发明人： Marcos Lopez , Micael Joel Hardy , Balaraman Kalyanaraman , Ming Zhao
IPC分类号： A61K51/08 , C07K1/13 , C07K5/10
CPC分类号： A61K51/088 , A61K51/0497 , C07F13/005 , C07K1/13 , C07K5/1027
摘要： 99mTc-labeled triphenylphosphonium contrasting agents that target the mitochondria and are useful for early detection of breast tumors using scintimammographic imaging. 99mTc-Mito10-MAG3 possesses advantageous radiopharmaceutical properties. The uptake in the myocardium is reduced by one to two orders of magnitude compared to 99mTc-MIBI. 99mTc-Mito10-MAG3 exhibits fast blood clearance, with a blood half-life of less than 2 minutes in rats. A diminished myocardial uptake combined with a prompt reduction of cardiovascular blood pool signal to facilitate improved signal-to-background ratios.

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