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1. 发明公开

US20240008736A1 Multi-Modal System for Fluorescence and Reflectance Imaging 审中-公开
公开(公告)号：US20240008736A1
公开(公告)日：2024-01-11
申请号：US18028514
申请日：2021-09-27
申请人： Manish Kulkarni
发明人： Manish D Kulkarni , James Ogg , Richard Graham , Noah Bareket
IPC分类号： A61B3/10 , A61B3/12 , A61B3/15 , A61B5/00
CPC分类号： A61B3/102 , A61B3/1025 , A61B3/1241 , A61B3/152 , A61B5/7257 , A61B5/742 , A61B2503/40
摘要： A multi-modal system that can perform optical coherence tomography (OCT), scanning laser ophthalmoscopy (fluorescence and reflectance), adaptive optics enhancement, and OCT-angiography simultaneously is presented. Such a system minimizes registration errors in multi-modality images, and accelerates biomedical research. Such a system could also permit enhanced high-speed diagnosis. This system would also permit a wide-selection of excitation wavelengths to measure fluorescence intensity from a variety of fluorophores and auto-fluorescing tissues. A novel animal positioning system that can easily align with the imaging beams for optimal image quality and high-speed experiment-setup and imaging of animals is also presented.

2. 发明申请

US20140293290A1 Method and System for Compact Optical Coherence Tomography 审中-公开
标题翻译：紧凑光学相干断层扫描的方法和系统
公开(公告)号：US20140293290A1
公开(公告)日：2014-10-02
申请号：US14302366
申请日：2014-06-11
申请人： MANISH KULKARNI
发明人： MANISH KULKARNI
IPC分类号： G01B9/02
CPC分类号： G01B9/02091 , A61B3/102 , A61B3/107 , G01B9/02007 , G01B9/02027 , G01B2290/65 , G01N21/4795
摘要： The tunable filter placed in front of the detector to make the interferometer more sensitive and accurate for reading various samples for diagnosis. Optical Coherence Tomography (OCT) system and apparatus of this instant application is very useful for diagnosis and management of ophthalmic diseases such as retinal diseases and glaucoma etc. Instant innovative OCT diagnostic system leverages advancements in cross technological platforms. Both the Michelson interferometric system and Mach-Zehnder interferometric system presented in this application could be used for the OCT imaging, which includes biological OCT imaging, medical OCT imaging, ophthalmic OCT imaging, corneal OCT imaging, retinal OCT imaging, and the like.
摘要翻译：可调滤波器放置在检测器前面，使干涉仪更灵敏，更准确，可用于读取各种样品进行诊断。光学相干断层扫描（OCT）系统和本设备可用于视网膜疾病和青光眼等眼科疾病的诊断和治疗。立即创新的OCT诊断系统利用跨技术平台的进步。本申请中介绍的迈克尔逊干涉仪系统和马赫 - 曾德干涉仪均可用于OCT成像，包括生物OCT成像，医学OCT成像，眼科OCT成像，角膜OCT成像，视网膜OCT成像等。

3. 发明授权

US08698728B2 Apparatus for integrated backlight and dynamic gamma/VCOM control on silicon chips 有权
标题翻译：用于集成背光和用于硅芯片的动态伽马/ VCOM控制的装置
公开(公告)号：US08698728B2
公开(公告)日：2014-04-15
申请号：US12610941
申请日：2009-11-02
申请人： Hendrik Santo , Dilip Sangam , Manish Kulkarni
发明人： Hendrik Santo , Dilip Sangam , Manish Kulkarni
IPC分类号： G09G3/36
CPC分类号： G09G3/3677 , G09G3/3406 , G09G3/3426 , G09G3/3611 , G09G2310/0237 , G09G2310/08 , G09G2320/0261
摘要： Integrated backlight unit (BLU) and liquid crystal systems and circuits in liquid crystal display (LCD) systems are described. An LCD system can include a BLU to emit light at different intensities, and a BLU controller coupled to the BLU and configured to control the intensities. An LCD unit can receive the emitted light, and emanate light at a selected luminosity. The LCD unit can include pixels corresponding to: a liquid crystalline medium to provide a transmittance of the light emitted or to transmit a color light; and transistors adapted to modulate reference voltages. An LCD unit controller can be coupled to the LCD unit and configured to control luminosity of the light emanated from the LCD unit. The BLU and the LCD unit, which can be integrated in a single integrated circuit, can be controlled during concurrent time periods for contrast enhancement of images displayed from the LCD unit.
摘要翻译：描述了液晶显示（LCD）系统中的集成背光单元（BLU）和液晶系统和电路。 LCD系统可以包括以不同强度发光的BLU和耦合到BLU并被配置为控制强度的BLU控制器。 LCD单元可以接收发射的光，并以选定的亮度发出光。 LCD单元可以包括对应于液晶介质的像素，以提供所发射的光的透射率或透射色光; 以及适于调制参考电压的晶体管。 LCD单元控制器可以耦合到LCD单元并且被配置为控制从LCD单元发出的光的亮度。可以在并发时间段内控制可集成在单个集成电路中的BLU和LCD单元，从而对从LCD单元显示的图像进行对比度增强。

4. 发明申请

US20110102450A1 APPARATUS FOR INTEGRATED BACKLIGHT AND DYNAMIC GAMMA/VCOM CONTROL ON SILICON CHIPS 有权
标题翻译：集成背光和动态伽马/硅胶控制的设备
公开(公告)号：US20110102450A1
公开(公告)日：2011-05-05
申请号：US12610941
申请日：2009-11-02
申请人： Hendrik Santo , Dilip S , Manish Kulkarni
发明人： Hendrik Santo , Dilip S , Manish Kulkarni
IPC分类号： G09G3/36 , G09G5/02
CPC分类号： G09G3/3677 , G09G3/3406 , G09G3/3426 , G09G3/3611 , G09G2310/0237 , G09G2310/08 , G09G2320/0261
摘要： Integrated backlight unit (BLU) and liquid crystal systems and circuits in liquid crystal display (LCD) systems are described. An LCD system can include a BLU to emit light at different intensities, and a BLU controller coupled to the BLU and configured to control the intensities. An LCD unit can receive the emitted light, and emanate light at a selected luminosity. The LCD unit can include pixels corresponding to: a liquid crystalline medium to provide a transmittance of the light emitted or to transmit a color light; and transistors adapted to modulate reference voltages. An LCD unit controller can be coupled to the LCD unit and configured to control luminosity of the light emanated from the LCD unit. The BLU and the LCD unit, which can be integrated in a single integrated circuit, can be controlled during concurrent time periods for contrast enhancement of images displayed from the LCD unit.
摘要翻译：描述了液晶显示（LCD）系统中的集成背光单元（BLU）和液晶系统和电路。 LCD系统可以包括以不同强度发光的BLU和耦合到BLU并被配置为控制强度的BLU控制器。 LCD单元可以接收发射的光，并以选定的亮度发出光。 LCD单元可以包括对应于液晶介质的像素，以提供所发射的光的透射率或透射色光; 以及适于调制参考电压的晶体管。 LCD单元控制器可以耦合到LCD单元并且被配置为控制从LCD单元发出的光的亮度。可以在并发时间段内控制可集成在单个集成电路中的BLU和LCD单元，从而对从LCD单元显示的图像进行对比度增强。

5. 发明授权

US06518975B1 Modularized architecture for color and image management system 失效
标题翻译：颜色和图像管理系统的模块化架构
公开(公告)号：US06518975B1
公开(公告)日：2003-02-11
申请号：US09165374
申请日：1998-10-02
申请人： Manish Kulkarni , Moshe Broudo
发明人： Manish Kulkarni , Moshe Broudo
IPC分类号： G09G502
CPC分类号： G06F8/30
摘要： A configurable color and image management system which allows a developer to create customized color and image management for a color-related application operating in a specified environment. A configurator is provided which has access to a library of plural classes of color and image management functionality, with each class including plural different modules of varying complexity and processing quality. The classes pertain to different aspects of color and image management functionality, such as a class to perform linearization and gamma correction, a class to perform color space transformation, a class to perform image correction, a class to perform gray color component replacement, a class to perform image expansion, and a class to perform halftone processing. The developer provides design parameters which define the operating environment within which the target color and image management system is designed to operate. Based on the design parameters, the configurator selects the highest quality modules in whichever classes of color and/or image management functionality are needed, all within the constraints defined by the parameters of the operating environment. Thereafter, a list of the selected modules are provided to a core module which provides a framework from which the selected modules can be invoked to realize the target color and image management system.
摘要翻译：可配置的颜色和图像管理系统，允许开发人员为在指定环境中运行的颜色相关应用程序创建定制的颜色和图像管理。提供一种配置器，其具有访问多种颜色和图像管理功能的库，每个类包括具有不同复杂度和处理质量的多个不同模块。这些类涉及颜色和图像管理功能的不同方面，例如执行线性化和伽马校正的类，执行颜色空间变换的类，执行图像校正的类，执行灰色成分替换的类，类执行图像扩展，以及执行半色调处理的类。开发人员提供设计参数，其中定义了目标颜色和图像管理系统设计的操作环境。基于设计参数，配置者选择要求颜色和/或图像管理功能的哪一类中的最高质量模块，均在由操作环境的参数定义的约束内。此后，将所选择的模块的列表提供给核心模块，该核心模块提供框架，从中可以调用所选择的模块以实现目标颜色和图像管理系统。

6. 发明申请

US20160256051A9 SYSTEM AND METHOD FOR IMAGING SUBSURFACE OF SPECIMEN 审中-公开
标题翻译：用于成像样本表面的系统和方法
公开(公告)号：US20160256051A9
公开(公告)日：2016-09-08
申请号：US13723006
申请日：2012-12-20
申请人： Manish Kulkarni
发明人： Manish Kulkarni
IPC分类号： A61B3/12 , A61B5/02 , A61B1/24 , A61B5/00 , A61B5/08
CPC分类号： A61B3/1241 , A61B1/24 , A61B3/102 , A61B3/12 , A61B5/004 , A61B5/0066 , A61B5/0088 , A61B5/02007 , A61B5/08 , A61B5/42 , A61B5/7221 , A61B5/7225
摘要： There is a need for robust and portable system, apparatus and method for imaging subsurface of specimens. We have described a modular OCDR-OCT system and OFDR-OCT system to obtain high quality images. The instant application also discusses proprietary algorithms that have been modified from existing algorithms and their use as a combination to suit a particular system. The imaging of stationary, moving and combination of both subsurface structures such as retina for diabetic patients is described.
摘要翻译：需要用于对样本的地下成像进行成像的强大且便携的系统，装置和方法。我们已经描述了一种模块化OCDR-OCT系统和OFDR-OCT系统，以获得高质量的图像。本应用程序还讨论了已经从现有算法中修改的专有算法及其作为组合的用途以适合特定系统。描述了两种地下结构如视网膜对糖尿病患者的静止，移动和组合的成像。

7. 发明申请

US20160367136A9 SYSTEM AND METHOD FOR IMAGING SUBSURFACE OF SPECIMEN 审中-公开
公开(公告)号：US20160367136A9
公开(公告)日：2016-12-22
申请号：US13723006
申请日：2012-12-20
申请人： Manish Kulkarni
发明人： Manish Kulkarni
IPC分类号： A61B3/12 , A61B5/02 , A61B1/24 , A61B5/00 , A61B5/08
CPC分类号： A61B3/1241 , A61B1/24 , A61B3/102 , A61B3/12 , A61B5/004 , A61B5/0066 , A61B5/0088 , A61B5/02007 , A61B5/08 , A61B5/42 , A61B5/7221 , A61B5/7225
摘要： There is a need for robust and portable system, apparatus and method for imaging subsurface of specimens. We have described a modular OCDR-OCT system and OFDR-OCT system to obtain high quality images. The instant application also discusses proprietary algorithms that have been modified from existing algorithms and their use as a combination to suit a particular system. The imaging of stationary, moving and combination of both subsurface structures such as retina for diabetic patients is described.

8. 发明申请

US20140180075A1 SYSTEM AND METHOD FOR IMAGING SUBSURFACE OF SPECIMEN 审中-公开
标题翻译：用于成像样本表面的系统和方法
公开(公告)号：US20140180075A1
公开(公告)日：2014-06-26
申请号：US13723006
申请日：2012-12-20
申请人： Manish Kulkarni
发明人： Manish Kulkarni
IPC分类号： A61B3/12 , A61B5/02 , A61B1/24 , A61B5/00 , A61B5/08
CPC分类号： A61B3/1241 , A61B1/24 , A61B3/102 , A61B3/12 , A61B5/004 , A61B5/0066 , A61B5/0088 , A61B5/02007 , A61B5/08 , A61B5/42 , A61B5/7221 , A61B5/7225
摘要： There is a need for robust and portable system, apparatus and method for imaging subsurface of specimens. We have described a modular OCDR-OCT system and OFDR-OCT system to obtain high quality images. The instant application also discusses proprietary algorithms that have been modified from existing algorithms and their use as a combination to suit a particular system. The imaging of stationary, moving and combination of both subsurface structures such as retina for diabetic patients is described.
摘要翻译：需要用于对样本的地下成像进行成像的强大且便携的系统，装置和方法。我们已经描述了一种模块化OCDR-OCT系统和OFDR-OCT系统，以获得高质量的图像。本应用程序还讨论了已经从现有算法中修改的专有算法及其作为组合的用途以适合特定系统。描述了两种地下结构如视网膜对糖尿病患者的静止，移动和组合的成像。

9. 发明授权

US06870636B2 Determining color mappings for a color printer 失效
标题翻译：确定彩色打印机的颜色映射
公开(公告)号：US06870636B2
公开(公告)日：2005-03-22
申请号：US09196689
申请日：1998-11-20
申请人： Manish Kulkarni
发明人： Manish Kulkarni
IPC分类号： H04N1/60 , G06K1/00
CPC分类号： H04N1/6033 , H04N1/6019
摘要： A method for deriving a reverse model look-up table whose entries represent device dependent colors as a function of device independent colors, based on a forward model look-up table whose entries represent device independent colors obtained in response to printout of corresponding device dependent colors. For each device independent target color, a binary search of the forward model look-up table is performed so as to locate a cell that contains the device independent target color. The grid points from the forward model look-up table that define the cell are interpolated so as to obtain device dependent colors corresponding to the device independent target color. The device dependent color is stored at the grid point for the reverse model look-up table at a position corresponding to the device independent target color.
摘要翻译：一种用于导出反向模型查找表的方法，其基于正向模型查找表，其条目表示响应于对应的设备依赖颜色的打印而获得的设备无关的颜色，该反向模型查找表的条目表示与设备无关的颜色的设备相关颜色。对于每个设备独立的目标颜色，执行正向模型查找表的二进制搜索，以便定位包含设备无关目标颜色的单元。内插定义单元的正向模型查找表中的网格点，以获得与设备无关的目标颜色对应的设备相关颜色。依赖于设备的颜色存储在与设备无关的目标颜色对应的位置处的反向型号查找表的网格点处。

10. 发明授权

US06360026B1 Method for determining a skew angle of a bitmap image and de-skewing and auto-cropping the bitmap image 失效
标题翻译：用于确定位图图像的偏斜角度和去偏移和自动裁剪位图图像的方法
公开(公告)号：US06360026B1
公开(公告)日：2002-03-19
申请号：US09037343
申请日：1998-03-10
申请人： Manish Kulkarni , Timothy L. Kohler
发明人： Manish Kulkarni , Timothy L. Kohler
IPC分类号： G06K936
CPC分类号： G06K9/3283
摘要： Determining a skew angle of a bitmap image comprising of background and image pixels and de-skewing the bitmap image by the determined skew angle. The bitmap image skew angle is determined by calculating plural estimates of the skew angle with corresponding reliability indicators and thereafter selecting the estimate skew angle with the best reliability indicator as the bitmap image skew angle and then de-skew the bitmap image by the determined skew angle. Thereafter, auto-cropping the de-skewed image around a rectangle defined by a first and last column and first and last row of pixels which are not all white.
摘要翻译：确定包括背景和图像像素的位图图像的偏斜角度，并且通过确定的倾斜角度去偏移位图图像。通过用对应的可靠性指标计算歪斜角的多个估计，然后选择具有最佳可靠性指标的估计偏斜角作为位图图像歪斜角来确定位图图像歪斜角度，然后通过确定的倾斜角度对位图图像进行去偏斜。此后，自动裁剪由第一列和最后一列定义的矩形以及不全部为白色的第一和最后一行像素。

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