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1. 发明申请

US20150165225A1 COMPUTER-AIDED SIMULATION TOOL FOR PROVIDING ASSISTANCE IN THE PLANNING OF THERMOTHERAPY 有权
标题翻译：计算机辅助模拟工具，用于在热神规划中提供帮助
公开(公告)号：US20150165225A1
公开(公告)日：2015-06-18
申请号：US14569193
申请日：2014-12-12
申请人： MAGFORCE AG
发明人： Jacek NADOBNY , Peng Liu , Jens-Thorsten Ollek , Heike C. Bender
IPC分类号： A61N2/00 , G06F19/00
CPC分类号： A61N2/004 , A61B34/10 , A61K9/5094 , A61K41/0052 , A61N1/406 , A61N2/00 , G06F19/00 , G16H50/50
摘要： The invention relates to a computer-aided simulation tool, in particular to computer-aided simulation methods, for providing assistance in the planning of thermotherapy, and to suitably configured computer equipment. The thermotherapy comprises hyperthermic treatment of a tumour volume within a volume of a human body. The hyperthermic treatment comprises the application of a magnetic field within a treatment volume by means of a magnetic field applicator. In at least one depot volume, thermal energy can be introduced by means of magnetic, paramagnetic and/or superparamagnetic nanoparticles deposited in the body, by power absorption in the applied magnetic field. Field strength values and optionally calculated temperature distributions are provided for assisting the user in the planning of the thermotherapy.
摘要翻译：本发明涉及一种计算机辅助模拟工具，特别是涉及计算机辅助模拟方法，用于在热疗计划中提供帮助，以及适当配置的计算机设备。热疗包括对体内体积肿瘤体积的高热治疗。高温处理包括通过磁场施加器在处理体积内施加磁场。在至少一个贮库体积中，通过在施加的磁场中的功率吸收，通过沉积在体内的磁性，顺磁性和/或超顺磁性纳米颗粒可引入热能。提供场强值和可选的计算温度分布，以帮助用户规划热疗。

2. 发明授权

US09827312B2 Method for carrying therapeutic substances into cells 有权
公开(公告)号：US09827312B2
公开(公告)日：2017-11-28
申请号：US14849053
申请日：2015-09-09
申请人： MAGFORCE AG
发明人： Andreas Jordan , Norbert Waldoefner , Regina Scholz
IPC分类号： A61K9/50 , A61K9/51 , A61K33/00 , A61K41/00 , A61K9/00 , A61K9/10 , A61K33/24 , A61K33/26 , A61K33/30 , A61K33/32 , A61K33/34 , A61K45/06 , A61N1/40 , B82Y5/00 , A61K31/136 , A61K31/282 , A61K31/407 , A61K31/513 , A61K31/546
CPC分类号： A61K41/0052 , A61K9/0009 , A61K9/0019 , A61K9/10 , A61K9/5094 , A61K9/5115 , A61K9/5146 , A61K31/136 , A61K31/282 , A61K31/407 , A61K31/513 , A61K31/546 , A61K33/00 , A61K33/24 , A61K33/26 , A61K33/30 , A61K33/32 , A61K33/34 , A61K45/06 , A61N1/406 , B82Y5/00 , Y10S977/773
摘要： The present invention relates to compositions containing nanoparticies and uses of said composition for transferring therapeutically active substances into cells by means of specifically coated nanoparticles. The chemical design of the particles is such that a large amount thereof is absorbed into the cells. No direct bond between nanoparticle and the therapeutically active substance is required for the transfer into the cells. Thanks to said transfer, an increased efficacy of the substance and simultaneously reduced systemic toxicity is achieved, i.e. an increase in the efficacy while the side effects are reduced.

3. 发明申请

US20160367673A1 AGGLOMERATING MAGNETIC ALKOXYSILANE-COATED NANOPARTICLES 有权
标题翻译： AGAGOMERATING MAGNETIC ALKOXYSILANE涂层纳米颗粒
公开(公告)号：US20160367673A1
公开(公告)日：2016-12-22
申请号：US15198708
申请日：2016-06-30
申请人： MagForce AG
发明人： Norbert WALDOEFNER , Andreas JORDAN
IPC分类号： A61K41/00 , H01F1/00 , A61K9/51
CPC分类号： A61K41/0052 , A61K9/5146 , H01F1/0054 , H01F41/16
摘要： The present invention relates to a method for producing a suspension of agglomerates of magnetic alkoxysilane-coated metal nanoparticles, wherein an aqueous suspension of magnetic metal nanoparticles is incubated with alkoxysilane, wherein the incubation is carried out essentially in the absence of an organic solvent. The present invention further relates to suspension of agglomerates of magnetic alkoxysilane-coated metal containing nanoparticles obtainable by the method of the present invention and to a composition comprising agglomerates of magnetic alkoxysilane-coated metal nanoparticles, wherein the agglomerates have an average size of 30 to 450 nm, preferably of 50 to 350 nm and especially of 70 to 300 nm as determined by light scattering.
摘要翻译：本发明涉及一种制备磁性烷氧基硅烷涂覆的金属纳米颗粒的附聚物的悬浮液的方法，其中将磁性金属纳米颗粒的水悬浮液与烷氧基硅烷一起温育，其中基本上在不存在有机溶剂的情况下进行温育。本发明还涉及通过本发明的方法获得的含有磁性烷氧基硅烷涂覆的含有金属纳米颗粒的纳米颗粒的悬浮液和包含磁性烷氧基硅烷涂覆的金属纳米颗粒的附聚物的组合物，其中所述附聚物的平均尺寸为30至450 通过光散射测定，优选为50至350nm，特别是70至300nm。

4. 发明授权

US09962442B2 Agglomerating magnetic alkoxysilane-coated nanoparticles 有权
公开(公告)号：US09962442B2
公开(公告)日：2018-05-08
申请号：US15198708
申请日：2016-06-30
申请人： MagForce AG
发明人： Norbert Waldoefner , Andreas Jordan
IPC分类号： A61K41/00 , H01F41/16 , H01F1/00 , A61K9/51
CPC分类号： A61K41/0052 , A61K9/5146 , H01F1/0054 , H01F41/16
摘要： The present invention relates to a method for producing a suspension of agglomerates of magnetic alkoxysilane-coated metal nanoparticles, wherein an aqueous suspension of magnetic metal nanoparticles is incubated with alkoxysilane, wherein the incubation is carried out essentially in the absence of an organic solvent. The present invention further relates to suspension of agglomerates of magnetic alkoxysilane-coated metal containing nanoparticles obtainable by the method of the present invention and to a composition comprising agglomerates of magnetic alkoxysilane-coated metal nanoparticles, wherein the agglomerates have an average size of 30 to 450 nm, preferably of 50 to 350 nm and especially of 70 to 300 nm as determined by light scattering.

5. 发明授权

US09814677B2 Magnetic transducers 有权
公开(公告)号：US09814677B2
公开(公告)日：2017-11-14
申请号：US14277904
申请日：2014-05-15
申请人： MagForce AG
发明人： Norbert Waldoefner , Kerstin Stief
IPC分类号： A61K9/14 , A61K45/06 , A61K33/26 , A61K41/00 , B82Y30/00 , C01G49/02 , C01G49/06 , C01G49/08 , C09C1/24
CPC分类号： A61K9/143 , A61K33/26 , A61K41/0052 , A61K45/06 , B82Y30/00 , C01G49/02 , C01G49/06 , C01G49/08 , C01P2004/42 , C01P2004/64 , C09C1/24
摘要： Embodiments herein relate to the production of biocompatible magnetic nanoparticles with a high SAR-value which produce a large amount of heat when exposed to an alternating magnetic field. The produced heat can be used among others for therapeutic purposes, in particular for combating cancer.

6. 发明授权

US09844680B2 Computer-aided simulation tool for providing assistance in the planning of thermotherapy 有权
公开(公告)号：US09844680B2
公开(公告)日：2017-12-19
申请号：US14569193
申请日：2014-12-12
申请人： MAGFORCE AG
发明人： Jacek Nadobny , Peng Liu , Jens-Thorsten Ollek , Heike C. Bender
IPC分类号： G06F7/60 , G06G7/56 , A61N2/00 , A61N1/40 , G06F19/00 , A61K41/00 , A61K9/50 , A61B34/10
CPC分类号： A61N2/004 , A61B34/10 , A61K9/5094 , A61K41/0052 , A61N1/406 , A61N2/00 , G06F19/00 , G16H50/50
摘要： The invention relates to a computer-aided simulation tool, in particular to computer-aided simulation methods, for providing assistance in the planning of thermotherapy, and to suitably configured computer equipment. The thermotherapy comprises hyperthermic treatment of a tumour volume within a volume of a human body. The hyperthermic treatment comprises the application of a magnetic field within a treatment volume by means of a magnetic field applicator. In at least one depot volume, thermal energy can be introduced by means of magnetic, paramagnetic and/or superparamagnetic nanoparticles deposited in the body, by power absorption in the applied magnetic field. Field strength values and optionally calculated temperature distributions are provided for assisting the user in the planning of the thermotherapy.

7. 发明申请

US20160067338A1 METHOD FOR CARRYING THERAPEUTIC SUBSTANCES INTO CELLS 有权
标题翻译：将治疗性物质携带到细胞中的方法
公开(公告)号：US20160067338A1
公开(公告)日：2016-03-10
申请号：US14849053
申请日：2015-09-09
申请人： MagForce AG
发明人： Andreas JORDAN , Norbert WALDOEFNER , Regina SCHOLZ
IPC分类号： A61K41/00 , A61K31/546 , A61K33/24 , A61K9/00 , A61K31/513 , A61K31/282 , A61K9/51 , A61K31/407 , A61K31/136
CPC分类号： A61K41/0052 , A61K9/0009 , A61K9/0019 , A61K9/10 , A61K9/5094 , A61K9/5115 , A61K9/5146 , A61K31/136 , A61K31/282 , A61K31/407 , A61K31/513 , A61K31/546 , A61K33/00 , A61K33/24 , A61K33/26 , A61K33/30 , A61K33/32 , A61K33/34 , A61K45/06 , A61N1/406 , B82Y5/00 , Y10S977/773
摘要： The present invention relates to compositions containing nanoparticies and uses of said composition for transferring therapeutically active substances into cells by means of specifically coated nanoparticles. The chemical design of the particles is such that a large amount thereof is absorbed into the cells. No direct bond between nanoparticle and the therapeutically active substance is required for the transfer into the cells. Thanks to said transfer, an increased efficacy of the substance and simultaneously reduced systemic toxicity is achieved, i.e. an increase in the efficacy while the side effects are reduced.
摘要翻译：本发明涉及包含纳米颗粒的组合物和所述组合物用于通过特异性涂覆的纳米颗粒将治疗活性物质转移到细胞中的用途。颗粒的化学设计使其大量被吸收到细胞中。纳米颗粒与治疗活性物质之间不需要直接结合进入细胞。由于所述转移，实现了物质的增加的功效并同时降低了全身毒性，即效力的提高而副作用降低。

8. 发明申请

US20140302154A1 MAGNETIC TRANSDUCERS 有权
标题翻译：磁性传感器
公开(公告)号：US20140302154A1
公开(公告)日：2014-10-09
申请号：US14277904
申请日：2014-05-15
申请人： MagForce AG
发明人： Norbert WALDOEFNER , Kerstin STIEF
IPC分类号： A61K9/14 , A61K45/06 , A61K33/26
CPC分类号： A61K9/143 , A61K33/26 , A61K41/0052 , A61K45/06 , B82Y30/00 , C01G49/02 , C01G49/06 , C01G49/08 , C01P2004/42 , C01P2004/64 , C09C1/24
摘要： Embodiments herein relate to the production of biocompatible magnetic nanoparticles with a high SAR-value which produce a large amount of heat when exposed to an alternating magnetic field. The produced heat can be used among others for therapeutic purposes, in particular for combating cancer.
摘要翻译：本文的实施方案涉及生产具有高SAR值的生物相容性磁性纳米颗粒，其在暴露于交变磁场时产生大量的热量。产生的热量可以用于治疗目的，特别是用于治疗癌症。

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