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1. 发明授权

US07509959B2 Method and apparatus for circulatory valve repair 有权
标题翻译：循环瓣膜修复方法和装置
公开(公告)号：US07509959B2
公开(公告)日：2009-03-31
申请号：US10883412
申请日：2004-06-30
申请人： Mehmet C. Oz , Gerald M. Lemole , Alan Lotvin , Juan P. Umana , William Allen , Howard P. Levin
发明人： Mehmet C. Oz , Gerald M. Lemole , Alan Lotvin , Juan P. Umana , William Allen , Howard P. Levin
IPC分类号： A61B19/00 , A61B17/08 , A61B17/10
CPC分类号： A61B17/0686 , A61B17/064 , A61B17/0644 , A61B17/08 , A61B17/10 , A61B17/122 , A61B17/1285 , A61B2017/00243 , A61B2017/0649 , A61F2/2427
摘要： An apparatus for the repair of a cardiovascular valve has leaflets comprising a grasper capable of grabbing and co-apting the leaflets of the valve. In a preferred embodiment the grasper has jaws that grasp and immobilize the leaflets, and then a fastener is inserted to co-apt the leaflets. The apparatus is particularly useful for repairing mitral valves to cure mitral regurgitation.
摘要翻译：用于修复心血管瓣膜的装置具有包括能够抓住和共同锁定瓣膜的小叶片的抓紧器的小叶。在优选实施例中，抓紧器具有夹持并固定传单的夹爪，然后插入紧固件以使传单合流。该装置特别适用于修复二尖瓣以治愈二尖瓣反流。

2. 发明授权

US06767324B2 Epicardial cooled stabilizer for beating heart surgery 有权
标题翻译：用于心跳手术的心外膜冷却稳定器
公开(公告)号：US06767324B2
公开(公告)日：2004-07-27
申请号：US09966237
申请日：2001-09-28
申请人： David A. D'Alessandro , Mehmet C. Oz
发明人： David A. D'Alessandro , Mehmet C. Oz
IPC分类号： A61B1700
CPC分类号： A61B17/0206 , A61B2017/0243 , A61B2018/00023
摘要： An epicardial cooled stabilizer system is useful for surgical or laparoscopic applications, especially beating heart surgery. The system comprises a stabilizer connected to a cooler/pump where coolant flows into tubing at the distal end of the stabilizer. The tubing is positioned at a surgical site to enhance traction and minimize trauma.
摘要翻译：心外膜冷却稳定器系统可用于手术或腹腔镜应用，特别是打心脏手术。该系统包括连接到冷却器/泵的稳定器，其中冷却剂流入稳定器远端的管道。管道定位在手术部位以增强牵引力并最小化创伤。

3. 发明授权

US06269819B1 Method and apparatus for circulatory valve repair 有权
标题翻译：循环瓣膜修复方法和装置
公开(公告)号：US06269819B1
公开(公告)日：2001-08-07
申请号：US09254111
申请日：1999-02-25
申请人： Mehmet C. Oz , Gerald M. Lemole , Alan Lotvin , Juan P. Umana , William Allen , Howard P. Levin
发明人： Mehmet C. Oz , Gerald M. Lemole , Alan Lotvin , Juan P. Umana , William Allen , Howard P. Levin
IPC分类号： A61B1900
CPC分类号： A61B17/0686 , A61B17/064 , A61B17/0644 , A61B17/08 , A61B17/10 , A61B17/122 , A61B17/1285 , A61B2017/00243 , A61B2017/0649 , A61F2/2427
摘要： An apparatus for the repair of a cardiovascular valve having leaflets comprises a grasper capable of grabbing and co-apting the leaflets of the valve. Preferably, the grasper has jaw that grasp, immobilize the leaflets, and then a fastener is inserted to co-apt the leaflets. The apparatus is particularly useful for repairing mitral valves to cure mitral regurgitation.
摘要翻译：用于修复具有小叶的心血管瓣膜的装置包括能够抓住并共同插入瓣膜的小叶的抓紧器。优选地，抓紧器具有抓握，固定传单的钳口，然后将紧固件插入以与传单共同适配。该装置特别适用于修复二尖瓣以治愈二尖瓣反流。

4. 发明授权

US5370989A Solution for prolonged organ preservation 失效
标题翻译：长期器官保存的解决方案
公开(公告)号：US5370989A
公开(公告)日：1994-12-06
申请号：US206197
申请日：1994-03-03
申请人： David M. Stern , Mehmet C. Oz , Roman Nowygrod , Shin Koga , David J. Pinsky
发明人： David M. Stern , Mehmet C. Oz , Roman Nowygrod , Shin Koga , David J. Pinsky
IPC分类号： A01N1/02
CPC分类号： A01N1/02 , A01N1/0226
摘要： The present invention provides an aqueous solution for organ preservation or maintenance, including: a vasodilator in an amount sufficient to maintain vascular homeostasis; D-glucose in an amount sufficient to support intracellular function and maintenance of cellular bioenergetics; magnesium ions in an amount sufficient to support intracellular function and maintenance of cellular bioenergetics; macromolecules of molecular weight greater than 20,000 daltons in an amount sufficient to maintain endothelial integrity and cellular viability; potassium ions in a concentration greater than about 110 mM; and a buffer in an amount sufficient to maintain the average pH of the organ preservation or maintenance solution during the period of organ preservation at about the physiologic pH value. The invention also provides a method of preserving or maintaining an organ, including contacting the organ with the solution.
摘要翻译：本发明提供了一种用于器官保存或维持的水溶液，包括：足以维持血管内环境稳定的血管扩张剂; D-葡萄糖的量足以支持细胞内功能和维持细胞生物能量; 足以支持细胞内功能和维持细胞生物能量的镁离子; 分子量大于20,000道尔顿的大分子，其量足以维持内皮完整性和细胞活力; 浓度大于约110mM的钾离子; 以及足以在器官保存期间在约生理pH值下保持器官保存或维持溶液的平均pH的缓冲剂。本发明还提供了保存或维持器官的方法，包括使器官与溶液接触。

5. 发明申请

US20100179833A1 AUTOMATED COACHING 审中-公开
标题翻译：自动教练
公开(公告)号：US20100179833A1
公开(公告)日：2010-07-15
申请号：US12649661
申请日：2009-12-30
申请人： MICHAEL F. ROIZEN , Mehmet C. Oz , Jeffrey D. Roizen
发明人： MICHAEL F. ROIZEN , Mehmet C. Oz , Jeffrey D. Roizen
IPC分类号： G06Q50/00 , G06Q10/00 , G06F3/01
CPC分类号： G06Q50/10 , G06Q50/2057 , G06Q50/22 , G06Q50/24
摘要： System and methods are disclosed that provide a coaching system that is programmed to process data entered automatically or manually for a given client and determine an indication of progress for the given client according to a coaching plan designed for the client. A response generator automatically generates a personalized response for the given client depending on the indication of progress for the given client, which response can be sent to the given client with or without first being reviewed by the client's coach.
摘要翻译：公开了提供一种辅导系统，其被编程为处理为给定客户端自动或手动输入的数据，并根据为客户设计的辅导计划确定给定客户端的进度指示。响应发生器根据给定客户的进度指示，自动生成针对给定客户端的个性化响应，哪个响应可以被发送给给定的客户端，有或者没有首先被客户的教练审查。

6. 发明申请

US20090287506A1 Methods and Systems for Improving Human Health Using Targeted Probiotics 有权
标题翻译：使用目标益生菌改善人类健康的方法和系统
公开(公告)号：US20090287506A1
公开(公告)日：2009-11-19
申请号：US12466750
申请日：2009-05-15
申请人： Michael F. Roizen , Mehmet C. Oz
发明人： Michael F. Roizen , Mehmet C. Oz
IPC分类号： G06Q50/00 , G06Q90/00
CPC分类号： G06F19/322 , G06F19/00 , G06F19/326 , G06F19/3456 , G06Q50/22 , G06Q50/24 , G06Q99/00 , G16H10/60 , Y02A90/22 , Y02A90/26
摘要： Methods and systems enable healthcare providers to identify metabolites that may cause a medical condition in a patient. The healthcare providers may then use the identified metabolite to identify a probiotic that may affect the regulation of that metabolite. Patient information, such as medical history and diagnosis data may then be used in combination with the identified probiotic to create a personalized medicament for that patient.
摘要翻译：方法和系统使医疗保健提供者能够识别可能导致患者医疗状况的代谢物。医疗保健提供者然后可以使用鉴定的代谢物来鉴定可能影响该代谢物调节的益生菌。然后可以将患者信息（例如病史和诊断数据）与所鉴定的益生菌组合使用以为该患者创建个性化药物。

7. 发明申请

US20090276037A1 Method And Apparatus For Circulatory Valve Repair 有权
标题翻译：循环瓣膜修复方法与装置
公开(公告)号：US20090276037A1
公开(公告)日：2009-11-05
申请号：US12209336
申请日：2008-09-12
申请人： Mehmet C. Oz , Gerald M. Lemole , Alan Lotvin , Juan P. Umana , William Allen , Howard R. Levin
发明人： Mehmet C. Oz , Gerald M. Lemole , Alan Lotvin , Juan P. Umana , William Allen , Howard R. Levin
IPC分类号： A61F2/24 , A61B17/00
CPC分类号： A61B17/0686 , A61B17/064 , A61B17/0644 , A61B17/08 , A61B17/10 , A61B17/122 , A61B17/1285 , A61B2017/00243 , A61B2017/0649 , A61F2/2427
摘要： An apparatus for the repair of a cardiovascular valve has leaflets comprising a grasper capable of grabbing and co-apting the leaflets of the valve. In a preferred embodiment, the grasper has jaws that grasp and immobilize the leaflets, and then a fastener is inserted to co-apt the leaflets. The apparatus is particularly useful for repairing mitral valves to cure mitral regurgitation.
摘要翻译：用于修复心血管瓣膜的装置具有包括能够抓住和共同锁定瓣膜的小叶片的抓紧器的小叶。在优选实施例中，抓紧器具有抓住和固定传单的钳口，然后将紧固件插入以与传单共同适配。该装置特别适用于修复二尖瓣以治愈二尖瓣反流。

8. 发明申请

US20090088482A1 Compositions and Methods For Treating Heart Failure 审中-公开
标题翻译：治疗心力衰竭的组合物和方法
公开(公告)号：US20090088482A1
公开(公告)日：2009-04-02
申请号：US11885391
申请日：2004-10-13
申请人： Simon Maybaum , Jie Wang , Mehmet C. Oz , Steve Xydas , Aftab Kherani
发明人： Simon Maybaum , Jie Wang , Mehmet C. Oz , Steve Xydas , Aftab Kherani
IPC分类号： A61K31/138
CPC分类号： A61K31/135
摘要： The present invention provides compositions and methods for the following: preventing and treating heart failure; preventing heart failure in a patient with a pre-heart failure condition; treating and preventing heart failure with ischemic and non-ischemic causes; treating and preventing heart failure in a subject status post myocardial infarction; reversing damage to the heart following myocardial infarction; by administering to a subject an effective amount of an adrenergic beta-agonist either alone or in combination with an effective amount of an adrenergic beta-1 antagonist. FIG. 1 is a bar graph representing relative infarct sizes, as expressed as a percentage of left ventricular circumference.
摘要翻译：本发明提供了以下的组合物和方法：预防和治疗心力衰竭; 预防心力衰竭病人的心力衰竭; 用缺血和非缺血性原因治疗和预防心力衰竭; 治疗和预防心肌梗死后受试者状态的心力衰竭; 逆转心肌梗死后的心脏损伤; 通过向受试者单独或与有效量的肾上腺素β-1拮抗剂组合施用有效量的肾上腺素能β受体激动剂。图。图1是表示相对梗死面积的条形图，表示为左心室周长的百分比。

9. 发明申请

US20120215790A1 System and Method for Determining an Objective Measure of Human Quality of Life 有权
标题翻译：确定人类生活质量目标度的系统和方法
公开(公告)号：US20120215790A1
公开(公告)日：2012-08-23
申请号：US13214945
申请日：2011-08-22
申请人： Michael F. Roizen , Mehmet C. Oz , Jennifer L. Roizen , Jeffrey D. Roizen
发明人： Michael F. Roizen , Mehmet C. Oz , Jennifer L. Roizen , Jeffrey D. Roizen
IPC分类号： G06F17/30
CPC分类号： A45D44/005
摘要： An objective measure of human QOL is determined by a QOL quantification system. The QOL quantification system comprises a QOL rules engine, a QOL measure datastore, a score data archive, a user computing device, and a network. The QOL measure datastore comprises quantifiable measures of QOL of a QOL factor. The QOL rules engine comprises instructions for receiving user data indicative of a plurality of attributes of a selected QOL factor of the user, obtaining measures of QOL from the QOL measures datastore associated with the selected QOL factor, evaluating the user data against the QOL measures of the selected QOL factor, determining a user score indicative of the QOL of the selected QOL factor of the user, storing the user score in the score data archive, and comparing the user score to a score stored in the score data archive. The QOL rules engine may also suggest change options to one or more QOL factors to improve the user score. The suggested change options may be presented as an ordered listed organized by a relative cost benefit measure.
摘要翻译：人类生活质量的客观量度由生活质量系统确定。 QOL量化系统包括QOL规则引擎，QOL测量数据存储，分数数据归档，用户计算设备和网络。生活质量测量数据存储区包括生活质量因子的可量化度量标准。 QOL规则引擎包括用于接收指示用户选择的生活质量因子的多个属性的用户数据的指令，从与选择的生活质量因子相关联的生活质量度量数据存储区获得生活质量的度量，所选择的生活质量因子，确定指示用户选择的生活质量因子的生活质量的用户分数，将用户分数存储在分数数据归档中，以及将用户分数与存储在分数数据归档中的得分进行比较。 QOL规则引擎还可以针对一个或多个生活质量因素建议更改选项，以改善用户分数。建议的变更选项可以按相关的成本效益计量方式列出。

10. 发明申请

US20120143217A1 METHOD AND APPARATUS FOR CIRCULATORY VALVE REPAIR 有权
标题翻译：循环阀维修方法与装置
公开(公告)号：US20120143217A1
公开(公告)日：2012-06-07
申请号：US13370690
申请日：2012-02-10
申请人： MEHMET C. OZ , Gerald M. Lemole , Alan Lotvin , Juan P. Umana , William Allen , Howard P. Levin
发明人： MEHMET C. OZ , Gerald M. Lemole , Alan Lotvin , Juan P. Umana , William Allen , Howard P. Levin
IPC分类号： A61B17/10
CPC分类号： A61B17/0686 , A61B17/064 , A61B17/0644 , A61B17/08 , A61B17/10 , A61B17/122 , A61B17/1285 , A61B2017/00243 , A61B2017/0649 , A61F2/2427
摘要： An apparatus for the repair of a cardiovascular valve has leaflets comprising a grasper capable of grabbing and co-apting the leaflets of the valve. In a preferred embodiment, the grasper has jaws that grasp and immobilize the leaflets, and then a fastener is inserted to co-apt the leaflets. The apparatus is particularly useful for repairing mitral valves to cure mitral regurgitation.
摘要翻译：用于修复心血管瓣膜的装置具有包括能够抓住和共同锁定瓣膜的小叶片的抓紧器的小叶。在优选实施例中，抓紧器具有抓住和固定传单的钳口，然后将紧固件插入以与传单共同适配。该装置特别适用于修复二尖瓣以治愈二尖瓣反流。

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