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1. 发明授权

US10329327B2 Tricalcium phosphate binding peptides and uses thereof 有权
公开(公告)号：US10329327B2
公开(公告)日：2019-06-25
申请号：US13991842
申请日：2011-12-06
申请人： Luis Alvarez , Linda G. Griffith , Yadir Guerrero , Linda Stockdale , Jaime Rivera
发明人： Luis Alvarez , Linda G. Griffith , Yadir Guerrero , Linda Stockdale , Jaime Rivera
IPC分类号： C07K7/08 , A61K38/10 , A61K35/28 , A61K38/18 , A61L27/12 , A61L27/38 , A61L27/54 , A61L27/56 , C07K14/485 , C12N5/0775
摘要： The invention is directed to a composition comprising all or a portion of a beta-tricalcium phosphate (β-TCP) bound to all or a portion of a β-TCP binding peptide and methods of use thereof.

2. 发明授权

US6084090A Human papilloma virus anti-sense oligonucleotides 失效
标题翻译：人乳头状瘤病毒反义寡核苷酸
公开(公告)号：US6084090A
公开(公告)日：2000-07-04
申请号：US929140
申请日：1997-09-05
申请人： Joseph DiPaolo , Luis Alvarez-Salas
发明人： Joseph DiPaolo , Luis Alvarez-Salas
IPC分类号： C12N15/113 , A61K31/70 , A61K31/7125 , A61K38/00 , A61K48/00 , A61P35/00 , C07H21/00 , C07K14/025 , C12N9/00 , C12N15/09 , C07H21/04
CPC分类号： C12N15/1131 , C07H21/00 , A61K38/00 , C12N2310/11 , C12N2310/12 , C12N2310/3125 , C12N2310/315 , C12N2310/321 , C12N2310/346
摘要： Antisense oligonucleotides having phosphorothioate backbone structure and sequences complementary to nucleotides contained with residues 415 to 445 of human papilloma virus 16 (HPV-16) are disclosed. Methods of treatment using antisense oligonucleotides having phosphorothioate backbone structure and nucleotide sequences complementary to nucleotides contained with residues 415 to 445 of HPV-16 are disclosed.
摘要翻译：公开了具有硫代磷酸酯骨架结构和与人乳头瘤病毒16（HPV-16）残基415至445所含核苷酸互补的序列的反义寡核苷酸。公开了使用具有硫代磷酸酯骨架结构的反义寡核苷酸和与HPV-16残基415至445所含核苷酸互补的核苷酸序列的方法。

3. 发明申请

US20150336125A1 Rim Detailing Tool 审中-公开
标题翻译：轮圈细部工具
公开(公告)号：US20150336125A1
公开(公告)日：2015-11-26
申请号：US14717012
申请日：2015-05-20
申请人： Angel Luis Alvarez
发明人： Angel Luis Alvarez
IPC分类号： B05B15/04
CPC分类号： B05B12/30
摘要： The present invention provides a tire rim detailing tool configured to removably adhere to an inner edge of a wheel to enclose a tire rim. In this way, the tire rim is protected from any cleaning supplies that may damage the tire rim during car detailing. The tire rim detailing tool includes a body portion that is preferably circular and includes a front side and a rear side. The rear side includes an absorbent pad that extends along an outer edge of the body portion. The absorbent pad is removably attached to an inner edge of a wheel via an adhesive to prevent any cleaning supplies from damaging the tire rim. The front side includes a handle that extends along a diameter of the body portion. Furthermore, the body portion is foldable along the diameter and a pair of chords that are equally spaced from and parallel to the diameter.
摘要翻译：本发明提供一种轮胎边缘细长工具，其构造成可移除地粘附到轮的内边缘以包围轮胎边缘。以这种方式，轮胎边缘被保护免受在汽车细节期间可能损坏轮胎边缘的任何清洁用品。轮胎胎面细长工具包括主体部分，该主体部分优选为圆形并且包括前侧和后侧。后侧包括沿主体部分的外边缘延伸的吸收垫。吸收垫通过粘合剂可移除地附接到轮的内边缘，以防止任何清洁用品损坏轮胎边缘。前侧包括沿主体部分的直径延伸的把手。此外，主体部分沿着直径可折叠，并且与直径等距并且平行的一对和弦可折叠。

4. 发明授权

US07355304B2 X-ray device 有权
标题翻译： X光装置
公开(公告)号：US07355304B2
公开(公告)日：2008-04-08
申请号：US10524576
申请日：2003-02-07
申请人： Francisco Diaz Carmena , Alfonso Querol Siles , Angel Diaz Carmena , José Luis Alvarez Dominguez
发明人： Francisco Diaz Carmena , Alfonso Querol Siles , Angel Diaz Carmena , José Luis Alvarez Dominguez
IPC分类号： H02J1/00
CPC分类号： H05G1/10 , Y10T307/696
摘要： X-Ray equipment, that as well as having a controlled current converter, a capacitor bank, an inverter, a supply source, and a high voltage transformer, has inlet voltage evaluation equipment that activates relays of the connection points of an auxiliary supply transformer so that it is not necessary to manually carry out any change in the supply connections depending on the supply voltage. Furthermore it is possible to carry out the charging of the capacitors in a programmed manner, and the charging voltage of the capacitor bank is fixed and independent of the supply voltage, the equipment being able to operate automatically at a voltage between 90 and 264 volts.
摘要翻译：具有受控电流转换器，电容器组，逆变器，供电源和高压变压器的X射线设备具有启动辅助电源变压器的连接点的继电器的入口电压评估设备不需要根据电源电压手动进行供电连接的任何更改。此外，可以以编程的方式执行电容器的充电，并且电容器组的充电电压是固定的并且与电源电压无关，设备能够在90和264伏之间的电压下自动运行。

5. 发明授权

US6067663A Feminine garment with sexually stimulating effect 失效
标题翻译：女性服装具有性刺激作用
公开(公告)号：US6067663A
公开(公告)日：2000-05-30
申请号：US51549
申请日：1999-03-22
申请人： Luis Alvarez Fernandez
发明人： Luis Alvarez Fernandez
IPC分类号： A41B9/04 , A61H19/00 , A41D5/00
CPC分类号： A41B9/04 , A41B9/002 , A61H19/30 , A61H19/34 , A61H2201/163 , A61H2201/165
摘要： Feminine garment with sexual stimulation effect characterized in that it is worn on the waist, buttocks and pubis of a woman, including a piece that surrounds the waist, provided with a ring at a front central part to which is joined or attached the front extremity of a perineal necklace having one or more rows of beads passing over the pubis between the legs and buttocks of a woman, the rear extremity being linked to the center of the rear part of the woman's back. The walking motion or the movement of the legs causes a friction on the external genital parts, thereby producing sexual stimulation on the wearer. The garment is intended to provide sexual, ludic or erotic therapy.
摘要翻译： PCT No.PCT / ES96 / 00159 Sec。 371日期1999年3月22日 102（e）1999年3月22日PCT PCT 1996年8月12日PCT公布。公开号WO98 / 06372 日期1998年2月19日具有性刺激效果的女性服装，其特征在于，其穿在腰部，女性的臀部和耻骨，包括围绕腰部的部分，在前中央部分处连接有环，将会阴项链的前肢连接在女子背部的后部的中心处，该会阴项链具有穿过耻骨之间的一排或多排珠子，位于女性的腿部和臀部之间。步行运动或腿的运动导致外部生殖部位的摩擦，从而对佩戴者产生性刺激。服装旨在提供性，淫乱或色情疗法。

6. 发明申请

US20220063479A1 HEADLIGHT OXIDATION PROTECTOR 有权
公开(公告)号：US20220063479A1
公开(公告)日：2022-03-03
申请号：US17463041
申请日：2021-08-31
申请人： Luis ALVAREZ
发明人： Luis ALVAREZ
IPC分类号： B60Q1/00 , B60Q1/04
摘要： A cover for the headlights of a vehicle is provided herein. The covers are intended to be used on the vehicle while parked during the day to help to prevent and eliminate headlights getting oxidized. Oxidation makes headlights look foggy, cloudy, yellow and, in some cases, physically rough. Embodiments of the protector are individually designed and manufactured to fit various makes, models, and years of vehicles.

7. 发明申请

US20140037593A1 Tricalcium Phosphate Binding Peptides And Uses Thereof 审中-公开
标题翻译：磷酸三钙结合肽及其用途
公开(公告)号：US20140037593A1
公开(公告)日：2014-02-06
申请号：US13991842
申请日：2011-12-06
申请人： Luis Alvarez , Linda G. Griffith , Yadir Guerrero , Linda Stockdale , Jaime Rivera
发明人： Luis Alvarez , Linda G. Griffith , Yadir Guerrero , Linda Stockdale , Jaime Rivera
IPC分类号： C07K7/08 , C12N5/0775 , A61K38/10 , A61K38/18 , C07K14/485 , A61K35/28
CPC分类号： C07K7/08 , A61K35/28 , A61K38/10 , A61K38/1808 , A61L27/12 , A61L27/3834 , A61L27/3847 , A61L27/54 , A61L27/56 , A61L2300/25 , A61L2300/252 , A61L2300/414 , A61L2400/08 , A61L2400/18 , A61L2430/02 , C07K14/485 , C12N5/0662 , A61K2300/00
摘要： The invention is directed to a composition comprising all or a portion of a beta-tricalcium phosphate (β-TCP) bound to all or a portion of a β-TCP binding peptide and methods of use thereof.
摘要翻译：本发明涉及一种组合物，其包含与β-TCP结合肽的全部或一部分结合的全部或部分β-磷酸三钙（β-TCP）及其使用方法。

8. 发明申请

US20120255558A1 TISSUE GUARD FOR MEDICAL APPLICATIONS 审中-公开
标题翻译：医疗应用组织护理
公开(公告)号：US20120255558A1
公开(公告)日：2012-10-11
申请号：US13079855
申请日：2011-04-05
申请人： Jose Luis Alvarez
发明人： Jose Luis Alvarez
IPC分类号： A61B19/00
CPC分类号： A61B17/02 , A61B17/0218 , A61B17/32002 , A61B2090/08021
摘要： A tissue guard for medical applications. The tissue guard may include a tissue shielding portion having a central area and a peripheral area, and an attachment portion that is coupled to the shielding portion and adapted to couple to a medical tool. The attachment portion may include a first prong and a second prong, disposed such that the medical tool is received between the prongs.
摘要翻译：用于医疗应用的组织护罩。组织护罩可以包括具有中心区域和周边区域的组织屏蔽部分，以及耦合到屏蔽部分并适于耦合到医疗工具的附接部分。附接部分可以包括第一插脚和第二插脚，其被布置成使得医疗工具被容纳在插脚之间。

9. 发明申请

US20090081249A1 Bi-Functional Polymer-Attached Inhibitors of Influenza Virus 审中-公开
标题翻译：双功能聚合物附着的流感病毒抑制剂
公开(公告)号：US20090081249A1
公开(公告)日：2009-03-26
申请号：US12197452
申请日：2008-08-25
申请人： Jayanta Haldar , Luis Alvarez de Cienfuegos , Alexander M. Klibanov , Jianzhu Chen
发明人： Jayanta Haldar , Luis Alvarez de Cienfuegos , Alexander M. Klibanov , Jianzhu Chen
IPC分类号： A61K39/385 , A61K47/48 , A61P31/16
CPC分类号： A61K47/6809 , A61K47/549 , A61K47/551 , A61K47/60 , A61K47/64 , A61K47/645 , A61K47/65
摘要： Antimicrobial compositions containing two or more antiviral agents coupled to a polymer and methods of making and using the compositions, are described herein. In one embodiment, two or more antiviral agents are covalently coupled to the polymer. Suitable antiviral agents include, but are not limited to, sialic acid, zanamivir, oseltamivir, amantadine, rimantadine, and combinations thereof. The polymer is preferably a water-soluble, biocompatible polymer. Suitable polymers include, but are not limited to, poly(isobutylene-alt-maleic anhydride) (PIBMA), poly(aspartic acid), poly(l-glutamic acid), polylysine, poly(acrylic acid), plyaginic acid, chitosan, carboxymethyl cellulose, carboxymethyl dextran, polyethyleneimine, and blends and copolymers thereof. In another embodiment, the compositions contain a physical mixture of polymer containing one antiviral agent and polymer containing a second antiviral agent. The compositions can be formulated for enteral or parenteral administration. Suitable oral/intranasal dosage forms include, but are not limited to, tablets, capsules, solutions, suspensions, emulsions, syrups, and lozenges. Suitable dosage forms for parenteral administration include, but are not limited to, solutions, suspensions, and emulsions. The compositions described herein are effective at treating a variety of infections, including viral infections such as influenza, while inhibiting or preventing the development of microbial resistance.
摘要翻译：包含与聚合物偶联的两种或多种抗病毒剂的抗微生物组合物以及制备和使用组合物的方法在本文中描述。在一个实施方案中，两种或多种抗病毒剂与聚合物共价偶联。合适的抗病毒剂包括但不限于唾液酸，扎那米韦，奥司他韦，金刚烷胺，金刚乙胺及其组合。聚合物优选为水溶性的生物相容性聚合物。合适的聚合物包括但不限于聚（异丁烯 - 马来酸酐）（PIBMA），聚（天冬氨酸），聚（1-谷氨酸），聚赖氨酸，聚（丙烯酸），聚阴离子酸，壳聚糖，羧甲基纤维素，羧甲基葡聚糖，聚乙烯亚胺及其共混物和共聚物。在另一个实施方案中，组合物含有含有一种抗病毒剂的聚合物和含有第二抗病毒剂的聚合物的物理混合物。组合物可以配制用于肠内或肠胃外给药。合适的口服/鼻内剂型包括但不限于片剂，胶囊，溶液，悬浮液，乳剂，糖浆剂和锭剂。用于肠胃外给药的合适剂型包括但不限于溶液，悬浮液和乳剂。本文描述的组合物在治疗多种感染（包括病毒感染例如流行性感冒）同时抑制或预防微生物耐药性方面是有效的。

10. 发明申请

US20070179110A1 EXPRESSION OF IMMUNOGENIC SUBSTANCES 审中-公开
标题翻译：表达免疫物质
公开(公告)号：US20070179110A1
公开(公告)日：2007-08-02
申请号：US11611708
申请日：2006-12-15
申请人： Stephen Russell , Luis Alvarez-Vallina , Siamak Agha-Mohammadi , Robert Hawkins
发明人： Stephen Russell , Luis Alvarez-Vallina , Siamak Agha-Mohammadi , Robert Hawkins
IPC分类号： A61K48/00 , C12N15/09
CPC分类号： C12N15/79 , A61K48/00 , C12N5/0636 , C12N2510/02
摘要： Disclosed is a method of regulating the expression in a human or animal subject of a nucleic acid sequence encoding a polypeptide which is immunogenic in the subject; the method comprising introducing into a mammal a cell comprising the nucleic acid sequence encoding the immunogenic polypeptide, said sequence being operably linked to a drug-regulatable promoter; and altering the concentration of regulatory drug to which the cell is exposed.
摘要翻译：公开了一种调节人或动物受试者中编码在受试者中具有免疫原性的多肽的核酸序列的表达的方法; 所述方法包括向哺乳动物中引入包含编码免疫原性多肽的核酸序列的细胞，所述序列可操作地连接于药物可调节启动子; 并改变细胞暴露于其中的调节药物的浓度。

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