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1. 发明授权

US08846093B2 Adhesive mixture for transdermal delivery of highly plasticizing drugs 有权
标题翻译：用于经皮递送高度增塑药物的粘合剂混合物
公开(公告)号：US08846093B2
公开(公告)日：2014-09-30
申请号：US13100581
申请日：2011-05-04
申请人： Sharad K. Govil , Ludwig J. Weimann
发明人： Sharad K. Govil , Ludwig J. Weimann
IPC分类号： A61K9/14 , A61K9/70 , A61K31/137 , A61K31/138 , A61K31/4402
CPC分类号： A61K9/7061 , A61K31/137 , A61K31/138 , A61K31/4402 , A61K45/06 , A61K47/32
摘要： Transdermal drug delivery patches and methods of their production are described. The patches can be made such that the accommodate highly plasticizing drugs such as selegiline and/or the use of protonated forms of various drugs.
摘要翻译：描述了透皮药物递送贴剂及其生产方法。可以制备贴片使得容纳高度增塑药物如司来吉兰和/或使用质子化形式的各种药物。

2. 发明申请

US20100040690A1 Adhesive mixture for transdermal delivery of highly plasticizing drugs 审中-公开
标题翻译：用于经皮递送高度增塑药物的粘合剂混合物
公开(公告)号：US20100040690A1
公开(公告)日：2010-02-18
申请号：US12589380
申请日：2009-10-22
申请人： Sharad K. Govil , Ludwig J. Weimann
发明人： Sharad K. Govil , Ludwig J. Weimann
IPC分类号： A61K47/32 , A61K9/00 , A61K31/137 , A61K31/138 , A61K31/24 , A61K31/4402
CPC分类号： A61K9/7061 , A61K31/137 , A61K31/138 , A61K31/4402 , A61K45/06 , A61K47/32
摘要： Transdermal drug delivery patches and methods of their production are described. The patches can be made such that the accommodate highly plasticizing drugs such as selegiline and/or the use of protonated forms of various drugs.
摘要翻译：描述了透皮药物递送贴剂及其生产方法。可以制备贴片使得容纳高度增塑药物如司来吉兰和/或使用质子化形式的各种药物。

3. 发明授权

US6010715A Transdermal patch incorporating a polymer film incorporated with an active agent 失效
标题翻译：包含掺入活性剂的聚合物膜的透皮贴剂
公开(公告)号：US6010715A
公开(公告)日：2000-01-04
申请号：US954861
申请日：1997-10-21
申请人： John J. Wick , Ludwig J. Weimann , Wayne C. Pollock
发明人： John J. Wick , Ludwig J. Weimann , Wayne C. Pollock
IPC分类号： A61K9/70 , A61F13/02
CPC分类号： A61K9/7084
摘要： Devices for the controlled release of an active agent to the skin or mucosa of a host are disclosed, which devices are laminates of a backing layer and a monolithic carrier layer formed from a melt blend of an active ingredient with a thermoplastic matrix polymer without first dissolving or suspending the polymer or active ingredient in a solvent therefor, so that the carrier layer is substantially free of residual solvent, wherein the thermoplastic matrix polymer has a melt temperature between about 170.degree. C. and about 200.degree. C. and is selected from polyether block amides, ethylene methacrylic acid copolymers, ethylene acrylic acid copolymers, copolymers of polyether prepolymers with polybutylene terephthalate, copolymers of polyether prepolymers with polyisobutylene terephthalate and polyether polyurethanes, the active ingredient is heat stable at the melt temperature of the matrix polymer and is selected from active agents, active agent enhancers and mixtures thereof, and the laminate is provided with means for affixing the laminate to the skin or mucosa of the host so that the active ingredient is continuously released from the carrier layer thereto. Methods for assembling the device are also disclosed.
摘要翻译：公开了用于将活性剂受控释放到宿主皮肤或粘膜的装置，哪些装置是背衬层和由活性成分与热塑性基质聚合物的熔体共混物形成的整体载体层的叠层体，而没有首先溶解或将聚合物或活性成分悬浮在其溶剂中，使得载体层基本上不含残留溶剂，其中热塑性基质聚合物的熔体温度在约170℃至约200℃之间，并且选自聚醚嵌段酰胺，乙烯甲基丙烯酸共聚物，乙烯丙烯酸共聚物，聚醚预聚物与聚对苯二甲酸丁二醇酯的共聚物，聚醚预聚物与聚异丁烯对苯二甲酸酯和聚醚聚氨酯的共聚物，活性成分在基体聚合物的熔融温度下是热稳定的，活性剂，活性剂增强剂及其混合物，以及Lami 本发明提供了用于将层压材料固定到主体的皮肤或粘膜上的装置，使得活性成分从载体层连续释放。还公开了组装装置的方法。

4. 发明授权

US5679373A Process of assembling a transdermal patch incorporating a polymer film incorporated with an active agent 失效
标题翻译：组装含有掺入活性剂的聚合物膜的透皮贴剂的方法
公开(公告)号：US5679373A
公开(公告)日：1997-10-21
申请号：US477042
申请日：1995-06-07
申请人： John Wick , Ludwig J. Weimann , Wayne C. Pollock
发明人： John Wick , Ludwig J. Weimann , Wayne C. Pollock
IPC分类号： A61M37/00 , A61K9/70 , A61F13/02
CPC分类号： A61K9/703 , A61K9/7084
摘要： Devices for the controlled release of an active agent to the skin or mucosa of a host are disclosed, which devices are laminates of a backing layer, a monolithic carrier layer of an active ingredient selected from active agent, active agent enhancers and mixtures thereof, melt-blended with a thermoplastic matrix polymer capable of controllably releasing the active ingredient, wherein the active ingredient is heat stable at the melt temperature of the matrix polymer, together with means for affixing the laminate to the skin or mucosa of the host so that the active ingredient is continuously released from the carrier layer thereto. Methods for assembling the device are also disclosed, in which a thermoplastic matrix polymer capable of controllably releasing an active ingredient is melt-blended with an active ingredient that is heat stable at the melt temperature of the matrix polymer, so that a melt-blend of the active ingredient and the thermoplastic matrix polymer is formed, which melt-blend is formed into a monolithic carrier layer, and the carrier layer is then combined with a backing layer and means for affixing the laminate to the skin or mucosa of the host so that the active ingredient is released from the carrier layer thereto.
摘要翻译：公开了将活性剂受控释放到宿主皮肤或粘膜的装置，哪些装置是背衬层的叠层，选自活性成分的活性成分的整体载体层，活性剂增强剂及其混合物，熔体与能够可控地释放活性成分的热塑性基质聚合物共混，其中活性成分在基质聚合物的熔融温度下是热稳定的，以及用于将层压材料固定到主体的皮肤或粘膜的装置，使得活性成分成分从载体层连续释放。还公开了用于组装装置的方法，其中能够可控地释放活性成分的热塑性基质聚合物与在基质聚合物的熔融温度下热稳定的活性成分熔融共混，使得熔融共混物形成活性成分和热塑性基质聚合物，将该熔融共混物形成为整体载体层，然后将载体层与背衬层组合，并将该层压材料固定在主体的皮肤或粘膜上，使得活性成分从载体层释放出来。

5. 发明申请

US20110004150A1 Transdermal Delivery Using Encapsulated Agent Activated by Ultrasound and or Heat 有权
标题翻译：使用通过超声和/或热激活的封装剂的透皮递送
公开(公告)号：US20110004150A1
公开(公告)日：2011-01-06
申请号：US12883153
申请日：2010-09-15
申请人： Ludwig J. Weimann
发明人： Ludwig J. Weimann
IPC分类号： A61K9/70 , A61K38/28 , A61K9/50 , A61M37/00
CPC分类号： A61K9/0009 , A61K9/0014 , A61K9/7084 , A61K9/7092 , A61M37/00 , A61M37/0092 , A61N1/30
摘要： A method for delivery of substance through at least one dermal layer, by providing a substance in microcapsules at a predetermined size, within a medium (150) for holding the microcapsules; placing the medium for holding the microcapsules on a surface of a patch (100) adjacent the skin (320) of a human or animal; and applying energy (200) to the patch, the energy having a characteristic of disturbing the integrity of the microcapsules, thereby resulting in release of the substance from the microcapsules. The energy may be selectively applied to release the substance at desired times. The substance may be a drug or other active agent.
摘要翻译：通过在用于保持微胶囊的介质（150）内通过在预定尺寸的微胶囊中提供物质来输送物质通过至少一个真皮层的方法; 将用于保持微胶囊的介质放置在与人或动物的皮肤（320）相邻的贴片（100）的表面上; 并且将能量（200）施加到贴剂上，该能量具有干扰微胶囊完整性的特征，从而导致物质从微胶囊中释放出来。可以选择性地施加能量以在期望的时间释放物质。该物质可以是药物或其它活性剂。

6. 发明授权

US5503844A Foam laminate transdermal patch 失效
标题翻译：泡沫层压透皮贴片
公开(公告)号：US5503844A
公开(公告)日：1996-04-02
申请号：US63515
申请日：1993-05-18
申请人： Alfred Kwiatek , Ludwig J. Weimann , Wayne C. Pollock , Sharad K. Govil
发明人： Alfred Kwiatek , Ludwig J. Weimann , Wayne C. Pollock , Sharad K. Govil
IPC分类号： A61K9/70 , A61F13/00 , A61F13/02
CPC分类号： A61K9/703 , A61K9/7084
摘要： Devices for the controlled release of an active agent to the skin or mucosa of a host are disclosed, which devices are laminates of a cellular foam layer having a first surface and a second surface, which foam layer has an active agent incorporated therein; a backing layer having an inner surface and an outer surface, wherein the inner surface is affixed to the second surface of the foam layer so that the active agent cannot permeate from the second surface of the foam layer through the outer surface of the backing layer; and means for affixing the laminate to the skin or mucosa of the host so that the active agent is capable of being continuously released from the first surface of the foam layer thereto. Methods for assembling the laminate devices are also disclosed, as are methods in which the foam layer is formed from a prepolymer solution on the backing layer. Methods are also disclosed for the polymerization of cellular urethane foams having active agents uniformly dispersed therethrough.
摘要翻译：公开了将活性剂控制释放到主体的皮肤或粘膜上的装置，哪些装置是具有第一表面和第二表面的泡沫层的层压体，该泡沫层具有并入其中的活性剂; 背衬层，其具有内表面和外表面，其中内表面固定到泡沫层的第二表面，使得活性剂不能通过背衬层的外表面从泡沫层的第二表面渗透; 以及用于将层压材料固定到主体的皮肤或粘膜的装置，使得活性剂能够从泡沫层的第一表面连续释放。还公开了组装层压装置的方法，以及其中泡沫层由背衬层上的预聚物溶液形成的方法。还公开了具有均匀分散在其中的活性剂的聚氨酯泡沫聚合的方法。

7. 发明申请

US20100076387A1 Twin Transdermal Drug Delivery Patch 失效
标题翻译：双透皮给药补丁
公开(公告)号：US20100076387A1
公开(公告)日：2010-03-25
申请号：US12564808
申请日：2009-09-22
申请人： Ludwig J. Weimann , Hashem Heitai
发明人： Ludwig J. Weimann , Hashem Heitai
IPC分类号： A61K9/70 , A61F13/02 , A61M35/00
CPC分类号： A61K9/703 , A61K9/7084 , A61K9/7092 , A61M2025/0056 , A61M2025/0073
摘要： A transdermal drug delivery device is shown and described. The device includes an occlusive or non-occlusive backing, an adhesive, at least one drug delivery region, an adhesive, and a release liner. The device has an open configuration and a closed configuration. When the device is in the closed configuration, the adhesive, the at least one drug delivery region, and the release liner are disposed between first and second portions of the backing.
摘要翻译：显示和描述透皮药物递送装置。该装置包括闭塞性或非闭塞性背衬，粘合剂，至少一种药物递送区域，粘合剂和释放衬垫。该设备具有打开的配置和关闭的配置。当装置处于关闭构型时，粘合剂，至少一个药物递送区域和释放衬垫被布置在背衬的第一和第二部分之间。

8. 发明授权

US5662926A Transdermal patch incorporating a polymer film incorporated with an active agent 失效
公开(公告)号：US5662926A
公开(公告)日：1997-09-02
申请号：US426492
申请日：1995-04-20
申请人： John Wick , Ludwig J. Weimann , Wayne C. Pollock
发明人： John Wick , Ludwig J. Weimann , Wayne C. Pollock
IPC分类号： A61M37/00 , A61K9/70 , A61F13/02
CPC分类号： A61K9/703 , A61K9/7084
摘要： Devices for the controlled release of an active agent to the skin or mucosa of a host are disclosed, which devices are laminates of a backing layer, a monolithic carrier layer of an active ingredient selected from active agent, active agent enhancers and mixtures thereof, melt-blended with a thermoplastic matrix polymer capable of controllably releasing the active ingredient, wherein the active ingredient is heat stable at the melt temperature of the matrix polymer, together with means for affixing the laminate to the skin or mucosa of the host so that the active ingredient is continuously released from the carrier layer thereto. Methods for assembling the device are also disclosed, in which a thermoplastic matrix polymer capable of controllably releasing an active ingredient is melt-blended with an active ingredient that is heat stable at the melt temperature of the matrix polymer, so that a melt-blend of the active ingredient and the thermoplastic matrix polymer is formed, which melt-blend is formed into a monolithic carrier layer, and the carrier layer is then combined with a backing layer and means for affixing the laminate to the skin or mucosa of the host so that the active ingredient is released from the carrier layer thereto.

9. 发明授权

US5629014A Foam laminate transdermal patch 失效
标题翻译：泡沫层压透皮贴片
公开(公告)号：US5629014A
公开(公告)日：1997-05-13
申请号：US476418
申请日：1995-06-07
申请人： Alfred Kwiatek , Ludwig J. Weimann , Wayne C. Pollock , Sharad K. Govil
发明人： Alfred Kwiatek , Ludwig J. Weimann , Wayne C. Pollock , Sharad K. Govil
IPC分类号： A61K9/70 , A61F13/00
CPC分类号： A61K9/703 , A61K9/7084
摘要： Devices for the controlled release of an active agent to the skin or mucosa of a host are disclosed, which devices are laminates of a cellular foam layer having a first surface and a second surface, which foam layer has an active agent incorporated therein; a backing layer having an inner surface and an outer surface, wherein the inner surface is affixed to the second surface of the foam layer so that the active agent cannot permeate from the second surface of the foam layer through the outer surface of the backing layer; and means for affixing the laminate to the skin or mucosa of the host so that the active agent is capable of being continuously released from the first surface of the foam layer thereto. Methods for assembling the laminate devices are also disclosed, as are methods in which the foam layer is formed from a prepolymer solution on the backing layer. Methods are also disclosed for the polymerization of cellular urethane foams having active agents uniformly dispersed therethrough.
摘要翻译：公开了将活性剂控制释放到主体的皮肤或粘膜上的装置，哪些装置是具有第一表面和第二表面的泡沫层的层压体，该泡沫层具有并入其中的活性剂; 背衬层，其具有内表面和外表面，其中内表面固定到泡沫层的第二表面，使得活性剂不能通过背衬层的外表面从泡沫层的第二表面渗透; 以及用于将层压材料固定到主体的皮肤或粘膜的装置，使得活性剂能够从泡沫层的第一表面连续释放。还公开了组装层压装置的方法，以及其中泡沫层由背衬层上的预聚物溶液形成的方法。还公开了具有均匀分散在其中的活性剂的聚氨酯泡沫聚合的方法。

10. 发明申请

US20210169410A1 WEARABLE DEVICE TO SCREEN OPIOID INTOXICATION 有权
公开(公告)号：US20210169410A1
公开(公告)日：2021-06-10
申请号：US17116566
申请日：2020-12-09
申请人： Ghassan S. Kassab , Ali Dabiri , Ludwig J. Weimann
发明人： Ghassan S. Kassab , Ali Dabiri , Ludwig J. Weimann
IPC分类号： A61B5/00 , A61B5/1473 , A61B5/145
摘要： A microneedle device comprising a membrane having an adhesive thereon and a microneedle substrate adhered to the membrane via the adhesive. The microneedle substrate may have a plurality of microneedles coupled thereto, or the microneedle substrate can comprise the plurality of microneedles. The microneedle device can be mated with a reagent container and the microneedles aligned with wells on the reagent container said wells configured to hold reagents thus comprising a system for detecting opioids or other drugs. In another embodiment, the device comprises a sweat-absorbent swatch adhered to a membrane. This embodiment can be mated to a screening pad comprising blisters of reagents on the base layer of the screening pad. Upon mating, a needle device can be used to pierce the blisters such that the reagents are released and react with the sweat absorbent swatch to indicate the presence of opioids or other drugs.

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