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    • 2. 发明申请
    • PYRROLOPYRIMIDINE AND PYRROLOTRIAZINE DERIVATIVES
    • 吡咯并嘧啶和吡咯烷酮衍生物
    • US20110137031A1
    • 2011-06-09
    • US10584946
    • 2005-01-06
    • Atsuro NakazatoTaketoshi OkuboDai NozawaTomoko TamitaLudo E.J. Kennis
    • Atsuro NakazatoTaketoshi OkuboDai NozawaTomoko TamitaLudo E.J. Kennis
    • C07D487/04
    • C07D487/04
    • An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastral diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alpecia, irritable bowel syndrome, sleep disorders, dermatitides, schizophrenia, pain, etc. A pyrrolopyrimidine or pyrrolotriazine derivative substituted with a carbamoyl group represented by the following formula [I]: has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.
    • 本发明的目的是提供一种抗CRF受体的拮抗剂,其作为治疗或预防药物是有效的,其涉及CRF被认为涉及的疾病,例如抑郁症,焦虑症,阿尔茨海默氏病,帕金森病,亨廷顿氏舞蹈病,进食 疾病,高血压,胃疾病,药物依赖,癫痫,脑梗塞,脑缺血,脑水肿,头部外伤,炎症,免疫相关疾病,特异性,肠易激综合征,睡眠障碍,皮肤病,精神分裂症,疼痛等。 由下式[I]表示的氨基甲酰基取代的吡咯并嘧啶或吡咯并三嗪衍生物:对CRF受体具有高亲和力,并且对于认为涉及CRF的疾病是有效的。