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1. 发明申请

US20090111835A1 THIENOPYRIMIDINE AND THIENOPYRIDINE DERIVATIVES SUBSTITUTED WITH CYCLIC AMINO GROUP 审中-公开
标题翻译：用环状氨基取代的三烯酰基嘧啶和三烯吡啶衍生物
公开(公告)号：US20090111835A1
公开(公告)日：2009-04-30
申请号：US12338698
申请日：2008-12-18
申请人： Atsuro Nakazato , Taketoshi Okubo , Dai Nozawa , Tomoko Tamita , Ludo E.J. Kennis
发明人： Atsuro Nakazato , Taketoshi Okubo , Dai Nozawa , Tomoko Tamita , Ludo E.J. Kennis
IPC分类号： A61K31/519 , C07D495/04 , A61K31/4365
CPC分类号： C07D495/04
摘要： An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastral diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alpecia, irritable bowel syndrome, sleep disorders, dermatitides, schizophrenia, pain, etc. A thienopyrimidine or thienopyridine derivative substituted with a cyclic amino group represented by the following formula [I]: has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.
摘要翻译：本发明的目的是提供一种抗CRF受体的拮抗剂，其作为治疗或预防药物是有效的，其涉及CRF被认为涉及的疾病，例如抑郁症，焦虑症，阿尔茨海默氏病，帕金森病，亨廷顿氏舞蹈病，进食疾病，高血压，胃疾病，药物依赖，癫痫，脑梗塞，脑缺血，脑水肿，头部外伤，炎症，免疫相关疾病，特异性，肠易激综合征，睡眠障碍，皮肤病，精神分裂症，疼痛等。由下式[I]表示的环状氨基取代的噻吩并嘧啶或噻吩并吡啶衍生物对CRF受体具有高亲和力，对于认为涉及CRF的疾病有效。

2. 发明申请

US20110137031A1 PYRROLOPYRIMIDINE AND PYRROLOTRIAZINE DERIVATIVES 失效
标题翻译：吡咯并嘧啶和吡咯烷酮衍生物
公开(公告)号：US20110137031A1
公开(公告)日：2011-06-09
申请号：US10584946
申请日：2005-01-06
申请人： Atsuro Nakazato , Taketoshi Okubo , Dai Nozawa , Tomoko Tamita , Ludo E.J. Kennis
发明人： Atsuro Nakazato , Taketoshi Okubo , Dai Nozawa , Tomoko Tamita , Ludo E.J. Kennis
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastral diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alpecia, irritable bowel syndrome, sleep disorders, dermatitides, schizophrenia, pain, etc. A pyrrolopyrimidine or pyrrolotriazine derivative substituted with a carbamoyl group represented by the following formula [I]: has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.
摘要翻译：本发明的目的是提供一种抗CRF受体的拮抗剂，其作为治疗或预防药物是有效的，其涉及CRF被认为涉及的疾病，例如抑郁症，焦虑症，阿尔茨海默氏病，帕金森病，亨廷顿氏舞蹈病，进食疾病，高血压，胃疾病，药物依赖，癫痫，脑梗塞，脑缺血，脑水肿，头部外伤，炎症，免疫相关疾病，特异性，肠易激综合征，睡眠障碍，皮肤病，精神分裂症，疼痛等。由下式[I]表示的氨基甲酰基取代的吡咯并嘧啶或吡咯并三嗪衍生物：对CRF受体具有高亲和力，并且对于认为涉及CRF的疾病是有效的。

3. 发明申请

US20080287397A1 Pyrrolopyrimidine Derivatives Substituted with Cyclic Amino Group 失效
标题翻译：用环状氨基取代的吡咯并嘧啶衍生物
公开(公告)号：US20080287397A1
公开(公告)日：2008-11-20
申请号：US12106873
申请日：2008-04-21
申请人： Atsuro NAKAZATO , Taketoshi Okubo , Dai Nozawa , Mikako Yamaguchi , Tomoko Tamita , Ludo E.J. Kennis , Marcel F.L. De Bruyn , Jean-Pierre A.M. Bongartz , Frans M.A. Van Den Keybus , Yves E.M. Van Roosbroeck , Marcel G.M. Luyckx , Robert J.M. Hendrickx
发明人： Atsuro NAKAZATO , Taketoshi Okubo , Dai Nozawa , Mikako Yamaguchi , Tomoko Tamita , Ludo E.J. Kennis , Marcel F.L. De Bruyn , Jean-Pierre A.M. Bongartz , Frans M.A. Van Den Keybus , Yves E.M. Van Roosbroeck , Marcel G.M. Luyckx , Robert J.M. Hendrickx
IPC分类号： A61K31/661 , C07D487/04 , A61P25/00 , A61P17/00 , A61P1/00 , A61P29/00 , A61K31/519
CPC分类号： C07D471/04 , C07D487/04 , C07F9/6561
摘要： An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastric diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alopecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, etc. This problem can be solved with a pyrrolopyrimidine or pyrrolopyridine derivative substituted with a cyclic amino group represented by formula [I] below which has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.
摘要翻译：本发明的目的是提供一种抗CRF受体的拮抗剂，其作为治疗或预防药物是有效的，其涉及CRF被认为涉及的疾病，例如抑郁症，焦虑症，阿尔茨海默氏病，帕金森病，亨廷顿氏舞蹈病，进食疾病，高血压，胃疾病，药物依赖，癫痫，脑梗塞，脑缺血，脑水肿，头部外伤，炎症，免疫相关疾病，脱发，肠易激综合征，睡眠障碍，癫痫，皮肤病，精神分裂症等。可以用由以下式[I]表示的环氨基取代的吡咯并嘧啶或吡咯并吡啶衍生物来解决问题，其具有对CRF受体的高亲和力，并且对于CRF被认为涉及的疾病是有效的。

4. 发明申请

US20110130364A1 PYRROLOPYRIDINE DERIVATIVES SUBSTITUTED WITH CYCLIC AMINO GROUP 失效
标题翻译：取代周期性氨基酸的吡咯啉衍生物
公开(公告)号：US20110130364A1
公开(公告)日：2011-06-02
申请号：US12951556
申请日：2010-11-22
申请人： Atsuro NAKAZATO , Taketoshi Okubo , Dai Nozawa , Mikako Yamaguchi , Tomoko Tamita , Ludo E.J. Kennis , Marcel F.L. De Bruyn , Jean-Pierre A.M. Bongartz , Frans M.A. Van Den Keybus , Yves E.M. Van Roosbroeck , Marcel G.M. Luyckx , Robert J.M. Hendrickx
发明人： Atsuro NAKAZATO , Taketoshi Okubo , Dai Nozawa , Mikako Yamaguchi , Tomoko Tamita , Ludo E.J. Kennis , Marcel F.L. De Bruyn , Jean-Pierre A.M. Bongartz , Frans M.A. Van Den Keybus , Yves E.M. Van Roosbroeck , Marcel G.M. Luyckx , Robert J.M. Hendrickx
IPC分类号： A61K31/675 , C07D487/04 , A61K31/519 , C07D471/04 , A61K31/437 , C07F9/6561 , A61K31/55 , A61K31/397 , A61K31/553 , A61P25/00 , A61P1/00 , A61P9/12 , A61P9/00 , A61P29/00 , A61P17/00
CPC分类号： C07D471/04 , C07D487/04 , C07F9/6561
摘要： An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastric diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alopecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, etc. This problem can be solved with a pyrrolopyrimidine or pyrrolopyridine derivative substituted with a cyclic amino group represented by formula [I] below which has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.
摘要翻译：本发明的目的是提供一种抗CRF受体的拮抗剂，其作为治疗或预防药物是有效的，其涉及CRF被认为涉及的疾病，例如抑郁症，焦虑症，阿尔茨海默氏病，帕金森病，亨廷顿氏舞蹈病，进食疾病，高血压，胃疾病，药物依赖，癫痫，脑梗塞，脑缺血，脑水肿，头部外伤，炎症，免疫相关疾病，脱发，肠易激综合征，睡眠障碍，癫痫，皮肤病，精神分裂症等。可以用由以下式[I]表示的环氨基取代的吡咯并嘧啶或吡咯并吡啶衍生物来解决问题，其具有对CRF受体的高亲和力，并且对于CRF被认为涉及的疾病是有效的。

5. 发明申请

US20110124862A1 PYRROLOPYRIMIDINE AND PYRROLOPYRIDINE DERIVATIVES SUBSTITUTED WITH A CYCLIC AMINO GROUP AS CRF ANTAGONISTS 审中-公开
标题翻译：以循环氨基作为CRF拮抗剂取代吡咯并嘧啶衍生物和吡咯啉衍生物
公开(公告)号：US20110124862A1
公开(公告)日：2011-05-26
申请号：US13018928
申请日：2011-02-01
申请人： Atsuro NAKAZATO , Taketoshi Okubo , Dai Nozawa , Tomoko Tamita , Ludo E.J. Kennis
发明人： Atsuro NAKAZATO , Taketoshi Okubo , Dai Nozawa , Tomoko Tamita , Ludo E.J. Kennis
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： C07D471/04 , C07D487/04
摘要： [Problem to be Solved] An object of the present invention is to provide an antagonist against CRF receptors and/or an agonist for δ receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal diseases, drug dependence, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alopecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, pain, etc.[Solution] A pyrrolopyrimidine or pyrrolopyridine derivative substituted with a cyclic amino group represented by the following formula [I] has a high affinity for CRF receptors and/or δ receptors, and is effective against diseases in which CRF is considered to be involved.
摘要翻译： [待解决的问题]本发明的目的是提供一种拮抗CRF受体拮抗剂和/或对δ受体的激动剂，其作为用于涉及CRF的疾病的治疗或预防剂是有效的，例如抑郁症，焦虑症，阿尔茨海默氏病，帕金森病，亨廷顿氏舞蹈病，进食障碍，高血压，胃肠道疾病，药物依赖，脑梗塞，脑缺血，脑水肿，头部外伤，炎症，免疫相关疾病，脱发，肠易激综合征，睡眠障碍，癫痫，皮肤病，精神分裂症，疼痛等。[溶液]由下式[I]表示的环状氨基取代的吡咯并嘧啶或吡咯并吡啶衍生物对CRF受体和/或δ受体具有高亲和性，对抗CRF被认为参与的疾病有效。

6. 发明申请

US20110065684A1 PHTHALAZINE DERIVATIVES AS PARP INHIBITORS 有权
标题翻译：苯乙烯衍生物作为PARP抑制剂
公开(公告)号：US20110065684A1
公开(公告)日：2011-03-17
申请号：US12856218
申请日：2010-08-13
申请人： Laurence Anne Mevellec , Ludo E.J. Kennis , Josephus Carolus Mertens , Jacobus A.J. Van Dun , Maria V.F. Somers , Walter B.L. Wouters
发明人： Laurence Anne Mevellec , Ludo E.J. Kennis , Josephus Carolus Mertens , Jacobus A.J. Van Dun , Maria V.F. Somers , Walter B.L. Wouters
IPC分类号： A61K31/55 , C07D401/04 , A61K31/502 , A61P25/28 , A61P25/16 , A61P35/00 , A61P9/10 , C07D403/12 , A61K31/542 , C07D513/04
CPC分类号： A61K31/55 , A61K31/502 , A61K31/506 , A61K31/517 , A61K31/542 , C07D237/34 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D417/14 , C07D451/04 , C07D471/04 , C07D513/04
摘要： The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2, L1, L2, X, Y, Q and Z have defined meanings.
摘要翻译：本发明提供式（I）化合物，它们作为PARP抑制剂的用途以及包含所述式（I）化合物的药物组合物，其中R1，R2，L1，L2，X，Y，Q和Z具有定义的含义。

7. 发明申请

US20080280928A1 Pyrrolopyrimidine and Pyrrolopyridine Derivatives Substituted with a Cyclic Amino Group As Crf Antagonists 失效
标题翻译：以环状氨基取代的吡咯并嘧啶和吡咯并吡啶衍生物作为Crf拮抗剂
公开(公告)号：US20080280928A1
公开(公告)日：2008-11-13
申请号：US11630042
申请日：2005-06-24
申请人： Atsuro Nakazato , Taketoshi Okubo , Dai Nozawa , Tomoko Tamita , Ludo E.J. Kennis
发明人： Atsuro Nakazato , Taketoshi Okubo , Dai Nozawa , Tomoko Tamita , Ludo E.J. Kennis
IPC分类号： A61K31/437 , C07D471/04 , A61K31/519 , A61P25/00 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04
摘要： [PROBLEM TO BE SOLVED] An object of the present invention is to provide an antagonist against CRF receptors and/or an agonist for δ receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal diseases, drug dependence, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alopecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, pain, etc. [SOLUTION] A pyrrolopyrimidine or pyrrolopyridine derivative substituted with a cyclic amino group represented by the following a [I] has a high affinity for CRF receptors and/or δ receptors, and is effective against diseases in which CRF is considered to be involved.
摘要翻译： [待解决的问题]本发明的目的是提供一种拮抗CRF受体拮抗剂和/或δ受体激动剂，其作为治疗或预防药物是有效的，其涉及CRF被认为是涉及的疾病，例如抑郁症，焦虑症，阿尔茨海默氏病，帕金森病，亨廷顿氏舞蹈病，进食障碍，高血压，胃肠道疾病，药物依赖，脑梗塞，脑缺血，脑水肿，头部外伤，炎症，免疫相关疾病，脱发，肠易激综合征，睡眠障碍，癫痫，皮肤病，精神分裂症，疼痛等。解决方案由以下[I]表示的环状氨基取代的吡咯并嘧啶或吡咯并吡啶衍生物对CRF受体和/或δ受体具有高亲和力，并且是对抗CRF被认为参与的疾病有效。

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