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1. 发明申请

US20080026031A1 Implantable polymeric device for sustained release of buprenorphine 审中-公开
标题翻译：用于持续释放丁丙诺啡的可植入聚合物
公开(公告)号：US20080026031A1
公开(公告)日：2008-01-31
申请号：US11801302
申请日：2007-05-08
申请人： Rajesh Patel , Louis Bucalo
发明人： Rajesh Patel , Louis Bucalo
IPC分类号： A61K9/00 , A61K31/485 , A61P25/04
CPC分类号： A61K9/0024 , A61K31/4748 , A61K31/485 , A61K47/32 , A61L31/048 , A61L31/125 , A61L31/16
摘要： The present invention provides compositions, methods, and kits for treatment of opiate addiction and pain. The invention provides a biocompatible nonerodible polymeric device which releases buprenorphine continuously with generally linear release kinetics for extended periods of time. Buprenorphine is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with buprenorphine.
摘要翻译：本发明提供了用于治疗阿片成瘾和疼痛的组合物，方法和试剂盒。本发明提供了一种生物相容性非必需的聚合物装置，其通过线性释放动力学持续长时间地释放丁丙诺啡。丁丙诺啡通过孔被释放，孔通过其被封装在其中的聚合物基质的表面。该装置可以皮下给予需要用丁丙诺非连续治疗的个体。

2. 发明申请

US20070275031A1 Implantable polymeric device for sustained release of buprenorphine with minimal initial burst 审中-公开
标题翻译：用于持续释放丁丙诺啡的植入式聚合物，具有最小的初始爆发
公开(公告)号：US20070275031A1
公开(公告)日：2007-11-29
申请号：US11805608
申请日：2007-05-23
申请人： Rajesh Patel , Louis Bucalo
发明人： Rajesh Patel , Louis Bucalo
IPC分类号： A61K31/282 , A61F13/00
CPC分类号： A61K9/0024 , A61K9/1682
摘要： The present invention provides compositions, methods, and kits for treatment of pain. The invention provides a biocompatible nonerodible polymeric device which releases buprenorphine continuously with generally linear release kinetics for extended periods of time, and exhibits minimal initial burst upon subcutaneous implantation. Buprenorphine is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with buprenorphine. Devices of the invention are washed with ethanol for greater than 30 minutes prior to subcutaneous implantation or have release characteristics of a device that has been washed with ethanol for greater than 30 minutes, such as a low peak to steady state plasma level ratio.
摘要翻译：本发明提供用于治疗疼痛的组合物，方法和试剂盒。本发明提供了一种生物相容的非可溶性聚合物装置，其通过延长的时间段以大致线性释放动力学连续释放丁丙诺啡，并且在皮下植入时显示出最小的初始爆发。丁丙诺啡通过孔被释放，孔通过其被封装在其中的聚合物基质的表面。该装置可以皮下给予需要用丁丙诺非连续治疗的个体。本发明的装置在皮下植入之前用乙醇洗涤超过30分钟，或者已经用乙醇洗涤超过30分钟的装置的释放特性，例如低峰 - 稳态血浆水平比。

3. 发明授权

US4122850A Apparatus for providing living beings with absorbable implants 失效
标题翻译：用于向生物提供可吸收植入物的装置
公开(公告)号：US4122850A
公开(公告)日：1978-10-31
申请号：US785290
申请日：1977-04-06
申请人： Louis Bucalo
发明人： Louis Bucalo
IPC分类号： A61K9/00 , A61M5/00 , A61M37/00
CPC分类号： A61K9/0024 , A61M37/00 , A61M37/0069 , A61M5/00
摘要： Apparatus for providing a living being with an implant which is absorbed into the body. The implant is situated in the body adjacent the outer skin. The implant is injected in a liquid, molten condition, but assumes a solid condition at body temperature. The composition of the implant is such that the implant will be absorbed by the body at a greater rate when the temperature of the implant is increased. By situating the implant adjacent the outer skin it is possible to elevate the temperature at the outer skin so as to increase the rapidity with which the implant is absorbed by the body. A syringe which contains the implant in solid condition is provided with a heating structure which is operated for the purpose of converting the composition into a liquid molten condition in preparation for injecting the composition into body tissue.
摘要翻译：用于提供具有被吸收到体内的植入物的生物体的装置。植入物位于与外皮相邻的身体中。植入物注入液体，熔融状态，但在体温下呈现固体状态。植入物的组成使得当植入物的温度增加时，植入物将以更大的速率被身体吸收。通过将植入物邻近外皮定位，可以提高外皮的温度，从而增加植入物被身体吸收的速度。在固体状态下包含植入物的注射器设置有加热结构，该加热结构的操作是为了将组合物转化为液体熔融状态，以准备将组合物注入体内组织。

4. 发明授权

US3999611A Devices relating to hooves 失效
标题翻译：与蹄有关的设备
公开(公告)号：US3999611A
公开(公告)日：1976-12-28
申请号：US524742
申请日：1974-11-18
申请人： Louis Bucalo
发明人： Louis Bucalo
IPC分类号： A01K15/02 , A01K29/00 , A01L5/00 , A61B5/103 , A01K47/06
CPC分类号： A01K15/02 , A01K29/005 , A01L5/00 , A61B5/1036
摘要： Devices for obtaining information with respect to the behavior of a hoof. A sensing device such as an accelerometer or load cell may be attached to the hoof to respond to forces such as impact of the hoof on the ground, and the information derived from the sensing device may be recorded.
摘要翻译：用于获取关于蹄的行为的信息的装置。诸如加速度计或称重传感器的感测装置可以附接到蹄以响应诸如蹄在地面上的冲击的力，并且可以记录从感测装置导出的信息。

5. 发明授权

US3961631A Methods for applying surgical splints 失效
标题翻译：手术夹板的应用方法
公开(公告)号：US3961631A
公开(公告)日：1976-06-08
申请号：US481136
申请日：1974-06-20
申请人： Louis Bucalo
发明人： Louis Bucalo
IPC分类号： A61F6/24 , A61B17/12 , A61F1/24
CPC分类号： A61F6/24
摘要： A surgical procedure wherein tissue which normally covers a body part is displaced away from a portion thereof to expose the latter portion of the body part so that a given treatment can be performed thereon. This exposed portion of the body part is covered with a layer of a highly viscous semisolid substance. Then the tissue is returned to a position covering the semisolid substance. In this way this semisolid substance becomes situated between the previously exposed portion of the body part and the tissue.
摘要翻译：外科手术，其中通常覆盖身体部位的组织从其一部分移开以暴露身体部分的后部，从而可以对其进行给定的治疗。身体部分的暴露部分被一层高粘度半固体物质覆盖。然后将组织返回到覆盖半固体物质的位置。以这种方式，这种半固体物质位于身体部分的先前暴露部分和组织之间。

6. 发明授权

US3932223A Culturing medium 失效
标题翻译：培养液
公开(公告)号：US3932223A
公开(公告)日：1976-01-13
申请号：US539254
申请日：1975-01-07
申请人： Louis Bucalo
发明人： Louis Bucalo
IPC分类号： A61B10/00 , A61B10/02 , A61F13/22 , C12K1/10
CPC分类号： A61B10/02 , A61F13/206
摘要： A culturing article according to which one part of a wick is placed in engagement with a body fluid in order to check for the presence of suspected microorganisms. An opposed part of the wick is maintained out of engagement with the body fluid, so that by capillary action the body fluid will progress along the wick from the one part toward the opposed part thereof. The progress of the body fluid from the one part toward the opposed part of the wick is limited to achieve a density gradient according to which the body fluid is most dense at the one part of the wick which engages the body fluid while the body fluid becomes gradually less dense from the one part toward the opposed part of the wick, to provide a density gradient. A culture medium engages the wick to encourage predetermined microorganisms to grow, and at a certain portion of the density gradient the microorganisms will be very clearly evident. The wick as well as the culture medium may be in the form of a roll which is encapsulated to be enclosed at all except the part of the wick which engages the body fluid, or the wick and culture medium may take the form of separate layers. The culture medium may have portions of different properties for encouraging different microorganisms to grow, so that it becomes possible to check simultaneously for the presence of different microorganisms.
摘要翻译：一种培养物品，其中芯体的一部分与体液接合以便检查是否存在疑似的微生物。芯体的相对部分保持与体液不接合，从而通过毛细管作用，体液将沿着芯从一部分朝向其相对部分前进。体液从芯部的一部分朝向相对部分的进程被限制以实现密度梯度，根据该密度梯度，身体流体在芯体的一部分处最接近体液，而体液变成从一个部分朝向芯的相对部分逐渐变小，提供密度梯度。培养基与油绳接合以促进预定的微生物生长，并且在密度梯度的某一部分，微生物将非常清楚。油芯以及培养基可以是卷状的形式，其被封装以除了与体液接合的芯的部分以外被封闭，或者芯和培养基可以采取分开的层的形式。培养基可以具有不同性质的部分以促进不同的微生物生长，使得可以同时检查不同微生物的存在。

7. 发明授权

US4279256A Nerve stimulation method 失效
标题翻译：神经刺激法
公开(公告)号：US4279256A
公开(公告)日：1981-07-21
申请号：US31982
申请日：1979-04-20
申请人： Louis Bucalo
发明人： Louis Bucalo
IPC分类号： A61B17/11 , A61B19/00 , A61F2/00 , A61F2/02 , A61N1/05 , A61N1/36 , H01H3/14 , H01H35/24
CPC分类号： H01H35/24 , A61B17/1128 , A61N1/36007 , H01H3/14 , A61B90/39 , A61F2002/30062 , A61F2002/30079 , A61F2002/3008 , A61F2210/0004 , A61F2210/009 , A61F2250/0098
摘要： Methods and devices for purposes such as nerve stimulation and sexual stimulation. For purposes of nerve stimulation, a plurality of electrically conductive bodies are suspended in a viscous substance and injected into tissue so as to extend between the outer skin and a nerve, for providing an electrical path from the outer skin to the nerve in order to stimulate the latter. For purposes of sexual stimulation, an energy pulse train is applied with an amplitude envelope varying cyclically in a manner corresponding to pelvic thrusting during sexual intercourse.
摘要翻译：用于神经刺激和性刺激的方法和装置。为了神经刺激的目的，将多个导电体悬浮在粘性物质中并注射到组织中以便在外皮和神经之间延伸，以提供从外皮到神经的电路径，以刺激后者。为了性刺激的目的，施加能量脉冲序列，其振幅包络以对应于性交期间的盆腔推力的方式周期性地变化。

8. 发明授权

US4257427A Method for collecting body fluids 失效
标题翻译：收集体液的方法
公开(公告)号：US4257427A
公开(公告)日：1981-03-24
申请号：US75249
申请日：1979-09-13
申请人： Louis Bucalo
发明人： Louis Bucalo
IPC分类号： A61B10/00 , A61B17/32 , C12Q1/24
CPC分类号： A61B10/0045 , C12Q1/24 , A61B2017/320012
摘要： A method for collecting fluids present at the body of a human being or animal. An enclosure is temporarily situated at a cavity of the body, this enclosure having within itself a hollow interior for receiving a body fluid while shielding the body from the interior of the enclosure and while a part of the enclosure is situated at the body cavity in proximity to a location where a body fluid which is to be collected is situated. The enclosure carries a transfer structure which creates between the interior of the enclosure and the above location of the body fluid conditions for only inward transfer of the body fluid from this latter location into the interior of the enclosure, the inward transfer conditions being maintained effective during at least part of the time while the enclosure remains at the body cavity. Thereafter, when the enclosure is separated from the body cavity, the desired body fluid will be situated in the interior of the enclosure.
摘要翻译：用于收集存在于人或动物体内的液体的方法。外壳临时位于主体的空腔处，该外壳本身具有中空的内部，用于接收体液，同时将本体从外壳的内部屏蔽，同时外壳的一部分位于体腔附近到要被收集的体液的位置。外壳带有转移结构，其在外壳的内部和体液状态的上述位置之间产生，用于仅将体液从后者的位置向内转移到外壳的内部，向内转移条件在至少部分时间，而外壳保持在体腔。此后，当外壳与体腔分离时，期望的体液将位于外壳的内部。

9. 发明授权

US4197846A Method for structure for situating in a living body agents for treating the body 失效
标题翻译：用于处理身体的活体药物的结构方法
公开(公告)号：US4197846A
公开(公告)日：1980-04-15
申请号：US590268
申请日：1975-06-25
申请人： Louis Bucalo
发明人： Louis Bucalo
IPC分类号： A61B5/06 , A61B17/11 , A61B19/00 , A61F2/00 , A61F2/02 , A61F2/26
CPC分类号： A61B5/06 , A61B17/1128 , A61F2/0059 , A61F2/26 , A61K9/0024 , A61K9/1664 , A61B90/39 , A61F2002/30062 , A61F2002/30079 , A61F2002/3008 , A61F2210/0004 , A61F2210/009 , A61F2250/0098
摘要： By way of a suitable syringe, for example, there is injected into the tissue of a living being an absorbable viscous substance in which a plurality of solid bodies are suspended to an extent sufficient to be distributed throughout the viscous substance and in an amount sufficient to change the characteristics of the tissue receiving the injection. The absorbable viscous substance with the solid bodies suspended therein may be initially enclosed in a plunger assembly capable of being connected with an injection needle.
摘要翻译：例如，通过合适的注射器，将作为可吸收粘性物质的生物体的组织注射到其中多个固体悬浮到足以分布在整个粘稠物质中的程度，其量足以改变接受注射的组织的特征。其中悬挂有固体的吸收性粘性物质最初可以封闭在能够与注射针连接的柱塞组件中。

10. 发明授权

US4186730A Methods for collecting body fluids 失效
标题翻译：收集体液的方法
公开(公告)号：US4186730A
公开(公告)日：1980-02-05
申请号：US746827
申请日：1976-12-02
申请人： Louis Bucalo
发明人： Louis Bucalo
IPC分类号： A61B10/00 , A61B17/32 , C12Q1/24
CPC分类号： A61B10/0045 , C12Q1/24 , A61B2017/320012
摘要： A method for collecting fluids present at the body of a human being or animal. An enclosure is temporarily situated at a cavity of the body, this enclosure having within itself a hollow interior for receiving a body fluid while shielding the body from the interior of the enclosure and while a part of the enclosure is situated at the body cavity in proximity to a location where a body fluid which is to be collected is situated. The enclosure carries a transfer structure which creates between the interior of the enclosure and the above location of the body fluid conditions for only inward transfer of the body fluid from this latter location into the interior of the enclosure, the inward transfer conditions being maintained effective during at least part of the time while the enclosure remains at the body cavity. Thereafter, when the enclosure is separated from the body cavity, the desired body fluid will be situated in the interior of the enclosure.
摘要翻译：用于收集存在于人或动物体内的液体的方法。外壳临时位于主体的空腔处，该外壳本身具有中空的内部，用于接收身体流体，同时将本体从外壳的内部屏蔽，同时外壳的一部分位于身体附近到要被收集的体液的位置。外壳带有转移结构，其在外壳的内部和体液状态的上述位置之间产生，用于仅将体液从后者的位置向内转移到外壳的内部，向内转移条件在至少部分时间，而外壳保持在体腔。此后，当外壳与体腔分离时，期望的体液将位于外壳的内部。

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