专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09427429B2 Cancer diagnosis and imaging 有权
标题翻译：癌症诊断和成像
公开(公告)号：US09427429B2
公开(公告)日：2016-08-30
申请号：US13581390
申请日：2011-02-28
申请人： Lloyd S. Gray
发明人： Lloyd S. Gray
IPC分类号： A61K31/4184 , A61K31/675 , A61K31/4015 , A61K51/04 , A61K33/24 , A61K45/06
CPC分类号： A61K31/4184 , A61K31/4015 , A61K31/675 , A61K33/24 , A61K45/06 , A61K51/0491 , A61K2300/00
摘要： The present invention provides a method for imaging a disease or condition in a mammal which includes the steps of; administering a therapeutically effective amount of a cell cycle inhibitor to effectively stop proliferation of eukaryotic cells at a cell cycle checkpoint between the G1 and S phase, stopping administration of the cell cycle inhibitor for a period of time, administering a marker to the mammal and imaging the mammal.
摘要翻译：本发明提供一种用于对哺乳动物的疾病或病症进行成像的方法，其包括以下步骤：施用治疗有效量的细胞周期抑制剂以有效地停止在G1期和S期之间的细胞周期检查点的真核细胞的增殖，停止给予细胞周期抑制剂一段时间，向哺乳动物施用标记物和成像哺乳动物。

2. 发明授权

US09212127B2 T type calcium channel inhibitors 有权
标题翻译： T型钙通道抑制剂
公开(公告)号：US09212127B2
公开(公告)日：2015-12-15
申请号：US11660693
申请日：2005-08-22
申请人： Lloyd S. Gray , Timothy L. MacDonald , Doris M. Haverstick , Jaclyn R. Patterson , William F. McCalmont
发明人： Lloyd S. Gray , Timothy L. MacDonald , Doris M. Haverstick , Jaclyn R. Patterson , William F. McCalmont
IPC分类号： C07C217/58 , C07C217/60 , C07C217/62 , A61K31/137 , A61K31/138 , A61K45/06
CPC分类号： A61K31/14 , A61K31/085 , A61K31/12 , A61K31/137 , A61K31/138 , A61K45/06 , C07C217/58 , C07C217/60 , C07C217/62 , A61K2300/00
摘要： The present invention provides novel T type calcium channel inhibitors of formula (I), the use thereof in the treatment of a disease or condition in a mammal associated with influx of extracellular calcium via T type calcium channels, wherein R1 is C1-C4 alkyl, hydroxy, or C1-C4 alkoxy; Z is NH, NCH3, O, S, or CH2; Y is NH, O, or CH2 with the proviso that Y and Z are not the same; R2 is H, halo, NH2, C1-C4 alkyl, hydroxy, or C1-C4 alkoxy; m and n are independently selected from integers ranging from 1-5 with the proviso that m+n=an integer ranging from 2-9; and R3 is H, halo, NH2, C1-C4 alkyl, hydroxy, or C1-C4 alkoxy.
摘要翻译：本发明提供式（I）的新型T型钙通道抑制剂，其用于治疗与通过T型钙通道流入胞外钙相关的哺乳动物中的疾病或病症，其中R 1为C 1 -C 4烷基，羟基或C 1 -C 4烷氧基; Z是NH，NCH 3，O，S或CH 2; Y是NH，O或CH 2，条件是Y和Z不相同; R2是H，卤素，NH2，C1-C4烷基，羟基或C1-C4烷氧基; m和n独立地选自1-5的整数，条件是m + n = 2-9的整数; 并且R 3是H，卤素，NH 2，C 1 -C 4烷基，羟基或C 1 -C 4烷氧基。

3. 发明申请

US20130064814A1 ANTAGONISTS OF PRODUCTS OF THE HS.459642 UNIGENE CLUSTER FOR THE INHIBITION OF PROLIFERATION, DEVELOPMENT OR DIFFERENTIATION OF STEM CELLS INCLUDING CANCER STEM CELLS 审中-公开
标题翻译： HS.459642联合基因产物的抑制抑制干细胞增殖，发育或分化，包括癌症干细胞的拮抗作用
公开(公告)号：US20130064814A1
公开(公告)日：2013-03-14
申请号：US13609942
申请日：2012-09-11
申请人： Lloyd S. Gray
发明人： Lloyd S. Gray
IPC分类号： C07K16/32 , C12N15/113 , A61P35/00 , A61K39/395 , A61K31/713
CPC分类号： A61K31/4184 , A61K31/496 , A61K39/395 , A61K45/06 , C12N15/113 , C12N15/1138 , C12N2310/11 , A61K2300/00
摘要： The present disclosure provides methods and compositions for inhibiting the proliferation, differentiation, or development of stem cells and cancer stem cells in a patient in need thereof. The methods involve administering to a patient a therapeutically effective amount of an antagonist of an Hs.459642 Unigene Cluster product, such as an inhibitor of CACNA1H. The compositions include an antagonist of an Hs.459642 Unigene Cluster product, such as an inhibitor of CACNA1H. Specific antagonists such as antibodies and antisense oligonucleotides, and combination therapy with one or more additional anti-cancer agents, are also provided by this disclosure. Such methods, antagonists, and compositions can be useful, for example, in the treatment of cancer.
摘要翻译：本公开提供了用于在有需要的患者中抑制干细胞和癌干细胞的增殖，分化或发育的方法和组合物。所述方法包括向患者施用治疗有效量的Hs.459642 Unigene Cluster产物的拮抗剂，例如CACNA1H的抑制剂。组合物包括Hs.459642 Unigene Cluster产物的拮抗剂，例如CACNA1H的抑制剂。特异性拮抗剂如抗体和反义寡核苷酸，以及与一种或多种另外的抗癌剂的组合疗法也由本公开提供。这样的方法，拮抗剂和组合物可用于例如治疗癌症。

4. 发明申请

US20120321561A1 CANCER DIAGNOSIS AND IMAGING 有权
标题翻译：癌症诊断和成像
公开(公告)号：US20120321561A1
公开(公告)日：2012-12-20
申请号：US13581390
申请日：2011-02-28
申请人： Lloyd S. Gray
发明人： Lloyd S. Gray
IPC分类号： A61K49/00 , A61K49/06 , A61K49/04 , A61K51/04
CPC分类号： A61K31/4184 , A61K31/4015 , A61K31/675 , A61K33/24 , A61K45/06 , A61K51/0491 , A61K2300/00
摘要： The present invention provides a method for imaging a disease or condition in a mammal which includes the steps of; administering a therapeutically effective amount of a cell cycle inhibitor to effectively stop proliferation of eukaryotic cells at a cell cycle checkpoint between the G1 and S phase, stopping administration of the cell cycle inhibitor for a period of time, administering a marker to the mammal and imaging the mammal.
摘要翻译：本发明提供一种用于对哺乳动物的疾病或病症进行成像的方法，其包括以下步骤：施用治疗有效量的细胞周期抑制剂以有效地停止在G1期和S期之间的细胞周期检查点的真核细胞的增殖，停止给予细胞周期抑制剂一段时间，向哺乳动物施用标记物和成像哺乳动物。

5. 发明申请

US20100222406A1 T Type Calcium Channel Blockers and the Treatment of Diseases 审中-公开
标题翻译： T型钙通道阻滞剂和疾病治疗
公开(公告)号：US20100222406A1
公开(公告)日：2010-09-02
申请号：US12687641
申请日：2010-01-14
申请人： Lloyd S. Gray , Doris M. Haverstick
发明人： Lloyd S. Gray , Doris M. Haverstick
IPC分类号： A61K31/40 , A61K31/137 , A61K31/075 , A61K31/085 , A61K31/045 , A61K31/10 , A61P35/00
CPC分类号： A61K31/045 , A61K31/075 , A61K31/085 , A61K31/10 , A61K31/137 , A61K31/40
摘要： The present invention provides a method for treating a disease or condition in a mammal associated with influx of extracellular calcium via T type calcium channels, which comprises administering to the mammal a therapeutically effective amount of a T type calcium channel inhibitor, a prodrug thereof, or a pharmaceutically acceptable salt of said inhibitor or prodrug, wherein the T type calcium channel inhibitor has a structure represented by Formula (I): Formula (I), wherein R1 is selected from the group consisting of C1-C4 alkyl, hydroxy and C1-C4 alkoxy; X is selected from the group consisting of N and CH; Z is selected from the group consisting of NH, O, S and CH2; R2 is selected from the group consisting of H, halo, NH2, C1-C4 alkyl, hydroxy and C1-C4 alkoxy; and R3 is selected from the group consisting of H, halo, NH2, C1-C4 alkyl, hydroxy and C1-C4 alkoxy. In one embodiment R1 is selected from the group consisting of C1-C4 alkyl, hydroxyl and C1-C4 alkoxy, X is N, Z is O or CH2, R2 is H, halo, NH2 or hydroxyl and R3 is H.
摘要翻译：本发明提供了一种用于治疗与通过T型钙通道流入细胞外钙的哺乳动物有关的疾病或病症的方法，其包括向哺乳动物施用治疗有效量的T型钙通道抑制剂，其前药或所述抑制剂或前药的药学上可接受的盐，其中所述T型钙通道抑制剂具有由式（I）表示的结构：式（I），其中R 1选自C 1 -C 4烷基，羟基和C 1 -C 4烷基， C4烷氧基; X选自N和CH; Z选自NH，O，S和CH 2; R 2选自H，卤素，NH 2，C 1 -C 4烷基，羟基和C 1 -C 4烷氧基; 并且R 3选自H，卤素，NH 2，C 1 -C 4烷基，羟基和C 1 -C 4烷氧基。在一个实施方案中，R 1选自C 1 -C 4烷基，羟基和C 1 -C 4烷氧基，X是N，Z是O或CH 2，R 2是H，卤素，NH 2或羟基，R 3是H.

6. 发明申请

US20090234019A1 T Type Calcium Channel Inhibitors 有权
标题翻译： T型钙通道抑制剂
公开(公告)号：US20090234019A1
公开(公告)日：2009-09-17
申请号：US11660693
申请日：2005-08-22
申请人： Lloyd S. Gray , Timothy L. MacDonald , Doris M. Haverstick , Jaclyn R. Patterson , William F. McClamont
发明人： Lloyd S. Gray , Timothy L. MacDonald , Doris M. Haverstick , Jaclyn R. Patterson , William F. McClamont
IPC分类号： A61K31/138 , C07C211/27 , A61P35/00
CPC分类号： A61K31/14 , A61K31/085 , A61K31/12 , A61K31/137 , A61K31/138 , A61K45/06 , C07C217/58 , C07C217/60 , C07C217/62 , A61K2300/00
摘要： The present invention provides novel T type calcium channel inhibitors of formula (I), the use thereof in the treatment of a disease or condition in a mammal associated with influx of extracellular calcium via T type calcium channels, whereinR1 is C1-C4 alkyl, hydroxy, or C1-C4 alkoxy;Z is NH, NCH3, O, S, or CH2;Y is NH, O, or CH2 with the proviso that Y and Z are not the same;R2 is H, halo, NH2, C1-C4 alkyl, hydroxy, or C1-C4 alkoxy;m and n are independently selected from integers ranging from 1-5 with the proviso that m+n=an integer ranging from 2-9; andR3 is H, halo, NH2, C1-C4 alkyl, hydroxy, or C1-C4 alkoxy.
摘要翻译：本发明提供式（I）的新型T型钙通道抑制剂，其用于治疗与通过T型钙通道流入胞外钙相关的哺乳动物中的疾病或病症，其中R 1为C 1 -C 4烷基，羟基或C 1 -C 4烷氧基; Z是NH，NCH 3，O，S或CH 2; Y是NH，O或CH 2，条件是Y和Z不相同; R2是H，卤素，NH2，C1-C4烷基，羟基或C1-C4烷氧基; m和n独立地选自1-5的整数，条件是m + n = 2-9的整数; 并且R 3是H，卤素，NH 2，C 1 -C 4烷基，羟基或C 1 -C 4烷氧基。

7. 发明申请

US20080160009A1 Inhibiting Cav3 Isoforms and the 25B Splice Varients for the Diagnosis and Treatment of Cancer 审中-公开
标题翻译：抑制Cav3同种型和25B接头变量用于诊断和治疗癌症
公开(公告)号：US20080160009A1
公开(公告)日：2008-07-03
申请号：US10589216
申请日：2005-02-11
申请人： Lloyd S. Gray , Timothy L. MacDonald
发明人： Lloyd S. Gray , Timothy L. MacDonald
IPC分类号： A61K39/00 , C07K16/00 , G01N33/53 , A61K31/135
CPC分类号： A61K31/4422
摘要： The invention provides a pharmaceutical composition comprising an antibody that specifically binds to a Cav3 isoform or its δ25 splice variants thereof. The present invention also relates to compositions and methods for inhibiting cancer cell proliferation, preventing, treating and/or controlling cancer and/or related disorders in a patient by administering to the patient a therapeutically effective amount of the T type calcium channel selective inhibitor. A preferred T type calcium channel selective inhibitor is mibefradil.
摘要翻译：本发明提供了一种药物组合物，其包含特异性结合Cav3同种型或其delta25剪接变体的抗体。本发明还涉及通过向患者施用治疗有效量的T型钙通道选择性抑制剂来抑制癌细胞增殖，预防，治疗和/或控制患者的癌症和/或相关病症的组合物和方法。优选的T型钙通道选择性抑制剂是mibefradil。

8. 发明申请

US20120264804A1 T TYPE CALCIUM CHANNEL BLOCKERS AND THE TREATMENT OF DISEASES 审中-公开
标题翻译： T型钙通道阻塞剂和治疗疾病
公开(公告)号：US20120264804A1
公开(公告)日：2012-10-18
申请号：US13267609
申请日：2011-10-06
申请人： Lloyd S. Gray , Doris M. Haverstick
发明人： Lloyd S. Gray , Doris M. Haverstick
IPC分类号： A61K31/40 , A61P35/00
CPC分类号： A61K31/045 , A61K31/075 , A61K31/085 , A61K31/10 , A61K31/137 , A61K31/40 , A61K45/06 , A61K2300/00
摘要： The present invention provides a method for treating a disease or condition in a mammal associated with influx of extracellular calcium via T type calcium channels, which comprises administering to the mammal a therapeutically effective amount of a T type calcium channel inhibitor, a prodrug thereof, or a pharmaceutically acceptable salt of said inhibitor or prodrug, wherein the T type calcium channel inhibitor blocks a splice variant of an α1H isoform of T type calcium channels.
摘要翻译：本发明提供了一种用于治疗与通过T型钙通道流入细胞外钙的哺乳动物有关的疾病或病症的方法，其包括向哺乳动物施用治疗有效量的T型钙通道抑制剂，其前药或所述抑制剂或前药的药学上可接受的盐，其中所述T型钙通道抑制剂阻断T型钙通道的α1H同种型的剪接变体。

9. 发明申请

US20080194669A1 T Type Calcium Channel Blockers and the Treatment of Diseases 审中-公开
标题翻译： T型钙通道阻滞剂和疾病治疗
公开(公告)号：US20080194669A1
公开(公告)日：2008-08-14
申请号：US11660401
申请日：2005-08-22
申请人： Lloyd S. Gray , Doris M. Haverstick
发明人： Lloyd S. Gray , Doris M. Haverstick
IPC分类号： A61K31/40 , C12N5/06 , A61P35/00
CPC分类号： A61K31/455 , A61K31/553
摘要： The present invention provides a method for treating a disease or condition in a mammal associated with influx of extracellular calcium via T type calcium channels, which comprises administering to the mammal a therapeutically effective amount of a T type calcium channel inhibitor, a prodrug thereof, or a pharmaceutically acceptable salt of said inhibitor or prodrug, wherein the T type calcium channel inhibitor has a structure represented by Formula (I): Formula (I), wherein R1 is selected from the group consisting of C1-C4 alkyl, hydroxy and C1-C4 alkoxy; X is selected from the group consisting of N and CH; Z is selected from the group consisting of NH, O, S and CH2; R2 is selected from the group consisting of H, halo, NH2, C1-C4 alkyl, hydroxy and C1-C4 alkoxy; and R3 is selected from the group consisting of H, halo, NH2, C1-C4 alkyl, hydroxy and C1-C4 alkoxy. In one embodiment R1 is selected from the group consisting of C1-C4 alkyl, hydroxyl and C1-C4 alkoxy, X is N, Z is O or CH2, R2 is H, halo, NH2 or hydroxyl and R3 is H.
摘要翻译：本发明提供了一种用于治疗与通过T型钙通道流入细胞外钙的哺乳动物有关的疾病或病症的方法，其包括向哺乳动物施用治疗有效量的T型钙通道抑制剂，其前药或所述抑制剂或前药的药学上可接受的盐，其中所述T型钙通道抑制剂具有由式（I）表示的结构：式（I），其中R 1选自C C 1 -C 4烷基，羟基和C 1 -C 4烷氧基; C 1 -C 4烷基，C 1 -C 4烷基， X选自N和CH; Z选自NH，O，S和CH 2 2; R 2选自H，卤素，NH 2，C 1 -C 4烷基，C 1 -C 4烷基，，羟基和C 1 -C 4烷氧基; 且R 3选自H，卤素，NH 2，C 1 -C 4烷基，烷基，羟基和C 1 -C 4烷氧基。在一个实施方案中，R 1选自C 1 -C 4 - 烷基，羟基和C 1〜 -C≡4烷氧基，X是N，Z是O或CH 2，R 2是H，卤素，NH 2 或羟基，R 3是H.

10. 发明授权

US06946475B1 Anticancer calcium channel blockers 有权
标题翻译：抗癌钙通道阻滞剂
公开(公告)号：US06946475B1
公开(公告)日：2005-09-20
申请号：US09544968
申请日：2000-04-07
申请人： Lloyd S. Gray , Timothy L. Macdonald , Doris Haverstick , Tiffany N. Heady
发明人： Lloyd S. Gray , Timothy L. Macdonald , Doris Haverstick , Tiffany N. Heady
IPC分类号： A61K31/40 , A61K31/445 , C07D207/08 , C07D207/46 , C07D211/20 , C07D211/22 , C07D295/02 , C07D295/03
CPC分类号： C07D207/08 , C07D211/22 , C07D295/03
摘要： The present invention is directed to compounds useful as cancer cell inhibitors, compositions containing such compounds and methods for inhibiting proliferation of electrically non-excitable cells.
摘要翻译：本发明涉及可用作癌细胞抑制剂的化合物，含有这些化合物的组合物和抑制电不可兴奋细胞增殖的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式