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1. 发明授权

US08019401B1 Stretchable electrode and method of making physiologic measurements 有权
标题翻译：可伸缩电极和进行生理测量的方法
公开(公告)号：US08019401B1
公开(公告)日：2011-09-13
申请号：US11633077
申请日：2006-12-04
申请人： Michael Smith , Lloyd Marks
发明人： Michael Smith , Lloyd Marks
IPC分类号： A61B5/04 , A61B5/053
CPC分类号： A61B5/0535 , A61B2562/164
摘要： A stretchable electrode for use in physiologic measurements on a human body, such as peripheral impedance plethysmography, is disclosed. One embodiment of the stretchable electrode comprises an uninsulated stainless steel wire braid formed into a tubular conductor surrounding an elastic core and attached to an elastic substrate or base. Other embodiments of the stretchable electrode include a garter spring, a flat braided or woven conductor and an undulating wire. The electrode is placed about a limb of a human body and elastically stretched so that the conductor is in substantially continuous circumferential electrical contact with the skin of the limb. A method of attaching the stretchable electrode to the limb of a human body is also disclosed.
摘要翻译：公开了一种用于人体生理测量的可拉伸电极，例如外周阻抗体积描记法。可拉伸电极的一个实施例包括未绝缘的不锈钢丝编织物，其形成为围绕弹性芯并连接到弹性基底或基底的管状导体。可拉伸电极的其它实施例包括一个绞合弹簧，一个扁平编织或编织导体和一个起伏的电线。电极围绕人体的肢体放置并弹性拉伸，使得导体与肢体的皮肤基本上连续地周向电接触。还公开了将可拉伸电极附接到人体肢体的方法。

2. 发明申请

US20090105600A1 Impedance based device for non-invasive measurement of blood pressure and ankle-brachial index 有权
标题翻译：用于无创测量血压和踝肱指数的基于阻抗的装置
公开(公告)号：US20090105600A1
公开(公告)日：2009-04-23
申请号：US11875355
申请日：2007-10-19
申请人： Lloyd Marks , Michael Smith
发明人： Lloyd Marks , Michael Smith
IPC分类号： A61B5/02
CPC分类号： A61B5/0535 , A61B5/02141 , A61B5/022 , A61B5/6824
摘要： A device for non-invasive measurement of blood pressure includes a blood pressure cuff, a plethysmographic electrode for acquiring an impedance plethysmogram distal to the cuff and a processing device to inflate and deflate the cuff generate the impedance plethysmogram and to determine the systolic and diastolic blood pressures. The device can be used to measure systolic or diastolic blood pressure or both. It can also be used to take ankle-brachial measurements. An autocorrelation technique can be used to correct noise.
摘要翻译：用于非侵入性测量血压的装置包括血压套管，用于获取袖带远端的阻抗体积描记图的体积描记电极和用于使袖带膨胀和收缩的处理装置产生阻抗体积图并确定收缩和舒张血压力。该装置可用于测量收缩压或舒张压或两者。它也可用于进行踝臂测量。可以使用自相关技术来校正噪声。

3. 发明授权

US07497832B2 Method and device for measuring peripheral vascular function 有权
标题翻译：用于测量外周血管功能的方法和装置
公开(公告)号：US07497832B2
公开(公告)日：2009-03-03
申请号：US10759130
申请日：2004-01-20
申请人： Michael Smith , Lloyd Marks
发明人： Michael Smith , Lloyd Marks
IPC分类号： A61B5/02
CPC分类号： A61B5/021 , A61B5/0535
摘要： A patient's peripheral pulse volume and blood pressure are measured. The quantities are used to obtain a quantitative measure of peripheral vascular function. The quantitative measure can be one or more of pulsatile limb blood flow, total limb blood flow, limb vascular compliance and limb vascular resistance.
摘要翻译：测量患者的外周脉搏体积和血压。这些量用于获得外周血管功能的定量测量。定量测量可以是脉搏性肢体血流量，总肢血流量，肢体血管顺应性和肢体血管阻力中的一种或多种。

4. 发明申请

US20050070808A1 Signal averaging using gating signal obtained from autocorrelation of input signals 有权
标题翻译：使用从输入信号的自相关获得的门控信号进行信号平均
公开(公告)号：US20050070808A1
公开(公告)日：2005-03-31
申请号：US10673328
申请日：2003-09-30
申请人： Lloyd Marks , Michael Smith
发明人： Lloyd Marks , Michael Smith
IPC分类号： A61B5/053 , A61B5/02
CPC分类号： A61B5/0535
摘要： A plethysmographic or other signal is autocorrelated to give a first-pass determination of the distances among individual waveforms. A waveform is isolated, tested to determine whether its amplitude remains in suitable bounds for signal averaging, and convolved with the signal to match it with the other waveforms for averaging. Thus, a separate gating signal is not needed for signal averaging.
摘要翻译：体积描记或其他信号是自相关的，以便对各个波形之间的距离进行一次通过确定。波形被隔离，进行测试以确定其幅度是否保持在合适的信号平均范围内，并与信号进行卷积以与其他波形匹配以进行平均。因此，信号平均不需要单独的门控信号。

5. 发明申请

US20050070807A1 Methods of diagnosis using pulse volume measurement 有权
标题翻译：使用脉搏体积测量的诊断方法
公开(公告)号：US20050070807A1
公开(公告)日：2005-03-31
申请号：US10673167
申请日：2003-09-30
申请人： Lloyd Marks , Michael Smith
发明人： Lloyd Marks , Michael Smith
IPC分类号： A61B5/053 , A61B5/02
CPC分类号： A61B5/412 , A61B5/0535
摘要： The utility of pulse volume measurement is expanded to detection of many conditions which have previously not been detected or have been detected using more complicated techniques. Such conditions include blood loss, septic shock, cardiogenic shock, neonatal sepsis, patent ductus arteriosus, limb ischemia, intra-aortic balloon pump performance, peripheral vascular disease, congestive heart failure, the effectiveness of vasoactive medications, syncope, dehydration, pre-eclampsia, deep vein thrombosis, thermal injuries, vascular instability due to renal dialysis, compromising of circulation to the hand caused by radial artery harvesting, changes in cardiac output, and hypertension. According to the present invention, such diagnoses can be performed by taking one measurement, by taking measurements over time to detect a change or by taking measurements before and after application of a treatment or stimulus.
摘要翻译：脉冲体积测量的实用程序被扩展到检测到先前没有被检测到或已经使用更复杂的技术检测到的许多条件。这种情况包括失血，败血症休克，心源性休克，新生儿败血症，动脉导管未闭，肢体缺血，主动脉内气囊泵性能，外周血管疾病，充血性心力衰竭，血管活性药物的效果，晕厥，脱水，先兆子痫，深静脉血栓形成，热损伤，肾透析引起的血管不稳定性，桡动脉收获引起的手臂循环受损，心输出量变化和高血压。根据本发明，可以通过进行一次测量，通过随时间测量来检测变化或通过在施用治疗或刺激之前和之后进行测量来进行这种诊断。

6. 发明申请

US20110251470A1 STRETCHABLE ELECTRODE AND METHOD OF MAKING PHYSIOLOGIC MEASUREMENTS 审中-公开
标题翻译：可伸缩电极及其生理生化测量方法
公开(公告)号：US20110251470A1
公开(公告)日：2011-10-13
申请号：US13165450
申请日：2011-06-21
申请人： Micheal Smith , Lloyd MARKS
发明人： Micheal Smith , Lloyd MARKS
IPC分类号： A61B5/145 , A61B5/04
CPC分类号： A61B5/0535 , A61B2562/164
摘要： A stretchable electrode for use in physiologic measurements on a human body, such as peripheral impedance plethysmography, is disclosed. One embodiment of the stretchable electrode comprises an uninsulated stainless steel wire braid formed into a tubular conductor surrounding an elastic core and attached to an elastic substrate or base. Other embodiments of the stretchable electrode include a garter spring, a flat braided or woven conductor and an undulating wire. The electrode may be placed about a limb of a human body and elastically stretched so that the conductor is in substantially continuous circumferential electrical contact with the skin of the limb. A method of attaching the stretchable electrode to the limb of a human body is also disclosed.
摘要翻译：公开了一种用于人体生理测量的可拉伸电极，例如外周阻抗体积描记法。可拉伸电极的一个实施例包括未绝缘的不锈钢丝编织物，其形成为围绕弹性芯并连接到弹性基底或基底的管状导体。可拉伸电极的其它实施例包括一个绞合弹簧，一个扁平编织或编织导体和一个起伏的电线。电极可以围绕人体的肢体放置并弹性拉伸，使得导体与肢体的皮肤基本上连续地周向电接触。还公开了将可拉伸电极附接到人体肢体的方法。

7. 发明申请

US20090177099A1 PERIPHERAL IMPEDANCE PLETHYSMOGRAPHY ELECTRODE AND SYSTEM WITH DETECTION OF ELECTRODE SPACING 有权
标题翻译：外部阻抗电极电极和电极间隔检测系统
公开(公告)号：US20090177099A1
公开(公告)日：2009-07-09
申请号：US12404933
申请日：2009-03-16
申请人： Michael SMITH , Lloyd Marks
发明人： Michael SMITH , Lloyd Marks
IPC分类号： A61B5/02
CPC分类号： A61B5/0535
摘要： In a system and method for peripheral impedance plethysmography, an electrode for application to the patient's limb includes two outer current electrodes and two inner voltage electrodes. A distance between the two inner electrodes is automatically input into an analyzing device, either as a pre-stored value or as determined automatically from the electrode. Peripheral blood flow is calculated in accordance with that distance.
摘要翻译：在用于外周阻抗体积描记术的系统和方法中，用于患者肢体的电极包括两个外部电流电极和两个内部电压电极。两个内部电极之间的距离被自动地输入到分析装置中，或者作为预先存储的值或者从电极自动确定。根据该距离计算外周血流量。

8. 发明授权

US07147601B2 Signal averaging using gating signal obtained from autocorrelation of input signals 有权
标题翻译：使用从输入信号的自相关获得的门控信号进行信号平均
公开(公告)号：US07147601B2
公开(公告)日：2006-12-12
申请号：US10673328
申请日：2003-09-30
申请人： Lloyd Marks , Michael Smith
发明人： Lloyd Marks , Michael Smith
IPC分类号： A61B5/02
CPC分类号： A61B5/0535
摘要： A plethysmographic or other signal is autocorrelated to give a first-pass determination of the distances among individual waveforms. A waveform is isolated, tested to determine whether its amplitude remains in suitable bounds for signal averaging, and convolved with the signal to match it with the other waveforms for averaging. Thus, a separate gating signal is not needed for signal averaging.
摘要翻译：体积描记或其他信号是自相关的，以便对各个波形之间的距离进行一次通过确定。波形被隔离，进行测试以确定其幅度是否保持在合适的信号平均范围内，并与信号进行卷积以与其他波形匹配以进行平均。因此，信号平均不需要单独的门控信号。

9. 发明授权

US07887491B2 Impedance based device for non-invasive measurement of blood pressure and ankle-brachial index 有权
标题翻译：用于无创测量血压和踝肱指数的基于阻抗的装置
公开(公告)号：US07887491B2
公开(公告)日：2011-02-15
申请号：US11875355
申请日：2007-10-19
申请人： Lloyd Marks , Michael Smith
发明人： Lloyd Marks , Michael Smith
IPC分类号： A61B5/02
CPC分类号： A61B5/0535 , A61B5/02141 , A61B5/022 , A61B5/6824
摘要： A device for non-invasive measurement of blood pressure includes a blood pressure cuff, a plethysmographic electrode for acquiring an impedance plethysmogram distal to the cuff and a processing device to inflate and deflate the cuff generate the impedance plethysmogram and to determine the systolic and diastolic blood pressures. The device can be used to measure systolic or diastolic blood pressure or both. It can also be used to take ankle-brachial measurements. An autocorrelation technique can be used to correct noise.
摘要翻译：用于非侵入性测量血压的装置包括血压套管，用于获取袖带远端的阻抗体积描记图的体积描记电极和用于使袖带膨胀和收缩的处理装置产生阻抗体积图并确定收缩和舒张血压力。该装置可用于测量收缩压或舒张压或两者。它也可用于进行踝臂测量。可以使用自相关技术来校正噪声。

10. 发明授权

US07485094B2 Methods of diagnosis using pulse volume measurement 有权
标题翻译：使用脉搏体积测量的诊断方法
公开(公告)号：US07485094B2
公开(公告)日：2009-02-03
申请号：US10673167
申请日：2003-09-30
申请人： Lloyd Marks , Michael Smith
发明人： Lloyd Marks , Michael Smith
IPC分类号： A61B5/02
CPC分类号： A61B5/412 , A61B5/0535
摘要： The utility of pulse volume measurement is expanded to detection of many conditions which have previously not been detected or have been detected using more complicated techniques. Such conditions include blood loss, septic shock, cardiogenic shock, neonatal sepsis, patent ductus arteriosus, limb ischemia, intra-aortic balloon pump performance, peripheral vascular disease, congestive heart failure, the effectiveness of vasoactive medications, syncope, dehydration, pre-eclampsia, deep vein thrombosis, thermal injuries, vascular instability due to renal dialysis, compromising of circulation to the hand caused by radial artery harvesting, changes in cardiac output, and hypertension. According to the present invention, such diagnoses can be performed by taking one measurement, by taking measurements over time to detect a change or by taking measurements before and after application of a treatment or stimulus.
摘要翻译：脉冲体积测量的实用程序被扩展到检测到先前没有被检测到或已经使用更复杂的技术检测到的许多条件。这种情况包括失血，败血症休克，心源性休克，新生儿败血症，动脉导管未闭，肢体缺血，主动脉内气囊泵性能，外周血管疾病，充血性心力衰竭，血管活性药物的效果，晕厥，脱水，先兆子痫，深静脉血栓形成，热损伤，肾透析引起的血管不稳定性，桡动脉收获引起的手臂循环受损，心输出量变化和高血压。根据本发明，可以通过进行一次测量，通过随时间测量来检测变化或通过在施用治疗或刺激之前和之后进行测量来进行这种诊断。

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