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1. 发明申请

US20190204343A1 DIAGNOSTIC METHOD FOR MULTIPLE SCLEROSIS 审中-公开
公开(公告)号：US20190204343A1
公开(公告)日：2019-07-04
申请号：US16355661
申请日：2019-03-15
申请人： Tormod Fladby , Lisbeth Johnsen , Kaj Blennow
发明人： Tormod Fladby , Lisbeth Johnsen , Kaj Blennow
IPC分类号： G01N33/68 , G01N33/569
CPC分类号： G01N33/6893 , G01N33/56972 , G01N33/6848 , G01N2333/70596 , G01N2800/2821
摘要： A method of detecting the presence, or monitoring the severity of a condition characterised by the presence of fragments of a marker protein in the brain of a patient. The method comprises: (i) providing a sample comprising macrophages obtained from the patient; and (ii) detecting the presence of the marker protein or fragments thereof in the macrophages. The presence of abnormal levels of the marker protein and/or fragments thereof in the macrophages is indicative of the presence of the condition in the patient. The condition and the marker proteins can be: Alzheimer's Disease and the Abeta peptide, Parkinson's Disease and ubiquitin, Multiple Sclerosis and myelin basic protein, FrontoTemporal Dementia and tau, Amyotrophic Lateral Sclerosis and tau, Parkinson's disease, Lewy Body dementia or Alzheimer's Disease and alpha-synuclein.

2. 发明申请

US20140051084A1 METHODS AND COMPOSITIONS FOR MONITORING PHAGOCYTIC ACTIVITY 审中-公开
标题翻译：监测PHAGOCY活性的方法和组合物
公开(公告)号：US20140051084A1
公开(公告)日：2014-02-20
申请号：US13989950
申请日：2011-11-28
申请人： Tormod Fladby , Lisbeth Johnsen , Hanne Mali Mollergard
发明人： Tormod Fladby , Lisbeth Johnsen , Hanne Mali Mollergard
IPC分类号： G01N33/68 , C07K16/18 , C07K14/47
CPC分类号： G01N33/6896 , C07K14/4711 , C07K16/18 , C07K2317/34 , G01N2800/2814 , G01N2800/2821
摘要： The invention relates to compositions and methods for monitoring phagocytic activity (e.g., diseases and conditions relating to phagocytic activity). In particular, the invention relates to compositions and methods for diagnosing, monitoring, and/or assessing risk of neurodegenerative diseases (e.g., AD).
摘要翻译：本发明涉及用于监测吞噬活性的组合物和方法（例如，与吞噬活性相关的疾病和病症）。特别地，本发明涉及用于诊断，监测和/或评估神经变性疾病（例如AD）的风险的组合物和方法。

3. 发明授权

US11231426B2 Methods and compositions for monitoring phagocytic activity 有权
公开(公告)号：US11231426B2
公开(公告)日：2022-01-25
申请号：US13989950
申请日：2011-11-28
申请人： Tormod Fladby , Lisbeth Johnsen , Hanne Mali Mollergard
发明人： Tormod Fladby , Lisbeth Johnsen , Hanne Mali Mollergard
IPC分类号： G01N33/68 , C07K14/47 , C07K16/18
摘要： The invention relates to compositions and methods for monitoring phagocytic activity (e.g., diseases and conditions relating to phagocytic activity). In particular, the invention relates to compositions and methods for diagnosing, monitoring, and/or assessing risk of neurodegenerative diseases (e.g., AD).

4. 发明授权

US09625474B2 Diagnostic method for Alzheimer's disease 有权
公开(公告)号：US09625474B2
公开(公告)日：2017-04-18
申请号：US12867479
申请日：2009-02-13
申请人： Tormod Fladby , Lisbeth Johnsen , Kaj Blennow
发明人： Tormod Fladby , Lisbeth Johnsen , Kaj Blennow
IPC分类号： G01N33/68 , G01N33/569
CPC分类号： G01N33/6893 , G01N33/56972 , G01N33/6848 , G01N2333/70596 , G01N2800/2821
摘要： A method of detecting the presence, or monitoring the severity of a condition characterized by the presence of fragments of a marker protein in the brain of a patient. The method comprises: (i) providing a sample comprising macrophages obtained from the patient; and (ii) detecting the presence of the marker protein or fragments thereof in the macrophages. The presence of abnormal levels of the marker protein and/or fragments thereof in the macrophages is indicative of the presence of the condition in the patient. The condition and the marker proteins can be: Alzheimer's Disease and the Abeta peptide, Parkinson's Disease and ubiquitin, Multiple Sclerosis and myelin basic protein, FrontoTemporal Dementia and tau, Amyotrophic Lateral Sclerosis and tau, Parkinson's disease, Lewy Body dementia or Alzheimer's Disease and alpha-synuclein.

5. 发明申请

US20110124010A1 DIAGNOSTIC METHOD 有权
标题翻译：诊断方法
公开(公告)号：US20110124010A1
公开(公告)日：2011-05-26
申请号：US12867479
申请日：2009-02-13
申请人： Tormod Fladby , Lisbeth Johnsen , Kaj Blennow
发明人： Tormod Fladby , Lisbeth Johnsen , Kaj Blennow
IPC分类号： G01N33/68 , C12Q1/02
CPC分类号： G01N33/6893 , G01N33/56972 , G01N33/6848 , G01N2333/70596 , G01N2800/2821
摘要： A method of detecting the presence, or monitoring the severity of a condition characterised by the presence of fragments of a marker protein in the brain of a patient. The method comprises: (i) providing a sample comprising macrophages obtained from the patient; and (ii) detecting the presence of the marker protein or fragments thereof in the macrophages. The presence of abnormal levels of the marker protein and/or fragments thereof in the macrophages is indicative of the presence of the condition in the patient. The condition and the marker proteins can be: Alzheimer's Disease and the Abeta peptide, Parkinson's Disease and ubiquitin, Multiple Sclerosis and myelin basic protein, FrontoTemporal Dementia and tau, Amyotrophic Lateral Sclerosis and tau, Parkinson's disease, Lewy Body dementia or Alzheimer's Disease and alpha-synuclein.
摘要翻译：一种检测患者脑中存在或监测特征在于存在标志蛋白片段的病症的严重程度的方法。该方法包括：（i）提供包含从患者获得的巨噬细胞的样品; 和（ii）检测巨噬细胞中标记蛋白或其片段的存在。在巨噬细胞中存在异常水平的标记蛋白和/或其片段表明患者中存在病症。条件和标记蛋白可以是：阿尔茨海默病和Abeta肽，帕金森病和泛素，多发性硬化和髓磷脂碱性蛋白，FrontoTemporal痴呆和tau，肌萎缩性侧索硬化和tau，帕金森病，路易体痴呆或阿尔茨海默病和阿尔茨海默氏症 - 突触核蛋白。

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