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1. 发明申请

US20080286355A1 Protease Inhibitors For the Treatment of Digestive Pathologies 审中-公开
标题翻译：用于治疗消化道病理学的蛋白酶抑制剂
公开(公告)号：US20080286355A1
公开(公告)日：2008-11-20
申请号：US10586085
申请日：2005-01-18
申请人： Lionel Bueno
发明人： Lionel Bueno
IPC分类号： A61K9/48 , A61K38/57 , A61P1/00 , A61K36/48
CPC分类号： A61K38/57 , A61K31/405
摘要： The invention relates to compositions and methods for the treatment of intestinal pathologies. The invention also relates to compositions and methods which can be used to regulate the paracellular permeability of the intestinal epithelium. The inventive compositions and methods are based in particular on the use of protease inhibitors which modulate the opening of the tight junctions of the intestinal epithelium. The invention can be used for preventive or curative treatment of different pathologies, such as functional digestive disorders (FGID), in particular intestinal functional disorders (IFD) causing hyperalgesia and in particular irritable bowel syndrome (IBS), in mammals, particularly humans.
摘要翻译：本发明涉及治疗肠道病理学的组合物和方法。本发明还涉及可用于调节肠上皮的细胞旁渗透性的组合物和方法。本发明的组合物和方法特别地基于调节肠上皮紧密连接的开口的蛋白酶抑制剂的用途。本发明可用于哺乳动物，特别是人类的不同病理学，例如功能性消化疾病（FGID），特别是导致痛觉过敏的肠功能障碍（IFD），特别是肠易激综合征（IBS）的预防或治疗。

2. 发明申请

US20080139451A1 Compositions for Treating Ocular Surface Pathologies 有权
标题翻译：用于治疗眼表病变的组合物
公开(公告)号：US20080139451A1
公开(公告)日：2008-06-12
申请号：US11792290
申请日：2005-12-09
申请人： Lionel Bueno , Marie-Therese Droy-Lefaix , Philippe Caron
发明人： Lionel Bueno , Marie-Therese Droy-Lefaix , Philippe Caron
IPC分类号： A61K38/00 , A61P27/02
CPC分类号： A61K31/00 , A61K31/551
摘要： The invention concerns compositions and methods for treating and/or preventing ocular pathologies. The invention also concerns compositions and methods enabling the regulation of paracellular permeability of the ocular epithelium. The compositions and methods of the invention are based in particular on the use of agents or conditions modulating the opening of tight junctions of the ocular epithelium. The invention can be used for preventive or curative treatment of various pathologies, such as pathologies of the ocular surface in mammals, particularly in human beings.
摘要翻译：本发明涉及用于治疗和/或预防眼病变的组合物和方法。本发明还涉及能够调节眼上皮细胞旁渗透性的组合物和方法。本发明的组合物和方法特别地基于调节眼部上皮紧密连接的开口的试剂或条件的使用。本发明可用于各种病理学的预防或治疗性治疗，例如哺乳动物，特别是人类中的眼表的病理学。

3. 发明申请

US20080085268A1 Use of lactobacillus farciminis for the prevention or treatment of digestive pathologies 有权
标题翻译：使用乳酸杆菌来预防或治疗消化性病变
公开(公告)号：US20080085268A1
公开(公告)日：2008-04-10
申请号：US11905450
申请日：2007-10-01
申请人： Jean Fioramonti , Lionel Bueno , Vassilla Theodorou , Florence Lamine
发明人： Jean Fioramonti , Lionel Bueno , Vassilla Theodorou , Florence Lamine
IPC分类号： A61K35/74 , A61P1/00
CPC分类号： A61K35/747 , A23L33/135
摘要： The invention relates to the use of lactic bacteria of the species Lactobacillus farciminis for the treatment or prevention of a pathology of the digestive tube, especially an acute or chronic inflammatory pathology of the intestine.
摘要翻译：本发明涉及用于乳酸乳杆菌的乳酸菌用于治疗或预防消化道病理学特别是肠道急性或慢性炎性病理学的用途。

4. 发明授权

US07628991B2 Use of Lactobacillus farciminis for the prevention or treatment of digestive pathologies 有权
标题翻译：使用乳酸乳杆菌来预防或治疗消化性病变
公开(公告)号：US07628991B2
公开(公告)日：2009-12-08
申请号：US11905450
申请日：2007-10-01
申请人： Jean Fioramonti , Lionel Bueno , Vassilia Theodorou , Florence Lamine
发明人： Jean Fioramonti , Lionel Bueno , Vassilia Theodorou , Florence Lamine
IPC分类号： A61K39/38 , A61K45/00 , A01N63/00
CPC分类号： A61K35/747 , A23L33/135
摘要： The invention relates to the use of lactic bacteria of the species Lactobacillus farciminis for the treatment or prevention of a pathology of the digestive tube, especially an acute or chronic inflammatory pathology of the intestine.
摘要翻译：本发明涉及用于乳酸乳杆菌的乳酸菌用于治疗或预防消化道病理学特别是肠道急性或慢性炎性病理学的用途。

5. 发明授权

US06426368B2 Method for preventing and treating alcoholism 失效
标题翻译：酒精中毒预防和治疗方法
公开(公告)号：US06426368B2
公开(公告)日：2002-07-30
申请号：US09804742
申请日：2001-03-13
申请人： Lionel Bueno , Maria Chovet , Laurent Diop , Antonio Guglietta , Hilary J. Little , Michael Francis Rafferty , Jiayuan Ren , Charles Price Taylor, Jr. , William Patrick Watson
发明人： Lionel Bueno , Maria Chovet , Laurent Diop , Antonio Guglietta , Hilary J. Little , Michael Francis Rafferty , Jiayuan Ren , Charles Price Taylor, Jr. , William Patrick Watson
IPC分类号： A61K31195
CPC分类号： A61K31/42 , A61K31/195 , A61K31/197 , A61K31/40 , A61K31/405 , A61K31/54 , A61K31/60 , A61K45/06 , A61K31/19 , A61K2300/00
摘要： GABA analogs are useful to prevent and treat gastrointestinal damage and ethanol withdrawal syndrome. Preferred treatments employ gabapentin or pregabalin.
摘要翻译： GABA类似物可用于预防和治疗胃肠损伤和乙醇戒断综合征。优选的疗法使用加巴喷丁或普瑞巴林。

6. 发明授权

US06242488B1 Method for preventing and treating pain 失效
标题翻译：预防和治疗疼痛的方法
公开(公告)号：US06242488B1
公开(公告)日：2001-06-05
申请号：US09567191
申请日：2000-05-09
申请人： Lionel Bueno , Maria Chovet , Laurent Diop , Antonio Guglietta , Hilary J. Little , Michael Francis Rafferty , Jiayuan Ren , Charles Price Taylor, Jr. , William Patrick Watson
发明人： Lionel Bueno , Maria Chovet , Laurent Diop , Antonio Guglietta , Hilary J. Little , Michael Francis Rafferty , Jiayuan Ren , Charles Price Taylor, Jr. , William Patrick Watson
IPC分类号： A61K31195
CPC分类号： A61K31/42 , A61K31/195 , A61K31/197 , A61K31/40 , A61K31/405 , A61K31/54 , A61K31/60 , A61K45/06 , A61K31/19 , A61K2300/00
摘要： GABA analogs are useful to prevent and treat gastrointestinal damage and ethanol withdrawal syndrome. Preferred treatments employ gabapentin or pregabalin.
摘要翻译： GABA类似物可用于预防和治疗胃肠道损伤和乙醇戒断综合征。优选的疗法使用加巴喷丁或普瑞巴林。

7. 发明授权

US08273708B2 Methods of treatment of ocular surface pathologies 有权
标题翻译：眼表病态治疗方法
公开(公告)号：US08273708B2
公开(公告)日：2012-09-25
申请号：US11792290
申请日：2005-12-09
申请人： Lionel Bueno , Marie-Thérése Droy-Lefaix , Philippe Caron
发明人： Lionel Bueno , Marie-Thérése Droy-Lefaix , Philippe Caron
IPC分类号： A61K38/00 , A61K31/67 , A61K47/06 , C12P15/00 , C12P13/00 , C12P7/00
CPC分类号： A61K31/00 , A61K31/551
摘要： The invention concerns compositions and methods for treating and/or preventing ocular pathologies. The invention also concerns compositions and methods enabling the regulation of paracellular permeability of the ocular epithelium. The compositions and methods of the invention are based in particular on the use of agents or conditions modulating the opening of tight junctions of the ocular epithelium. The invention can be used for preventive or curative treatment of various pathologies, such as pathologies of the ocular surface in mammals, particularly in human beings.
摘要翻译：本发明涉及用于治疗和/或预防眼病变的组合物和方法。本发明还涉及能够调节眼上皮细胞旁渗透性的组合物和方法。本发明的组合物和方法特别地基于调节眼部上皮紧密连接的开口的试剂或条件的使用。本发明可用于各种病理学的预防或治疗性治疗，例如哺乳动物，特别是人类中的眼表的病理学。

8. 发明授权

US07452877B2 Methods for treating digestive functional pathologies 失效
标题翻译：治疗消化功能病变的方法
公开(公告)号：US07452877B2
公开(公告)日：2008-11-18
申请号：US10504087
申请日：2003-03-14
申请人： Lionel Bueno
发明人： Lionel Bueno
IPC分类号： A61K31/551
CPC分类号： A61K31/505 , A61K31/00
摘要： Methods are disclosed for treating hyperalgesia associated with irritable bowel syndrome comprising administering a direct and selective inhibitor of MLCK.
摘要翻译：公开了用于治疗与肠易激综合征相关的痛觉过敏的方法，其包括施用MLCK的直接和选择性抑制剂。

9. 发明申请

US20050244389A1 Use of lactobacillus farciminis for the prevention or pathology of digestive pathologies 有权
标题翻译：使用乳酸杆菌来预防或病理消化性病变
公开(公告)号：US20050244389A1
公开(公告)日：2005-11-03
申请号：US10509255
申请日：2003-03-21
申请人： Jean Fioramonti , Lionel Bueno , Vassilia Theodorou , Florence Lamine
发明人： Jean Fioramonti , Lionel Bueno , Vassilia Theodorou , Florence Lamine
IPC分类号： A23L1/30 , A61K35/74 , A61K35/747 , A61P1/00 , A61P29/00 , A61K45/00 , C12N1/20
CPC分类号： A61K35/747 , A23L33/135
摘要： The invention relates to the use of lactic bacteria of the species Lactobacillus farciminis for the treatment or prevention of a pathology of the digestive tube, especially an acute or chronic inflammatory pathology of the intestine.
摘要翻译：本发明涉及用于乳酸乳杆菌的乳酸菌用于治疗或预防消化道病理学特别是肠道急性或慢性炎性病理学的用途。

10. 发明申请

US20050054577A1 Compositions for treating digestive functional pathologies 失效
标题翻译：用于治疗消化功能性病变的组合物
公开(公告)号：US20050054577A1
公开(公告)日：2005-03-10
申请号：US10504087
申请日：2003-03-14
申请人： Lionel Bueno
发明人： Lionel Bueno
IPC分类号： A61K45/00 , A61K31/00 , A61K31/352 , A61K31/505 , A61K31/551 , A61K45/06 , A61P1/00 , A61P1/04 , A61P1/10 , A61P1/12 , A61P25/02 , A61P25/04 , A61P29/00 , A61P43/00 , A61K38/08
CPC分类号： A61K31/505 , A61K31/00
摘要： The invention concerns compositions and methods for treating intestinal pathologies. The invention also concerns compositions and methods enabling the regulation of paracellular permeability of the intestinal epithelium. The inventive compositions and methods are based in particular on the use of agents or conditions modulating the opening of tight junctions of the intestinal epithelium. The invention can be used for preventive or curative treatment of various pathologies, such as intestinal functional disorders (IFD) resulting in hyperalgesia and particularly irritable bowel syndrome (IBS), in mammals, particularly humans.
摘要翻译：本发明涉及治疗肠道病理学的组合物和方法。本发明还涉及能够调节肠上皮的细胞旁通透性的组合物和方法。本发明的组合物和方法特别地基于调节肠上皮的紧密连接的打开的试剂或条件的使用。本发明可用于预防或治疗各种病症，例如在哺乳动物，特别是人类中导致痛觉过敏，特别是肠易激综合征（IBS）的肠功能障碍（IFD）。

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