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1. 发明申请

US20090098587A1 METHOD OF SCREENING FOR DISORDERS OF GLUCOSE METABOLISM 审中-公开
标题翻译：葡萄糖代谢障碍筛查方法
公开(公告)号：US20090098587A1
公开(公告)日：2009-04-16
申请号：US12099740
申请日：2008-04-08
申请人： Donald Hetzel , Stephen L. Monfre , Kevin H. Hazen , Timothy L. Ruchti , Thomas B. Blank , Linda Hockersmith , Andrew Cone
发明人： Donald Hetzel , Stephen L. Monfre , Kevin H. Hazen , Timothy L. Ruchti , Thomas B. Blank , Linda Hockersmith , Andrew Cone
IPC分类号： C12Q1/54
CPC分类号： C12Q1/54 , A61B5/14532 , A61B5/7264 , G01N33/66 , G01N2800/042 , G16H50/20 , G16H50/70
摘要： A method of screening for disorders of glucose metabolism such as impaired glucose tolerance and diabetes allows prevention, or early detection and treatment of diabetic complications such as cardiovascular disease, retinopathy, and other disorders of the major organs and systems. A mathematical algorithm evaluates the shape of a subject's glucose profile and classifies the profile into one of several predefined clusters, each cluster corresponding either to a normal condition or one of several abnormal conditions. The series of blood glucose values making up the glucose tolerance curve may be measured using any glucose analyzer including: invasive, minimally invasive and noninvasive types. The method is executed on a processing device programmed to perform the steps of the method. Depending on the outcome of the screening, a subject may be provided with additional information concerning their condition and/or counseled to consult further with their health care provider.
摘要翻译：筛选葡萄糖代谢紊乱如葡萄糖耐量异常和糖尿病的方法允许预防或早期检测和治疗糖尿病并发症如心血管疾病，视网膜病变和主要器官和系统的其他病症。数学算法评估受试者的葡萄糖谱的形状并将轮廓分类为几个预定义的簇之一，每个簇对应于正常条件或几个异常条件之一。构成葡萄糖耐量曲线的一系列血糖值可以使用任何葡萄糖分析仪来测量，包括：侵入性，微创和非侵入性类型。该方法在被编程为执行该方法的步骤的处理装置上执行。根据筛查结果，可以向受试者提供有关其病情的信息和/或咨询，以进一步咨询其医护人员。

2. 发明申请

US20060264718A1 Method and apparatus for improving performance of noninvasive analyte property estimation 有权
标题翻译：用于改善非侵入性分析物质性能估计性能的方法和装置
公开(公告)号：US20060264718A1
公开(公告)日：2006-11-23
申请号：US11168941
申请日：2005-06-27
申请人： Timothy Ruchti , Linda Hockersmith , Stephen Monfre , Kevin Hazen
发明人： Timothy Ruchti , Linda Hockersmith , Stephen Monfre , Kevin Hazen
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B2560/0223 , G01N21/359
摘要： The invention relates to noninvasive analyte property determination. More particularly, the invention relates to a method and apparatus for performing conditional additional acquisition of noninvasive spectra to improve analyzer performance. Conditional additional data acquisition is used to confirm, update, and/or supplement spectral data.
摘要翻译：本发明涉及非侵入性分析物质的测定。更具体地，本发明涉及用于执行非侵入性光谱的条件附加获取以提高分析仪性能的方法和装置。条件附加数据采集用于确认，更新和/或补充光谱数据。

3. 发明授权

US07698105B2 Method and apparatus for improving performance of noninvasive analyte property estimation 有权
标题翻译：用于改善非侵入性分析物质性能估计性能的方法和装置
公开(公告)号：US07698105B2
公开(公告)日：2010-04-13
申请号：US11168941
申请日：2005-06-27
申请人： Timothy L. Ruchti , Linda Hockersmith , Stephen L. Monfre , Kevin H. Hazen
发明人： Timothy L. Ruchti , Linda Hockersmith , Stephen L. Monfre , Kevin H. Hazen
IPC分类号： G06F11/00 , A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B2560/0223 , G01N21/359
摘要： The invention relates to noninvasive analyte property determination. More particularly, the invention relates to a method and apparatus for performing conditional additional acquisition of noninvasive spectra to improve analyzer performance. Conditional additional data acquisition is used to confirm, update, and/or supplement spectral data.
摘要翻译：本发明涉及非侵入性分析物质的测定。更具体地，本发明涉及用于执行非侵入性光谱的条件附加获取以提高分析仪性能的方法和装置。条件附加数据采集用于确认，更新和/或补充光谱数据。

4. 发明申请

US20050209515A1 Method and apparatus for presentation of noninvasive glucose concentration information 失效
标题翻译：用于呈现无创葡萄糖浓度信息的方法和装置
公开(公告)号：US20050209515A1
公开(公告)日：2005-09-22
申请号：US11012428
申请日：2004-12-14
申请人： Linda Hockersmith , Kevin Hazen , Timothy Ruchti
发明人： Linda Hockersmith , Kevin Hazen , Timothy Ruchti
IPC分类号： A61B5/00 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/7415 , A61B5/743 , A61B5/7475 , A61B5/749 , A61B2560/0456 , G06F19/00 , G16H15/00
摘要： The invention relates generally to the extraction and/or presentation of glucose concentrations estimated as a function of time into a format that facilitates conveyance of the underlying information. More particularly, glucose concentration histories are presented in terms of risk of behavior, in a video format, and/or in an audio format. The reduction of data into video format, selected by time period, cluster, or glucose concentration response, into an animated or video presentation allows diagnosis and treatment information to be more readily determined and used. Alternatively, glucose concentrations are output through a voice synthesizer or an earcon. These information presentations are useful for both the medical professional and the end user. The information presentation is preferably used with a noninvasive, implantable, semi-continuous, and/or continuous analyte analyzer, such as a glucose concentration analyzer.
摘要翻译：本发明一般涉及将作为时间的函数估计的葡萄糖浓度的提取和/或表现提升为促进底层信息传递的格式。更具体地，葡萄糖浓度历史以行为风险，视频格式和/或音频格式呈现。将通过时间段，群集或葡萄糖浓度响应选择的视频格式的数据减少为动画或视频呈现允许更容易地确定和使用诊断和治疗信息。或者，葡萄糖浓度通过语音合成器或耳塞输出。这些信息介绍对于医疗专业人员和最终用户都是有用的。信息呈现优选与非侵入性，可植入，半连续和/或连续的分析物分析仪一起使用，例如葡萄糖浓度分析仪。

5. 发明授权

US07395158B2 Method of screening for disorders of glucose metabolism 失效
标题翻译：筛选葡萄糖代谢紊乱的方法
公开(公告)号：US07395158B2
公开(公告)日：2008-07-01
申请号：US10219200
申请日：2002-08-13
申请人： Stephen L. Monfre , Linda Hockersmith , Donald Hetzel , Kevin H. Hazen , Andrew Cone
发明人： Stephen L. Monfre , Linda Hockersmith , Donald Hetzel , Kevin H. Hazen , Andrew Cone
IPC分类号： G06F19/00 , G01N33/48
CPC分类号： A61B5/7264 , A61B5/14532 , Y10T436/144444
摘要： A method of screening for disorders of glucose metabolism such as impaired glucose tolerance and diabetes allows prevention, or early detection and treatment of diabetic complications such as cardiovascular disease, retinopathy, and other disorders of the major organs and systems. A mathematical algorithm evaluates the shape of a subject's glucose profile and classifies the profile into one of several predefined clusters, each cluster corresponding either to a normal condition or one of several abnormal conditions. The series of blood glucose values making up the glucose tolerance curve may be measured using any glucose analyzer including: invasive, minimally invasive and noninvasive types. The method is executed on a processing device programmed to perform the steps of the method. Depending on the outcome of the screening, a subject may be provided with additional information concerning their condition and/or counseled to consult further with their health care provider.
摘要翻译：筛选葡萄糖代谢紊乱如葡萄糖耐量异常和糖尿病的方法允许预防或早期检测和治疗糖尿病并发症如心血管疾病，视网膜病变和主要器官和系统的其他病症。数学算法评估受试者的葡萄糖谱的形状并将轮廓分类为几个预定义的簇之一，每个簇对应于正常条件或几个异常条件之一。构成葡萄糖耐量曲线的一系列血糖值可以使用任何葡萄糖分析仪来测量，包括：侵入性，微创和非侵入性类型。该方法在被编程为执行该方法的步骤的处理装置上执行。根据筛查结果，可以向受试者提供有关其病情的信息和/或咨询，以进一步咨询其医护人员。

6. 发明申请

US20050159656A1 Method and apparatus for presentation of noninvasive glucose concentration information 审中-公开
标题翻译：用于呈现无创葡萄糖浓度信息的方法和装置
公开(公告)号：US20050159656A1
公开(公告)日：2005-07-21
申请号：US11012441
申请日：2004-12-14
申请人： Linda Hockersmith , Kevin Hazen , Timothy Ruchti
发明人： Linda Hockersmith , Kevin Hazen , Timothy Ruchti
IPC分类号： A61B5/00 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/7415 , A61B5/743 , A61B5/7475 , A61B5/749 , A61B2560/0456 , G16H15/00
摘要： The invention relates to the extraction and/or presentation of glucose concentrations estimated as a function of time into a format that facilitates conveyance of the underlying information. More particularly, short term actions, such as exercise, diabetes drug treatment, and/or food intake, are correlated to glucose response profiles. Optionally, glucose concentration responses are back correlated to parameters, such as time, exercise, diabetes drug treatment and/or food intake. The resulting correlated data are output to the user in a time compressed format, in video format, and/or as a cluster allowing diagnosis and treatment information to be more readily determined and used. These information presentations are useful for both the medical professional and the end user. The information presentation is preferably used with a noninvasive, implantable, semi-continuous, and/or continuous analyte analyzer, such as a glucose concentration analyzer.
摘要翻译：本发明涉及将作为时间的函数估计的葡萄糖浓度的提取和/或表现提升为促进底层信息传递的格式。更具体地，诸如运动，糖尿病药物治疗和/或食物摄入的短期作用与葡萄糖反应曲线相关。任选地，葡萄糖浓度反应与诸如时间，运动，糖尿病药物治疗和/或食物摄取的参数反向相关。所得到的相关数据以视频格式的时间压缩格式和/或作为更易于确定和使用的诊断和治疗信息的集群输出给用户。这些信息介绍对于医疗专业人员和最终用户都是有用的。信息呈现优选与非侵入性，可植入，半连续和/或连续的分析物分析仪一起使用，例如葡萄糖浓度分析仪。

7. 发明授权

US06487429B2 Use of targeted glycemic profiles in the calibration of a noninvasive blood glucose monitor 失效
公开(公告)号：US06487429B2
公开(公告)日：2002-11-26
申请号：US09766872
申请日：2001-01-18
申请人： Linda Hockersmith , Thomas B. Blank , Stephen L. Monfre , Timothy L. Ruchti
发明人： Linda Hockersmith , Thomas B. Blank , Stephen L. Monfre , Timothy L. Ruchti
IPC分类号： A61B500
CPC分类号： A61B5/14532
摘要： A method of calibrating a non-invasive blood glucose measurement instrument to a diabetic test subject employs targeted glycemic profiles in anti-correlated pairs. During calibration, reference blood glucose determinations are made using conventional invasive sampling methods. Concurrently, noninvasive spectral measurements are made using the noninvasive glucose monitor. Through controlled oral ingestion by the subject of calculated amounts of carbohydrate, the subject's blood glucose level is manipulated to mimic the patterns of the targeted profiles. During a first visit, a first profile of a pair is induced; during a second visit the inverse of the first profile is induced. The targeted profiles produce reference blood glucose values in which correlation to sampling factors is reduced or eliminated, thus the resulting calibration is correlated to glucose, and not to other analytes, sampling factors or environmental factors. A formula is provided for calculating the required amount of carbohydrate to ingest to induce a targeted glycemic profile in a test subject.

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