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1. 发明授权

US5540834A Synthesis of porous inorganic particles by polymerization-induced colloid aggregation (PICA) 失效
标题翻译：通过聚合诱导胶体聚集（PICA）合成多孔无机颗粒
公开(公告)号：US5540834A
公开(公告)日：1996-07-30
申请号：US294374
申请日：1994-08-23
申请人： Peter W. Carr , Alon V. McCormick , Michael J. Annen , Lifang Sun , Jason R. Brown
发明人： Peter W. Carr , Alon V. McCormick , Michael J. Annen , Lifang Sun , Jason R. Brown
IPC分类号： B01J20/02 , C04B38/00 , B01D15/08
CPC分类号： B01J20/282 , B01J20/0211 , B01J20/06 , B01J20/2803 , B01J20/28054 , B01J20/305 , C04B38/009 , B01J2220/54
摘要： The present invention provides improved methods for the preparation of porous inorganic particles. The methods involve combining an aqueous sol containing a colloidal dispersion of inorganic particles with a polymerizable organic material, polymerizing this material, and thereby forming aggregates of colloidal particles and polymer.
摘要翻译：本发明提供了制备多孔无机颗粒的改进方法。该方法包括将含有无机颗粒的胶体分散体的水性溶胶与可聚合的有机材料结合，使该材料聚合，从而形成胶体颗粒和聚合物的聚集体。

2. 发明授权

US09265835B2 Compositions of rotigotine, derivatives thereof, or pharmaceutically acceptable salts of rotigotine or its derivative 有权
标题翻译：罗替戈汀或其衍生物或罗替戈汀或其衍生物的药学上可接受的盐的组合物
公开(公告)号：US09265835B2
公开(公告)日：2016-02-23
申请号：US13989550
申请日：2011-11-25
申请人： Youxin Li , Aiping Wang , Wanhui Liu , Kaoxiang Sun , Jun Li , Lifang Sun
发明人： Youxin Li , Aiping Wang , Wanhui Liu , Kaoxiang Sun , Jun Li , Lifang Sun
IPC分类号： A61K9/50 , A61K31/38 , C07D333/20 , A61K47/34 , A61K9/16 , A61K31/381
CPC分类号： A61K47/34 , A61K9/1617 , A61K9/1647 , A61K31/381
摘要： The disclosure relates to a composition comprising rotigotine or a pharmaceutically acceptable salt thereof; at least one poly(lactide-co-glycolide) (PLGA); and at least one fatty acid, wherein the at least one fatty acid is at least 0.5% in weight relative to the total weight of the composition. The composition as disclosed herein has significantly reduced burse release effect. The disclosure also provides a method of treating Parkinson's disease comprising administering an effective amount of the composition as disclosed to a subject in need thereof.
摘要翻译：本公开涉及包含罗替戈汀或其药学上可接受的盐的组合物; 至少一种聚（丙交酯 - 共 - 乙交酯）（PLGA）; 和至少一种脂肪酸，其中所述至少一种脂肪酸相对于所述组合物的总重量为至少0.5重量％。本文公开的组合物显着降低了排泄效果。本公开还提供了治疗帕金森病的方法，其包括向有需要的受试者施用有效量的所公开的组合物。

3. 发明申请

US20130309314A1 COMPOSITIONS OF ROTIGOTINE, DERIVATIVES THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS OF ROTIGOTINE OR ITS DERIVATIVE 有权
标题翻译：罗替丁组合物，其衍生物，或药理学或药理学上可接受的盐或其衍生物
公开(公告)号：US20130309314A1
公开(公告)日：2013-11-21
申请号：US13989550
申请日：2011-11-25
申请人： Youxin Li , Aiping Wang , Wanhui Liu , Kaoxiang Sun , Jun Li , Lifang Sun
发明人： Youxin Li , Aiping Wang , Wanhui Liu , Kaoxiang Sun , Jun Li , Lifang Sun
IPC分类号： A61K47/34
CPC分类号： A61K47/34 , A61K9/1617 , A61K9/1647 , A61K31/381
摘要： The disclosure provides a composition comprising rotigotine or a pharmaceutically acceptable salt thereof; at least one poly(lactide-co-glycolide) (PLGA); and at least one fatty acid, wherein the at least one fatty acid is at least 0.5% in weight relative to the total weight of the composition. The composition as disclosed herein has significantly reduced burse release effect. The disclosure also provides a method of treating Parkinson's disease comprising administering an effective amount of the composition as disclosed to a subject in need thereof.
摘要翻译：本公开提供了包含罗替戈汀或其药学上可接受的盐的组合物; 至少一种聚（丙交酯 - 共 - 乙交酯）（PLGA）; 和至少一种脂肪酸，其中所述至少一种脂肪酸相对于所述组合物的总重量为至少0.5重量％。本文公开的组合物显着降低了排泄效果。本公开还提供了治疗帕金森病的方法，其包括向有需要的受试者施用有效量的所公开的组合物。

4. 发明授权

US08404849B2 Processes for producing modulators of cystic fibrosis transmembrane conductance regulator 有权
标题翻译：生产囊性纤维化跨膜电导调节剂调节剂的方法
公开(公告)号：US08404849B2
公开(公告)日：2013-03-26
申请号：US13112868
申请日：2011-05-20
申请人： Lifang Sun , Khisal Ahmed Alvi , Caroline Joyce Decker , Yongmin Li
发明人： Lifang Sun , Khisal Ahmed Alvi , Caroline Joyce Decker , Yongmin Li
IPC分类号： C07D215/38
CPC分类号： C07D487/08
摘要： The present invention relates to the process for producing modulators of cystic fibrosis transmembrane conductance regulator (CFTR).
摘要翻译：本发明涉及生产囊性纤维化跨膜电导调节剂（CFTR）调节剂的方法。

5. 发明申请

US20110288121A1 Processes for Producing Modulators of Cystic Fibrosis Transmembrane Conductance Regulator 有权
标题翻译：用于生产囊性纤维化跨膜电导调节剂调节剂的方法
公开(公告)号：US20110288121A1
公开(公告)日：2011-11-24
申请号：US13112868
申请日：2011-05-20
申请人： Lifang Sun , Khisal Ahmed Alvi , Caroline Joyce Decker , Yongmin Li
发明人： Lifang Sun , Khisal Ahmed Alvi , Caroline Joyce Decker , Yongmin Li
IPC分类号： A61K31/4709 , A61P11/00 , C07D215/233
CPC分类号： C07D487/08
摘要： The present invention relates to the process for producing modulators of cystic fibrosis transmembrane conductance regulator (CFTR).
摘要翻译：本发明涉及生产囊性纤维化跨膜电导调节剂（CFTR）调节剂的方法。

6. 发明授权

US06734318B2 Fluorous triphase and other multiphase systems 失效
标题翻译：含氟三相等多相体系
公开(公告)号：US06734318B2
公开(公告)日：2004-05-11
申请号：US09877944
申请日：2001-06-08
申请人： Dennis P. Curran , Stephen G. Weber , Hiroyuki Nakamura , Bruno Linclau , Lifang Sun
发明人： Dennis P. Curran , Stephen G. Weber , Hiroyuki Nakamura , Bruno Linclau , Lifang Sun
IPC分类号： C07F704
CPC分类号： C07D207/333 , C07B37/04 , C07B61/00 , C07B63/00 , C07C1/325 , C07C17/02 , C07C45/46 , C07D307/46 , C07D333/22 , C07C15/52 , C07C22/04 , C07C23/10 , C07C49/84
摘要： A method of reacting a first compound to produce a second compound includes the step of contacting a first non-fluorous phase including the first compound with a first fluorous phase at a first phase interface. The first compound distributes between the first fluorous phase and the first non-fluorous phase. The method further includes the steps of contacting the first fluorous phase with a second non-fluorous phase at a second phase interface and including at least a third compound in the second non-fluorous phase that reacts with the first compound to produce the second compound. The second compound has a distribution coefficient less than the first compound. This method can, for example be used to separate the second compound from unreacted first compound wherein, for example, the first compound is of a fluorous nature and distributes more readily into (or transports more quickly through) the fluorous phase than does the second compound. In general, the fluorous phase serves as a barrier to prevent the two non-fluorous phases from mixing, but molecules that can migrate through the fluorous phase can pass from one side to the other.
摘要翻译：使第一化合物反应以产生第二化合物的方法包括使第一化合物的第一非氟相与第一相界面处的第一氟相接触的步骤。第一化合物在第一氟相和第一非氟相之间分配。该方法还包括以下步骤：在第二相界面处使第一氟相与第二非氟相接触，并且在第二非氟相中包含至少第三化合物，其与第一化合物反应以产生第二化合物。第二化合物的分配系数小于第一化合物。该方法可以例如用于将第二化合物与未反应的第一化合物分离，其中例如第一化合物具有氟性质，并且比第二化合物更容易地分配（或更快地通过）氟相。通常，氟相用作阻止两个非氟相混合的屏障，但是可以迁移穿过氟相的分子可以从一侧传递到另一侧。

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