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1. 发明授权

US08680247B2 Monoclonal antibodies against glypican-3 有权
标题翻译：针对磷脂酰肌醇蛋白聚糖-3的单克隆抗体
公开(公告)号：US08680247B2
公开(公告)日：2014-03-25
申请号：US12668965
申请日：2008-07-17
申请人： Jonathan Alexander Terrett , Li-Sheng Lu , Haichun Huang , Dapeng Yao , Chin Pan , Heidi Leblanc , Timothy Sproul , Mark Yamanaka
发明人： Jonathan Alexander Terrett , Li-Sheng Lu , Haichun Huang , Dapeng Yao , Chin Pan , Heidi Leblanc , Timothy Sproul , Mark Yamanaka
IPC分类号： C07K16/30 , A61K39/395 , A61K39/44 , C07K16/46
CPC分类号： C07K16/28 , A61K39/00 , C07K16/303 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Glypican-3 with high affinity. Nucleic acid molecules encoding Glypican-3 antibodies, expression vectors, host cells and methods for expressing the Glypican-3 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the Glypican-3 antibodies are also provided. Methods for detecting Glypican-3, as well as methods for treating various Glypican-3-related conditions, including hepatocellular cancer, are disclosed.
摘要翻译：本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合磷脂酰肌醇蛋白聚糖-3的人单克隆抗体。还提供了编码磷脂酰肌醇蛋白聚糖-3抗体的核酸分子，表达载体，宿主细胞和用于表达糖蛋白聚糖-3抗体的方法。还提供了免疫偶联物，双特异性分子和包含磷脂酰肌醇蛋白聚糖-3抗体的药物组合物。公开了检测磷酸三钙-3的方法，以及用于治疗各种磷酸三钙3相关病症（包括肝细胞癌）的方法。

2. 发明授权

US08609816B2 Human monoclonal antibodies to O8E 有权
标题翻译： O8E的人单克隆抗体
公开(公告)号：US08609816B2
公开(公告)日：2013-12-17
申请号：US12092866
申请日：2006-12-08
申请人： Alan J. Korman , Mark J. Selby , Li-Sheng Lu , Alison Witte , Haichun Huang
发明人： Alan J. Korman , Mark J. Selby , Li-Sheng Lu , Alison Witte , Haichun Huang
IPC分类号： C07K16/00 , C07K17/00 , C12P21/08
CPC分类号： C07K16/2827 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07H21/00 , C07K16/30 , C07K16/3015 , C07K2317/14 , C07K2317/21 , C07K2317/40 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92 , C07K2319/55 , C12N15/00 , C12N15/09 , C12N15/62
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.
摘要翻译：本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合O8E的人单克隆抗体。还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。还提供了免疫偶联物，双特异性分子和包含本公开的抗体的药物组合物。本公开还提供了治疗癌症的方法。

3. 发明申请

US20090074660A1 Human Monoclonal Antibodies To O8E 有权
标题翻译：人类单克隆抗体O8E
公开(公告)号：US20090074660A1
公开(公告)日：2009-03-19
申请号：US12092866
申请日：2006-12-08
申请人： Alan J. Korman , Mark J. Selby , Li-Sheng Lu , Alison Witte , Haichun Huang
发明人： Alan J. Korman , Mark J. Selby , Li-Sheng Lu , Alison Witte , Haichun Huang
IPC分类号： A61K51/10 , C07K16/00 , C07H21/00 , C12N5/00 , A61P35/00 , C12P21/00 , C12N15/63 , A61K39/395
CPC分类号： C07K16/2827 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07H21/00 , C07K16/30 , C07K16/3015 , C07K2317/14 , C07K2317/21 , C07K2317/40 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92 , C07K2319/55 , C12N15/00 , C12N15/09 , C12N15/62
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.
摘要翻译：本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合O8E的人单克隆抗体。还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。还提供了免疫缀合物，双特异性分子和包含本公开的抗体的药物组合物。本公开还提供了治疗癌症的方法。

4. 发明申请

US20090028872A1 HUMAN MONOCLONAL ANTIBODIES TO CD70 有权
标题翻译：人类单克隆抗体CD70
公开(公告)号：US20090028872A1
公开(公告)日：2009-01-29
申请号：US12065436
申请日：2006-09-26
申请人： Jonathan Alexander Terret , Li-Sheng Lu , David John King , Josephine M. Cardarelli , Chin Pan , Haichun Huang , Marco A. Coccia
发明人： Jonathan Alexander Terret , Li-Sheng Lu , David John King , Josephine M. Cardarelli , Chin Pan , Haichun Huang , Marco A. Coccia
IPC分类号： A61K39/395 , C07K16/18 , C12N15/11 , C12N15/00 , C12N5/06 , A61P31/00 , A61P37/00
CPC分类号： C07K16/2875 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , Y02A50/386 , Y02A50/466
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to CD70 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for treating cancer, autoimmune disease, inflammation and viral infections.
摘要翻译：本公开提供以高亲和力特异性结合CD70的分离的单克隆抗体，特别是人单克隆抗体。还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。还提供了免疫偶联物，双特异性分子和包含本公开的抗体的药物组合物。本公开还提供了治疗癌症，自身免疫疾病，炎症和病毒感染的方法。

5. 发明申请

US20100209432A1 MONOCLONAL ANTIBODIES AGAINST GLYPICAN-3 有权
标题翻译：对抗GLYPICAN-3的单克隆抗体
公开(公告)号：US20100209432A1
公开(公告)日：2010-08-19
申请号：US12668965
申请日：2008-07-17
申请人： Jonathan Alexander Terrette , Li-sheng Lu , Haichun Huang , Dapeng Yao , Chin Pan , Heidi Leblanc , Timothy Sproul , Mark Yamanaka
发明人： Jonathan Alexander Terrette , Li-sheng Lu , Haichun Huang , Dapeng Yao , Chin Pan , Heidi Leblanc , Timothy Sproul , Mark Yamanaka
IPC分类号： A61K39/395 , C07K16/18 , C07H21/04 , C12N15/63 , C12N5/10 , A61P35/00
CPC分类号： C07K16/28 , A61K39/00 , C07K16/303 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Glypican-3 with high affinity. Nucleic acid molecules encoding Glypican-3 antibodies, expression vectors, host cells and methods for expressing the Glypican-3 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the Glypican-3 antibodies are also provided. Methods for detecting Glypican-3, as well as methods for treating various Glypican-3-related conditions, including hepatocellular cancer, are disclosed.
摘要翻译：本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合磷脂酰肌醇蛋白聚糖-3的人单克隆抗体。还提供了编码磷脂酰肌醇蛋白聚糖-3抗体的核酸分子，表达载体，宿主细胞和用于表达糖蛋白聚糖-3抗体的方法。还提供了免疫偶联物，双特异性分子和包含磷脂酰肌醇蛋白聚糖-3抗体的药物组合物。公开了检测磷酸三钙-3的方法，以及用于治疗各种磷酸三钙3相关病症（包括肝细胞癌）的方法。

6. 发明申请

US20150035762A1 ELECTRONIC DEVICE AND PAIRING METHOD THEREOF 审中-公开
标题翻译：电子设备及其配对方法
公开(公告)号：US20150035762A1
公开(公告)日：2015-02-05
申请号：US14166807
申请日：2014-01-28
申请人： Li-Sheng Lu
发明人： Li-Sheng Lu
IPC分类号： G06F3/041 , H04W8/00
CPC分类号： G06F3/041 , G06F3/04883 , H04M1/7253 , H04M2250/22 , H04W8/005
摘要： An electronic device and a pairing method including following steps are provided. A first touch operation performed on a first touch unit of a first electronic device is detected, and a first azimuth angle of a first pointing direction (defined by the first touch operation) with respect to a reference direction is obtained. The first azimuth angle is compared with a second azimuth angle to obtain an included angle between the first pointing direction and a second pointing direction. When a value obtained by subtracting 180 degrees from an absolute value of the included angle is smaller than a threshold, a pairing relationship is established between the first and second electronic devices. The second azimuth angle is an azimuth angle of the second pointing direction (defined by a second touch operation performed on a second touch unit of the second electronic device) with respect to the reference direction.
摘要翻译：提供了包括以下步骤的电子设备和配对方法。检测对第一电子设备的第一触摸单元执行的第一触摸操作，并且获得第一指向方向（由第一触摸操作定义）相对于参考方向的第一方位角。将第一方位角与第二方位角进行比较，以获得第一指向和第二指向之间的夹角。当通过从夹角的绝对值减去180度而获得的值小于阈值时，在第一和第二电子设备之间建立配对关系。第二方位角是相对于基准方向的第二指示方向（由第二电子设备的第二触摸单元执行的第二触摸操作限定）的方位角。

7. 发明授权

US08222375B2 Human monoclonal antibodies to protein tyrosine kinase 7 (PTK7) and methods for using anti-PTK7 antibodies 有权
标题翻译：蛋白酪氨酸激酶7（PTK7）的人单克隆抗体和使用抗PTK7抗体的方法
公开(公告)号：US08222375B2
公开(公告)日：2012-07-17
申请号：US12095986
申请日：2006-12-08
申请人： Jonathan Alexander Terrett , Li-Sheng Lu , Chin Pan
发明人： Jonathan Alexander Terrett , Li-Sheng Lu , Chin Pan
IPC分类号： C07K16/40 , C07K16/00 , A61K39/395
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/40 , C07K2317/21 , C07K2317/565 , C07K2317/77
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies.
摘要翻译：本发明提供了以高亲和力特异性结合PTK7的分离的单克隆抗体，特别是人单克隆抗体。还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。本发明还提供用于检测PTK7的方法，以及使用抗PTK7抗体治疗各种疾病（包括癌症和感染性疾病）的方法。

8. 发明授权

US08124738B2 Human monoclonal antibodies to CD70 有权
标题翻译： CD70的人单克隆抗体
公开(公告)号：US08124738B2
公开(公告)日：2012-02-28
申请号：US12065436
申请日：2006-09-26
申请人： Jonathan Alexander Terret , Li-sheng Lu , David John King , Josephine M. Cardarelli , Chin Pan , Haichun Huang , Marco A. Coccia
发明人： Jonathan Alexander Terret , Li-sheng Lu , David John King , Josephine M. Cardarelli , Chin Pan , Haichun Huang , Marco A. Coccia
IPC分类号： C07K16/00 , A61K39/395 , A61K39/00
CPC分类号： C07K16/2875 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , Y02A50/386 , Y02A50/466
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to CD70 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for treating cancer, autoimmune disease, inflammation and viral infections.
摘要翻译：本公开提供以高亲和力特异性结合CD70的分离的单克隆抗体，特别是人单克隆抗体。还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。还提供了免疫偶联物，双特异性分子和包含本公开的抗体的药物组合物。本公开还提供了治疗癌症，自身免疫疾病，炎症和病毒感染的方法。

9. 发明授权

US09505845B2 Treating lung cancer using human monoclonal antibodies to protein tyrosine kinase 7 (PTK7) 有权
标题翻译：用蛋白酪氨酸激酶7（PTK7）的人单克隆抗体治疗肺癌
公开(公告)号：US09505845B2
公开(公告)日：2016-11-29
申请号：US13442499
申请日：2012-04-09
申请人： Jonathan Alexander Terrett , Li-Sheng Lu , Chin Pan
发明人： Jonathan Alexander Terrett , Li-Sheng Lu , Chin Pan
IPC分类号： A61K39/395 , C07K16/30 , C07K16/40 , A61K39/00
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/40 , C07K2317/21 , C07K2317/565 , C07K2317/77
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies.
摘要翻译：本发明提供了以高亲和力特异性结合PTK7的分离的单克隆抗体，特别是人单克隆抗体。还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。本发明还提供用于检测PTK7的方法，以及使用抗PTK7抗体治疗各种疾病（包括癌症和感染性疾病）的方法。

10. 发明授权

US09102738B2 Human monoclonal antibodies to protein tyrosine kinase 7 (PTK7) 有权
标题翻译：蛋白酪氨酸激酶7（PTK7）的人单克隆抗体
公开(公告)号：US09102738B2
公开(公告)日：2015-08-11
申请号：US13468624
申请日：2012-05-10
申请人： Jonathan Alexander Terrett , Li-Sheng Lu , Chin Pan
发明人： Jonathan Alexander Terrett , Li-Sheng Lu , Chin Pan
IPC分类号： C07K16/40 , C07K16/00 , C07K16/30 , A61K39/00
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/40 , C07K2317/21 , C07K2317/565 , C07K2317/77
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies.
摘要翻译：本发明提供了以高亲和力特异性结合PTK7的分离的单克隆抗体，特别是人单克隆抗体。还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。本发明还提供用于检测PTK7的方法，以及使用抗PTK7抗体治疗各种疾病（包括癌症和感染性疾病）的方法。

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