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1. 发明授权

US08486244B2 Test strip comprising patterned electrodes 有权
标题翻译：测试条包括图案化电极
公开(公告)号：US08486244B2
公开(公告)日：2013-07-16
申请号：US12644421
申请日：2009-12-22
申请人： Marco F. Cardosi , Leanne Mills , Emma Vanessa Jayne Day , Richard Michael Day , Christopher Philip Leach
发明人： Marco F. Cardosi , Leanne Mills , Emma Vanessa Jayne Day , Richard Michael Day , Christopher Philip Leach
IPC分类号： G01N27/26 , C12N1/00
CPC分类号： G01N27/3272 , Y10T156/10
摘要： Described herein is an electrochemical enzymatic analyte test strip and method for making the test strip. The test strip utilizes isolated conductive areas inside the electrodes to define electrode whiskers. The method utilizes laser ablation to define electrode patterns.
摘要翻译：本文描述的是用于制备测试条的电化学酶分析物测试条和方法。测试条使用电极内部的隔离导电区域来限定电极晶须。该方法利用激光消融来定义电极图案。

2. 发明授权

US07740801B2 System for determination of an analyte in a bodily fluid sample that includes an electroluminescent component 有权
标题翻译：用于测定包含电致发光组分的体液样品中的分析物的系统
公开(公告)号：US07740801B2
公开(公告)日：2010-06-22
申请号：US11591138
申请日：2006-10-31
申请人： Selwayan Saini , Marco Fabio Cardosi , Leanne Mills , Stephen Patrick Blythe
发明人： Selwayan Saini , Marco Fabio Cardosi , Leanne Mills , Stephen Patrick Blythe
IPC分类号： G01N21/76
CPC分类号： G01N21/69 , G01N21/76 , G01N2021/6439
摘要： A system for the determination of an analyte in a bodily fluid sample includes an analytical test strip and an analytical meter. The analytical test strip has a substrate layer, an electroluminescent component (either an electroluminescent module and/or an electroluminescent lamp) disposed on the substrate layer, and a sample chamber configured for receiving a bodily fluid sample disposed above the substrate layer. Moreover, the analytical meter is configured for insertion of the analytical test strip therein and subsequent determination of the analyte.
摘要翻译：用于测定体液样品中的分析物的系统包括分析测试条和分析计。分析测试条具有设置在基底层上的基底层，电致发光元件（电致发光模块和/或电致发光灯），以及被配置为接收设置在基底层上方的体液样品的样本室。此外，分析仪被配置用于在其中插入分析测试条并随后确定分析物。

3. 发明申请

US20080164142A1 SURFACE TREATMENT OF CARBON COMPOSITE MATERIAL TO IMPROVE ELECTROCHEMICAL PROPERTIES 审中-公开
标题翻译：碳复合材料的表面处理提高电化学性能
公开(公告)号：US20080164142A1
公开(公告)日：2008-07-10
申请号：US11553547
申请日：2006-10-27
申请人： Manuel Alvarez-Icaza , Alun Griffith , Leanne Mills , Dominic Steele
发明人： Manuel Alvarez-Icaza , Alun Griffith , Leanne Mills , Dominic Steele
IPC分类号： H05F3/00
CPC分类号： G01N27/3272
摘要： The invention described herein includes a screen printing process for depositing carbon electrodes including a method for selectively removing components that degrade the electrochemical performance from the surface of said carbon electrodes. In one embodiment of the present invention, the process includes applying a corona treatment to the carbon electrodes.
摘要翻译：本文描述的发明包括用于沉积碳电极的丝网印刷方法，其包括用于选择性地除去从所述碳电极的表面降解电化学性能的组分的方法。在本发明的一个实施例中，该方法包括对碳电极施加电晕处理。

4. 发明申请

US20080100689A1 Method for manufacturing an analytical test strip with an electroluminescent component 审中-公开
标题翻译：用于制造具有电致发光元件的分析测试条的方法
公开(公告)号：US20080100689A1
公开(公告)日：2008-05-01
申请号：US11591366
申请日：2006-10-31
申请人： Selwayan Saini , Marco Fabio Cardosi , Leanne Mills , Stephen Patrick Blythe
发明人： Selwayan Saini , Marco Fabio Cardosi , Leanne Mills , Stephen Patrick Blythe
IPC分类号： B41J2/435
CPC分类号： C12Q1/001 , G01N21/66 , G01N21/8483
摘要： A method for manufacturing an analytical test strip with an electroluminescent component (either an electroluminescent module and/or an electroluminescent lamp) includes sequentially applying to a substrate layer, a rear electrode layer disposed on the substrate layer, an electrically-insulating layer disposed over the rear electrode layer, a phosphor layer disposed over the electrically insulating layer, and a front electrode layer (at least a portion of which is translucent) disposed over the phosphor layer. The sequential application is accomplished such that it forms an electroluminescent component of the analytical test strip.
摘要翻译：制造具有电致发光元件（电致发光模块和/或电致发光灯）的分析测试条的方法包括：顺序地施加到基底层，设置在基底层上的背面电极层，设置在基底层上的电绝缘层背面电极层，设置在电绝缘层上的荧光体层和设置在荧光体层上的前电极层（其至少一部分是半透明的）。顺序应用完成，使得其形成分析测试条的电致发光部件。

5. 发明授权

US08460537B2 Methods for determining an analyte concentration using signal processing algorithms 有权
标题翻译：使用信号处理算法确定分析物浓度的方法
公开(公告)号：US08460537B2
公开(公告)日：2013-06-11
申请号：US12553976
申请日：2009-09-03
申请人： Stephen Patrick Blythe , Marco F Cardosi , Leanne Mills , Manuel Alvarez-Icaza , Emma Vanessa Jayne Day , Richard Michael Day , Christopher Philip Leach
发明人： Stephen Patrick Blythe , Marco F Cardosi , Leanne Mills , Manuel Alvarez-Icaza , Emma Vanessa Jayne Day , Richard Michael Day , Christopher Philip Leach
IPC分类号： G01F1/64 , G01N17/00 , G01N27/26
CPC分类号： G01N27/3273
摘要： A method for determining an analyte concentration in blood is described that reduces the effects of hematocrit using a test strip attached to a test meter. The test strip includes a working electrode and a reference electrode. The test meter applies a test voltage between the working electrode and the reference electrode. After a user applies a blood sample containing an analyte onto the test strip, the test meter measures a plurality of test currents for a test time interval.
摘要翻译：描述了用于测定血液中分析物浓度的方法，其使用连接到测试仪的测试条减少了血细胞比容的影响。测试条包括工作电极和参考电极。测试仪在工作电极和参比电极之间施加测试电压。在用户将含有分析物的血液样本应用到测试条上之后，测试仪测量测试时间间隔的多个测试电流。

6. 发明授权

US08293096B2 Systems and methods for determining a substantially hematocrit independent analyte concentration 有权
标题翻译：用于确定基本上血细胞比容的独立分析物浓度的系统和方法
公开(公告)号：US08293096B2
公开(公告)日：2012-10-23
申请号：US12692120
申请日：2010-01-22
申请人： Marco F. Cardosi , Stephen Patrick Blythe , Matthew Finch , Arlene Thompson , Nina Antonia Naylor , Eric Jason Bailey , Michael Patrick Dolan , Gretchen Anderson , Lorraine Comstock , Mary McEvoy , Thomas Sutton , Richard Michael Day , Leanne Mills , Emma Vanessa Jayne Day , Christopher Philip Leach
发明人： Marco F. Cardosi , Stephen Patrick Blythe , Matthew Finch , Arlene Thompson , Nina Antonia Naylor , Eric Jason Bailey , Michael Patrick Dolan , Gretchen Anderson , Lorraine Comstock , Mary McEvoy , Thomas Sutton , Richard Michael Day , Leanne Mills , Emma Vanessa Jayne Day , Christopher Philip Leach
IPC分类号： G01N27/327
CPC分类号： G01N27/3274
摘要： A method and system is provided to allow for determination of substantially Hematocrit independent analyte concentration. In one example, an analyte measurement system is provided that includes a test strip and a test meter. The test strip includes a reference electrode and a working electrode, in which the working electrode is coated with a reagent layer. The test meter includes an electronic circuit and a signal processor. The electronic circuit applies a plurality of voltages to the reference electrode and the working electrode over respective durations. The signal processor is configured to determine a substantially hematocrit-independent concentration of the analyte from a plurality of current values as measured by the processor upon application of a plurality of test voltages to the reference and working electrodes over a plurality of durations interspersed with rest voltages lower than the test voltages being applied to the electrodes.
摘要翻译：提供了一种方法和系统，用于确定基本上血细胞比容的独立分析物浓度。在一个示例中，提供了包括测试条和测试仪的分析物测量系统。测试条包括参考电极和工作电极，其中工作电极涂覆有试剂层。测试仪包括电子电路和信号处理器。电子电路在相应的持续时间内对参考电极和工作电极施加多个电压。所述信号处理器被配置成确定来自多个电流值的分析物的基本上与血细胞比容无关的浓度，所述多个电流值在由静止电压施加多个测试电压至参考电极和工作电极的多个持续时间时由处理器测量低于施加到电极的测试电压。

7. 发明申请

US20110162978A1 SYSTEMS AND METHODS FOR DETERMINING A SUBSTANTIALLY HEMATOCRIT INDEPENDENT ANALYTE CONCENTRATION 有权
标题翻译：用于确定重大分析纯化分析物浓度的系统和方法
公开(公告)号：US20110162978A1
公开(公告)日：2011-07-07
申请号：US12692120
申请日：2010-01-22
申请人： Marco F. CARDOSI , Stephen Patrick Blythe , Matthew Finch , Arlene Thompson , Nina Antonia Naylor , Eric Jason Bailey , Michael Patrick Dolan , Gretchen Anderson , Lorraine Comstock , Mary Mcevoy , Thomas Sutton , Richard Michael Day , Leanne Mills , Emma Vanessa Jayne Day , Christopher Philip Leach
发明人： Marco F. CARDOSI , Stephen Patrick Blythe , Matthew Finch , Arlene Thompson , Nina Antonia Naylor , Eric Jason Bailey , Michael Patrick Dolan , Gretchen Anderson , Lorraine Comstock , Mary Mcevoy , Thomas Sutton , Richard Michael Day , Leanne Mills , Emma Vanessa Jayne Day , Christopher Philip Leach
IPC分类号： C12Q1/26 , G01N27/416 , C12Q1/54
CPC分类号： G01N27/3274
摘要： A method and system is provided to allow for determination of substantially Hematocrit independent analyte concentration. In one example, an analyte measurement system is provided that includes a test strip and a test meter. The test strip includes a reference electrode and a working electrode, in which the working electrode is coated with a reagent layer. The test meter includes an electronic circuit and a signal processor. The electronic circuit applies a plurality of voltages to the reference electrode and the working electrode over respective durations. The signal processor is configured to determine a substantially hematocrit-independent concentration of the analyte from a plurality of current values as measured by the processor upon application of a plurality of test voltages to the reference and working electrodes over a plurality of durations interspersed with rest voltages lower than the test voltages being applied to the electrodes.
摘要翻译：提供了一种方法和系统，用于确定基本上血细胞比容的独立分析物浓度。在一个示例中，提供了包括测试条和测试仪的分析物测量系统。测试条包括参考电极和工作电极，其中工作电极涂覆有试剂层。测试仪包括电子电路和信号处理器。电子电路在相应的持续时间内对参考电极和工作电极施加多个电压。所述信号处理器被配置成确定来自多个电流值的分析物的基本上与血细胞比容无关的浓度，所述多个电流值在由静止电压施加多个测试电压至参考电极和工作电极的多个持续时间时由处理器测量低于施加到电极的测试电压。

8. 发明申请

US20080101985A1 System for determination of an analyte in a bodily fluid sample that includes an electroluminescent component 有权
标题翻译：用于测定包含电致发光组分的体液样品中的分析物的系统
公开(公告)号：US20080101985A1
公开(公告)日：2008-05-01
申请号：US11591138
申请日：2006-10-31
申请人： Selwayan Saini , Marco Fabio Cardosi , Leanne Mills , Stephen Patrick Blythe
发明人： Selwayan Saini , Marco Fabio Cardosi , Leanne Mills , Stephen Patrick Blythe
IPC分类号： G01N21/00
CPC分类号： G01N21/69 , G01N21/76 , G01N2021/6439
摘要： A system for the determination of an analyte in a bodily fluid sample includes an analytical test strip and an analytical meter. The analytical test strip has a substrate layer, an electroluminescent component (either an electroluminescent module and/or an electroluminescent lamp) disposed on the substrate layer, and a sample chamber configured for receiving a bodily fluid sample disposed above the substrate layer. Moreover, the analytical meter is configured for insertion of the analytical test strip therein and subsequent determination of the analyte.
摘要翻译：用于测定体液样品中的分析物的系统包括分析测试条和分析计。分析测试条具有设置在基底层上的基底层，电致发光元件（电致发光模块和/或电致发光灯），以及被配置为接收设置在基底层上方的体液样品的样本室。此外，分析仪被配置用于在其中插入分析测试条并随后确定分析物。

9. 发明授权

US08936713B2 Fill sufficiency method and system 有权
标题翻译：填充充足的方法和系统
公开(公告)号：US08936713B2
公开(公告)日：2015-01-20
申请号：US12965680
申请日：2010-12-10
申请人： James Iain Rodgers , Leanne Mills , Marco Cardosi , Chris Leach , James Moffat
发明人： James Iain Rodgers , Leanne Mills , Marco Cardosi , Chris Leach , James Moffat
IPC分类号： G01N27/327
CPC分类号： G01N27/3274
摘要： Described and illustrated herein are one exemplary method and a measurement system having a meter and a test strip. The test strip has a first working electrode, reference electrode and second working electrode. In this method, acceptable fill data from known first current and known second current are used to predict an estimated second current at proximate the second time period (for a given batch of test strips) during the test sequence. The estimated second current at proximate the second time interval is then compared with a measured actual second current at proximate the second time interval during an actual test to determine if the measured actual second current is substantially equal to or within an acceptable percent deviation from the estimated second current so as to determine sufficient volume of a physiological fluid sample in the test strip.
摘要翻译：本文描述和示出了具有仪表和测试条的一个示例性方法和测量系统。测试条具有第一工作电极，参考电极和第二工作电极。在该方法中，使用来自已知第一电流和已知第二电流的可接受的填充数据来预测在测试序列期间接近第二时间段（对于给定批次的测试条）的估计的第二电流。然后在实际测试期间，将接近第二时间间隔的估计的第二电流与接近第二时间间隔的测量的实际第二电流进行比较，以确定测量的实际第二电流是否基本上等于或在与估计的以确定测试条中的生理液体样本的足够体积。

10. 发明申请

US20120048746A1 ANALYTE TEST STRIP WITH ELECTRICALLY DISTINGUISHABLE DIVIDED ELECTRODE 审中-公开
标题翻译：分析电阻分离电极的测试条
公开(公告)号：US20120048746A1
公开(公告)日：2012-03-01
申请号：US12871616
申请日：2010-08-30
申请人： Stephen Patrick BLYTHE , Leanne Mills , Stephen Mackintosh
发明人： Stephen Patrick BLYTHE , Leanne Mills , Stephen Mackintosh
IPC分类号： G01N27/26
CPC分类号： G01N33/5438 , G01N27/3272
摘要： An analyte test strip for use with a test meter includes a first insulating layer, a first electrically conductive layer disposed on the first insulating layer, a second insulating layer disposed above the first insulating layer, and a patterned spacer layer, positioned between the first insulating layer and the first electrically conductive layer, that defines a sample-receiving chamber. Moreover, the electrically conductive layer includes an electrode portion that is divided into a first electrode sub-portion and a second electrode sub-portion. The electrically conductive layer also includes (i) a first electrical contact pad in electrical communication with the first electrode sub-portion and configured to communicate an electrical response of the first electrical sub-portion to the test meter, and (ii) a second electrical contact pad in electrical communication with the second electrode sub-portion and configured to communicate an electrical response of the second electrical sub-portion to the test meter. In addition, the first electrode sub-portion is electrically isolated from the second electrode sub-portion and the first electrical contact pad is electrically isolated from the second electrical contact pad. Furthermore, the ratio of the area of the first electrode sub-portion and the area of the second electrode sub-portion is predetermined such that the ratio can be electrically distinguished by the test meter based on the first and second electrode sub-portion electrical responses.
摘要翻译：一种与测试仪一起使用的分析物测试条包括第一绝缘层，设置在第一绝缘层上的第一导电层，设置在第一绝缘层上方的第二绝缘层，以及图案化间隔层，位于第一绝缘层之间层和第一导电层，其限定了样品接收室。此外，导电层包括被分成第一电极子部分和第二电极子部分的电极部分。导电层还包括（i）与第一电极子部分电连通并且被配置为将第一电子部分的电响应传递到测试仪的第一电接触焊盘，以及（ii）第二电接触焊盘接触垫与第二电极子部分电连通并且被配置为将第二电子部分的电响应传达到测试仪。此外，第一电极子部分与第二电极子部分电隔离，并且第一电接触焊盘与第二电接触焊盘电隔离。此外，第一电极子部分的面积与第二电极子部分的面积的比率是预先确定的，使得该比值可以通过测试仪器基于第一和第二电极子部分的电响应。

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