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    • 2. 发明授权
    • Composition containing enamel matrix from tooth germs for inducing
binding between living mineralized tissue parts
    • 含有来自牙胚的釉质基质的组合物,用于诱导活的矿化组织部件之间的结合
    • US5418221A
    • 1995-05-23
    • US217024
    • 1994-03-24
    • Lars HammarstromLeif BlomlofSven Lindskog
    • Lars HammarstromLeif BlomlofSven Lindskog
    • C12N15/09A61K20060101A61K6/00A61K35/12A61K35/32C12P21/00A61K38/00A61F13/00C12N5/00
    • A61K6/0032Y10S514/90
    • Binding between parts of living mineralized tissue such as between a tooth and the jaw bone is induced with a composition containing mammalian enamel matrix isolated from tooth germs and a carrier such as water, and optionally an adhesive containing fibrinogen, factor XIII and thrombin. The enamel matrix is a precursor to tooth enamel and induces binding by forming cementum tissue. The enamel matrix may be obtained from bovine or porcine species. The composition is particularly applicable in dental therapies including loosening of teeth due to periodontitis, transplantation of teeth or in reintroduction of teeth disconnected by accident. The composition may also be used for healing of artificial implants such as tooth implants and implants of skeletal replacements such as artificial hip joints. In the case of a dislocated tooth, the composition is applied to a surface of the tooth root and the tooth is put back into its alveolus and lightly fixed for some weeks. In the treatment of periodontitis, a tooth root surface is exposed by incision, the surface is cleaned, the composition is applied to the cleaned root surface and the incision is closed and optionally stitched to promote healing.
    • 使用含有从牙胚和载体例如水分离的哺乳动物釉质基质的组合物以及任选地含有纤维蛋白原,因子XIII和凝血酶的粘合剂的组合物诱导活的矿化组织的部分之间,例如牙齿和颚骨之间的结合。 牙釉质基质是牙釉质的前体,通过形成牙骨质组织诱导结合。 釉质基质可以从牛或猪种获得。 该组合物特别适用于牙科治疗,包括由牙周炎,牙齿移植引起的牙齿松动,或重新引入由意外断开的牙齿。 组合物还可用于人造植入物的愈合,例如牙齿植入物和骨骼替代物的植入物,例如人造髋关节。 在脱牙的情况下,将组合物施用于牙根的表面,并将牙齿放回其肺泡并轻度固定数周。 在牙周炎治疗中,牙根表面通过切口暴露,表面被清洁,组合物施用于清洁的根表面,并且切口被封闭并且可选地缝合以促进愈合。