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1. 发明申请

US20150177246A1 FUSION GENE OF CEP55 GENE AND RET GENE 审中-公开
标题翻译： CEP55基因和RET基因的融合基因
公开(公告)号：US20150177246A1
公开(公告)日：2015-06-25
申请号：US14417052
申请日：2013-07-23
申请人： NATIONAL CANCER CENTER , LSIP, LLC
发明人： Tatsuhiro Shibata , Fumie Hosoda
IPC分类号： G01N33/574 , C07K16/32 , C07K14/82 , C12Q1/68 , C12N9/12
CPC分类号： G01N33/5748 , C07K14/4702 , C07K14/71 , C07K14/82 , C07K16/32 , C07K2319/00 , C12N9/12 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Y207/10001 , G01N33/574 , G01N33/57446 , G01N2800/52
摘要： In order to identify genes that can serve as indicators for predicting the effectiveness of drug treatments in cancers and provide novel methods for predicting the effectiveness of treatments with drugs targeting said genes, transcriptome sequencing was performed of diffuse-type gastric cancer. As a result, in-frame fusion transcripts between the CEP55 gene and the RET gene were identified. It was also found that said gene fusions induce activation of RET protein, thereby causing canceration of cells. Further, it was demonstrated that the RET protein activation and canceration caused by said gene fusion can be suppressed by using a RET tyrosine kinase inhibitor, and that treatments with a RET tyrosine kinase inhibitor are effective in patients with detection of said gene fusion.
摘要翻译：为了鉴定可以作为预测癌症药物治疗有效性的指标的基因，并提供用于预测用于靶向所述基因的药物治疗有效性的新方法，对扩散型胃癌进行转录组测序。结果，鉴定了CEP55基因和RET基因之间的帧内融合转录本。还发现所述基因融合物诱导RET蛋白的激活，从而引起细胞癌变。此外，通过使用RET酪氨酸激酶抑制剂可以抑制由所述基因融合引起的RET蛋白活化和癌变，并且用RET酪氨酸激酶抑制剂进行治疗对于检测所述基因融合的患者是有效的。

2. 发明申请

US20140286978A1 CYTOTOXIC T LYMPHOCYTE INDUCER 审中-公开
标题翻译： CYTOTOXIC T淋巴细胞诱导因子
公开(公告)号：US20140286978A1
公开(公告)日：2014-09-25
申请号：US14117575
申请日：2012-04-24
申请人： TOKYO INSTITUTE OF TECHNOLOGY , LSIP, LLC , SAITAMA MEDICAL UNIVERSITY
发明人： Hiroshi Handa , Masaaki Kawano , Masanori Matsui
IPC分类号： A61K39/145 , A61K39/00
CPC分类号： A61K39/145 , A61K35/76 , A61K38/162 , A61K39/0011 , A61K39/12 , A61K2039/5258 , A61K2039/55561 , C12N2710/22023 , C12N2710/22034 , C12N2760/16134
摘要： The invention provides a cytotoxic T lymphocyte inducer comprising a virus-like particle composed of VP1 of simian virus 40. The T cell epitope peptide is inserted into a DE loop and/or an HI loop of the VP1.
摘要翻译：本发明提供了包含由猿猴病毒40的VP1组成的病毒样颗粒的细胞毒性T淋巴细胞诱导剂.T细胞表位肽插入到VP1的DE环和/或HI环中。

3. 发明申请

US20170014338A1 NASAL VACCINE FOR STREPTOCOCCUS PNEUMONIAE 有权
公开(公告)号：US20170014338A1
公开(公告)日：2017-01-19
申请号：US15119335
申请日：2015-02-16
申请人： LSIP, LLC
发明人： Yoshikazu YUKI , Hiroshi KIYONO , Kazunari AKIYOSHI , Shinichi SAWADA
IPC分类号： A61K9/00 , A61K47/36 , A61K39/09
CPC分类号： A61K9/0043 , A61K9/06 , A61K39/092 , A61K47/36 , A61K2039/543 , A61K2039/552 , A61K2039/55555
摘要： The present invention provides a nasal vaccine for Streptococcus pneumoniae, and a production method therefor. This nasal vaccine formulation for primates includes a complex of PspA, i.e. the vaccine antigen, and a nanogel in which hydrophobic cholesterol is added, as side chains, to pullulan having amino groups. Furthermore, the present invention provides a production method for the nasal vaccine formulation for primates.
摘要翻译：本发明提供了一种用于肺炎链球菌的鼻疫苗及其制备方法。用于灵长类动物的鼻用疫苗制剂包括作为侧链的PspA复合物，即疫苗抗原和其中加入疏水性胆固醇的纳米凝胶，具有具有氨基的支链淀粉。此外，本发明提供了用于灵长类动物的鼻用疫苗制剂的制备方法。

4. 发明申请

US20160195535A1 METHOD FOR DETECTING PROSTATIC BASAL CELLS 审中-公开
标题翻译：检测前列腺细胞的方法
公开(公告)号：US20160195535A1
公开(公告)日：2016-07-07
申请号：US14653562
申请日：2013-12-18
申请人： NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY , LSIP, LLC
发明人： Shigetsugu Hatakeyama , Shinya Tanaka
IPC分类号： G01N33/574 , C07K16/18
CPC分类号： G01N33/57434 , C07K16/18 , G01N2333/435 , G01N2333/4703 , G01N2333/4742 , G01N2333/4748
摘要： The purpose of the present invention is to provide a method for detecting prostatic basal cells by searching for molecules that are expressed specifically in prostatic basal cells and analyzing said molecules. The problem can be solved using a method for detecting prostatic basal cells that is characterized by using immunohistochemical staining to visualize the expression of TRIM29 (Tripartite motif-containing protein 29) protein in prostatic basal cells.
摘要翻译：本发明的目的是提供一种通过搜索在前列腺基底细胞中特异性表达并分析所述分子的分子来检测前列腺基底细胞的方法。使用检测前列腺基底细胞的方法可以解决问题，其特征在于使用免疫组织化学染色来观察前列腺基底细胞中TRIM29（含三聚体基序的蛋白29）蛋白的表达。

5. 发明授权

US09176236B2 Device for measuring radiation intensity of small sealed radiation source for cancer therapy 有权
标题翻译：用于测量癌症治疗的小型密封辐射源的辐射强度的装置
公开(公告)号：US09176236B2
公开(公告)日：2015-11-03
申请号：US14434374
申请日：2013-10-02
申请人： THE UNIVERSITY OF TOKUSHIMA , LSIP, LLC
发明人： Minoru Sakama , Hitoshi Ikushima , Takaharu Yamada , Hisashi Takai , Teruyoshi Ichiraku
IPC分类号： A61N5/10 , G01T1/161
CPC分类号： G01T1/161 , A61N5/1001 , A61N5/1048 , A61N5/1075
摘要： The invention provides a radiation intensity measuring apparatus for each of small sealed radiation sources for cancer therapy that is capable of measuring multiple cartridges. The apparatus includes a device for setting up multiple cartridges and a device for measuring the radiation intensities of radiation passing through a narrow slit. Radiation is emitted from multiple radiation sources and the radiation measurement device moves simultaneously together with the slit along with the side of cartridge holding device while scanning the radiation intensities. Included is a radiation detection scanning device for measuring radiation intensities for each of the radiation sources passing through the narrow slit, and a slit shielding system for restricting radiation originated originating from both the side neighboring radiation sources. The moving device is configured move the radiation measurement device along the direction in the side of cartridge where multiple radiation sources are lined up close to each other.
摘要翻译：本发明提供了一种能够测量多个盒的用于癌症治疗的小型密封辐射源的辐射强度测量装置。该装置包括用于设置多个盒的装置和用于测量通过狭窄狭缝的辐射的辐射强度的装置。辐射从多个辐射源发射，并且辐射测量装置在扫描辐射强度的同时与狭缝一起同时与盒保持装置的侧面一起移动。包括用于测量通过窄狭缝的每个辐射源的辐射强度的辐射检测扫描装置，以及用于限制源自两个相邻辐射源的辐射的狭缝屏蔽系统。移动装置被配置为沿着盒的侧面上的方向移动辐射测量装置，其中多个辐射源彼此靠近排列。

6. 发明申请

US20150241568A1 DEVICE FOR MEASURING RADIATION INTENSITY OF SMALL SEALED RADIATION SOURCE FOR CANCER THERAPY 有权
标题翻译：用于测量癌症治疗小切口辐射源辐射强度的装置
公开(公告)号：US20150241568A1
公开(公告)日：2015-08-27
申请号：US14434374
申请日：2013-10-02
申请人： THE UNIVERSITY OF TOKUSHIMA , LSIP, LLC
发明人： Minoru Sakama , Hitoshi Ikushima , Takaharu Yamada , Hisashi Takai , Teruyoshi Ichiraku
IPC分类号： G01T1/161 , A61N5/10
CPC分类号： G01T1/161 , A61N5/1001 , A61N5/1048 , A61N5/1075
摘要： Provided is a radiation intensity measuring apparatus for each of small sealed radiation sources for cancer therapy capable of measuring multiple cartridges efficiently and rapidly.A radiation intensity measuring apparatus for radiation sources S in the state that the multiple radiation sources S are packed in a seed cartridge SC of a cartridge C, includes holding means 10 capable of holding the multiple cartridges C; radiation intensity measuring means 30 for measuring intensity of the radiation emitted from the multiple radiation sources S; and moving means 20 for moving the radiation intensity measuring means 30 toward or away from the holding means 10, and the radiation intensity measuring means 30 includes: a sensor 31 for measuring radiation intensity, and a shielding member 35 having a slit 35h provided for restricting radiation irradiated to the sensor 31; and the moving means 20 is configured to be able to relatively move the radiation intensity measuring means 30 along the direction in which the multiple radiation sources S are arranged in the measurement state.
摘要翻译：提供了用于癌细胞治疗的小型密封辐射源的每个辐射强度测量装置，其能够有效且快速地测量多个盒。在多个辐射源S被包装在盒C的种子盒SC中的状态下的用于辐射源S的辐射强度测量装置包括能够保持多个盒C的保持装置10; 用于测量从多个辐射源S发射的辐射的强度的辐射强度测量装置30; 以及用于使辐射强度测量装置30朝向或远离保持装置10移动的移动装置20，并且辐射强度测量装置30包括：用于测量辐射强度的传感器31和具有狭缝35h的屏蔽构件35，照射到传感器31的辐射; 并且移动装置20被构造成能够使辐射强度测量装置30沿着测量状态下的多个辐射源S的排列方向相对移动。

7. 发明申请

US20160289663A1 NOVEL CHIMERIC GENE ATF7IP-PDGFRB OF ACUTE LYMPHOBLASTIC LEUKEMIA 审中-公开
标题翻译：急性淋巴细胞白血病基因ATF7IP-PDGFRB
公开(公告)号：US20160289663A1
公开(公告)日：2016-10-06
申请号：US15037907
申请日：2014-11-17
申请人： NATIONAL CENTER FOR CHILD HEALTH AND DEVELOPMENT , NATIONAL CANCER CENTER , LSIP, LLC
发明人： Nobutaka Kiyokawa , Kenji Matsumoto , Kenichiro Kobayashi , Hitoshi Ichikawa
IPC分类号： C12N9/96 , C12N9/12 , G01N33/574 , A61K31/506 , C07K14/47
CPC分类号： C12N9/96 , A61K31/404 , A61K31/5025 , A61K31/506 , A61K45/06 , C07K14/4702 , C07K14/71 , C07K2319/00 , C12N9/12 , C12Y207/10001 , G01N33/502 , G01N33/57484 , G01N2500/00 , G01N2500/10 , A61K2300/00
摘要： To identify a mutation that can serve as an indicator for predicting the effectiveness of drug treatment in cancers such as leukemia; to provide a means for detecting said mutation; and to provide a means for identifying, based on said mutation, patients with cancer or subjects with a risk of cancer, in whom a drug targeting a gene having said mutation or a protein encoded by said gene shows a therapeutic effect.A method for detecting a gene fusion serving as a responsible mutation (driver mutation) for cancer, the method comprising the step of detecting an ATF7IP-PDGFRB fusion polynucleotide or a polypeptide encoded thereby, in an isolated sample from a subject.
摘要翻译：一种用于检测用于癌症的负责突变（驱动突变）的基因融合体的方法，该方法包括在受试者的分离样品中检测ATF7IP-PDGFRB融合多核苷酸或由其编码的多肽的步骤。

8. 发明申请

US20160076107A1 METHOD FOR DETECTING T-CELL LYMPHOMA 审中-公开
标题翻译：检测T细胞淋巴瘤的方法
公开(公告)号：US20160076107A1
公开(公告)日：2016-03-17
申请号：US14888206
申请日：2014-05-01
申请人： LSIP, LLC
发明人： SHIGERU CHIBA , Mamiko YANAGIMOTO , Seishi OGAWA
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： A method for detecting T-cell lymphoma characterized in that gene mutations of at least one base selected from a group comprising base numbers 50, 331, 334, and 482 or gene mutations of base numbers 49 to 51 in the base sequence of an RHOA gene collected from a subject are analyzed, and the analysis results and T-cell lymphoma are associated with each other.
摘要翻译：一种检测T细胞淋巴瘤的方法，其特征在于，在RHOA基因的碱基序列中，选自碱基序号为50,331,334和482的碱基数为49〜51的基因突变，分析从受试者收集的结果，分析结果和T细胞淋巴瘤相互关联。

9. 发明申请

US20150079626A1 METHOD OF OBTAINING A CELL POPULATION CONTAINING CANCER STEM CELLS 审中-公开
标题翻译：获得包含癌细胞的细胞群体的方法
公开(公告)号：US20150079626A1
公开(公告)日：2015-03-19
申请号：US14218253
申请日：2014-03-18
申请人： LSIP, LLC , National University Corporation Okayama University
发明人： Masaharu SENO , Akifumi MIZUTANI , Tomonari KASAI
IPC分类号： G01N33/50 , C12N5/095
CPC分类号： G01N33/5011 , A61K35/13 , A61K35/545 , C12N5/0693 , C12N5/0695 , C12N2501/40 , C12N2501/905 , C12N2502/30 , C12N2506/45 , G01N33/5073 , G01N2500/04
摘要： The present invention relates to a method of obtaining a cell population containing cancer stem cells, which comprises culturing iPS cells in the presence of culture supernatant of cancer cells.
摘要翻译：本发明涉及一种获得含有癌干细胞的细胞群的方法，该方法包括在癌细胞的培养物上清液存在下培养iPS细胞。

10. 发明申请

US20140137274A1 INDUCED MALIGNANT STEM CELLS 审中-公开
标题翻译：诱导的恶性肿瘤细胞
公开(公告)号：US20140137274A1
公开(公告)日：2014-05-15
申请号：US13690446
申请日：2012-11-30
申请人： National Cancer Center , LSIP, LLC
发明人： Tetsuya Ishikawa
IPC分类号： C12N5/095 , G01N33/50
CPC分类号： C12N5/0695 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2503/00 , C12N2506/30 , C12N2510/00 , G01N33/5011 , G01N33/5073
摘要： PROBLEMThere are provided induced malignant stem cells capable of in vitro proliferation that are useful in cancer research and drug discovery for cancer therapy, as well as processes for production thereof, cancer cells derived from these cells, and applications of these cells.MEANS FOR SOLVINGAn induced malignant stem cell capable of in vitro proliferation are characterized by satisfying the following two requirements: (1) having at least one aberration selected from among (a) an aberration of methylation (high or low degree of methylation) in a tumor suppressor gene or a cancer-related genetic region in endogenous genomic DNA, (b) a somatic mutation of a tumor suppressor gene or a somatic mutation of an endogenous cancer-related gene in endogenous genomic DNA, (c) abnormal expression (increased or reduced/lost expression) of an endogenous oncogene or an endogenous tumor suppressor gene, (d) abnormal expression (increased or reduced/lost expression) of a noncoding RNA such as an endogenous cancer-related microRNA, (e) abnormal expression of an endogenous cancer-related protein, (f) an aberration of endogenous cancer-related metabolism (hypermetabolism or hypometabolism), (g) an aberration of endogenous cancer-related sugar chain, (h) an aberration of copy number variations in endogenous genomic DNA, and (i) instability of microsatellites in endogenous genomic DNA in an induced malignant stem cell; and (2) expressing genes including POU5F1 gene, NANOG gene, SOX2 gene, and ZFP42 gene.
摘要翻译：问题提供能够进行体外增殖的诱导性恶性干细胞，其可用于癌症研究和药物发现用于癌症治疗，以及其生产方法，衍生自这些细胞的癌细胞以及这些细胞的应用。解决方法诱导能够体外增殖的恶性干细胞的特征在于满足以下两个要求：（1）具有选自以下的至少一种像差：（a）甲基化的差异（高或低甲基化程度）在肿瘤抑制基因或内源性基因组DNA中的癌症相关遗传区域，（b）肿瘤抑制基因的体细胞突变或内源性基因组DNA中内源性癌症相关基因的体细胞突变，（c）异常表达（增加或内源性癌基因或内源性肿瘤抑制基因的减少/丧失表达），（d）非编码RNA如内源性癌相关微小RNA的异常表达（增加或减少/丧失表达），（e）内源性癌症相关蛋白，（f）内源性癌症相关代谢（高代谢或代谢异常）的差异，（g）内源性癌症相关糖链的差异，（h）拷贝的差异内源基因组DNA的数量变化，（i）微卫星在诱导的恶性干细胞内源基因组DNA中的不稳定性; 和（2）表达包括POU5F1基因，NANOG基因，SOX2基因和ZFP42基因的基因。

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