专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US11235055B2 Nucleic acids encoding mosaic conserved region HIV immunogenic polypeptides 有权
公开(公告)号：US11235055B2
公开(公告)日：2022-02-01
申请号：US16023871
申请日：2018-06-29
申请人： Los Alamos National Security, LLC , Oxford University Innovation Limited
发明人： Bette T. M. Korber , Tomas Hanke , Andrew McMichael
IPC分类号： A61K39/21 , A61K39/12 , C07K14/16 , C07K14/005
摘要： Disclosed herein are mosaic conserved region HIV polypeptides and immunogenic polypeptides including one or more of the mosaic conserved region polypeptides. In some embodiments, the immunogenic polypeptides are included in an immunogenic composition, such as a polyvalent immunogenic composition. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject having or at risk of HIV infection. In some embodiments, the methods include inducing an immune response in a subject comprising administering to the subject at least one of the disclosed immunogenic polypeptides or a nucleic acid encoding at least one of the immunogenic polypeptides.

2. 发明授权

US10946090B2 Consensus/ancestral immunogens 有权
公开(公告)号：US10946090B2
公开(公告)日：2021-03-16
申请号：US15813992
申请日：2017-11-15
申请人： Duke University , The University of Alabama at Birmingham Research Foundation , Los Alamos National Security, LLC
发明人： Barton F. Haynes , Feng Gao , Bette T. Korber , Beatrice H. Hahn , George M. Shaw , Denise L. Monti , Ying Ying Li , Julie Decker , Hua-Xin Liao
IPC分类号： A61K39/21 , C07K14/005 , C07K16/42 , A61K39/12 , A61K39/00
摘要： The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.

3. 发明授权

US10887682B1 Resonance-enhanced compact nonlinear acoustic source of low frequency collimated beam for imaging applications in highly attenuating media 有权
公开(公告)号：US10887682B1
公开(公告)日：2021-01-05
申请号：US15902939
申请日：2018-02-22
申请人： Los Alamos National Security, LLC
发明人： Cristian Pantea , Dipen N. Sinha
IPC分类号： H04R1/28 , H04R3/04
摘要： Acoustic signal sources include acoustic resonators that include acoustic nonlinear materials. Acoustic signals at higher frequencies are mixed in the nonlinear materials to produce a lower frequency acoustic signal. Resonance provides increased efficiency in producing acoustic signals at difference frequencies corresponding to resonance frequencies. Higher frequency acoustic signals used in nonlinear mixing are preferably at frequencies corresponding to resonance frequencies as well.

4. 发明授权

US10883901B1 High efficiency environmental sampling with rapidly cured peelable coatings 有权
公开(公告)号：US10883901B1
公开(公告)日：2021-01-05
申请号：US15785295
申请日：2017-10-16
申请人： Los Alamos National Security, LLC
发明人： Vladimir Henzl , Rollin Lakis , Sylvia Ann Junghans
IPC分类号： G01N1/02 , C08F2/48 , B01J20/291 , G01N21/76 , B01J20/32 , C08L33/08 , B01J20/286
摘要： A rapidly curable liquid gel for collecting an analyte from a sampling surface includes a polymer precursor mixture including a monomer and/or an oligomer; and an additive to enhance extraction of the analyte from the sampling surface. A kit for collecting an analyte from a sampling surface may include the rapidly curable liquid gel and a portable device for rapidly curing the gel. The rapidly curable liquid gel is cured to thereby form a peelable sampling film, and the sampling film is removed from the sampling surface, thereby collecting the analyte. In one embodiment, the rapidly curable liquid gel is UV-curable, the polymer precursor mixture further includes a photoinitiator compound, and the portable device includes a UV light source configured to emit UV light of a wavelength range absorbed by the photoinitiator compound.

5. 发明授权

US10776718B2 Source identification by non-negative matrix factorization combined with semi-supervised clustering 有权
公开(公告)号：US10776718B2
公开(公告)日：2020-09-15
申请号：US15690176
申请日：2017-08-29
申请人： Los Alamos National Security, LLC
发明人： Boian S. Alexandrov , Ludmil B. Alexandrov , Filip L. Iliev , Valentin G. Stanev , Velimir V. Vesselinov
IPC分类号： G06N20/00 , G06F17/16 , G06K9/62 , G06N7/00
摘要： Machine-learning methods and apparatus are provided to solve blind source separation problems with an unknown number of sources and having a signal propagation model with features such as wave-like propagation, medium-dependent velocity, attenuation, diffusion, and/or advection, between sources and sensors. In exemplary embodiments, multiple trials of non-negative matrix factorization are performed for a fixed number of sources, with selection criteria applied to determine successful trials. A semi-supervised clustering procedure is applied to trial results, and the clustering results are evaluated for robustness using measures for reconstruction quality and cluster separation. The number of sources is determined by comparing these measures for different trial numbers of sources. Source locations and parameters of the signal propagation model can also be determined. Disclosed methods are applicable to a wide range of spatial problems including chemical dispersal, pressure transients, and electromagnetic signals, and also to non-spatial problems such as cancer mutation.

6. 发明授权

US10737261B1 Reversibly bonded devices and methods of making and using the same 有权
公开(公告)号：US10737261B1
公开(公告)日：2020-08-11
申请号：US15719187
申请日：2017-09-28
申请人： Los Alamos National Security, LLC
发明人： Pulak Nath , Jen-Huang Huang
IPC分类号： B01L3/00 , G01N33/50
摘要： The present disclosure concerns embodiments of reversibly bonded devices that comprise a reversible bonding component. The reversible bonding component is able to exhibit strong adhesive properties so as to couple device components, but upon exposure to an energy source, the strong adhesive properties are weakened. By weakening the adhesive strength of the reversible bonding component, the device can be deconstructed to access internal biological samples for analysis and characterization.

7. 发明授权

US10590398B2 Productivity and bioproduct formation in phototropin knock/out mutants in microalgae 有权
公开(公告)号：US10590398B2
公开(公告)日：2020-03-17
申请号：US15831178
申请日：2017-12-04
申请人： NMC, INC. , LOS ALAMOS NATIONAL SECURITY, LLC
发明人： Sangeeta Negi , Richard Thomas Sayre , Shawn Robert Starkenburg
IPC分类号： C12N9/12 , C12P19/04 , C12P23/00 , C12N1/12 , C12P7/64 , C07K14/405 , C12N9/02 , C12N9/22 , C12N15/01 , C12N15/11
摘要： Phototropin is a blue light receptor, which mediates a variety of blue-light elicited physiological processes in plants and algae. In higher plants these processes include phototropism, chloroplast movement and stomatal opening. In the green alga Chlamydomonas reinhardtii, phototropin plays a vital role in progression of the sexual life cycle and in the control of the eye spot size and light sensitivity Phototropin is also involved in blue-light mediated changes in the synthesis of chlorophylls, carotenoids, chlorophyll binding proteins. We compared the transcriptome of phototropin knock out (PHOT KO) mutant and wild-type parent to analyze differences in gene expression in high light grown cultures (500 μmol photons m−2 s−1). Our results indicate the up-regulation of genes involved in photosynthetic electron transport chain, carbon fixation pathway, starch, lipid, and cell cycle control genes. With respect to photosynthetic electron transport genes, genes encoding proteins of the cytochrome b6f and ATP synthase complex were up regulated potentially facilitating proton-coupled electron transfer. In addition genes involved in limiting steps in the Calvin cycle Ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO), Sidoheptulose 1,7 bisphosphatase (SBPase), Glyceraldehyde-3-phosphate dehydrogenase (3PGDH) and that mediate cell-cycle control (CDK) were also up regulated along with starch synthase and fatty acid biosynthesis genes involved in starch and lipid synthesis. In addition, transmission electron micrographs show increased accumulation of starch granules in PHOT mutant compared to wild type, which is consistent with the higher expression of starch synthase genes. Collectively, the altered patterns of gene expression in the PHOT mutants were associated with a two-fold increase in growth and biomass accumulation compared to wild type when grown in environmental photobioreactors (Phenometrics) that simulate a pond environment. In conclusion, our studies suggest that phototropin may be a master gene regulator that suppresses rapid cell growth and promotes gametogenesis and sexual recombination in wild type strains.

8. 发明授权

US10587402B2 Long-haul high rate quantum key distribution 有权
公开(公告)号：US10587402B2
公开(公告)日：2020-03-10
申请号：US16023472
申请日：2018-06-29
申请人： Los Alamos National Security, LLC
发明人： Jane E. Nordholt , Richard J. Hughes , Raymond T. Newell , Charles G. Peterson , Rolando D. Somma
IPC分类号： H04L9/08 , H04B10/508 , H04B10/516 , H04B10/70 , H04B10/85 , H04L9/32
摘要： Multiple bit values can be encoded on a single photon in a quantum key distribution (QKD) system using a plurality of sidebands of an optical carrier frequency. Computational and conjugate bases can be defined, and photons decoded based on a selected state from either basis. If n sidebands are available, as many as log2 n bits can be encoded on a single photon. Errors in detected bit values due to selection of an incorrect basis state or other errors can be at least partially corrected by bit distillation to identity bit strings for which a transmitter and a receiver record the same values, without insecure transmission of these values.

9. 发明授权

US10567655B2 System and method for automated extraction of high resolution structural dynamics from video 有权
公开(公告)号：US10567655B2
公开(公告)日：2020-02-18
申请号：US15708986
申请日：2017-09-19
申请人： Los Alamos National Security, LLC
发明人： Yongchao Yang , Garrett Kenyon , Charles Farrar , David Mascarenas
IPC分类号： H04N5/20 , H04N5/232 , H04N21/2343 , G01H9/00 , G06T7/262 , G01N29/44 , G01N29/46 , H04N5/50
摘要： A method for extracting vibrational modes of a structure includes: receiving a plurality of video frames, each of the video frames including a plurality of pixels; decomposing each of the video frames on a plurality of spatial scales in accordance with complex steerable pyramid filters to obtain a filter response for each of the spatial scales; computing a plurality of local phases of the pixels of each frame; removing a temporal mean from each frame to obtain a plurality of factored vibration motion functions; performing principal component analysis on the factored vibration motion functions to obtain principal components; blind source separating the principal components to compute a plurality of modal coordinates; computing frequency and damping ratios in accordance with the modal coordinates; and outputting the computed frequency and damping ratios.

10. 发明授权

US10521295B2 Low cost, hardened single board computer for command and data handling 有权
公开(公告)号：US10521295B2
公开(公告)日：2019-12-31
申请号：US15985536
申请日：2018-05-21
申请人： Los Alamos National Security, LLC
发明人： Robert Bernard Merl , Paul Stanley Graham
IPC分类号： G06F11/10 , G06F11/07 , G06F13/40 , G06F11/14 , G06F1/20
摘要： A radiation hardened single board computer (SBC) includes a processor; synchronous dynamic random-access memory (SDRAM); non-volatile memory; a field programmable gate array (FPGA); and board-level physical layer interfaces.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式