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1. 发明授权

US10351912B2 Detection of high grade dysplasia in cervical cells 有权
公开(公告)号：US10351912B2
公开(公告)日：2019-07-16
申请号：US13279947
申请日：2011-10-24
申请人： Irina A. Sokolova , Steven A. Seelig , Larry E. Morrison , Walter King , Alicia Algeciras-Schimnich
发明人： Irina A. Sokolova , Steven A. Seelig , Larry E. Morrison , Walter King , Alicia Algeciras-Schimnich
IPC分类号： C12Q1/68 , C12P19/34 , C12Q1/6886
摘要： Methods of using probes and probe sets for the detection of high grade dysplasia and carcinoma in cervical cells are described. Methods of the invention include hybridizing one or more chromosomal probes to a biological sample obtained from a subject and detecting the hybridization pattern of the chromosomal probes to the sample to determine whether the subject has high grade dysplasia or carcinoma. Methods of the invention also include preliminary screening the cells for a marker associated with a risk for cancer, and preferably involves screening for HPV infected cells by in situ hybridization using an HPV probe mixture.

2. 发明申请

US20110300540A1 METHODS AND PROBE COMBINATIONS FOR DETECTING MELANOMA 审中-公开
标题翻译：用于检测MELANOMA的方法和探针组合
公开(公告)号：US20110300540A1
公开(公告)日：2011-12-08
申请号：US13151935
申请日：2011-06-02
申请人： Boris Bastian , Larry E. Morrison , Susan Jewell
发明人： Boris Bastian , Larry E. Morrison , Susan Jewell
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6841 , C12Q2537/143 , C12Q2600/112 , C12Q2600/158
摘要： The present invention is based on the discovery of methods and combinations of probes to chromosomal regions that are gained or lost or imbalanced in melanoma that provide highly specific and sensitive assays for the detection of melanoma cells.
摘要翻译：本发明基于探针到染色体区域的方法和组合的发现，所述染色体区域在黑色素瘤中获得或失去或不平衡，其提供用于检测黑素瘤细胞的高度特异性和敏感性测定。

3. 发明申请

US20090298087A1 METHODS AND PROBES FOR THE DETECTION OF CANCER 有权
标题翻译：检测癌症的方法和探索
公开(公告)号：US20090298087A1
公开(公告)日：2009-12-03
申请号：US12536647
申请日：2009-08-06
申请人： Larry E. Morrison , Irina A. Sokolova , Steven A. Seelig , Kevin C. Halling
发明人： Larry E. Morrison , Irina A. Sokolova , Steven A. Seelig , Kevin C. Halling
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6841 , C12Q1/6886 , C12Q2600/156
摘要： Probe sets and methods of using probes and probe sets for the detection of cancer are described. Methods for detecting cancer that include hybridizing a set of chromosomal probes to a biological sample obtained from a patient, and identifying if cancer cells are present the sample. Also included are methods of selecting a combination of probes for the detection of cancer.
摘要翻译：描述了使用探针和探针组进行癌症检测的探针组和方法。用于检测癌症的方法，其包括将一组染色体探针与从患者获得的生物样品杂交，以及鉴定是否存在癌细胞是否存在样品。还包括选择用于检测癌症的探针组合的方法。

4. 发明申请

US20090258350A1 Diagnostic methods for determining prognosis of non-small cell lung cancer 有权
公开(公告)号：US20090258350A1
公开(公告)日：2009-10-15
申请号：US12082709
申请日：2008-04-14
申请人： Larry E. Morrison , John Coon
发明人： Larry E. Morrison , John Coon
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6841 , C12Q2600/118
摘要： The invention provides methods for identifying early stage non-small cell lung cancer (NSCLC) patients who will have a favorable prognosis for the recurrence of lung cancer after surgical resection. The invention is based on the discovery that assessment of chromosomal copy number abnormalities at two or more of chromosome 5p15, 7p12, 8q24 and centromere 6 can be used for prognostic classification. The invention preferably uses fluorescence in situ hybridization with fluorescently labeled nucleic acid probes to hybridize to patient samples to quantify the chromosomal copy number of the these genetic loci. Assessment of the copy number abnormality patterns using four classifiers produced statistically significant prognostic classification for NSCLC: (i) the Range3 pattern of cells showing a difference on a cell by cell basis, of at least three FISH probe signals between the FISH signals at the chromosomal locus with the largest number of FISH signals minus the FISH signals at the chromosomal locus with the lowest number of FISH signals; (ii) the MYC/EGFR % loss pattern assessing the percentage of cells showing fewer MYC FISH probe signals than EGFR FISH probe signals; (iii) a combination of the Range3 pattern and the MYC/CEP6 ratio pattern of a percentage of cells showing a relative loss of MYC FISH probe signals to the FISH probe signal for CEP6; (iv) the combination of the MYC/5p15 ratio pattern showing the relative ratio of MYC and 5p15 locus signals of ≧0.80 and the 5p15/CEP6 ratio pattern assessing percentage of cells having a relative ratio of 5p15 FISH probe signals to CEP6 FISH probe signals ≧1.1 versus MYC/5p15 ratio of

5. 发明授权

US06306587B1 Template-directed photoligation 失效
标题翻译：模板定向照片
公开(公告)号：US06306587B1
公开(公告)日：2001-10-23
申请号：US08967011
申请日：1997-11-10
申请人： Garfield P. Royer , Larry E. Morrison , Kenneth A. Cruickshank
发明人： Garfield P. Royer , Larry E. Morrison , Kenneth A. Cruickshank
IPC分类号： A01N102
CPC分类号： C07D493/04 , C07D311/14 , C07D311/16 , C07D311/18 , C12Q1/6816 , C12Q1/6827 , C12Q2533/107 , C12Q2531/143 , C12Q2531/113 , C12Q2537/119 , C12Q2523/313 , C12Q2523/101
摘要： Methods, apparatus and compositions are presented for ligating ligands together which bind to a common receptor. One embodiment includes polynucleotide probes having photoreactive functional groups. The probes are capable of assuming substantially contiguous reactive positions on a target polynucleotide placing the photoreactive group in juxtaposition. Activation of the photoreactive functional groups with radiant energy form a probe reaction product in which the probes are bound to each other.
摘要翻译：提出了将配体结合到共同受体上的方法，装置和组合物。一个实施方案包括具有光反应性官能团的多核苷酸探针。探针能够在放置光反应性基团并置的靶多核苷酸上假设基本上连续的反应位置。具有辐射能的光反应性官能团的活化形成探针反应产物，其中探针彼此结合。

6. 发明授权

US08043805B2 Detection of high grade dysplasia in cervical cells 有权
标题翻译：检测宫颈细胞高度发育不良
公开(公告)号：US08043805B2
公开(公告)日：2011-10-25
申请号：US12422859
申请日：2009-04-13
申请人： Irina A. Sokolova , Steven A. Seelig , Larry E. Morrison , Walter King , Alicia Algeciras-Schimnich
发明人： Irina A. Sokolova , Steven A. Seelig , Larry E. Morrison , Walter King , Alicia Algeciras-Schimnich
IPC分类号： C12Q1/68 , C12P19/34 , C12M1/34 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q2600/112
摘要： Methods of using probes and probe sets for the detection of high grade dysplasia and carcinoma in cervical cells are described. Methods of the invention include hybridizing one or more chromosomal probes to a biological sample obtained from a subject and detecting the hybridization pattern of the chromosomal probes to the sample to determine whether the subject has high grade dysplasia or carcinoma. Methods of the invention also include preliminary screening the cells for a marker associated with a risk for cancer, and preferably involves screening for HPV infected cells by in situ hybridization using an HPV probe mixture.
摘要翻译：描述了使用探针和探针组检测宫颈细胞中高度发育不良和癌症的方法。本发明的方法包括将一种或多种染色体探针与从受试者获得的生物样品杂交，并检测染色体探针与样品的杂交模式，以确定受试者是否具有高等级异型增生或癌。本发明的方法还包括对与癌症风险相关的标志物的细胞进行初步筛选，并且优选包括使用HPV探针混合物通过原位杂交筛选HPV感染的细胞。

7. 发明授权

US08034577B2 Methods and probes for detecting esophageal cancer 有权
标题翻译：检测食管癌的方法和探针
公开(公告)号：US08034577B2
公开(公告)日：2011-10-11
申请号：US11356786
申请日：2006-02-17
申请人： Kevin Halling , Larry E. Morrison , Shannon Brankley
发明人： Kevin Halling , Larry E. Morrison , Shannon Brankley
IPC分类号： G01N33/53
CPC分类号： C12Q1/6886 , C12Q2600/112
摘要： Probe sets and methods of using probes and probe sets for selectively detecting high grade dysplasia and esophageal adenocarcinoma or low grade dysplasia from biologic samples are described. Methods of the invention include contacting a biological sample obtained from a subject with a set of chromosomal probes to selectively detect an esophageal carcinoma or precursor lesion in the sample, if any, under conditions for specifically hybridizing the probes to their nucleic targets present in the sample. The presence or absence of high grade dysplasia and esophageal adenocarcinoma or low grade dysplasia is thereafter specifically determined from the hybridization pattern detected for the set of chromosomal probes to the biological sample.
摘要翻译：描述了使用探针和探针组的探针组和方法，用于选择性地检测生物样品中的高度发育不良和食管腺癌或低度发育不良。本发明的方法包括将获自受试者的生物样品与一组染色体探针接触以选择性地检测样品中的食管癌或前体病变（如果有的话），以在探针与其存在于样品中的核酸靶特异性杂交的条件下。此后，从针对该生物样品的染色体组探针检测的杂交模式特异性地确定存在或不存在高等级异型增生和食管腺癌或低度发育不良。

8. 发明申请

US20090269768A1 DETECTION OF HIGH GRADE DYSPLASIA IN CERVICAL CELLS 有权
标题翻译：检测宫颈细胞中的高等级DYSPLASIA
公开(公告)号：US20090269768A1
公开(公告)日：2009-10-29
申请号：US12422859
申请日：2009-04-13
申请人： IRINA A. SOKOLOVA , STEVEN A. SEELIG , LARRY E. MORRISON , WALTER KING , ALICIA ALGECIRAS-SCHIMNICH
发明人： IRINA A. SOKOLOVA , STEVEN A. SEELIG , LARRY E. MORRISON , WALTER KING , ALICIA ALGECIRAS-SCHIMNICH
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112
摘要： Methods of using probes and probe sets for the detection of high grade dysplasia and carcinoma in cervical cells are described. Methods of the invention include hybridizing one or more chromosomal probes to a biological sample obtained from a subject and detecting the hybridization pattern of the chromosomal probes to the sample to determine whether the subject has high grade dysplasia or carcinoma. Methods of the invention also include preliminary screening the cells for a marker associated with a risk for cancer, and preferably involves screening for HPV infected cells by in situ hybridization using an HPV probe mixture.
摘要翻译：描述了使用探针和探针组检测宫颈细胞中高度发育不良和癌症的方法。本发明的方法包括将一种或多种染色体探针与从受试者获得的生物样品杂交，并检测染色体探针与样品的杂交模式，以确定受试者是否具有高等级异型增生或癌。本发明的方法还包括对与癌症风险相关的标志物的细胞进行初步筛选，并且优选包括使用HPV探针混合物通过原位杂交筛选HPV感染的细胞。

9. 发明授权

US5663319A Probe compositions for chromosome identification and methods 失效
标题翻译：用于染色体鉴定和方法的探针组合物
公开(公告)号：US5663319A
公开(公告)日：1997-09-02
申请号：US476694
申请日：1995-06-07
申请人： Michael L. Bittner , Larry E. Morrison , Mona S. Legator
发明人： Michael L. Bittner , Larry E. Morrison , Mona S. Legator
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6816 , C12Q1/6841 , Y10S435/81
摘要： Direct label probe compositions which stain DNA of a preselected single chromosome or region of a chromosome of a multi-chromosomal genome are provided that comprise mixed DNA segments which are covalently bound to fluorophore groups through linking groups. The mixed DNA segments are derived from the DNA present in the preselected chromosome or chromosome region. These probe compositions can be used concurrently or sequentially with other probe compositions.
摘要翻译：提供了染色多染色体基因组的预选单个染色体或染色体区域的DNA的直接标记探针组合物，其包含通过连接基团共价结合荧光团的混合DNA片段。混合的DNA片段来源于预选染色体或染色体区域中存在的DNA。这些探针组合物可以与其它探针组合物同时或顺序使用。

10. 发明授权

US5449602A Template-directed photoligation 失效
标题翻译：模板定向照片
公开(公告)号：US5449602A
公开(公告)日：1995-09-12
申请号：US143586
申请日：1988-01-13
申请人： Garfield P. Royer , Larry E. Morrison , Kenneth A. Cruickshank
发明人： Garfield P. Royer , Larry E. Morrison , Kenneth A. Cruickshank
IPC分类号： G01N33/50 , C07D311/14 , C07D311/16 , C07D311/18 , C07D493/04 , C07H21/04 , C12N15/09 , C12Q1/68 , C07H15/12 , C07H17/00 , C12N15/00
CPC分类号： C07D493/04 , C07D311/14 , C07D311/16 , C07D311/18 , C12Q1/6816 , C12Q1/6827
摘要： Methods, apparatus and compositions are presented for ligating ligands together which bind to a common target. One embodiment includes polynucleotide probes having photoreactive functional groups. The probes are capable of assuming substantially contiguous reactive positions on a target polynucleotide placing the photoreactive groups in juxtaposition. Activation of the photoreactive functional groups with radiant energy form a probe reaction product in which the probes are bound to each other.
摘要翻译：提出了将配体结合到共同靶标上的方法，装置和组合物。一个实施方案包括具有光反应性官能团的多核苷酸探针。探针能够在靶向多核苷酸上假定基本连续的反应性位置，使得多个光反应基团并置。具有辐射能的光反应性官能团的活化形成探针反应产物，其中探针彼此结合。

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