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1. 发明授权

US10081870B2 Plasma enhanced chemical vapor deposition apparatus and method for controlling the same 有权
公开(公告)号：US10081870B2
公开(公告)日：2018-09-25
申请号：US14007254
申请日：2012-03-16
申请人： Jinhyouk Shin , Jeonggyu Kim , Kwangho Lee , Jangwoo Lee , Moonkap Lee , Junggeun Oh
发明人： Jinhyouk Shin , Jeonggyu Kim , Kwangho Lee , Jangwoo Lee , Moonkap Lee , Junggeun Oh
IPC分类号： C23C16/513 , C23C16/458 , C23C16/50 , C23C16/54 , H01J37/32 , C23C14/24 , C23C16/448 , C23C16/455 , C23C14/56
CPC分类号： C23C16/513 , C23C14/24 , C23C14/243 , C23C14/56 , C23C14/562 , C23C14/568 , C23C16/4485 , C23C16/45548 , C23C16/458 , C23C16/50 , C23C16/54 , H01J37/3244 , H01J37/32706 , H01J37/32715 , H01J37/32743 , H01J37/32788 , H01J37/32862
摘要： There is disclosed a plasma enhanced chemical vapor deposition apparatus including a chamber in which plasma reaction is performed to provide a functional film to an object received therein, a pallet mechanically and electrically connected with the object, a conveyer to convey the pallet to an inside from an outside of the chamber, and a power supplier to supply an electric power to the pallet, the power supplier comprising a moving contact distant from the pallet when the pallet is conveyed and contacting with the pallet when the pallet is stopped.

2. 发明申请

US20120149687A1 HETEROCYCLIC COMPOUNDS AND USES THEREOF 有权
公开(公告)号：US20120149687A1
公开(公告)日：2012-06-14
申请号：US13286061
申请日：2011-10-31
申请人： Kwangho Lee , Deqiang Niu , Russell C. Petter , Matthew F. Baevsky , Juswinder Singh
发明人： Kwangho Lee , Deqiang Niu , Russell C. Petter , Matthew F. Baevsky , Juswinder Singh
IPC分类号： A61K31/5377 , C07D239/34 , C07D413/12 , C07D403/12 , A61K31/506 , C07D295/155 , A61K31/5375 , A61K31/551 , C07D267/10 , A61K31/553 , C07D417/12 , A61K31/541 , A61P35/00 , C12N5/09 , C07D239/42
CPC分类号： A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/551 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D403/14
摘要： The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

3. 发明申请

US20100063278A1 N-Formyl Hydroxylamines compounds 失效
标题翻译： N-甲酰基羟胺化合物
公开(公告)号：US20100063278A1
公开(公告)日：2010-03-11
申请号：US12476824
申请日：2009-06-02
申请人： Kathryn Rene Bracken , Simon Bushell , Karl Dean , Charles Francavilla , Rakesh K. Jain , Kwangho Lee , Mohindra Seepersaud , Lei Shu , Arathi Sundaram , Zhengyu Yuan
发明人： Kathryn Rene Bracken , Simon Bushell , Karl Dean , Charles Francavilla , Rakesh K. Jain , Kwangho Lee , Mohindra Seepersaud , Lei Shu , Arathi Sundaram , Zhengyu Yuan
IPC分类号： C07D403/12 , C07D401/12
CPC分类号： C07D401/12 , C07D403/12
摘要： Novel N-formyl hydroxylamine compounds and their derivatives are discloses. These N-formyl hydroxylamine compounds inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as MMPs. Methods of preparation and use of the compounds are also disclosed.
摘要翻译：公开了新的N-甲酰羟胺化合物及其衍生物。这些N-甲酰基羟胺化合物抑制肽原甲酰化酶（PDF），一种存在于原核生物中的酶。这些化合物可用作抗微生物剂和抗生素。本发明的化合物显示出对其它金属蛋白酶如MMP的肽基变性酶的选择性抑制。还公开了化合物的制备和使用方法。

4. 发明申请

US20080161558A1 N-Formyl Hydroxylamines 失效
标题翻译： N-甲酰基羟胺
公开(公告)号：US20080161558A1
公开(公告)日：2008-07-03
申请号：US11914659
申请日：2006-05-22
申请人： Kathryn Rene Bracken , Simon Bushell , Karl Dean , Charles Francavilla , Rakesh K. Jain , Kwangho Lee , Mohindra Seepersaud , Lei Shu , Arathi Sundaram , Zhengyu Yuan
发明人： Kathryn Rene Bracken , Simon Bushell , Karl Dean , Charles Francavilla , Rakesh K. Jain , Kwangho Lee , Mohindra Seepersaud , Lei Shu , Arathi Sundaram , Zhengyu Yuan
IPC分类号： C07D403/12 , C07D401/12
CPC分类号： C07D401/12 , C07D403/12
摘要： Novel N-formyl hydroxylamine compounds and their derivatives are disclosed. These N-formyl hydroxylamine compounds inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as MMPs. Methods of preparation and use of the compounds are also disclosed.
摘要翻译：公开了新的N-甲酰羟胺化合物及其衍生物。这些N-甲酰基羟胺化合物抑制肽原甲酰化酶（PDF），一种存在于原核生物中的酶。这些化合物可用作抗微生物剂和抗生素。本发明的化合物显示出对其它金属蛋白酶如MMP的肽基变性酶的选择性抑制。还公开了化合物的制备和使用方法。

5. 发明申请

US20120260856A1 PLASMA ENHANCED CHEMICAL VAPOR DEPOSITION APPARATUS AND METHOD FOR CONTROLLING THE SAME 审中-公开
标题翻译：等离子体增强化学蒸气沉积装置及其控制方法
公开(公告)号：US20120260856A1
公开(公告)日：2012-10-18
申请号：US13428529
申请日：2012-03-23
申请人： Junggeun OH , Kwangho LEE , Jangwoo LEE , Jeonggyu KIM , Jinhyouk SHIN
发明人： Junggeun OH , Kwangho LEE , Jangwoo LEE , Jeonggyu KIM , Jinhyouk SHIN
IPC分类号： B65D19/26 , C23C16/50
CPC分类号： C23C16/0236 , C23C16/4587 , C23C16/50 , C23C16/54 , H01J37/32715
摘要： There is disclosed a plasma enhanced chemical vapor deposition apparatus including a pallet to load and convey an object thereon to provide a functional film to the object by plasma reaction, wherein the pallet includes a base, a jig to fix the object, and a fixing part disposed on the base at an upper side of the fixing part Lo fix the object to the pallet.
摘要翻译：公开了一种等离子体增强化学气相沉积装置，其包括用于加载和传送物体的托盘，以通过等离子体反应向物体提供功能膜，其中托盘包括基座，固定物体的夹具和固定部件在固定部分Lo的上侧设置在基座上，将物体固定在托盘上。

6. 发明申请

US20120157426A1 MUTANT-SELECTIVE EGFR INHIBITORS AND USES THEREOF 有权
标题翻译：突变选择性EGFR抑制剂及其用途
公开(公告)号：US20120157426A1
公开(公告)日：2012-06-21
申请号：US13291706
申请日：2011-11-08
申请人： Kwangho Lee , Deqiang Niu , Matthew F. Baevsky
发明人： Kwangho Lee , Deqiang Niu , Matthew F. Baevsky
IPC分类号： A61K31/506 , C07D239/47 , C12N5/071 , C07D239/48 , A61P35/00 , C07D403/12 , A61K31/505
CPC分类号： C07D403/12 , A61K31/155 , A61K31/505 , A61K31/506 , A61K45/06 , C07D239/42 , C07D239/47 , C07D239/48 , C12N9/12 , C12Y207/10 , A61K2300/00
摘要： The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
摘要翻译：本发明提供化合物，其药学上可接受的组合物及其使用方法。

7. 发明授权

US08044199B2 N-formyl hydroxylamines compounds 失效
标题翻译： N-甲酰羟胺化合物
公开(公告)号：US08044199B2
公开(公告)日：2011-10-25
申请号：US12476824
申请日：2009-06-02
申请人： Kathryn Rene Bracken , Simon Bushell , Karl Dean , Charles Francavilla , Rakesh K. Jain , Kwangho Lee , Mohindra Seepersaud , Lei Shu , Arathi Sundaram , Zhengyu Yuan
发明人： Kathryn Rene Bracken , Simon Bushell , Karl Dean , Charles Francavilla , Rakesh K. Jain , Kwangho Lee , Mohindra Seepersaud , Lei Shu , Arathi Sundaram , Zhengyu Yuan
IPC分类号： C07D403/02
CPC分类号： C07D401/12 , C07D403/12
摘要： Novel N-formyl hydroxylamine compounds of formula I: wherein R1 is hydrogen, alkyl, heteroaryl, heterocycloalkyl, aryl, heteroaryl or cycloalkyl; R3 is hydrogen, halogen or alkoxy; R4 is pyridazinyl; n is 0 to 3; and wherein one or more of the ring nitrogen heteroatoms of said pyridazinyl is optionally oxidized and their derivatives are disclosed. These N-formyl hydroxylamine compounds inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as MMPs. Methods of preparation and use of the compounds are also disclosed.
摘要翻译：式I的新型N-甲酰基羟胺化合物：其中R 1是氢，烷基，杂芳基，杂环烷基，芳基，杂芳基或环烷基; R3是氢，卤素或烷氧基; R4是哒嗪基; n为0〜3; 并且其中所述哒嗪基的一个或多个环氮杂原子被任选地氧化并且其公开了它们的衍生物。这些N-甲酰基羟胺化合物抑制肽原甲酰化酶（PDF），一种存在于原核生物中的酶。这些化合物可用作抗微生物剂和抗生素。本发明的化合物显示出对其它金属蛋白酶如MMP的肽基变性酶的选择性抑制。还公开了化合物的制备和使用方法。

8. 发明授权

US09238629B2 Heteroaryl compounds and uses thereof 有权
公开(公告)号：US09238629B2
公开(公告)日：2016-01-19
申请号：US13286062
申请日：2011-10-31
申请人： Kwangho Lee , Deqiang Niu , Russell C. Petter , Juswinder Singh
发明人： Kwangho Lee , Deqiang Niu , Russell C. Petter , Juswinder Singh
IPC分类号： A61K31/505 , C07D239/48 , C07D239/47 , A61K31/16 , A61K31/506 , A61K45/06
CPC分类号： C07D239/48 , A61K31/16 , A61K31/505 , A61K31/506 , A61K45/06 , C07D239/47 , A61K2300/00
摘要： The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

9. 发明申请

US20120240856A1 PLASMA ENHANCED CHEMICAL VAPOR DEPOSITION APPARATUS AND METHOD FOR CONTROLLING THE SAME 有权
标题翻译：等离子体增强化学蒸气沉积装置及其控制方法
公开(公告)号：US20120240856A1
公开(公告)日：2012-09-27
申请号：US13428483
申请日：2012-03-23
申请人： Junggeun OH , Kwangho Lee , Jangwoo Lee , Jeonggyu Kim , Jinhyouk Shin
发明人： Junggeun OH , Kwangho Lee , Jangwoo Lee , Jeonggyu Kim , Jinhyouk Shin
IPC分类号： C23C16/50
CPC分类号： C23C16/54 , C23C16/458 , C23C16/50 , C23C16/505 , C23C16/509
摘要： There is disclosed a plasma enhanced chemical vapor deposition apparatus including a loading station to load an object on a pallet, an operation station to form a functional film by performing plasma reaction to the object loaded on the pallet, a unloading station to separate the object from the pallet, a circulation station to convey the pallet from the unloading station to the loading station, and a conveyer to convey the pallet to the stations sequentially to circulate the pallet.
摘要翻译：公开了一种等离子体增强化学气相沉积装置，其包括：装载站，用于将物体装载在托盘上;操作台，通过对装载在托盘上的物体进行等离子体反应而形成功能膜;卸载站，托盘，用于将托盘从卸载站传送到装载站的循环站，以及用于将托盘顺序地传送到站的传送器，以使托盘循环。

10. 发明申请

US20110016548A1 CONTROL OF ENDOGENOUS DNMT1 GENE EXPRESSION BY EXOGENOUS BINARY REGULATORY SYSTEMS 审中-公开
标题翻译：异源二进制调节系统内源DNMT1基因表达的控制
公开(公告)号：US20110016548A1
公开(公告)日：2011-01-20
申请号：US12838300
申请日：2010-07-16
申请人： PETER W. LAIRD , KWANGHO LEE
发明人： PETER W. LAIRD , KWANGHO LEE
IPC分类号： C12N15/87 , C12N15/63 , C12N5/10 , C07K2/00 , C07K14/00 , C07K14/035 , C07H21/04
CPC分类号： A61K31/353 , Y02A50/401
摘要： Provided are methods for controlling endogenous gene expression comprising control of the DNA methyltransferase (Dnmt1) for modulation of DNA methylation and epigenetic mechanisms. Provided are transcriptional regulatory systems involving multiple (e.g., three) exogenous binary systems, lacI, tetR and Gal4, for reversible up/down regulation of endogenous target genes Provided are lac operator and repressor modifications for improved repression relative to wild type (WT) lac and tet systems. Provided are endogenous Dnmt1 promoter modifications, comprising targeted lac operator sequences that do not significantly alter promoter activity absent repressors, yet show substantially reduced expression of the targeted allele upon lac repressor introduction. The lacO targeted Dnmt1 allele is introducible into the mouse germline, to provide a respective upregulatable transcriptional control system in vivo (e.g., two binary systems, tet operator/tetVP16 and Gal4 binding sequence/Gal4VP16, and ES cell gene targeting experiments are conducted with a Dnmt1 promoter construct combining all three cis elements.
摘要翻译：提供了用于控制内源基因表达的方法，包括用于调节DNA甲基化和表观遗传机制的DNA甲基转移酶（Dnmt1）的控制。提供了涉及多个（例如三个）外源二元体系（lacI，tetR和Gal4）用于内源性靶基因的可逆上/下调节的转录调控系统。提供了用于改善相对于野生型（WT）lac的抑制的lac操纵子和阻遏物修饰和tet系统。提供内源性Dnmt1启动子修饰，其包含不显着改变启动子活性的靶向lac操纵子序列，不存在阻遏物，并且在lac阻抑物引入时显示目标等位基因的表达显着降低。将lacO靶向的Dnmt1等位基因导入小鼠种系，以在体内提供相应的可上调的转录控制系统（例如，两个二元系统，tet操纵子/ tetVP16和Gal4结合序列/ Gal4VP16，并且用a细胞基因靶向实验用结合所有三个顺式元件的Dnmt1启动子构建体。

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