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1. 发明授权

US4755598A 1 '-(substituted)ethyl-7.beta.-[2-(2-aminothiazol-4-yl)acetamido]-3-[[[1-(2 -dimethylaminoethyl)-1H-tetrazol-5-yl]thio]methyl]ceph-3-em-4-carboxylate derivatives having antibacterial utility 失效
标题翻译： 1' - （取代的）乙基-7β-[2-（2-氨基噻唑-4-基）乙酰氨基] -3 - [[[1-（2-二甲基氨基乙基）-1H-四唑-5-基]硫基]甲基 ] ceph-3-em-4-羧酸酯衍生物
公开(公告)号：US4755598A
公开(公告)日：1988-07-05
申请号：US616260
申请日：1984-06-01
申请人： Kunio Takanohashi , Tomoyuki Fujii , Mitsuo Numata
发明人： Kunio Takanohashi , Tomoyuki Fujii , Mitsuo Numata
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07C68/02 , C07D501/36 , C07D501/38 , C07D501/56
CPC分类号： C07D501/38 , C07C68/02 , C07D501/36
摘要： A compound of the formula: ##STR1## wherein R is 2-methylpropyl, 2,2-dimethylpropyl, 1-ethylpropyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, n-pentyl, an alkyl group of 6 or 7 carbon atoms, or an alkenyl group of 2 to 7 carbon atoms, or a pharmaceutically acceptable salt thereof and processes for preparing the same are provided. The compound can orally be applied as antibiotics having improved absorbability.
摘要翻译：下式的化合物：其中R是2-甲基丙基，2,2-二甲基丙基，1-乙基丙基，1-甲基丁基，2-甲基丁基，3-甲基丁基，正戊基，烷基 6或7个碳原子的链烯基或2至7个碳原子的链烯基，或其药学上可接受的盐及其制备方法。该化合物可口服施用，具有改善的吸收性的抗生素。

2. 发明授权

US5424478A Process for producing vitamin A derivatives 失效
标题翻译：生产维生素A衍生物的方法
公开(公告)号：US5424478A
公开(公告)日：1995-06-13
申请号：US215813
申请日：1994-03-22
申请人： Mitsutaka Tanaka , Tadashi Hanaoka , Kunio Takanohashi
发明人： Mitsutaka Tanaka , Tadashi Hanaoka , Kunio Takanohashi
IPC分类号： C07C69/07 , C07C403/12
CPC分类号： C07C403/12 , C07C2101/16
摘要： The present specification relates to an industrially advantageous process for producing vitamin A derivatives which are useful as medicaments, feed additives, food additives and the like. The process provides vitamin A derivatives, particularly all-trans vitamin A derivatives in high yield and purity.
摘要翻译：本说明书涉及可用作药物，饲料添加剂，食品添加剂等的维生素A衍生物的工业上有利的方法。该方法以高产率和纯度提供维生素A衍生物，特别是全反式维生素A衍生物。

3. 发明授权

US5247095A Intermediates for D-biotin synthesis and their production 失效
标题翻译：中间体生物合成及其生产
公开(公告)号：US5247095A
公开(公告)日：1993-09-21
申请号：US935105
申请日：1992-08-27
申请人： Toru Yamano , Kazuo Nakahama , Kunio Takanohashi
发明人： Toru Yamano , Kazuo Nakahama , Kunio Takanohashi
IPC分类号： C07D495/04 , C12P17/18 , C12P41/00
CPC分类号： C07D495/04 , C12P17/18 , C12P41/004
摘要： There are disclosed a compound of the general formula (I): ##STR1## wherein the group R--CO-- is an acyl group and its production. There is also disclosed a process for producing optically active (.+-.)-(3a.alpha., 4.alpha., 6a.alpha.)-tetrahydro-4-acetoxy-1,3-dibenzyl-1H-thieno[3,4-d]imidazol-2(3H)-one by using the compound (I). The compound (I) can be used as an intermediate for producing D-biotin which is useful as medicaments and feed additives for animals.

4. 发明授权

US4845246A Ascorbic acid ester 失效
标题翻译：抗坏血酸酯
公开(公告)号：US4845246A
公开(公告)日：1989-07-04
申请号：US205094
申请日：1988-06-10
申请人： Kunio Takanohashi , Mitsutaka Tanaka , Toru Yamano
发明人： Kunio Takanohashi , Mitsutaka Tanaka , Toru Yamano
IPC分类号： C07H7/06
CPC分类号： C07H7/06
摘要： 6-O-(2-keto-L-gulonoyl)-L-ascorbate substantially free from 2-keto-L-gulonic acid is produced by allowing an acid to act on 2-keto-L-gulonic acid in an inert organic solvent and recovering 6-O-(2-keto-L-gulonoyl)-L-ascorbate from the reaction mixture.6-O-(2-keto-L-gulonoyl)-L-ascorbate is more fat-soluble than L-ascorbic acid and is expected of the use as a prodrug for L-ascorbic acid that can be absorbed from the intestinal tract.

5. 发明授权

US4794182A 2-Alkyl-4-amino-5-aminomethylpyrimidines 失效
标题翻译： 2-烷基-4-氨基-5-氨基甲基嘧啶
公开(公告)号：US4794182A
公开(公告)日：1988-12-27
申请号：US073697
申请日：1987-07-14
申请人： Kunio Takanohashi , Toru Yamano , Mitsutaka Tanaka
发明人： Kunio Takanohashi , Toru Yamano , Mitsutaka Tanaka
IPC分类号： C07D239/42
CPC分类号： C07D239/42
摘要： A novel 2-lower alkyl-4-amino-5-substituted iminopyrimidine compound represented by the formula: ##STR1## wherein R is a lower alkyl, and Y is hydroxyl or amino which may be protected or a salt thereof is obtainable by allowing a formylpyrimidine compound represented by the formula: ##STR2## wherein R is a lower alkyl to react with a compound represented by the formula H.sub.2 N--Y, wherein Y is hydroxyl or amino which may be protected, or a salts thereof. The iminopyrimidine compound gives the known pyrimidine compound represented by the formula: ##STR3## wherein R is as defined above in high yield. Therefor, the process is very useful as an industrial production method.
摘要翻译：由下式表示的新型2-低级烷基-4-氨基-5-取代的亚氨基嘧啶化合物：其中R为低级烷基，Y为可被保护的羟基或氨基或其盐可通过使由下式表示的甲酰嘧啶化合物：其中R是与式H2N-Y表示的化合物反应的低级烷基，其中Y是可被保护的羟基或氨基，或其盐。亚氨基嘧啶化合物以高产率得到由下式表示的已知嘧啶化合物：其中R如上定义。因此，该方法作为工业生产方法是非常有用的。

6. 发明授权

US4695639A Thiazole derivatives 失效
标题翻译：噻唑衍生物
公开(公告)号：US4695639A
公开(公告)日：1987-09-22
申请号：US568921
申请日：1984-01-06
申请人： Kunio Takanohashi , Tsuneaki Yoshida , Shoichiro Fujii
发明人： Kunio Takanohashi , Tsuneaki Yoshida , Shoichiro Fujii
IPC分类号： C07D277/20 , C07D277/40 , C07D277/74 , C07D277/76 , C07D417/12 , C07D501/36
CPC分类号： C07D277/587 , C07C317/00 , C07C323/00 , C07D277/74 , C07D417/12
摘要： A novel aminothiazoleacetic acid derivative which is an advantageous synthetic intermediate for .beta.-lactam antibiotics, and its production method and use. Starting with diketene, the production method comprises the following squence of steps. ##STR1## (In the above formulas, R is lower alkyl or phenyl; R.sub.1 and R.sub.2 each are hydrogen or lower alkyl; X and X' each are halogen; W is S or SO.sub.2 ; and W' is OH or ##STR2##
摘要翻译：一种新颖的氨基噻唑乙酸衍生物，其是β-内酰胺抗生素的有利合成中间体及其制备方法和用途。从双烯酮开始，生产方法包括以下步骤。（图像） + TR （在上式中，R为低级烷基或苯基; R 1和R 2各自为氢或低级烷基; X和X'各自为卤素; W为S或SO 2; W'为OH或“IMAGE”

7. 发明授权

US5902885A Production of L-ascorbic acid 失效
标题翻译：生产L-抗坏血酸
公开(公告)号：US5902885A
公开(公告)日：1999-05-11
申请号：US2513
申请日：1993-01-08
申请人： Kunio Takanohashi , Mitsutaka Tanaka , Toru Yamano
发明人： Kunio Takanohashi , Mitsutaka Tanaka , Toru Yamano
IPC分类号： C07D307/62
CPC分类号： C07D307/62
摘要： L-ascorbic acid is produced by allowing an acid to act on 2-keto-L-gulonic acid in a mixture solvent of an inert organic solvent and an aliphatic ketone in the presence of water and a surfactant.The method produces L-ascorbic acid in a high yield 90% or more and is an industrially advantageous method.
摘要翻译：通过在水和表面活性剂的存在下，在惰性有机溶剂和脂族酮的混合溶剂中使酸作用于2-酮-L-古洛糖酸来制备L-抗坏血酸。该方法以高产率生产L-抗坏血酸90％以上，是工业上有利的方法。

8. 发明授权

US4316018A Crystallized cephalosporin salts 失效
标题翻译：结晶头孢菌素盐
公开(公告)号：US4316018A
公开(公告)日：1982-02-16
申请号：US147053
申请日：1980-05-06
申请人： Yoshinobu Yoshimura , Nobuhide Morikawa , Kunio Takanohashi
发明人： Yoshinobu Yoshimura , Nobuhide Morikawa , Kunio Takanohashi
IPC分类号： C07D501/00 , A61K20060101 , A61K31/545 , A61K31/546 , C07D20060101 , C07D501/02 , C07D501/04 , C07D501/06 , C07D501/20 , C07D501/36 , C07D501/46 , C07D501/56
CPC分类号： C07D501/36
摘要： Crystallized cephalosporin salts, particularly crystalline addition salt of pivaloyloxymethyl 7.beta.-[2-(2-aminothiazol-4-yl)acetamido]-3-[[[1-(2-dimethylaminoethyl)-1H-tetrazol-5-yl]thio]methyl]ceph-3-em-4-carboxylate with hydrochloric acid, tartaric acid or citric acid, which is very stable and is readily adsorbable through intestinal tract, with little individual differences, when the salt is applied orally.
摘要翻译： 3β-[2-（2-氨基噻唑-4-基）乙酰氨基] -3 - [[[1-（2-二甲基氨基乙基）-1H-嘌呤-5-基]]的新戊酰氧基甲基酯结晶加成盐，硫代]甲基]头孢-3-烯-4-羧酸盐与盐酸，酒石酸或柠檬酸反应，当盐被口服时，它是非常稳定的并且通过肠道容易吸附，几乎没有个体差异。

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