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    • 1. 发明申请
    • Scored tablet
    • 得分平板电脑
    • US20060228409A1
    • 2006-10-12
    • US10548579
    • 2004-03-26
    • Junichi MiyabeKouji MuraiTomohiko GotoYasuhiko Ueno
    • Junichi MiyabeKouji MuraiTomohiko GotoYasuhiko Ueno
    • A61K9/20
    • A61K9/2072
    • An object of the present invention is to provide a dividable tablet that is easily and accurately divided without any particular limitation on dividing method thereof and has superior strength. That is, the present invention provides a dividable tablet whose lower surface is a curved surface gradually rising from the central part exactly below the dividing line and whose upper surface is divided into two or more surfaces by a dividing line, wherein, in a side view of the tablet seen from the extended line of the dividing line, in a virtual triangle connecting the center of the lower surface and any two points on each of the two or more upper surfaces having the farthest distance from a tangent line to the center of the lower surface, the angle at the center of the lower surface is greater than or equal to 70°, and the ratio c/d of the distance (c) between any one of the points on each of the two or more upper surfaces having the farthest distance from the tangent line to the center of the lower surface and the tangent line to the center of the lower surface and the distance (d) between the lowest part of the dividing line and the center of the lower surface is 1/0.70≦c/d≦1/0.40.
    • 本发明的目的是提供容易且精确地分割的可分割片剂,对其分割方法没有特别限制,并且具有优异的强度。 也就是说,本发明提供了一种可分割片剂,其下表面是从正好在分割线下方的中心部分逐渐上升的曲面,并且其上表面被分割线分成两个或更多个表面,其中,在侧视图 在从分割线的延长线看到的平板中,以连接下表面的中心的虚拟三角形和从切线到中心的两个或多个上表面中的每一个上的任何两个点 下表面的中心处的角度大于或等于70°,并且两个或更多个上表面中的每一个上的任何一个点之间的距离(c)的比c / d具有 从切线到下表面的中心和下表面中心的切线距离最远的距离和分界线的最下部分与下表面的中心之间的距离(d)为1 / 0.70 < = c / d <= 1 /0.40。
    • 4. 发明申请
    • Seamless capsule containing water-soluble active substance
    • 无水胶囊含有水溶性活性物质
    • US20070154541A1
    • 2007-07-05
    • US11568150
    • 2005-04-21
    • Kouji MuraiYasuki Kato
    • Kouji MuraiYasuki Kato
    • A61K9/48
    • A61K31/335A61K9/4833
    • A seamless capsule containing a water-soluble active substance in which the water-soluble active substance is protected from becoming unstable and a process for producing the same. The seamless capsule includes: content having a water-soluble active substance and an oily compound, a shell covering the content, and an intermediate layer, which is between the content and the shell and comprises an oily compound which does not dissolve or merge with the water-soluble active substance, is not dissolved in or merged with water, has a melting point of 10 to 65° C., and is not dissolved in or merged with the content at a temperature not higher than the melting point during the production process of the seamless capsule. The process for producing the seamless capsule using a device equipped with three or more layered nozzles with sequentially increasing diameters.
    • 一种含有其中保护水溶性活性物质不会变得不稳定的水溶性活性物质的无缝胶囊及其制造方法。 无缝胶囊包括:含有水溶性活性物质和油性化合物的内容物,覆盖物质的壳体和位于内容物与壳体之间的中间层,并且包含不溶解或与其结合的油性化合物 水溶性活性物质不溶于或与水合并,熔点为10〜65℃,并且在生产过程中不溶于熔点以下的温度下不溶解或与其结合 的无缝胶囊。 使用装备有三个或更多个具有顺序增加的直径的分层喷嘴的装置来生产无缝胶囊的方法。