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1. 发明授权

US08105478B2 Method for measuring the concentration or change in concentration of a redox-active substance and corresponding device 有权
标题翻译：用于测量氧化还原活性物质浓度或浓度变化的方法及相应的装置
公开(公告)号：US08105478B2
公开(公告)日：2012-01-31
申请号：US10587837
申请日：2005-01-26
申请人： Heike Barlag , Walter Gumbrecht , Konrad Mund
发明人： Heike Barlag , Walter Gumbrecht , Konrad Mund
IPC分类号： G01N27/26 , G01N33/53 , G01N33/487
CPC分类号： G01N27/3277 , G01N2333/916 , Y10T436/143333
摘要： In order to follow the change in concentration of a redox-active substance, potential suitable for a reducing process or oxidation process are applied to the working electrode of a measuring device. The potential of the working electrode is pulsed and measuring phases and relaxation phases are alternately produced, the pulse lengths of the measuring phase and relaxation phase being predetermined in a suitable manner. In this manner, a rapid relaxation of the concentration gradient is forced electrochemically so that the measurement can be carried out on simple transducer arrays. The device includes a transducer array in addition to a suitable potentiostat. The transducer array may include a planar metal substrate on which at least one flexible insulator having a firm connection between the metal surface and the insulator surface is located. The array is generated by suitably structuring the substrate.
摘要翻译：为了跟踪氧化还原活性物质的浓度变化，适用于还原过程或氧化过程的电位被施加到测量装置的工作电极。工作电极的电位是脉冲的，交替地产生测量相位和弛豫阶段，测量相位和弛豫阶段的脉冲长度以合适的方式被预先确定。以这种方式，电化学强迫浓缩梯度的快速松弛，使得可以在简单的换能器阵列上进行测量。除了合适的恒电位仪之外，该装置还包括一个换能器阵列。换能器阵列可以包括平面金属基底，其上定位有在金属表面和绝缘体表面之间具有牢固连接的至少一个柔性绝缘体。该阵列通过适当地构造基底而产生。

2. 发明申请

US20100155263A1 METHOD AND SYTEM FOR DETERMINING THE CONCENTRATION OF AN ANALYTE/ENZUME COMPLEX OR OF AN ANALYTE/ENZYME CONJUGATE, ESPECIALLY FOR THE ELECTROCHEMICAL DETECTION OF THE ANALYTE, AND CORRESPONDING MEASURING DEVICE 有权
标题翻译：用于确定分析物/酶复合物浓度或分析物/酶合成浓度的方法和系统，特别是用于分析仪的电化学检测和相应的测量装置
公开(公告)号：US20100155263A1
公开(公告)日：2010-06-24
申请号：US11989938
申请日：2006-07-31
申请人： Heike Barlag , Walter Gumbrecht , Konrad Mund
发明人： Heike Barlag , Walter Gumbrecht , Konrad Mund
IPC分类号： G01N33/543
CPC分类号： C12Q1/001 , G01N27/3271 , Y10S435/817
摘要： A method follow the change in concentration of a redox-active substance, whereby suitable potentials for a reduction process or an oxidation process are applied to the working electrode of a measuring device. The potential of the working electrode is pulsed and measuring phases and relaxation phases are alternately produced, the pulse lengths of measuring phase and relaxation phase being determined in a suitable manner. A rapid relaxation of the concentration gradient is electrochemically forced so that the measurement can be carried out on simple transducer arrays. A device for carrying out the method includes a transducer array in addition to a suitable potentiostat. The transducer array can be formed of a planar metal substrate on which at least one flexible insulator is disposed, the metal surface and the insulator surface being firmly linked. The transducer array can also be formed of silicone-based CMOS structures.
摘要翻译：一种遵循氧化还原活性物质浓度变化的方法，由此将适当的还原过程或氧化过程的电位施加到测量装置的工作电极上。工作电极的电位是脉冲的，并且交替地产生测量相位和松弛相位，测量相位和弛豫阶段的脉冲长度以适当的方式确定。浓度梯度的快速弛豫是电化学强制的，以便可以在简单的换能器阵列上进行测量。用于执行该方法的装置包括除合适的恒电位仪之外的换能器阵列。换能器阵列可以由其上设置有至少一个柔性绝缘体的平面金属基板形成，金属表面和绝缘体表面牢固地连接。换能器阵列也可以由硅基CMOS结构形成。

3. 发明申请

US20080099347A1 Method for measuring the concentration or change in concentration of a redox-active substance and corresponding device 有权
标题翻译：用于测量氧化还原活性物质浓度或浓度变化的方法及相应的装置
公开(公告)号：US20080099347A1
公开(公告)日：2008-05-01
申请号：US10587837
申请日：2005-01-26
申请人： Heike Barlag , Walter Gumbrecht , Konrad Mund
发明人： Heike Barlag , Walter Gumbrecht , Konrad Mund
IPC分类号： G01N27/26 , G01N27/28
CPC分类号： G01N27/3277 , G01N2333/916 , Y10T436/143333
摘要： In order to follow the change in concentration of a redox-active substance, potential suitable for a reducing process or oxidation process are applied to the working electrode of a measuring device. The potential of the working electrode is pulsed and measuring phases and relaxation phases are alternately produced, the pulse lengths of the measuring phase and relaxation phase being predetermined in a suitable manner. In this manner, a rapid relaxation of the concentration gradient is forced electrochemically so that the measurement can be carried out on simple transducer arrays. The device includes a transducer array in addition to a suitable potentiostat. The transducer array may include a planar metal substrate on which at least one flexible insulator having a firm connection between the metal surface and the insulator surface is located. The array is generated by suitably structuring the substrate.
摘要翻译：为了跟踪氧化还原活性物质的浓度变化，适用于还原过程或氧化过程的电位被施加到测量装置的工作电极。工作电极的电位是脉冲的，交替地产生测量相位和弛豫阶段，测量相位和弛豫阶段的脉冲长度以合适的方式被预先确定。以这种方式，电化学强迫浓缩梯度的快速松弛，使得可以在简单的换能器阵列上进行测量。除了合适的恒电位仪之外，该装置还包括一个换能器阵列。换能器阵列可以包括平面金属基底，其上定位有在金属表面和绝缘体表面之间具有牢固连接的至少一个柔性绝缘体。该阵列通过适当地构造基底而产生。

4. 发明申请

US20060216813A1 Dna chip comprising a microarray made of an microelectrode system 有权
标题翻译： Dna芯片包括由微电极系统制成的微阵列
公开(公告)号：US20060216813A1
公开(公告)日：2006-09-28
申请号：US10539817
申请日：2003-12-15
申请人： Walter Gumbrecht , Konrad Mund , Meinrad Schienle , Roland Thewes
发明人： Walter Gumbrecht , Konrad Mund , Meinrad Schienle , Roland Thewes
IPC分类号： C12M1/34
CPC分类号： G01N33/5438 , C12Q1/6825
摘要： A DNA chip includes a carrier and a microarray of spots containing immobilised catcher molecules which are arranged on the carrier. Each spot contains a microelectrode system for the impedance spectroscopic detection of binding events occurring between the catcher molecules and target molecules of an analyte solution applied to the spots. The microelectrode system has a pair of polarisation electrodes in order to produce an alternating electromagnetic field and a pair of sensor electrodes for measuring a voltage drop in the analyte.
摘要翻译： DNA芯片包括布置在载体上的载体和含有固定捕获剂分子的斑点的微阵列。每个斑点包含用于阻抗光谱检测在施加到斑点的分析物溶液的捕获剂分子和靶分子之间发生的结合事件的微电极系统。微电极系统具有一对极化电极以产生交变电磁场和一对传感器电极，用于测量分析物中的电压降。

5. 发明授权

US4919770A Method for determining the concentration of electro-chemically convertible substances 失效
标题翻译：确定电化学可转换物质浓度的方法
公开(公告)号：US4919770A
公开(公告)日：1990-04-24
申请号：US945065
申请日：1986-12-19
申请人： Walter Preidel , Konrad Mund
发明人： Walter Preidel , Konrad Mund
IPC分类号： G01N33/487
CPC分类号： G01N33/48714
摘要： The invention involves a method for determining the concentration of electro-chemically convertible substances in a solution by means of an analyzer equipped with a test electrode, so that a precise determination of the concentration, dependable over extended periods, is possible. The invention provides for a potential varying with time within a potential interval to be impressed on the test electrode, for an ac voltage of a predetermined amplitude and frequency to be superimposed on this potential, and for the real and/or imaginary portions of the impedance to be determined for at least one potential step, thus determining the concentration. The method is particularly suited for determining the concentration of glucose in body fluids.
摘要翻译：本发明涉及一种通过配备有测试电极的分析仪测定溶液中的电化学可转换物质的浓度的方法，从而可以在长时间内可靠地确定浓度的精确测定。本发明提供了在电势间隔内随时间变化的电位，以施加在测试电极上，对于要叠加在该电位上的预定幅度和频率的交流电压，以及阻抗的实部和/或虚部确定至少一个潜在步骤，从而确定浓度。该方法特别适用于测定体液中葡萄糖的浓度。

6. 发明授权

US4603704A Electrode for medical applications 失效
标题翻译：电极用于医疗应用
公开(公告)号：US4603704A
公开(公告)日：1986-08-05
申请号：US569832
申请日：1984-01-11
申请人： Konrad Mund , Helmut Freller , Friedrich Hoerauf
发明人： Konrad Mund , Helmut Freller , Friedrich Hoerauf
IPC分类号： A61B5/0408 , A61N1/05 , A61N1/372 , A61N1/04
CPC分类号： A61N1/0565 , A61B5/0408
摘要： In order to expand the availability of effective and usable electrodes for medical applications, an electrode is proposed which is comprised of an electrically conductive carrier material and of a porous layer in its active region which is composed of a carbide, nitride or carbonitride of one of the metals titanium, vanadium, zirconium, niobium, molybdenum, hafnium, tantalum or tungsten.
摘要翻译：为了扩大用于医疗应用的有效和可用的电极的可用性，提出了一种电极，其由导电载体材料和在其有源区域中的多孔层组成，其由碳化物，氮化物或碳氮化物组成，其中碳化物，氮化物或碳氮化物金属钛，钒，锆，铌，钼，铪，钽或钨。

7. 发明授权

US3940510A Process for the manufacture of silver-coated tungsten carbide electrode material 失效
标题翻译：镀银碳化钨电极材料制造工艺
公开(公告)号：US3940510A
公开(公告)日：1976-02-24
申请号：US394772
申请日：1973-09-06
申请人： Karl Hohne , Konrad Mund
发明人： Karl Hohne , Konrad Mund
IPC分类号： H01M4/88 , B01J23/50 , B01J37/16 , H01M4/90 , H01M10/52 , B08B3/00 , C25B11/00
CPC分类号： B01J23/50 , B01J37/16 , H01M4/90
摘要： The invention concerns a method for the manufacture of an electrode material containing silver-coated tungsten carbide for electrochemical cells, particularly fuel cells and storage cells. Silver is precipitated on finely-divided tungsten carbide particles by reduction of a silver salt, and the tungsten carbide particles are thereby joined to form particles of larger grain size.
摘要翻译：本发明涉及制造用于电化学电池，特别是燃料电池和储存电池的镀银碳化钨的电极材料的方法。通过还原银盐将银沉淀在细碎碳化钨颗粒上，由此碳化钨颗粒接合形成较大晶粒尺寸的颗粒。

8. 发明授权

US07572624B2 DNA chip comprising a microarray made of an microelectrode system 有权
标题翻译： DNA芯片包括由微电极系统制成的微阵列
公开(公告)号：US07572624B2
公开(公告)日：2009-08-11
申请号：US10539817
申请日：2003-12-15
申请人： Walter Gumbrecht , Konrad Mund , Meinrad Schienle , Roland Thewes
发明人： Walter Gumbrecht , Konrad Mund , Meinrad Schienle , Roland Thewes
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01N33/5438 , C12Q1/6825
摘要： A DNA chip includes a carrier and a microarray of spots containing immobilised catcher molecules which are arranged on the carrier. Each spot contains a microelectrode system for the impedance spectroscopic detection of binding events occurring between the catcher molecules and target molecules of an analyte solution applied to the spots. The microelectrode system has a pair of polarisation electrodes in order to produce an alternating electromagnetic field and a pair of sensor electrodes for measuring a voltage drop in the analyte.
摘要翻译： DNA芯片包括布置在载体上的载体和含有固定捕获剂分子的斑点的微阵列。每个斑点包含用于阻抗光谱检测在施加到斑点的分析物溶液的捕获剂分子和靶分子之间发生的结合事件的微电极系统。微电极系统具有一对极化电极以产生交变电磁场和一对传感器电极，用于测量分析物中的电压降。

9. 发明授权

US5558640A System for infusion of medicine into the body of a patient 失效
标题翻译：将药物输入患者体内的系统
公开(公告)号：US5558640A
公开(公告)日：1996-09-24
申请号：US400953
申请日：1995-03-08
申请人： Manfred Pfeiler , Konrad Mund , Walter Preidel , Goesta Sjoeholm
发明人： Manfred Pfeiler , Konrad Mund , Walter Preidel , Goesta Sjoeholm
IPC分类号： A61M5/00 , A61M1/36 , A61M5/142 , A61M5/172 , A61M31/00 , A61K9/22 , A61N1/18
CPC分类号： A61M5/14276 , A61M5/1723
摘要： A system for infusing medicine into the body of a patient includes an implantable infusion apparatus containing a dosing unit with a reservoir for the medicine and a medicine delivery pump for pumping doses of the medicine from the reservoir into the patient. The infusion apparatus also includes a sensor for sensing a parameter of the patient for controlling the dosing of medicine according to the sensed parameter. The dosing unit and the sensor are galvanically separable and are each provided with separate telemetry communication units for communication with an external programmer/controller. The external programmer/controller includes telemetry communication units for selectable communication with the dosing unit or the sensor or both simultaneously. The telemetry communication units of the external programmer/controller, the dosing unit and the sensor are constructed for bi-directional communication between the external controller and each one of the dosing unit and the sensor.
摘要翻译：用于将药物注入患者体内的系统包括可植入输注装置，其包含具有用于药物的储存器的计量单元和用于将药物的剂量从储存器泵送到患者中的药物输送泵。输注装置还包括传感器，用于感测患者的参数，以根据所感测的参数来控制药物的给药。配量单元和传感器是电流可分离的，并且每个都具有用于与外部编程器/控制器通信的单独的遥测通信单元。外部编程器/控制器包括用于与计量单元或传感器或两者同时选择通信的遥测通信单元。外部编程器/控制器，计量单元和传感器的遥测通信单元被构造用于在外部控制器和每个配量单元和传感器之间进行双向通信。

10. 发明授权

US4853091A Method and apparatus for the electrochemical determination of oxygen concentration 失效
标题翻译：用于电化学测定氧浓度的方法和装置
公开(公告)号：US4853091A
公开(公告)日：1989-08-01
申请号：US186755
申请日：1988-04-26
申请人： Konrad Mund , Walter Preidel , J. Raghavendra Rao , Gerhard Richter
发明人： Konrad Mund , Walter Preidel , J. Raghavendra Rao , Gerhard Richter
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1473 , A61B5/15 , A61N1/365 , G01N27/27 , G01N27/416 , G01N27/49
CPC分类号： A61B5/14542 , A61B5/1473 , G01N33/4925 , G01N27/404
摘要： The electrochemical determination of the oxygen concentration, particularly in biological matter, is possible by means of an oxygen sensor with a measuring electrode and a counter electrode over long periods of time, even if the sensor is implanted, by taking the following measures; two potentials are cyclically impressed on the measuring electrode, with one potential (measuring potential) in the range -1.4 V.ltoreq..rho.Ag/AgCl.ltoreq.-0.4 V, and the other potential (recovery potential) in the range -0.2 V.ltoreq..rho.Ag/AgCl.ltoreq.+0.2 V; the dwelling time at the measuring potential is small as compared to the duration of the cycle; and the current flowing during the measuring period is evaluated as the measuring signal.
摘要翻译：通过采取以下措施，即使传感器被植入，氧浓度的电化学测定，特别是生物物质的电化学测定也可以通过具有测量电极和对电极长时间的氧传感器来实现。在测量电极上周期性地施加两个电势，其中一个电位（测量电位）在-1.4V Ag / AgCl

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