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1. 发明申请

US20060258580A1 Modulators of Nod1 signaling 审中-公开
标题翻译： Nod1信号调制器
公开(公告)号：US20060258580A1
公开(公告)日：2006-11-16
申请号：US11249283
申请日：2005-10-13
申请人： Naohiro Inohara , Koichi Fukase , Yukari Fujimoto
发明人： Naohiro Inohara , Koichi Fukase , Yukari Fujimoto
IPC分类号： A61K38/17 , A61K31/22
CPC分类号： A61K38/17 , A61K31/22 , A61K38/05
摘要： The present invention relates to intracellular signaling molecules, in particular the Nod1 protein. The present invention provides methods of identifying modulators of Nod1 signaling. The present invention further provides methods of altering Nod1 signaling.
摘要翻译：本发明涉及细胞内信号传导分子，特别是Nod1蛋白。本发明提供鉴定Nod1信号传导调节剂的方法。本发明还提供了改变Nod1信号传导的方法。

2. 发明授权

US05998595A Azidohalogenobenzyl derivatives, sugar compounds and protection of hydroxy groups 失效
标题翻译：叠氮基苄基衍生物，糖类化合物和保护羟基
公开(公告)号：US05998595A
公开(公告)日：1999-12-07
申请号：US961174
申请日：1997-10-30
申请人： Shoichi Kusumoto , Koichi Fukase
发明人： Shoichi Kusumoto , Koichi Fukase
IPC分类号： C07C247/16 , C07H15/18 , C07H15/203 , C07H1/00
CPC分类号： C07H15/18 , C07C247/16 , C07H15/203 , C07B2200/11 , Y02P20/55
摘要： Azidohalogenobenzyl derivatives of the formula (I) ##STR1## wherein A is a halogen atom, B is a halogen atom or a hydrogen atom, and X is a group reactive with a hydroxy group, methods of protecting hydroxy group(s) using said derivatives, and sugar compounds wherein a hydrogen atom of at least one hydroxy group is substituted by an azidohalogenobenzyl group. According to the present invention, there are provided novel derivatives capable of introducing a group into a compound having hydroxy group(s), which group is useful as a stable hydroxy-protecting group even in solid phase synthesis for the purpose of the extension of sugar chain under continuous acidic conditions and of being removed under mild conditions; sugar compounds protected by using said derivatives; and methods of protecting hydroxy group(s) using said derivatives.
摘要翻译：式（I）的叠氮基苄基衍生物，其中A是卤素原子，B是卤素原子或氢原子，X是与羟基反应的基团，使用所述衍生物保护羟基的方法和糖至少一个羟基的氢原子被叠氮基卤代苄基取代的化合物。根据本发明，提供了能够将基团引入到具有羟基的化合物中的新的衍生物，该基团即使在用于延长糖的目的的固相合成中也可用作稳定的羟基保护基在连续酸性条件下并在温和条件下除去; 通过使用所述衍生物保护的糖化合物; 以及使用所述衍生物保护羟基的方法。

3. 发明授权

US5548077A Method of producing a conjugate utilizing a 2-amino-pyridine compound 失效
标题翻译：使用2-氨基 - 吡啶化合物生产结合物的方法
公开(公告)号：US5548077A
公开(公告)日：1996-08-20
申请号：US311733
申请日：1994-09-23
申请人： Shoichi Kusumoto , Koichi Fukase , Sumihiro Hase
发明人： Shoichi Kusumoto , Koichi Fukase , Sumihiro Hase
IPC分类号： C07D213/74 , C07D213/75 , C07D213/02 , C07H17/02
CPC分类号： C07D213/74 , C07D213/75
摘要： 2-Aminopyridine derivatives having a bifunctional or unifunctional structure and capable of serving as reactants in synthetically converting organic compounds, such as carbohydrates, proteins, lipids or polymer resins, to desired conjugated structures suited for various purposes and detectable by fluorescence spectrometry with high sensitivity, a fluorescent labeling agent comprising the same, and methods of their production are disclosed.
摘要翻译：具有双官能或单官能结构并能够在合成转化的有机化合物如碳水化合物，蛋白质，脂质或聚合物树脂中的反应物的2-氨基吡啶衍生物转化成适用于各种目的的所需缀合结构并且可通过高灵敏度的荧光光谱法检测，公开了包含该荧光标记物的荧光标记物及其制备方法。

4. 发明授权

US08298513B2 Hexatriene-β-carbonyl compound 失效
标题翻译：六碳三烯 - 羰基化合物
公开(公告)号：US08298513B2
公开(公告)日：2012-10-30
申请号：US12525599
申请日：2008-02-05
申请人： Koichi Fukase , Katsunori Tanaka , Yasuyoshi Watanabe , Tsuyoshi Tahara , Koki Hasegawa
发明人： Koichi Fukase , Katsunori Tanaka , Yasuyoshi Watanabe , Tsuyoshi Tahara , Koki Hasegawa
IPC分类号： A61K49/00
CPC分类号： C07K1/13 , A61K49/0039 , A61K49/0041 , A61K49/0047 , A61K49/0056 , A61K49/0058 , A61K51/081 , A61K51/083 , A61K51/085 , A61K51/088 , A61K51/10 , A61K51/1093 , C07C229/44 , C07C237/04 , C07D271/12 , C07D311/16 , C07D311/90 , C07D413/12 , C07D495/04 , C07F5/02 , C07F7/1804
摘要： A label with which labeling is easy when labeling a molecule, i.e., a label that has a high reaction rate upon labeling and that produces a high reaction yield, as well as a precursor for the production of the label are provided. This is achieved by a hexatriene-β-carbonyl compound represented by Formula (I), a hexatriene-β-carbonyl compound represented by Formula (II), a hexatriene-β-carbonyl compound represented by Formula (III) and a hexatriene-β-carbonyl compound represented by Formula (IV). (wherein R1, R2, R3, R4, R5, X1, X2 and Z are as defined in the specification)
摘要翻译：提供了标记分子时标签易于标记的标签，即标记时具有高反应速率并产生高反应产率的标记，以及用于生产标签的前体。由式（I）表示的己三烯 - 羰基化合物，由式（II）表示的己三烯 - 羰基化合物，由式（III）表示的己三烯 - 羰基化合物和式由式（Ⅳ）表示的己三烯 - 羰基化合物。（其中R1，R2，R3，R4，R5，X1，X2和Z如说明书中所定义）

5. 发明申请

US20100008857A1 NOVEL HEXATRIENE-BETA-CARBONYL COMPOUND 失效
标题翻译：新型六甲基 - 碳腈化合物
公开(公告)号：US20100008857A1
公开(公告)日：2010-01-14
申请号：US12525599
申请日：2008-02-05
申请人： Koichi Fukase , Katsunori Tanaka , Yasuyoshi Watanabe , Tsuyoshi Tahara , Koki Hasegawa
发明人： Koichi Fukase , Katsunori Tanaka , Yasuyoshi Watanabe , Tsuyoshi Tahara , Koki Hasegawa
IPC分类号： A61K49/00 , C07D257/02 , C07D271/12 , C07D311/82 , C07K16/00
CPC分类号： C07K1/13 , A61K49/0039 , A61K49/0041 , A61K49/0047 , A61K49/0056 , A61K49/0058 , A61K51/081 , A61K51/083 , A61K51/085 , A61K51/088 , A61K51/10 , A61K51/1093 , C07C229/44 , C07C237/04 , C07D271/12 , C07D311/16 , C07D311/90 , C07D413/12 , C07D495/04 , C07F5/02 , C07F7/1804
摘要： A label with which labeling is easy when labeling a molecule, i.e., a label that has a high reaction rate upon labeling and that produces a high reaction yield, as well as a precursor for the production of the label are provided. This is achieved by a hexatriene-β-carbonyl compound represented by Formula (I), a hexatriene-β-carbonyl compound represented by Formula (II), a hexatriene-β-carbonyl compound represented by Formula (III) and a hexatriene-β-carbonyl compound represented by Formula (IV). (wherein R1, R2, R3, R4, R5, X1, X2 and Z are as defined in the specification)
摘要翻译：提供了标记分子时标签易于标记的标签，即标记时具有高反应速率并产生高反应产率的标记，以及用于生产标签的前体。由式（I）表示的六亚乙基-β-羰基化合物，式（II）表示的六亚乙基-β-羰基化合物，式（III）表示的六亚乙基-β-羰基化合物和六（IV）表示的羰基化合物。（其中R1，R2，R3，R4，R5，X1，X2和Z如说明书中所定义）

6. 发明申请

US20090035851A1 Modulators Of NOD1 Signaling 审中-公开
标题翻译： NOD1信号调制器
公开(公告)号：US20090035851A1
公开(公告)日：2009-02-05
申请号：US12016448
申请日：2008-03-31
申请人： Naohiro Inohara , Koichi Fukase , Yukari Fujimoto
发明人： Naohiro Inohara , Koichi Fukase , Yukari Fujimoto
IPC分类号： C12N5/08 , C12N5/02
CPC分类号： A61K38/17 , A61K31/22 , A61K38/05
摘要： The present invention relates to intracellular signaling molecules, in particular the Nod1 protein. The present invention provides methods of identifying modulators of Nod1 signaling. The present invention further provides methods of altering Nod1 signaling.
摘要翻译：本发明涉及细胞内信号传导分子，特别是Nod1蛋白。本发明提供鉴定Nod1信号传导调节剂的方法。本发明还提供了改变Nod1信号传导的方法。

7. 发明授权

US5386033A 2-aminopyridine compounds 失效
标题翻译： 2-氨基吡啶化合物
公开(公告)号：US5386033A
公开(公告)日：1995-01-31
申请号：US31476
申请日：1993-03-15
申请人： Shoichi Kusumoto , Sumihiro Hase , Koichi Fukase
发明人： Shoichi Kusumoto , Sumihiro Hase , Koichi Fukase
IPC分类号： C07D213/73 , C07D213/74 , C07D213/75 , C07H17/02 , C09K11/06 , G01N33/533 , C07D213/02
CPC分类号： C07D213/75 , C07D213/74 , Y02P20/55
摘要： 2-Aminopyridine derivatives having a bifunctional or unifunctional structure and capable of serving as reactants in synthetically converting organic compounds, such as carbohydrates, proteins, lipids or polymer resins, to desired conjugated structures suited for various purposes and detectable by fluorescence spectrometry with high sensitivity, a fluorescent labeling agent comprising the same, and methods of their production are disclosed.
摘要翻译：具有双官能或单官能结构并能够在合成转化的有机化合物如碳水化合物，蛋白质，脂质或聚合物树脂中的反应物的2-氨基吡啶衍生物转化成适用于各种目的的所需缀合结构并且可通过高灵敏度的荧光光谱法检测，公开了包含该荧光标记物的荧光标记物及其制备方法。

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