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1. 发明授权

US06330475B1 System and a corresponding method for treating defibrillation in a heart 失效
标题翻译：系统和相应的治疗心脏除颤的方法
公开(公告)号：US06330475B1
公开(公告)日：2001-12-11
申请号：US09454965
申请日：1999-12-06
申请人： Alexis C Renirie , Vincent Schouten , Koen Weijand
发明人： Alexis C Renirie , Vincent Schouten , Koen Weijand
IPC分类号： A61N139
CPC分类号： A61N7/00 , A61B2017/00703 , A61N1/395 , A61N1/3956
摘要： There is provided an implanted system and method for delivering subsonic mechanical waves to one or more selected patient areas, said areas including the patient's heart and/or lungs. The mechanical waves are delivered for the purpose of treating fibrillation or like arrhythmias, for enhancing lung gas exchange, enhancing cardiac muscle fiber relaxation, and enhancing coronary perfusion. Mechanical waves are generated in a frequency range of about 1,100,000 Hz, and preferably 1-50,000 Hz. The waves may be delivered continuously for short or long time periods, or may be controlled in timing either with respect to detected portions of a patient's heartbeat signal or in response to a detected event such as fibrillation. In one preferred embodiment, the implantable system includes a defibrillation shock generator and control for responding to a defibrillation event by first delivering a sequence of mechanical waves and then delivering an electrical defibrillation shock. In another embodiment, the system and method treat incipient fibrillation or arrhythmia by delivering mechanical waves of predetermined timing to the patient's heart and/or lungs. In a specific embodiment, mechanical waves are delivered through an array of transducers to the patient's atrial wall, to treat atrial fibrillation.
摘要翻译：提供了一种用于将亚音速机械波传送到一个或多个所选患者区域的植入系统和方法，所述区域包括患者的心脏和/或肺。输送机械波是为了治疗纤维性颤动或类似心律失常的目的，用于增强肺气体交换，增强心肌纤维松弛和增强冠状动脉灌注。在约1,100,000Hz，优选1-50,000Hz的频率范围内产生机械波。波浪可以连续递送短时间或长时间段，或者可以相对于患者的心跳信号的检测到的部分或响应于诸如原纤维化的检测到的事件在时间上进行控制。在一个优选实施例中，可植入系统包括除颤电击发生器和通过首先递送一系列机械波然后递送电除颤电击来响应除颤事件的控制。在另一个实施方案中，该系统和方法通过将预定时间的机械波输送给患者的心脏和/或肺来治疗初期纤维性颤动或心律失常。在具体实施例中，机械波通过换能器阵列传送到患者的心房壁，以治疗房颤。

2. 发明申请

US20070043400A1 Neural electrode treatment 有权
标题翻译：神经电极治疗
公开(公告)号：US20070043400A1
公开(公告)日：2007-02-22
申请号：US11205415
申请日：2005-08-17
申请人： Adrianus Donders , Koen Weijand , Mark Knudson
发明人： Adrianus Donders , Koen Weijand , Mark Knudson
IPC分类号： A61N1/00
CPC分类号： A61N1/36146 , A61N1/36053 , A61N1/36085 , A61N1/36114
摘要： An apparatus for applying a signal to a nerve for the treatment of a disorder includes a first electrode and a second electrode. Each of the electrodes is adapted to be secured to a nerve of a patient. A signal generator is electrically connected to each of the first and second electrodes. The signal generator is adapted to create a signal having a first waveform at the first electrode and a second waveform at the second electrode. The waveforms have parameters selected to block propagation of neural action potentials. The waveforms have a repeating pattern of cycles of pulses with a delay period between at least selected ones of said pulses. In one embodiment, the first and second waveforms are out of phase for a cycle of one of the waveforms to occur during a delay period of the other of the waveforms.
摘要翻译：用于向神经施加信号以用于治疗病症的装置包括第一电极和第二电极。每个电极适于固定到患者的神经。信号发生器电连接到第一和第二电极中的每一个。信号发生器适于产生在第一电极处具有第一波形的信号和在第二电极处的第二波形。波形具有选择的参数以阻止神经动作电位的传播。这些波形具有脉冲周期的重复模式，其中延迟周期至少在所选择的脉冲之间。在一个实施例中，在另一个波形的延迟周期期间，波形中的一个波形的周期是第一和第二波形异相。

3. 发明授权

US06408205B1 System for delivering mechanical waves 失效
标题翻译：传送机械波的系统
公开(公告)号：US06408205B1
公开(公告)日：2002-06-18
申请号：US09454966
申请日：1999-12-06
申请人： Alexis Renirie , Vincent Schouten , Koen Weijand
发明人： Alexis Renirie , Vincent Schouten , Koen Weijand
IPC分类号： A61N139
CPC分类号： A61N7/00 , A61B2017/00703 , A61N1/395 , A61N1/3956
摘要： There is provided an implanted system and method for delivering subsonic mechanical waves to one or more selected patient areas, said areas including the patient's heart and/or lungs. The mechanical waves are delivered for the purpose of treating fibrillation or like arrhythmias, for enhancing lung gas exchange, enhancing cardiac muscle fiber relaxation, and enhancing coronary perfusion. Mechanical waves are generated in a frequency range of about 1,100,000 Hz, and preferably 1-50,000 Hz. The waves may be delivered continuously for short or long time periods, or may be controlled in timing either with respect to detected portions of a patient's heartbeat signal or in response to a detected event such as fibrillation. In one preferred embodiment, the implantable system includes a defibrillation shock generator and control for responding to a defibrillation event by first delivering a sequence of mechanical waves and then delivering an electrical defibrillation shock. In another embodiment, the system and method treat incipient fibrillation or arrhythmia by delivering mechanical waves of predetermined timing to the patient's heart and/or lungs. In a specific embodiment, mechanical waves are delivered through an array of transducers to the patient's atrial wall, to treat atrial fibrillation.
摘要翻译：提供了一种用于将亚音速机械波传送到一个或多个所选患者区域的植入系统和方法，所述区域包括患者的心脏和/或肺。输送机械波是为了治疗纤维性颤动或类似心律失常的目的，用于增强肺气体交换，增强心肌纤维松弛和增强冠状动脉灌注。在约1,100,000Hz，优选1-50,000Hz的频率范围内产生机械波。波浪可以连续递送短时间或长时间段，或者可以相对于患者的心跳信号的检测到的部分或响应于诸如原纤维化的检测到的事件在时间上进行控制。在一个优选实施例中，可植入系统包括除颤电击发生器和通过首先递送一系列机械波然后递送电除颤电击来响应除颤事件的控制。在另一个实施方案中，该系统和方法通过将预定时间的机械波输送给患者的心脏和/或肺来治疗初期纤维性颤动或心律失常。在具体实施例中，机械波通过换能器阵列传送到患者的心房壁，以治疗房颤。

4. 发明授权

US6110098A System and method of mechanical treatment of cardiac fibrillation 失效
标题翻译：心脏颤动的机械治疗系统和方法
公开(公告)号：US6110098A
公开(公告)日：2000-08-29
申请号：US769070
申请日：1996-12-18
申请人： Alexis Renirie , Vincent Schouten , Koen Weijand
发明人： Alexis Renirie , Vincent Schouten , Koen Weijand
IPC分类号： A61B17/00 , A61N1/39 , A61N7/00 , A61M1/12
CPC分类号： A61N7/00 , A61N1/3956 , A61B2017/00703 , A61N1/395
摘要： There is provided an implanted system and method for delivering subsonic mechanical waves to one or more selected patient areas, the areas including the patient's heart and/or lungs. The mechanical waves are delivered for the purpose of treating fibrillation or like arrhythmias, for enhancing lung gas exchange, enhancing cardiac muscle fiber relaxation, and enhancing coronary perfusion. Mechanical waves are generated in a frequency range of about 1-100,000 Hz, and preferably 1-50,000 Hz. The waves may be delivered continuously for short or long time periods, or may be controlled in timing either with respect to detected portions of a patient's heartbeat signal or in response to a detected event such as fibrillation. In one preferred embodiment, the implantable system includes a defibrillation shock generator and control for responding to a defibrillation event by first delivering a sequence of mechanical waves and then delivering an electrical defibrillation shock. In another embodiment, the system and method treat incipient fibrillation or arrhythmia by delivering mechanical waves of predetermined timing to the patient's heart and/or lungs. In a specific embodiment, mechanical waves are delivered through an array of transducers to the patient's atrial wall, to treat atrial fibrillation.
摘要翻译：提供了一种用于将亚音速机械波传送到一个或多个所选患者区域的植入系统和方法，所述区域包括患者的心脏和/或肺。输送机械波是为了治疗纤维性颤动或类似心律失常的目的，用于增强肺气体交换，增强心肌纤维松弛和增强冠状动脉灌注。在约1-100,000Hz，优选1-50,000Hz的频率范围内产生机械波。波浪可以连续递送短时间或长时间段，或者可以相对于患者的心跳信号的检测到的部分或响应于诸如原纤维化的检测到的事件在时间上进行控制。在一个优选实施例中，可植入系统包括除颤电击发生器和通过首先递送一系列机械波然后递送电除颤电击来响应除颤事件的控制。在另一个实施方案中，该系统和方法通过将预定时间的机械波输送给患者的心脏和/或肺来治疗初期纤维性颤动或心律失常。在具体实施例中，机械波通过换能器阵列传送到患者的心房壁，以治疗房颤。

5. 发明申请

US20070055324A1 Multi-mode coordinator for medical device function 审中-公开
标题翻译：用于医疗器械功能的多模式协调器
公开(公告)号：US20070055324A1
公开(公告)日：2007-03-08
申请号：US11554212
申请日：2006-10-30
申请人： David Thompson , Koen Weijand , Daniel Greeninger
发明人： David Thompson , Koen Weijand , Daniel Greeninger
IPC分类号： A61N1/36
CPC分类号： A61N1/37252 , H04B1/385 , H04B1/401 , Y10S128/903
摘要： The invention is directed to an externally applied coordinator for communication and/or control of 2 or more implantable medical devices that may utilize different telemetry communication techniques. The coordinator receives telemetry signals from 2 or more implantable medical devices and provides functional direction to each of the devices to provide coordinated therapy and/or diagnostic function. The coordinator automatically configures itself for communication with a given medical device based either on the telemetry signal it receives or programmed by the physician. Specifically the coordinator is implemented as a software based, power efficient receiver/transmitter based upon an inexpensive, simple motor-controller DSP.
摘要翻译：本发明涉及用于通信和/或控制可以利用不同遥测通信技术的2个或更多个可植入医疗设备的外部应用协调器。协调器接收来自2个或更多可植入医疗装置的遥测信号，并为每个装置提供功能方向，以提供协调的治疗和/或诊断功能。协调器根据医生接收或编程的遥测信号，自动配置自身以与给定的医疗设备进行通信。具体来说，协调器是基于一个基于软件的功率高效的接收机/发射机，基于廉价的简单的电机控制器DSP。

6. 发明授权

US5772605A System and method for detecting facial symmetry 失效
标题翻译：用于检测面部对称的系统和方法
公开(公告)号：US5772605A
公开(公告)日：1998-06-30
申请号：US768686
申请日：1996-12-18
申请人： Koen Weijand
发明人： Koen Weijand
IPC分类号： A61B5/053 , A61B5/00
CPC分类号： A61B5/0531
摘要： There is provided a system and method for detecting facial symmetry of patients with hemiparesis, or unilateral facial palsy, by facial impedance measurement which quantifies lack of facial symmetry and thereby provides a program for therapeutic stimulus of paralyzed facial muscles. A mid-line of facial current is generated between an upper electrode above the eyes and a lower electrode on the chin, the facial current being sub-threshold so as to avoid any muscle stimulus. Impedance measurements are taken by determining the voltage between symmetrically placed facial electrodes, or between electrode pairs consisting of one electrode positioned around the eye, cheek or mouth, and a reference electrode placed on the patient's chin so as to provide an effective bottom point of the Wheatstone bridge formed by the face. The voltage measurements translate into impedance measurements which are indicative of muscle paralysis, and provide a simple but reliable method of obtaining objective data useful for facial movement assessment. Objective current can be either sinusoidal or a train of pulses. In one specific embodiment, the measurement subsystem comprises a sigma-delta loop which includes the patient's face as a signal domain; the phase of the injected current is modulated in a manner similar to the negative feedback branch of a standard sigma-delta loop circuit, thereby providing a digital output which is relatively free of signal artifacts.
摘要翻译：提供了一种用于通过面部阻抗测量来检测偏瘫或单侧面部麻痹患者的面部对称性的系统和方法，其量化了面部对称性的缺乏，从而为瘫痪的面部肌肉的治疗刺激提供了程序。在眼睛上方的上部电极和下巴的下部电极之间产生面线电流的中线，面部电流为次阈值，以避免任何肌肉刺激。通过确定对称放置的面部电极之间的电压或由围绕眼睛，脸颊或嘴部的一个电极组成的电极对和放置在患者的下巴上的参考电极之间的电压进行阻抗测量，以便提供有效的底点惠斯通电桥由脸形成。电压测量转化为阻抗测量值，它们表示肌肉瘫痪，并提供一种简单而可靠的方法来获得有用的面部运动评估的客观数据。客观电流可以是正弦波或一串脉冲。在一个具体实施例中，测量子系统包括包括患者面部作为信号域的Σ-Δ回路; 以类似于标准Σ-Δ环路电路的负反馈支路的方式调制注入电流的相位，从而提供相对没有信号伪影的数字输出。

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