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1. 发明授权

US09556216B2 2′-Ethynyl nucleoside derivatives for treatment of viral infections 有权
标题翻译：用于治疗病毒感染的2'-乙炔基核苷衍生物
公开(公告)号：US09556216B2
公开(公告)日：2017-01-31
申请号：US14421249
申请日：2013-08-27
申请人： Sampath-Kumar Anandan , Virender Singh Aulakh , Martijn Fenaux , Xiaodong Lin , Liang Mao , Oliver Saunders , Zachary Kevin Sweeney , Fumiaki Yokokawa , Weidong Zhong
发明人： Sampath-Kumar Anandan , Virender Singh Aulakh , Martijn Fenaux , Xiaodong Lin , Liang Mao , Oliver Saunders , Zachary Kevin Sweeney , Fumiaki Yokokawa , Weidong Zhong
IPC分类号： C07H19/10 , A61K31/7072 , A61K31/7068 , A61K45/06
CPC分类号： A61K31/7072 , A61K31/7068 , A61K45/06 , A61K47/22 , C07H19/06 , C07H19/067 , C07H19/10
摘要： The present invention provides a compound of formula A: or a pharmaceutically acceptable salt thereof, wherein B, Q, R1, R5, R6, R7, R8 and Z are as defined herein, which is a 2′-branched nucleoside useful for the treatment or prevention of viral infections, particularly dengue fever, yellow fever, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, Kunjin virus, Murray Valley encephalitis, St Louis encephalitis, Omsk hemorrhagic fever virus, bovine viral diarrhea virus, Zika virus and Hepatitis C virus.
摘要翻译：本发明提供式A化合物或其药学上可接受的盐，其中B，Q，R 1，R 5，R 6，R 7，R 8和Z如本文所定义，其为可用于治疗的2'-支链核苷或预防病毒感染，特别是登革热，黄热病，西尼罗病毒，日本脑炎病毒，蜱传脑炎病毒，昆金病毒，墨累谷脑炎，圣路易脑炎，鄂木斯克出血热病毒，牛病毒性腹泻病毒，Zika病毒和丙型肝炎病毒。

2. 发明申请

US20150306172A1 CYCLIC PEPTIDES AND USE AS MEDICINES 审中-公开
标题翻译：循环肽和用作药物
公开(公告)号：US20150306172A1
公开(公告)日：2015-10-29
申请号：US14717872
申请日：2015-05-20
申请人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
发明人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
IPC分类号： A61K38/13 , A61K45/06 , C07K7/64
CPC分类号： A61K38/13 , A61K38/12 , A61K45/06 , C07K7/64 , C07K7/645 , A61K2300/00
摘要： The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, and A-B are as defined herein, which are non-immunosuppressive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.
摘要翻译：本发明提供式I化合物; 或其药学上可接受的盐，其中R1，R2，R3，R4，R5和AB如本文所定义，其为非免疫抑制性，亲环蛋白结合，mPTP阻断剂，因此可用于预防或治疗疾病或病症例如HCV感染，中风，多发性硬化，HBV感染，HPV感染，哮喘，癌症，肌营养不良，败血症，缺血/再灌注损伤和心力衰竭。

3. 发明授权

US09072696B2 Cyclic peptides and use as medicines 有权
标题翻译：循环肽并用作药物
公开(公告)号：US09072696B2
公开(公告)日：2015-07-07
申请号：US14037644
申请日：2013-09-26
申请人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
发明人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
IPC分类号： A61K38/12 , C07K7/64 , A61K45/06
CPC分类号： A61K38/13 , A61K38/12 , A61K45/06 , C07K7/64 , C07K7/645 , A61K2300/00
摘要： The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein the variables R1, R2, R3, R4, R5, and A-B are defined herein, which are non-immunosuppresive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.
摘要翻译：本发明提供式I化合物; 或其药学上可接受的盐，其中本文定义的变量R1，R2，R3，R4，R5和AB是非免疫抑制性亲环蛋白结合的mPTP阻断剂，因此可用于预防或治疗疾病或疾病如HCV感染，中风，多发性硬化，HBV感染，HPV感染，哮喘，癌症，肌营养不良，败血症，缺血/再灌注损伤和心力衰竭。

4. 发明授权

US08063064B2 Non-nucleoside reverse transcriptase inhibitors 有权
标题翻译：非核苷逆转录酶抑制剂
公开(公告)号：US08063064B2
公开(公告)日：2011-11-22
申请号：US12708466
申请日：2010-02-18
申请人： Joshua Kennedy-Smith , Wylie Solang Palmer , Zachary Kevin Sweeney
发明人： Joshua Kennedy-Smith , Wylie Solang Palmer , Zachary Kevin Sweeney
IPC分类号： C07D471/04 , A61K31/437 , A61P31/18
CPC分类号： C07D471/04 , C07D231/12 , C07D231/56 , C07D487/04
摘要： The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein A is A2 and R1, R2, R3, R4a, R4b, R5, R6, Ar, X1, X2, X4, X4 and X5 are as herein defined. Also disclosed in the present invention are methods of treating an HIV infection with compounds defined herein and pharmaceutical compositions containing said compounds.
摘要翻译：本发明提供了可用于治疗HIV感染或预防HIV感染或治疗AIDS或ARC的化合物。本发明化合物是式Ⅰ化合物，其中A是A2，R 1，R 2，R 3，R 4a，R 4b，R 5，R 6，Ar，X 1，X 2，X 4，X 4和X 5如本文所定义。本发明还公开了用本文定义的化合物治疗HIV感染的方法和含有所述化合物的药物组合物。

5. 发明申请

US20110059975A1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS 有权
标题翻译：非核苷酸逆转录酶抑制剂
公开(公告)号：US20110059975A1
公开(公告)日：2011-03-10
申请号：US12708466
申请日：2010-02-18
申请人： Joshua Kennedy-Smith , Wylie Solang Palmer , Zachary Kevin Sweeney
发明人： Joshua Kennedy-Smith , Wylie Solang Palmer , Zachary Kevin Sweeney
IPC分类号： A61K31/5025 , C07D231/12 , A61K31/415 , C07D231/56 , A61K31/416 , C07D471/04 , A61K31/437 , C07D487/04 , A61K31/519 , A61K31/4985 , C07D237/24 , A61K31/50 , A61P31/18
CPC分类号： C07D471/04 , C07D231/12 , C07D231/56 , C07D487/04
摘要： The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein A is A2 and R1, R2, R3, R4a, R4b, R5, R6, Ar, X1, X2, X4, X4 and X5 are as herein defined. Also disclosed in the present invention are methods of treating an HIV infection with compounds defined herein and pharmaceutical compositions containing said compounds.
摘要翻译：本发明提供了可用于治疗HIV感染或预防HIV感染或治疗AIDS或ARC的化合物。本发明化合物是式Ⅰ化合物，其中A是A2，R 1，R 2，R 3，R 4a，R 4b，R 5，R 6，Ar，X 1，X 2，X 4，X 4和X 5如本文所定义。本发明还公开了用本文定义的化合物治疗HIV感染的方法和含有所述化合物的药物组合物。

6. 发明授权

US07778111B2 Methods and systems for underwater navigation 有权
标题翻译：水下导航方法与系统
公开(公告)号：US07778111B2
公开(公告)日：2010-08-17
申请号：US12051740
申请日：2008-03-19
申请人： Wesley J. Hawkinson , Kevin Sweeney , Randolph G. Hartman
发明人： Wesley J. Hawkinson , Kevin Sweeney , Randolph G. Hartman
IPC分类号： G01S15/88
CPC分类号： G01S15/60 , G01C21/165 , G01S15/025 , G01S15/06 , Y02A90/36
摘要： A method for navigating underwater is disclosed. The method uses a navigation system to project a first velocity measurement along one or more signal beams having a second velocity measurement, where the second velocity measurement is related to at least one of the one or more signal beams. The method determines a position and location of an object associated with the navigation system based on a prediction of at least the second velocity measurement, and the navigation system is adjusted to perform within a prescribed measurement range based on a covariance of the first and second velocity measurements. The performance adjustments made in determining the position and location of the object are operable independent of the navigation system maintaining each of the signal beams due to one or more external environmental conditions.
摘要翻译：公开了一种导航水下的方法。该方法使用导航系统沿着具有第二速度测量的一个或多个信号波束投影第一速度测量，其中第二速度测量与所述一个或多个信号波束中的至少一个相关。该方法基于至少第二速度测量的预测来确定与导航系统相关联的对象的位置和位置，并且基于第一和第二速度的协方差来调整导航系统在规定的测量范围内执行测量。在确定物体的位置和位置时进行的性能调整可独立于由于一个或多个外部环境条件维持每个信号光束的导航系统而操作。

7. 发明申请

US20100070055A1 CONTROL OF CONCEPT ZONES 有权
标题翻译：控制概念区
公开(公告)号：US20100070055A1
公开(公告)日：2010-03-18
申请号：US12544438
申请日：2009-08-20
申请人： Magnus KENNEDY , Kevin SWEENEY , Jon WILLIAMSON
发明人： Magnus KENNEDY , Kevin SWEENEY , Jon WILLIAMSON
IPC分类号： G06F17/00 , G05D23/19
CPC分类号： H04L12/282 , G05B15/02 , G05B19/0426 , H04L2012/285
摘要： There is provided a method, apparatus and computer program product for controlling parameters of objects in a building control system, the method comprising receiving input from at least one of the objects, wherein the at least one object is associated with a first subset of objects; selecting at least one parameter, wherein the at least one parameter depends on the input; selecting a second subset of objects from the objects, wherein the objects of the second subset are selected based on the at least one selected parameter; and performing a first action on objects in the second subset of objects.
摘要翻译：提供了一种用于控制建筑物控制系统中的对象的参数的方法，装置和计算机程序产品，所述方法包括从至少一个对象接收输入，其中所述至少一个对象与对象的第一子集相关联; 选择至少一个参数，其中所述至少一个参数取决于所述输入; 从所述对象中选择对象的第二子集，其中基于所述至少一个所选参数选择所述第二子集的对象; 以及对对象的第二子集中的对象执行第一动作。

8. 发明授权

US07625949B2 Methods for treating retroviral infections 有权
标题翻译：治疗逆转录病毒感染的方法
公开(公告)号：US07625949B2
公开(公告)日：2009-12-01
申请号：US11112590
申请日：2005-04-22
申请人： James Patrick Dunn , Donald Roy Hirschfeld , Tania Silva , Zachary Kevin Sweeney , Harit Vora
发明人： James Patrick Dunn , Donald Roy Hirschfeld , Tania Silva , Zachary Kevin Sweeney , Harit Vora
IPC分类号： A61K31/18 , A61K31/165 , A61K31/33 , A61K31/497 , A61K31/435 , A61K31/44 , A61K31/40 , A61K31/405
CPC分类号： A61K31/277
摘要： The present invention provides compounds for treating or preventing an HIV infection, or treating AIDS or ARC comprising administering a compound according to formula I where Ar, R1-R5, R11c and X1 are as defined herein.
摘要翻译：本发明提供用于治疗或预防HIV感染或治疗AIDS或ARC的化合物，其包括给予式I化合物，其中Ar，R 1 -R 5，R 11c和X 1如本文所定义。

9. 发明授权

US07625897B2 Non-nucleoside reverse transcriptase inhibitors 失效
标题翻译：非核苷逆转录酶抑制剂
公开(公告)号：US07625897B2
公开(公告)日：2009-12-01
申请号：US11541011
申请日：2006-09-29
申请人： Yoshihito David Saito , Mark Smith , Zachary Kevin Sweeney
发明人： Yoshihito David Saito , Mark Smith , Zachary Kevin Sweeney
IPC分类号： C07D253/06 , A61K31/53 , A61P31/18
CPC分类号： C07D237/04 , C07D237/02 , C07D253/06 , C07D253/07 , C07D273/04
摘要： The present invention provides compounds of formula I where R1 to R4 are as defined herein which are useful for treating or preventing an human immunodeficiency virus (HIV) infection, or treating AIDS or ARC. The invention further provides for methods of treating or preventing HIV infection with compounds according to formula I and compositions containing the same. The invention still further provides process for the preparation of compounds of formula I wherein R4 is A1 and X1 is NH or O.
摘要翻译：本发明提供式I化合物，其中R 1至R 4如本文所定义，其可用于治疗或预防人类免疫缺陷病毒（HIV）感染或治疗AIDS或ARC。本发明进一步提供了用式I化合物和含有该化合物的组合物治疗或预防HIV感染的方法。本发明还提供制备其中R 4为Al且X 1为NH或O的式I化合物的方法。

10. 发明申请

US20090170856A1 HETEROCYCLIC ANTIVIRAL COMPOUNDS 有权
标题翻译：杂环抗病毒化合物
公开(公告)号：US20090170856A1
公开(公告)日：2009-07-02
申请号：US12341594
申请日：2008-12-22
申请人： Roland Joseph Billedeau , Zachary Kevin Sweeney
发明人： Roland Joseph Billedeau , Zachary Kevin Sweeney
IPC分类号： A61K31/437 , C07D471/04 , C07D487/04 , A61K31/5025 , A61P31/18
CPC分类号： C07D471/04 , C07D487/04
摘要： Compounds of formula I, wherein R1, R2, R3, X1, X2 and Ar, are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.
摘要翻译：其中R 1，R 2，R 3，X 1，X 2和Ar如本文所定义或其药学上可接受的盐的式I化合物抑制HIV-1逆转录酶，并提供预防和治疗HIV-1感染和治疗的方法的艾滋病和/或ARC。本发明还涉及含有用于预防和治疗HIV-1感染和治疗AIDS和/或ARC的式I化合物的组合物。

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