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    • 5. 发明授权
    • Crystallization device
    • 结晶装置
    • US08876972B2
    • 2014-11-04
    • US11879694
    • 2007-07-17
    • Tomokazu HasegawaKensaku HamadaMasaru SatoMoritoshi Motohara
    • Tomokazu HasegawaKensaku HamadaMasaru SatoMoritoshi Motohara
    • C30B29/58B01D9/00
    • B01D9/005
    • A crystallization device is for protein crystallization with a small amount of a sample in the liquid to liquid diffusion method. It is easy to fill the device with protein solution and precipitant solution and easy to pick up grown crystals from the device. The device comprises a channel plate made of polydimethylsiloxane (PDMS) and the first and second cover sheets made of polyethylene terephthalate. The channel plate includes at least one elongated channel having one side which extends in the longitudinal direction of the channel, the one side being exposed at the bottom surface of the channel plate. The channel has both ends which communicate with a protein solution inlet and a precipitant solution inlet respectively. The channel also communicates midway with a gel inlet and a vent hole. When picking up grown crystals from the device, the second cover sheet is cut off with a cutter knife so that the channel is exposed.
    • 结晶装置用于在液体/液体扩散方法中用少量样品进行蛋白质结晶。 使用蛋白质溶液和沉淀剂溶液容易填充设备,并容易从设备中取出生长的晶体。 该装置包括由聚二甲基硅氧烷(PDMS)制成的通道板和由聚对苯二甲酸乙二醇酯制成的第一和第二覆盖片。 通道板包括至少一个细长通道,其具有在通道的纵向方向上延伸的一侧,一侧在通道板的底表面处露出。 通道的两端分别与蛋白质溶液入口和沉淀剂溶液入口分别连通。 该通道还与凝胶入口和通气孔中途连通。 当从设备拾起生长的晶体时,用切割刀切割第二覆盖片,使得通道暴露。
    • 8. 发明申请
    • Crystallization device
    • 结晶装置
    • US20080019888A1
    • 2008-01-24
    • US11879694
    • 2007-07-17
    • Tomokazu HasegawaKensaku HamadaMasaru SatoMoritoshi Motohara
    • Tomokazu HasegawaKensaku HamadaMasaru SatoMoritoshi Motohara
    • B01D9/02
    • B01D9/005
    • A crystallization device is for protein crystallization with a small amount of a sample in the liquid to liquid diffusion method. It is easy to fill the device with protein solution and precipitant solution and easy to pick up grown crystals from the device. The device comprises a channel plate made of polydimethylsiloxane (PDMS) and the first and second cover sheets made of polyethylene terephthalate. The channel plate includes at least one elongated channel having one side which extends in the longitudinal direction of the channel, the one side being exposed at the bottom surface of the channel plate. The channel has both ends which communicate with a protein solution inlet and a precipitant solution inlet respectively. The channel also communicates midway with a gel inlet and a vent hole. When picking up grown crystals from the device, the second cover sheet is cut off with a cutter knife so that the channel is exposed.
    • 结晶装置用于在液体/液体扩散方法中用少量样品进行蛋白质结晶。 使用蛋白质溶液和沉淀剂溶液容易填充设备,并容易从设备中取出生长的晶体。 该装置包括由聚二甲基硅氧烷(PDMS)制成的通道板和由聚对苯二甲酸乙二醇酯制成的第一和第二覆盖片。 通道板包括至少一个细长通道,其具有在通道的纵向方向上延伸的一侧,一侧在通道板的底表面处露出。 通道的两端分别与蛋白质溶液入口和沉淀剂溶液入口分别连通。 该通道还与凝胶入口和通气孔中途连通。 当从设备拾起生长的晶体时,用切割刀切割第二覆盖片,使得通道暴露。