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1. 发明申请

US20050199574A1 Tamper-indicating closure, package and method of manufacture 有权
标题翻译：防篡改封闭件，包装和制造方法
公开(公告)号：US20050199574A1
公开(公告)日：2005-09-15
申请号：US10799114
申请日：2004-03-11
申请人： Kenneth Bloom , Stephen Eilertson , Wendell Willingham
发明人： Kenneth Bloom , Stephen Eilertson , Wendell Willingham
IPC分类号： B65D41/34
CPC分类号： B65D41/3409
摘要： A tamper-indicating closure that includes a base wall having a cylindrical skirt for removably engaging a container finish. A tamper band is frangibly connected to the skirt, and a plurality of wings extend inwardly from an inner surface of the tamper band for engagement with a container finish. The wings are resiliently flexibly connected to the inner surface of the band along lines that are disposed at a counterclockwise angle with respect to the axis of the skirt as viewed from inside the skirt.
摘要翻译：一种防窜改封闭件，其包括具有圆筒形裙部的底壁，用于可拆卸地接合容器端面。窜改带易于连接到裙部，并且多个翼从篡改带的内表面向内延伸，用于与容器饰面接合。翼部沿着从裙部内侧观察时相对于裙部的轴线以逆时针方向设置的线弹性地柔性地连接到带的内表面。

2. 发明申请

US20060278601A1 Plastic closure, closure and container package, and method of manufacture 审中-公开
标题翻译：塑料封闭，容器包装及其制造方法
公开(公告)号：US20060278601A1
公开(公告)日：2006-12-14
申请号：US11150738
申请日：2005-06-10
申请人： Kenneth Bloom , Paul Graham
发明人： Kenneth Bloom , Paul Graham
IPC分类号： B65D45/00 , B65D45/32 , B65D53/00
CPC分类号： B65D51/145 , B29C45/1615 , B29C45/1635 , B29L2031/265 , B29L2031/56 , B29L2031/565 , B65D41/045
摘要： A method of making a closure having an end panel and a sealing liner on one face of the end panel includes providing an injection mold having at least first and second mold elements, at least one of which is movable with respect to the other. The first and second mold elements are positioned to form a first mold cavity, and the end panel is injection molded within the first mold cavity. At least one of the first and second mold elements then is moved to form a second mold cavity in which a face of the end panel forms at least one mold cavity wall, and the sealing liner is injection molded onto the face of the end panel. The end panel and liner are then removed from the second mold cavity. The liner/disk subassembly thus is provided more easily and economically than if the liner were compression molded in situ onto the undersurface of a separately formed disk. The closure preferably is a two-piece closure, and the method preferably includes the step of assembling the end panel to a separately formed closure shell.
摘要翻译：在端板的一个面上制造具有端板和密封衬套的封闭件的方法包括提供具有至少第一和第二模具元件的注塑模具，其中至少一个模具元件可相对于另一个元件移动。第一和第二模具元件被定位成形成第一模具腔，并且端板在第一模腔内被注射模制。然后第一和第二模具元件中的至少一个被移动以形成第二模腔，其中端板的表面形成至少一个模腔壁，并且将密封衬套注塑到端板的表面上。然后将端板和衬套从第二模腔中取出。因此，如果衬垫在原位压缩成型到单独形成的盘的下表面上，则衬垫/盘子组件被更容易和经济地提供。封闭件优选地是两件式封闭件，并且该方法优选地包括将端板组装到单独形成的封闭壳体的步骤。

3. 发明申请

US20060201976A1 Integrally molded dispensing valve and method of manufacture 有权
公开(公告)号：US20060201976A1
公开(公告)日：2006-09-14
申请号：US11076376
申请日：2005-03-09
申请人： Kenneth Bloom , Brian Brozell , Darin Pugne
发明人： Kenneth Bloom , Brian Brozell , Darin Pugne
IPC分类号： B65D35/38
CPC分类号： B65D47/2031
摘要： A dispensing valve includes an annular ring of relatively rigid molded plastic construction and a flexible resilient valve element integrally molded with the ring. The ring and the valve element have at least one mechanical interlock to secure the valve element to the ring as the valve element is molded onto the ring. In some embodiments of the disclosure, the mechanical interlock includes openings in an inner periphery of the ring and pegs on the outer periphery of the valve element that are molded into the openings as the valve element is molded onto the ring.

4. 发明申请

US20050098529A1 Plastic closure, closure and container package, and method of manufacture 有权
公开(公告)号：US20050098529A1
公开(公告)日：2005-05-12
申请号：US11017179
申请日：2004-12-20
申请人： Kenneth Bloom , Stephen Eilertson
发明人： Kenneth Bloom , Stephen Eilertson
IPC分类号： B65B55/24 , B65D51/14 , B65D45/32
CPC分类号： B65D51/145 , B65B55/24
摘要： A plastic closure includes a plastic closure shell having a base wall with a central opening and a skirt with at least one internal thread or bead for securing the closure to a container finish. A plastic disk is retained within the shell parallel to but spaced from the base wall. The disk includes a plurality of axially extending spacer elements around the disk to engage the undersurface of the base wall and space the disk from the base wall of the shell, and angularly spaced fingers extending from the disk through the central opening of the base wall to retain the disk within the shell. A resilient liner is disposed on an underside of the disk for sealing engagement with the container finish.

5. 发明申请

US20090111139A1 Diagnostic technique for determining oncogenic signature indicative of tumorous growth 审中-公开
标题翻译：用于确定指示肿瘤生长的致癌特征的诊断技术
公开(公告)号：US20090111139A1
公开(公告)日：2009-04-30
申请号：US11929858
申请日：2007-10-30
申请人： Kenneth Bloom , Gary Fogel , Jose DeLa Torre Bueno
发明人： Kenneth Bloom , Gary Fogel , Jose DeLa Torre Bueno
IPC分类号： C12Q1/02 , G06G7/58
CPC分类号： G01N33/574 , G01N33/6842 , G01N2800/52 , G16B5/00 , G16B25/00
摘要： A priori knowledge is obtained from known tumor samples, indicative of cellular pathways associated with those known tumor samples. Multiple pathways are found for each tumor. This becomes a priori knowledge. Later unknown tumor samples are then analyzed against the a priori knowledge to find the pathways etc within the unknown tumor samples. Multiple pathways are collected to form an oncogenic signature. The oncogenic signature is used to find a cocktail of multiple treatments that treats each of the multiple pathways.
摘要翻译：从已知肿瘤样品获得先前的知识，指示与已知肿瘤样品相关的细胞途径。发现每个肿瘤的多个途径。这成为先验知识。然后根据先验知识分析未知肿瘤样品，以找到未知肿瘤样品中的途径等。收集多个途径以形成致癌标记。致癌标记用于找到治疗多个途径中的每一个的多种治疗的混合物。

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