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1. 发明申请

US20080300227A1 Drugs for treating hypertension combined with hyperuricemia and/or hypercholesterolemia 审中-公开
标题翻译：用于治疗高血压与高尿酸血症和/或高胆固醇血症的药物
公开(公告)号：US20080300227A1
公开(公告)日：2008-12-04
申请号：US12221385
申请日：2008-08-01
申请人： Akira Tomiyama , Hiroshi Tomiyama , Hidetoshi Miyamoto , Keiichoro Hayashi , Seiichiro Mochizuki
发明人： Akira Tomiyama , Hiroshi Tomiyama , Hidetoshi Miyamoto , Keiichoro Hayashi , Seiichiro Mochizuki
IPC分类号： A61K31/56 , A61K31/41 , A61K31/5415 , A61P9/12 , A61K31/498 , A61K31/4965
CPC分类号： A61K31/4184
摘要： The invention is directed to a drug for treating hypertension combined with serum hyperuricemia and/or hypercholesterolemia, with the active ingredients being 2-propyl-3-{[21-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}-5,6,7, 8-tetrahydrocyclohepta imidazole-4-(3H)-one and a prodrug or salt thereof. Pratosartan can be used in combination with one or more diuretics chosen from sulfonamide-, phenoxyacetic acid- and thiazide-type diuretics, triamterene, amiloride, spironolactone, potassium canrenoate and traxanox sodium. Also, pratosartan can be used in combination with one or more hypolipidemic drugs chosen from statins, fibrates, cholesterol absorption inhibitors, cholesterol sequestrants and cholesterol excretion enhancers.
摘要翻译：本发明涉及一种用于治疗高血压与血清高尿酸血症和/或高胆固醇血症联合的药物，其中活性成分是2-丙基-3 - {[21-（1H-四唑-5-基）联苯-4-基]甲基 } -5,6,7,8-四氢环庚基咪唑-4-（3H） - 酮及其前药或盐。普拉托沙坦可与一种或多种选自磺酰胺，苯氧基乙酸和噻嗪类利尿剂，三氯硝苯胺，阿米洛利，螺内酯，坎培硝酸钾和曲霉素钠的利尿剂组合使用。此外，普拉沙沙坦可与一种或多种选自他汀类，贝特类，胆固醇吸收抑制剂，胆固醇多价螯合剂和胆固醇排泄增强剂的降血脂药联合使用。

2. 发明申请

US20070254932A1 Drugs for Treating Duplication of Hypertension With Hyperuricemia and/or Hypercholesterolemia 审中-公开
标题翻译：用于治疗高尿酸血症和/或高胆固醇血症复发高血压药物
公开(公告)号：US20070254932A1
公开(公告)日：2007-11-01
申请号：US11629689
申请日：2004-10-13
申请人： Akira Tomiyama , Hiroshi Tomiyama , Hidetoshi Miyamoto , Keiichoro Hayashi , Seiichiro Mochizuki
发明人： Akira Tomiyama , Hiroshi Tomiyama , Hidetoshi Miyamoto , Keiichoro Hayashi , Seiichiro Mochizuki
IPC分类号： A61K31/41 , A61P25/20
CPC分类号： A61K31/4184
摘要： The purpose in this invention is to providing drugs for treating or preventing duplication of hypertension with serum hyperuricemia and/or hypercholesterolemia that is much frequency among the duplication onset in geriatric diseases. This invention is related to drugs for treating or preventing duplication of hypertension with serum hyperuricemia and/or hypercholesterolemia of which active principles are 2-propyl-3-{[2′-(1H-tetrazole-5-yl) biphenyl 4-yl]methyl}-5,6,7,8-tetrahydrocyclohepta imidazole-4-(3H)-one and that prodrug or that salt. Pratosartan is able to use in combination with one or more than two diuretics chosen from sulfonamide-, phenoxyacetic acid- and thiazide-type diuretics, triamterene, amiloride, spironolactone, potassium canrenoate and traxanox sodium. Also, pratosartan is able to use in combination with one or more than two hypolipidemic drugs chosen from statins, fibrates, cholesterol absorption inhibitors, cholesterol sequestrants and cholesterol excretion enhancers.
摘要翻译：本发明的目的是提供用于治疗或预防高血压与血清高尿酸血症和/或高胆固醇血症重复的药物，其在老年疾病的重复发作中频率很高。本发明涉及用于治疗或预防高血压与血清高尿酸血症和/或高胆固醇血症重叠的药物，其活性成分为2-丙基-3 - {[2' - （1H-四唑-5-基）联苯-4-基] 甲基} -5,6,7,8-四氢环庚基咪唑-4-（3H） - 酮，该前药或该盐。普拉托沙坦能够与选自磺酰胺，苯氧基乙酸和噻嗪类利尿剂，三氯硝苯胺，阿米洛利，螺内酯，甘蔗酸钾和曲霉素钠的一种或两种以上的利尿剂组合使用。此外，普拉沙沙坦能够与选自他汀类，贝特类，胆固醇吸收抑制剂，胆固醇多价螯合剂和胆固醇排泄增强剂的一种或两种以上降血脂药联合使用。

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