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1. 发明授权

US07348170B2 Fungus-origin lysyl oxidases 失效
标题翻译：真菌来源的赖氨酰氧化酶
公开(公告)号：US07348170B2
公开(公告)日：2008-03-25
申请号：US10498517
申请日：2002-12-25
申请人： Kensuke Yuuki , Atsuki Toumoto , Masayuki Machida , Keietsu Abe , Katsuya Gomi , Kiyoshi Asai , Motoaki Sano , Taishin Kin , Hideki Nagasaki , Akira Hosoyama , Osamu Akita , Naotake Ogasawara , Satoru Hisahara
发明人： Kensuke Yuuki , Atsuki Toumoto , Masayuki Machida , Keietsu Abe , Katsuya Gomi , Kiyoshi Asai , Motoaki Sano , Taishin Kin , Hideki Nagasaki , Akira Hosoyama , Osamu Akita , Naotake Ogasawara , Satoru Hisahara
IPC分类号： C12N9/02 , C12N15/00 , C12N1/00 , C12P21/06 , C07H21/04
CPC分类号： C12N9/80 , C12N9/0022 , C12N9/48 , C12P21/06
摘要： Lysyl oxidase derived from filamentous fungi and a DNA encoding thereof are provided. Lysyl oxidase including a protein described in of the following (a) or (b): (a) a protein having an amino acid sequence set forth in SEQ ID NO: 2; or (b) a protein having an amino acid sequence obtained by modifying a part of the amino acid sequence set forth in SEQ ID NO: 2, and functioning as lysyl oxidase.
摘要翻译：提供衍生自丝状真菌的赖氨酰氧化酶及其编码的DNA。包含以下（a）或（b）所述的蛋白质的赖氨酰氧化酶：（a）具有SEQ ID NO：2所示的氨基酸序列的蛋白质; 或（b）具有通过修饰SEQ ID NO：2所示氨基酸序列的一部分而作为赖氨酰氧化酶起作用的氨基酸序列的蛋白质。

2. 发明授权

US6127161A Leucine aminopeptidase gene, recombinant DNA, and process for producing leucine aminopeptidase 失效
标题翻译：亮氨酸氨基肽酶基因，重组DNA，以及产生亮氨酸氨基肽酶的方法
公开(公告)号：US6127161A
公开(公告)日：2000-10-03
申请号：US330095
申请日：1999-06-11
申请人： Genryou Umitsuki , Keietsu Abe
发明人： Genryou Umitsuki , Keietsu Abe
IPC分类号： C12N15/09 , C12N1/15 , C12N9/48 , C12N15/00 , C12N15/57 , C12Q1/68 , C12R1/66 , C07H21/04 , C12N1/20
CPC分类号： C12N9/48
摘要： The present invention relates to an Aspergillus sojae leucine aminopeptidase gene or variants thereof, a recombinant DNA including the gene or the variants, and a process for producing leucine aminopeptidase using the recombinant DNA.
摘要翻译：本发明涉及一种Aspergillus sojae亮氨酸氨基肽酶基因或其变体，包含该基因或变体的重组DNA，以及使用重组DNA产生亮氨酸氨基肽酶的方法。

3. 发明授权

US07763444B2 Koji mold-origin phospholipase A2 失效
标题翻译： Koji霉菌源磷脂酶A2
公开(公告)号：US07763444B2
公开(公告)日：2010-07-27
申请号：US12489827
申请日：2009-06-23
申请人： Katsuhiko Kitamoto , Manabu Arioka , Shotaro Yamaguchi , Masayuki Machida , Keietsu Abe , Katsuya Gomi , Kiyoshi Asai , Motoaki Sano , Taishin Kin , Hideki Nagasaki , Akira Hosoyama , Osamu Akita , Naotake Ogasawara , Satoru Kuhara
发明人： Katsuhiko Kitamoto , Manabu Arioka , Shotaro Yamaguchi , Masayuki Machida , Keietsu Abe , Katsuya Gomi , Kiyoshi Asai , Motoaki Sano , Taishin Kin , Hideki Nagasaki , Akira Hosoyama , Osamu Akita , Naotake Ogasawara , Satoru Kuhara
IPC分类号： C12N1/15 , C12N15/74 , C07H21/00
CPC分类号： C12N9/20 , C12Y301/01004
摘要： It is intended to provide koji mold-origin phospholipase A2 and a DNA encoding it. Namely, phospholipase A2 comprising the following protein (a) or (b): (a) a protein having an amino acid sequence represented by SEQ ID NO: 1 or 2; and (b) a protein having an amino acid sequence derived from an amino acid sequence represented by SEQ ID NO: 1 or 2 by a partial modification and serving as phospholipase A2.
摘要翻译：旨在提供曲霉起源磷脂酶A2和编码它的DNA。即，包含以下蛋白质（a）或（b）的磷脂酶A2：（a）具有SEQ ID NO：1或2所示的氨基酸序列的蛋白质; 和（b）通过部分修饰具有源自SEQ ID NO：1或2所示的氨基酸序列的氨基酸序列并作为磷脂酶A2的蛋白质。

4. 发明申请

US20090263888A1 KOJI MOLD-ORIGIN PHOSPHOLIPASE A2 失效
标题翻译： KOJI MOLD-ORIGIN磷脂酶A2
公开(公告)号：US20090263888A1
公开(公告)日：2009-10-22
申请号：US12489827
申请日：2009-06-23
申请人： Katsuhiko Kitamoto , Manabu Arioka , Shotaro Yamaguchi , Masayuki Machida , Keietsu Abe , Katsuya Gomi , Kiyoshi Asai , Motoaki Sano , Taishin Kin , Hideki Nagasaki , Akira Hosoyama , Osamu Akita , Naotake Ogasawara , Satoru Kuhara
发明人： Katsuhiko Kitamoto , Manabu Arioka , Shotaro Yamaguchi , Masayuki Machida , Keietsu Abe , Katsuya Gomi , Kiyoshi Asai , Motoaki Sano , Taishin Kin , Hideki Nagasaki , Akira Hosoyama , Osamu Akita , Naotake Ogasawara , Satoru Kuhara
IPC分类号： C12N1/15 , C07H21/00 , C12N15/74
CPC分类号： C12N9/20 , C12Y301/01004
摘要： It is intended to provide koji mold-origin phospholipase A2 and a DNA encoding it. Namely, phospholipase A2 comprising the following protein (a) or (b): (a) a protein having an amino acid sequence represented by SEQ ID NO: 1 or 2; and (b) a protein having an amino acid sequence derived from an amino acid sequence represented by SEQ ID NO: 1 or 2 by a partial modification and serving as phospholipase A2.
摘要翻译：旨在提供曲霉起源磷脂酶A2和编码它的DNA。即，包含以下蛋白质（a）或（b）的磷脂酶A2：（a）具有SEQ ID NO：1或2所示的氨基酸序列的蛋白质; 和（b）通过部分修饰具有源自SEQ ID NO：1或2所示的氨基酸序列的氨基酸序列并作为磷脂酶A2的蛋白质。

5. 发明申请

US20060234320A1 Pyroglutamyl peptidase and its gene 审中-公开
标题翻译：焦谷氨酰肽酶及其基因
公开(公告)号：US20060234320A1
公开(公告)日：2006-10-19
申请号：US10500251
申请日：2002-12-26
申请人： Masayuki Machida , Keietsu Abe , Katsuya Gomi , Kiyoshi Asai , Motoaki Sano , Taishin Kin , Hideki Nagasaki , Akira Hosoyama , Osamu Akita , Naotake Ogasawara , Satoru Kuhara , Chikara Tokunaga , Itaru Toda , Chiaki Saitoh , Akihiro Senoh
发明人： Masayuki Machida , Keietsu Abe , Katsuya Gomi , Kiyoshi Asai , Motoaki Sano , Taishin Kin , Hideki Nagasaki , Akira Hosoyama , Osamu Akita , Naotake Ogasawara , Satoru Kuhara , Chikara Tokunaga , Itaru Toda , Chiaki Saitoh , Akihiro Senoh
IPC分类号： G01N33/569 , C07H21/04 , C12P21/06 , C12N9/50 , C12N15/74 , C12N1/16
CPC分类号： C12N9/80 , C12N9/0022 , C12N9/48 , C12P21/06
摘要： The present invention provides DNA encoding novel pyroglutamyl peptidase derived from Aspergillus oryzae, pyroglutamyl peptidase which is produced by using the DNA, and a method for producing a protein lysate with a good flavor at a high hydrolysis rate.
摘要翻译：本发明提供了编码来自米曲霉的新型焦谷氨酰肽酶的DNA，通过使用该DNA产生的焦谷氨酰肽酶，以及以高水解速率生产具有良好风味的蛋白质裂解物的方法。

6. 发明授权

US4722846A Novel variant and process for producing light colored soy sauce using such variant 失效
标题翻译：使用这种变体生产浅色酱油的新型和方法
公开(公告)号：US4722846A
公开(公告)日：1988-02-02
申请号：US720265
申请日：1985-04-05
申请人： Keietsu Abe , Hironaga Hashiba , Kinji Uchida
发明人： Keietsu Abe , Hironaga Hashiba , Kinji Uchida
IPC分类号： A23L27/50 , A23L1/238
CPC分类号： A23L27/50 , A23Y2280/35
摘要： A novel variant belonging to the genus Pediococcus which does not cause fermentation of D-glucose but causes fermentation of pentose, and a process for producing a light-colored soy sauce which comprises adding the variant in the koji preparation step or in the early stage of brewing of soy sauce moromi.
摘要翻译：属于不引起D-葡萄糖发酵但引起戊糖发酵的类球菌属的新型变体，以及生产浅色酱油的方法，其包括在曲曲制备步骤或早期阶段添加变体酿造酱油酱油。

7. 发明申请

US20050287634A1 Novel genes of cell wall-degrading enzymes derived from aspergillus, and method for the production the enzymes 失效
标题翻译：来自曲霉的细胞壁降解酶的新基因，以及生产酶的方法
公开(公告)号：US20050287634A1
公开(公告)日：2005-12-29
申请号：US11085185
申请日：2005-03-22
申请人： Masayuki Machida , Motoaki Sano , Misao Sunagawa , Tasuku Nakajima , Keietsu Abe , Katsuya Gomi , Kiyoshi Asai , Taishin Kin , Hideki Nagasaki , Akira Hosoyama , Osamu Akita , Naotake Ogasawara , Satoru Kuhara
发明人： Masayuki Machida , Motoaki Sano , Misao Sunagawa , Tasuku Nakajima , Keietsu Abe , Katsuya Gomi , Kiyoshi Asai , Taishin Kin , Hideki Nagasaki , Akira Hosoyama , Osamu Akita , Naotake Ogasawara , Satoru Kuhara
IPC分类号： C07H21/04 , C12N1/16 , C12N9/24 , C12N15/74 , C12P19/04 , C12P21/06
CPC分类号： C12P19/04 , C12N9/2405 , C12Y302/01039 , C12Y302/01058
摘要： The purpose of the present invention is to isolate a gene encoding novel exo-, or endo-β-1,3-glucanase, to obtain a microorganism having an enhanced expression of said gene and to degrade β-1,3-glucan to its low molecular weight form by means of said enzymes. The present invention relates to a gene or DNA encoding novel enzymes having β-1,3-glucanase activity (exo-, or endo-β-1,3-glucanase), a recombinant expression vector comprising them, a microorganism having the recombinant expression vector, the novel enzymes having β-1,3-glucanase activity, and a method for the production of said enzymes.
摘要翻译：本发明的目的是分离编码新的外切或内切-β-1,3-葡聚糖酶的基因，以获得具有增强的所述基因表达的微生物，并将β-1,3-葡聚糖降解为其低分子量形式通过所述酶。本发明涉及编码具有β-1,3-葡聚糖酶活性的新型酶（外切-β-1,3-葡聚糖酶）的基因或DNA，包含它们的重组表达载体，具有重组表达的微生物载体，具有β-1,3-葡聚糖酶活性的新型酶以及所述酶的生产方法。

8. 发明授权

US6162632A OxlT sequence and its use 失效
标题翻译： OxIT序列及其用途
公开(公告)号：US6162632A
公开(公告)日：2000-12-19
申请号：US30267
申请日：1998-02-25
申请人： Peter C. Maloney , Keietsu Abe , Zhong-Shi Ruan
发明人： Peter C. Maloney , Keietsu Abe , Zhong-Shi Ruan
IPC分类号： C07K14/195 , C12N1/20
CPC分类号： C07K14/195
摘要： A DNA sequence encoding a transport protein responsible for the physical movement of oxalate and formate across the plasma membrane is provided. The protein, OxlT, can be isolated from the gram negative anaerobe, Oxalobacter formigenes. The protein is part of the three protein oxalate/formate antiport exchange system that allows for conversion of extracellular oxalate to formate+CO.sub.2.The OxlT coding sequence can be used to provide a metabolic energy system to the cell. The system comprises the OxlT transport protein in combination with oxalylCoA decarboxylase and formyl-CoA transferase. Expression cassettes can be designed to express all or part of the system in a target host. Such energy generating systems can be used in industrial settings that utilize fermentation. The energy generating systems of the invention extend culture longevity and increase product yield.In another aspect of the invention, the OxlT coding sequence can be used in pharmaceutical compositions for manipulating serum oxalic acid levels in patients in need thereof. In this manner, liposomes comprising the energy generating system can be developed and administered to humans and other animals.
摘要翻译：提供编码负责草酸盐和甲酸盐穿过质膜的物理运动的转运蛋白的DNA序列。蛋白质OxlT可以从革兰氏阴性厌氧菌（Oxalobacter formigenes）中分离出来。蛋白质是三种蛋白质草酸盐/甲酸盐逆转录酶交换体系的一部分，允许将细胞外草酸转化为甲酸+二氧化碳。 OxlT编码序列可用于向细胞提供代谢能系统。该系统包含OxlT转运蛋白与草酰CoA脱羧酶和甲酰辅酶A转移酶的组合。表达盒可以设计成在目标主机中表达系统的全部或部分。这种能量产生系统可用于利用发酵的工业环境中。本发明的能量产生系统延长了养殖寿命，提高了产量。在本发明的另一方面，OxlT编码序列可用于在有需要的患者中操纵血清草酸水平的药物组合物中。以这种方式，可以开发包含能量产生系统的脂质体并将其施用于人和其他动物。

9. 发明授权

US09387175B2 Agent for evading immune response 有权
标题翻译：避免免疫反应的代理
公开(公告)号：US09387175B2
公开(公告)日：2016-07-12
申请号：US14238616
申请日：2012-08-03
申请人： Keietsu Abe , Kazuyoshi Kawakami , Tadafumi Ajiri , Manabu Fukumoto , Seiichi Takami , Takanari Togashi , Kimihide Muragaki , Toru Takahashi
发明人： Keietsu Abe , Kazuyoshi Kawakami , Tadafumi Ajiri , Manabu Fukumoto , Seiichi Takami , Takanari Togashi , Kimihide Muragaki , Toru Takahashi
IPC分类号： A61K38/16 , A61K9/16 , C01G49/08 , C09C1/24 , A61K49/18 , B82Y5/00 , B82Y40/00 , B22F1/00 , B82Y30/00
CPC分类号： A61K9/1676 , A61K38/168 , A61K49/1863 , B22F1/0018 , B22F1/0062 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C01G49/08 , C01P2004/62 , C01P2006/12 , C09C1/24
摘要： It has been found that modification of surfaces of nanoparticles with a RolA protein decreases an immunostimulation activity of the nanoparticles on myeloid dendritic cells and also decreases phagocytosis of the nanoparticles by macrophages. The present invention provides nanoparticles being modified with a biological molecule and having an immune-response evasion function.
摘要翻译：已经发现用RolA蛋白修饰纳米颗粒的表面降低了纳米颗粒在骨髓树突状细胞上的免疫刺激活性，并且还降低了巨噬细胞对纳米颗粒的吞噬作用。本发明提供了用生物分子修饰并具有免疫应答逃避功能的纳米颗粒。

10. 发明申请

US20120023616A1 METHODS FOR PREVENTING OR INHIBITING MICROBIAL INFECTION OF PLANTS AND PLANT EXHIBITING RESISTANCE TO MICROBIAL INFECTION 审中-公开
标题翻译：预防或抑制植物微生物感染和植物感染微生物感染的方法
公开(公告)号：US20120023616A1
公开(公告)日：2012-01-26
申请号：US13256904
申请日：2010-03-16
申请人： Marie Nishimura , Yoko Nishizawa , Takashi Fujikawa , Ichiro Mitsuhara , Eiichi Minami , Keietsu Abe , Takashi Tachiki , Shigekazu Yano
发明人： Marie Nishimura , Yoko Nishizawa , Takashi Fujikawa , Ichiro Mitsuhara , Eiichi Minami , Keietsu Abe , Takashi Tachiki , Shigekazu Yano
IPC分类号： A01H1/00 , A61K38/47 , C12N5/10 , A61P31/04 , A01H5/00 , A61K35/66 , A61P31/10 , A01H5/10 , A61K35/74 , C12N15/82
CPC分类号： C12N15/8282 , C12N9/2402 , C12Y302/01084
摘要： This invention provides a method for preventing or inhibiting infection with a plant-infecting microorganism and imparting resistivity to plants, a method for preparing plants having resistance to diseases caused by microorganisms such as plant pathogenic filamentous fungi, and a microbial pesticide formulation. The method for preventing or inhibiting infection of a host plant with plant-infecting microorganisms comprises degrading α-1,3-glucan on cell walls of the microorganisms by α-1,3-glucanase.
摘要翻译：本发明提供一种预防或抑制植物感染微生物感染并赋予植物电阻率的方法，一种制备具有抗病性的植物的方法，所述微生物如植物病原性丝状真菌和微生物农药制剂具有抗性。用植物感染微生物预防或抑制宿主植物感染的方法包括通过α-1,3-葡聚糖酶降解微生物细胞壁上的α-1,3-葡聚糖。

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