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1. 发明授权

US5741689A Methods to inhibit serine kinase activity and to alter intersubunit binding activity of phosphatidylinositol 3-kinase, and serine kinase active sequence of the same 失效
标题翻译：抑制丝氨酸激酶活性和改变磷脂酰肌醇3-激酶的亚基间结合活性的方法和相同的丝氨酸激酶活性序列
公开(公告)号：US5741689A
公开(公告)日：1998-04-21
申请号：US185424
申请日：1994-01-21
申请人： Ritu Bala Dhand , Michael Derek Waterfield , Ian Donald Hiles , Ivan Tarasovich Gout , Masato Kasuga , Kazuyoshi Yonezawa , Peter End , Michael Fry , George Panayotou
发明人： Ritu Bala Dhand , Michael Derek Waterfield , Ian Donald Hiles , Ivan Tarasovich Gout , Masato Kasuga , Kazuyoshi Yonezawa , Peter End , Michael Fry , George Panayotou
IPC分类号： A61K38/00 , C12N9/12
CPC分类号： C12N9/1205 , A61K38/00 , C07K2319/00
摘要： The invention provides for a method to inhibit the binding between the p85 and p110 subunits of said PI3-kinase and thus a method to modulate PI3-kinase activity and modulate the response of cells to external stimuli. In particular, disabling, by conventional means, residues located in the inter-SH2 domain of said p85 subunit, specifically a region containing amino acid residue 478 to amino acid residue 513 of p85.alpha. subunit, or amino acid residue 445 to amino acid residue 485 of p85.beta. subunit of said PI3-kinase. Interference with these binding regions will affect binding between the subunits and results in inhibiting PI3-kinase activity. This invention further relates to a methods to modulate the serine kinase activity of the PI3-kinase which can be achieved by disabling the DRHNSN sequence of the p110 subunit and can also be used to effect changes in overall PI3-kinase activity. This invention is further related to an (ant)agonist which affects serine kinase activity of PI3-kinase. An agonist is provided which stimulates the phosphorylation of the p85 subunit at the serine residue at position 608, wherein phosphorylation at the serine residue indirectly results in inhibiting PI3-kinase activity.
摘要翻译：本发明提供了抑制所述PI3激酶的p85和p110亚基之间的结合的方法，因此提供了调节PI3-激酶活性并调节细胞对外部刺激的反应的方法。特别地，通过常规方法使位于所述p85亚基的SH2结构域之间的残基，特别是含有p85α亚基的氨基酸残基478至氨基酸残基513或氨基酸残基445至氨基酸残基485的区域的所述PI3激酶的p85β亚基。与这些结合区域的干扰将影响亚单位之间的结合并导致抑制PI3-激酶活性。本发明还涉及调节PI3激酶的丝氨酸激酶活性的方法，其可以通过使p110亚单位的DRHNSN序列失活来实现，并且还可以用于影响整体PI3-激酶活性的变化。本发明还涉及影响PI3激酶丝氨酸激酶活性的（蚂蚁）激动剂。提供了激动剂，其刺激位置608的丝氨酸残基处的p85亚基的磷酸化，其中丝氨酸残基处的磷酸化间接导致抑制PI3-激酶活性。

2. 外观设计

USD342345S Electric hair clipper 失效
公开(公告)号：USD342345S
公开(公告)日：1993-12-14
申请号：US612885
申请日：1990-11-14
申请人： Kazuyoshi Yonezawa
设计人： Kazuyoshi Yonezawa

3. 发明授权

US4701595A Portable hand-held electric hair dryer with a retractable hand grip 失效
标题翻译：便携式手持式电吹风机，可伸缩手柄
公开(公告)号：US4701595A
公开(公告)日：1987-10-20
申请号：US791074
申请日：1985-10-24
申请人： Hideo Okutsu , Koushirou Mikami , Kazuyoshi Yonezawa , Kuniharu Ichikawa
发明人： Hideo Okutsu , Koushirou Mikami , Kazuyoshi Yonezawa , Kuniharu Ichikawa
IPC分类号： A45D20/12 , A45D20/30 , H05B1/02 , F24H3/04
CPC分类号： A45D20/12 , A45D20/30
摘要： A portable hand-held hair dryer having a housing formed with an elongate front edge portion along the edgewise direction of which is extended an air outlet for discharge of heated air. A hand grip is slidably connected to the front edge portion of the housing for movement therealong in a straight path between a retracted position in which the hand grip overlies the front edge portion to block the air outlet and a projected position in which the hand grip extends outwardly of the housing to be ready for being grasped by the hand of the user after opening the air outlet. A recess is formed in the housing at a portion adjacent to the function of the hand grip in its projected position so as to receive a portion of the user's hand grasping the hand grip. This recess is advantageous for providing a comfortable support of the hair dryer with a minimum projected length of the hand grip. A voltage selection switch is positioned so as to be accessible only when the hand grip is in its retracted position.
摘要翻译：一种便携式手持式吹风机，其具有形成有沿其沿方向的细长前边缘部分的壳体，其延伸有用于排出加热空气的空气出口。手柄可滑动地连接到壳体的前边缘部分，用于在缩回位置之间以直线路径在其中握持在前边缘部分以阻挡空气出口的缩回位置和手柄延伸的突出位置在壳体外部准备好在打开出气口之后用用户的手握住。在壳体中在与手柄的突出位置相邻的部分处形成凹部，以便容纳使用者的手抓住手柄的一部分。该凹槽有利于以最小的手柄伸出长度提供舒适的吹风机支撑。电压选择开关被定位成仅当手柄处于其缩回位置时才可接近。

4. 外观设计

USD304866S Electric shaver 失效
公开(公告)号：USD304866S
公开(公告)日：1989-11-28
申请号：US81172
申请日：1987-08-04
申请人： Kazuyoshi Yonezawa , Florian Seiffert
设计人： Kazuyoshi Yonezawa , Florian Seiffert

5. 外观设计

USD289566S Hair dryer 失效
公开(公告)号：USD289566S
公开(公告)日：1987-04-28
申请号：US707898
申请日：1985-03-04
申请人： Kazuyoshi Yonezawa , Kuniharu Ichikawa , Yonosuke Iwai
设计人： Kazuyoshi Yonezawa , Kuniharu Ichikawa , Yonosuke Iwai

6. 外观设计

USD290887S Electric shaver 失效
公开(公告)号：USD290887S
公开(公告)日：1987-07-14
申请号：US763014
申请日：1985-08-06
申请人： Florian Seiffert , Kazuyoshi Yonezawa
设计人： Florian Seiffert , Kazuyoshi Yonezawa

7. 外观设计

USD296655S Combined electric drill and screwdriver 失效
公开(公告)号：USD296655S
公开(公告)日：1988-07-12
申请号：US826262
申请日：1986-02-05
申请人： Kazuyoshi Yonezawa , Yonosuke Iwai , Florian Seiffert
设计人： Kazuyoshi Yonezawa , Yonosuke Iwai , Florian Seiffert

8. 外观设计

USD294740S Hair dryer casing 失效
公开(公告)号：USD294740S
公开(公告)日：1988-03-15
申请号：US834441
申请日：1986-02-20
申请人： Kazuyoshi Yonezawa , Florian Seiffert
设计人： Kazuyoshi Yonezawa , Florian Seiffert

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