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1. 发明申请

US20200165572A1 ENGINEERED SUBSTRATES FOR HIGH-THROUGHPUT GENERATION OF 3D MODELS OF TUMOR DORMANCY, RELAPSE AND MICROMETASTASES FOR PHENOTYPE SPECIFIC DRUG DISCOVERY AND DEVELOPMENT 审中-公开
公开(公告)号：US20200165572A1
公开(公告)日：2020-05-28
申请号：US16708027
申请日：2019-12-09
申请人： Kaushal Rege , Taraka Sai Pavan Grandhi , Thrimoorthy Potta
发明人： Kaushal Rege , Taraka Sai Pavan Grandhi , Thrimoorthy Potta
IPC分类号： C12N5/09 , G01N33/50 , C12N5/00 , C08J3/075
摘要： Methods to form a novel aminoglycoside based hydrogel for high-throughput generation of 3D dormant, relapsed and micrometastatic tumor microenvironments are disclosed. In addition, methods of screening agents against tumor cells grown in the 3D environments disclosed herein that include, for example, screening of lead drugs and therapies for an effect on dormant, relapsed and/or micrometastatic tumor cells.

2. 发明申请

US20160281056A1 METHODS AND DEVICES FOR HIGH-THROUGHPUT MANUFACTURE OF USER DESIRED 3D POLYMERIC SCAFFOLDS 有权
标题翻译：用户希望的3D聚合物的高通量制造的方法和装置
公开(公告)号：US20160281056A1
公开(公告)日：2016-09-29
申请号：US15077743
申请日：2016-03-22
申请人： Kaushal Rege , Taraka Sai Pavan Grandhi , Andrew Dobos
发明人： Kaushal Rege , Taraka Sai Pavan Grandhi , Andrew Dobos
IPC分类号： C12N5/00
CPC分类号： C08F10/00 , A61L27/18 , A61L27/227 , A61L27/24 , A61L27/54 , A61L27/56 , A61L2300/416 , C12M25/14 , C12N5/0068 , C08L67/04
摘要： Biomedical devices and methods are disclosed for the development of 3D polymeric scaffolds for cell culture, high throughput screens for biomolecule purification, and generation of bone mimetic materials. The devices may feature multiple geometries, and scaffold generation capabilities include multiple gel types utilizing organic and aqueous phase pregel. Additionally, macroporous and non-macroporous morphologies are possible.
摘要翻译：公开了生物医学装置和方法用于开发用于细胞培养的3D聚合物支架，用于生物分子纯化的高通量筛选和骨模拟物质的产生。该装置可以具有多个几何形状，并且支架生成能力包括利用有机和水相预凝胶的多种凝胶类型。此外，大孔和非大孔形态是可能的。

3. 发明申请

US20220151927A1 AMINOGLYCOSIDE ANTIBIOTIC-DERIVED MICROBEAD-ENCAPSULATED SPHEROIDS AND METHODS OF MAKING AND USING THE SAME 有权
公开(公告)号：US20220151927A1
公开(公告)日：2022-05-19
申请号：US17529930
申请日：2021-11-18
申请人： Kaushal Rege , Rajeshwar Nitiyanandan , Tanya Nanda
发明人： Kaushal Rege , Rajeshwar Nitiyanandan , Tanya Nanda
IPC分类号： A61K9/127 , A61K35/12
摘要： The instant disclosure is directed to compositions comprising an encapsulated spheroid, and methods of making and using the same. A composition may comprise a spheroid comprising a plurality of cells and aminoglycoside antibiotic-derived hydrogel beads, wherein the spheroid is encapsulated by the aminoglycoside antibiotic-derived hydrogel beads to form an encapsulated spheroid. A method may comprise administering the composition to a subject in need thereof. Another method may comprise administering a compound to the encapsulated spheroid. A method of creating an encapsulated spheroid may comprise coating a surface with an aminoglycoside antibiotic-derived hydrogel, culturing a plurality of cells on the surface, thereby creating a spheroid, and encapsulating the spheroid with a plurality of aminoglycoside antibiotic-derived hydrogel beads.

4. 发明授权

US09856332B2 Methods for high-throughput in-situ manufacture of user desired 3D polymeric scaffolds 有权
公开(公告)号：US09856332B2
公开(公告)日：2018-01-02
申请号：US15077743
申请日：2016-03-22
申请人： Kaushal Rege , Taraka Sai Pavan Grandhi , Andrew Dobos
发明人： Kaushal Rege , Taraka Sai Pavan Grandhi , Andrew Dobos
IPC分类号： C12M1/16 , C08F10/00 , C12M1/12 , C12N5/00
CPC分类号： C08F10/00 , A61L27/18 , A61L27/227 , A61L27/24 , A61L27/54 , A61L27/56 , A61L2300/416 , C12M25/14 , C12N5/0068 , C08L67/04
摘要： Biomedical devices and methods are disclosed for the development of 3D polymeric scaffolds for cell culture, high throughput screens for biomolecule purification, and generation of bone mimetic materials. The devices may feature multiple geometries, and scaffold generation capabilities include multiple gel types utilizing organic and aqueous phase pregel. Additionally, macroporous and non-macroporous morphologies are possible.

5. 发明申请

US20170115275A1 ENGINEERED SUBSTRATES FOR HIGH-THROUGHPUT GENERATION OF 3D MODELS OF TUMOR DORMANCY, RELAPSE AND MICROMETASTASES FOR PHENOTYPE SPECIFIC DRUG DISCOVERY AND DEVELOPMENT 审中-公开
公开(公告)号：US20170115275A1
公开(公告)日：2017-04-27
申请号：US15332928
申请日：2016-10-24
申请人： Kaushal Rege , Taraka Sai Pavan Grandhi , Thrimoorthy Potta
发明人： Kaushal Rege , Taraka Sai Pavan Grandhi , Thrimoorthy Potta
IPC分类号： G01N33/50 , C12N5/09 , C08J3/075 , C12N5/00
CPC分类号： C12N5/0693 , C08J3/075 , C08J2371/02 , C12N5/0068 , C12N2503/02 , C12N2533/30 , C12N2537/10 , G01N33/5011
摘要： Methods to form a novel aminoglycoside based hydrogel for high-throughput generation of 3D dormant, relapsed and micrometastatic tumor microenvironments are disclosed. In addition, methods of screening agents against tumor cells grown in the 3D environments disclosed herein that include, for example, screening of lead drugs and therapies for an effect on dormant, relapsed and/or micrometastatic tumor cells.

6. 发明申请

US20070049741A1 Aminoglycoside-polyamine displacers and methods of use in displacement chromatography 有权
标题翻译：氨基糖苷 - 多胺置换剂及其在置换色谱中的应用
公开(公告)号：US20070049741A1
公开(公告)日：2007-03-01
申请号：US11217193
申请日：2005-09-01
申请人： Kaushal Rege , Shanghui Hu , Jonathan Dordick , Steven Cramer
发明人： Kaushal Rege , Shanghui Hu , Jonathan Dordick , Steven Cramer
IPC分类号： C07H21/00 , C07H19/16 , C08B37/00 , C07K1/10
CPC分类号： B01D15/362 , B01D15/422 , C07H13/04 , C07H15/224 , C07H15/226 , C07H15/232 , C07H15/236 , C07H19/16 , C07H21/00
摘要： Aminoglycoside-polyamines are disclosed along with methods of use thereof in displacement chromatography and as DNA-binding ligands. The aminoglycoside-polyamines are derivatives of carbohydrates, such as sugars, amino sugars, deoxysugars, glycosides, nucleosides and their substituted counterparts. The subject polyamines possess a group in place of at least one hydrogen atom of at least one hydroxyl group of the carbohydrate compound. In these compounds R1 is an alkyl group or an azaalkyl group, and R2 is a primary or secondary amino group.
摘要翻译：公开了氨基糖苷 - 多胺及其在置换色谱法中的应用方法以及DNA结合配体。氨基糖苷 - 多胺是碳水化合物的衍生物，例如糖，氨基糖，脱氧糖，糖苷，核苷及其取代的对应物。本发明聚胺具有代替碳水化合物化合物的至少一个羟基的至少一个氢原子的基团。在这些化合物中，R 1是烷基或氮杂烷基，R 2是伯或仲氨基。

7. 发明申请

US20050176937A1 High throughput screening of potential displacer molecules 审中-公开
标题翻译：潜在置换剂分子的高通量筛选
公开(公告)号：US20050176937A1
公开(公告)日：2005-08-11
申请号：US11103293
申请日：2005-04-11
申请人： Steven Cramer , Kaushal Rege , Jonathan Dordick , Nihal Tugcu
发明人： Steven Cramer , Kaushal Rege , Jonathan Dordick , Nihal Tugcu
IPC分类号： B01D15/42 , C07K1/22 , C07H21/04 , C07K1/10
CPC分类号： B01D15/422 , C07K1/22
摘要： A bioproduct may be selectively separated from one or more impurities by means of a displacement chromatography system that includes a solvent, a chromatographic resin and a chemically selective displacer. The method includes: dissolving the bioproduct and the one or more impurities in a solvent; loading the bioproduct and the one or more impurities, in the solvent, on a chromatographic resin; displacing the bioproduct from the chromatographic resin with chemically selective displacer; and retaining the one or more impurities on the chromatographic resin. For this method, the bioproduct and the impurities have similar binding affinity for the chromatographic resin in the absence of the displacer.
摘要翻译：生物产物可以通过置换色谱系统选择性地与一种或多种杂质分离，所述置换色谱系统包括溶剂，色谱树脂和化学选择性置换器。该方法包括：将生物产物和一种或多种杂质溶解在溶剂中; 在溶剂中将生物产物和一种或多种杂质装载在色谱树脂上; 用化学选择性置换器置换色谱树脂的生物产物; 并将一种或多种杂质保留在色谱树脂上。对于该方法，生物产物和杂质在没有置换剂的情况下对色谱树脂具有相似的结合亲和力。

8. 发明授权

US06881540B2 High throughtput screening of potential displacer molecules 有权
标题翻译：潜在置换剂分子的高通量筛选
公开(公告)号：US06881540B2
公开(公告)日：2005-04-19
申请号：US09791317
申请日：2001-02-23
申请人： Steven Cramer , Kaushal Rege , Jonathan Dordick
发明人： Steven Cramer , Kaushal Rege , Jonathan Dordick
IPC分类号： B01D15/42 , C07K1/22 , C12Q1/68
CPC分类号： C07K1/22 , B01D15/422
摘要： An effective technique for the high throughput screening of displacers is described. In this technique, potential displacers are employed to displace a biomolecule (e.g., protein) adsorbed on a chromatographic resin in small-scale batch displacement experiments. The amount of protein displaced from a specific resin by a defined concentration of displacer is determined by monitoring the supermatant for the protein. By evaluating the displaced protein rather than the displacer itself, this technique enables a single detection technique (e.g., absorbance, fluorescence, etc.) to be employed for all batch displacement experiments. By monitoring the amount of protein displaced, the effacy of a large number of potential displacers can be rapidly evaluated. The entire experimental procedure can be carried out rapidly and is thus amenable to high throughput parallel screening of molecules possessing a large range of affinities and physico-chemical properties. The error of the technique is within 5% of protein displaced, thus making it a very reliable technique. The technique can be extended to different stationary phase materials, biomolecules, and modes of interaction.
摘要翻译：描述了用于置换器的高通量筛选的有效技术。在该技术中，使用潜在的置换剂来置换小规模批量置换实验中吸附在色谱树脂上的生物分子（例如蛋白质）。通过监测蛋白质的超级蛋白质来确定由特定树脂从限定浓度的置换剂中排出的蛋白质的量。通过评估置换的蛋白质而不是置换剂本身，该技术使得能够将单个检测技术（例如，吸光度，荧光等）用于所有的批量置换实验。通过监测蛋白质置换量，可以快速评估大量潜在置换剂的效率。整个实验程序可以快速进行，因此适合高通量平行筛选具有大范围亲和力和物理化学性质的分子。该技术的误差在蛋白质置换的5％以内，因此使其成为非常可靠的技术。该技术可以扩展到不同的固定相材料，生物分子和相互作用模式。

9. 发明申请

US20160279264A1 Lipid Substitution on Aminoglycoside Based Polymers: Plasmid Delivery, Anticancer Drug Delivery and Transgene Expression 有权
标题翻译：基于氨基糖苷的聚合物的脂质取代：质粒递送，抗癌药物递送和转基因表达
公开(公告)号：US20160279264A1
公开(公告)日：2016-09-29
申请号：US15034425
申请日：2014-11-05
申请人： Kaushal REGE , Bhavani MIRYALA , Thrimoorthy POTTA
发明人： Kaushal REGE , Bhavani MIRYALA , Thrimoorthy POTTA
IPC分类号： A61K48/00 , A61K47/48
CPC分类号： A61K48/0041 , A61K47/543 , A61K47/59 , A61K47/61 , C12N15/87
摘要： A method to form a lipid-containing aminoglycoside-based polymer, where the method includes reacting an aminoglycoside with a diepoxide to form an aminoglycoside-based polymeric material, and then reacting the aminoglycoside-based polymeric material with an acyl chloride to form the lipid-containing aminoglycoside-based polymer.
摘要翻译：一种形成含脂质的氨基糖苷类聚合物的方法，其中所述方法包括使氨基糖苷与二环氧化物反应形成氨基糖苷类聚合物，然后使氨基糖苷类聚合物与酰氯反应形成脂质 - 含有氨基糖苷类聚合物。

10. 发明授权

US07439343B2 Aminoglycoside-polyamine displacers and methods of use in displacement chromatography 有权
标题翻译：氨基糖苷 - 多胺置换剂及其在置换色谱中的应用
公开(公告)号：US07439343B2
公开(公告)日：2008-10-21
申请号：US11217193
申请日：2005-09-01
申请人： Kaushal Rege , Shanghui Hu , Jonathan S. Dordick , Steven M. Cramer
发明人： Kaushal Rege , Shanghui Hu , Jonathan S. Dordick , Steven M. Cramer
IPC分类号： C07H1/06 , C07H15/20 , C07H17/00
CPC分类号： B01D15/362 , B01D15/422 , C07H13/04 , C07H15/224 , C07H15/226 , C07H15/232 , C07H15/236 , C07H19/16 , C07H21/00
摘要： Aminoglycoside-polyamines are disclosed along with methods of use thereof in displacement chromatography and as DNA-binding ligands. The aminoglycoside-polyamines are derivatives of carbohydrates, such as sugars, amino sugars, deoxysugars, glycosides, nucleosides and their substituted counterparts. The subject polyamines possess a group in place of at least one hydrogen atom of at least one hydroxyl group of the carbohydrate compound. In these compounds R1 is an alkyl group or an azaalkyl group, and R2 is a primary or secondary amino group.
摘要翻译：公开了氨基糖苷 - 多胺及其在置换色谱法中的用途及其作为DNA结合配体。氨基糖苷 - 多胺是碳水化合物的衍生物，例如糖，氨基糖，脱氧糖，糖苷，核苷及其取代的对应物。本发明聚胺具有代替碳水化合物化合物的至少一个羟基的至少一个氢原子的基团。在这些化合物中，R 1是烷基或氮杂烷基，R 2是伯或仲氨基。

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