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    • 3. 发明授权
    • Measuring activity toward production of activated blood coagulation
factor XII, plasma kallikrein or bradykinin using reconstituted
kallikrein-kinin system
    • 使用重组的激肽释放酶 - 激肽系统测量活性凝血因子XII,血浆激肽释放酶或缓激肽的生产活性
    • US5648228A
    • 1997-07-15
    • US284972
    • 1994-08-04
    • Katsumi NishikawaHitoshi Kawakubo
    • Katsumi NishikawaHitoshi Kawakubo
    • C12Q1/56G01N33/86
    • C12Q1/56C12Q2337/12G01N2333/96455G01N2333/96458
    • The present invention provides a method for measuring the activity of tested substances utilizing a reconstituted plasma kallikrein-kinin system. A series of enzymatic reactions is started wherein an activation of a blood coagulation factor XII is an initiating reaction. The series of reactions is started in the presence of the tested substance in the reconstituted plasma kallikrein-kinin system. Then, the series of reactions is stopped and the physiologically active substance produced in the reaction series is quantitatively determined. In the activity measuring method of the present invention, the real activity (a promoting or inhibiting ability) of the tested substance against the production of the produced physiologically active substance can be easily, simply, quickly and precisely measured. In the reconstituted plasma kallikrein-kinin reaction system the contaminating other factors are substantially removed. Accordingly, the method of measuring the activity in accordance with the present invention is a very advantageous means for ascertaining action which is useful for adjusting the bioregulations in, for example, the plasma kallikrein-kinin system, the blood clotting system, the fibrinolysis system, etc. It may also be used for developing or screening drugs which are related to the systems.
    • 本发明提供了利用重构的血浆激肽释放酶 - 激肽系统测量被测物质的活性的方法。 开始一系列酶促反应,其中凝血因子XII的活化是起始反应。 在重构的血浆激肽释放酶 - 激肽系统中测试物质的存在下开始一系列反应。 然后,停止一系列反应,并定量测定反应系列产生的生理活性物质。 在本发明的活性测定方法中,可以容易地简单,快速,精确地测定被测物质对生成的生理活性物质的生成的实际活性(促进抑制能力)。 在重建的血浆激肽释放酶 - 激肽反应系统中,污染的其他因子基本上被除去。 因此,根据本发明的测定活性的方法是用于确定可用于调节例如血浆激肽释放酶 - 激肽系统,血液凝固系统,纤维蛋白溶解系统中的生物调节的作用的非常有利的手段, 它也可用于开发或筛选与系统有关的药物。
    • 6. 发明授权
    • Semiconductor memory
    • 半导体存储器
    • US5848003A
    • 1998-12-08
    • US884265
    • 1997-06-27
    • Katsumi Nishikawa
    • Katsumi Nishikawa
    • G11C11/413G11C11/401G11C29/00G11C29/04G11C7/00
    • G11C29/80G11C29/83
    • There are provided memory cell arrays MA1 to MA4 each of which includes a predetermined number of redundant memory cell rows and a predetermined number of redundant memory cell columns, and which are caused to partially operate by a block selecting signal BS. Replacement address programming circuits RAP1 to RAP4 of the number smaller than the number of the redundant memory cell rows, are provided. Each of the replacement address programming circuits stores the row address of a defective memory cell(s) existing in the memory cell arrays MA1-MA4, and outputs a redundant row selection discriminating signal RSJ1-RSJ4 of an activated level when a row address signal XA designates the stored row address. Further, selection circuits RS1 to RS8 are provided for selecting one of the redundant row selection discriminating signals RSJ1 to RSJ4 and selecting a corresponding redundant memory row. The number of redundant column address programming circuits included in redundant column selection circuits RYS1 and RYS2 is made smaller than the number of the redundant memory cell columns.
    • 提供了存储单元阵列MA1至MA4,每个存储单元阵列包括预定数量的冗余存储单元行和预定数量的冗余存储单元列,并且由块选择信号BS部分地进行操作。 提供比数量小于冗余存储单元行的数量的替换地址编程电路RAP1至RAP4。 每个替换地址编程电路存储存储在存储单元阵列MA1-MA4中的有缺陷的存储单元的行地址,并且当行地址信号XA(A))输出激活电平的冗余行选择判别信号RSJ1-RSJ4时, 指定存储的行地址。 此外,提供选择电路RS1至RS8用于选择冗余行选择识别信号RSJ1至RSJ4中的一个并选择相应的冗余存储器行。 包括在冗余列选择电路RYS1和RYS2中的冗余列地址编程电路的数量小于冗余存储单元列的数量。