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1. 发明申请

US20130045241A1 STABILIZED AQUEOUS DISPERSION OF FOLPET ANALOGUES, METHOD OF PREPARING THE SAME AND COMPOSITION THEREOF 审中-公开
标题翻译：稳定化水分散型的水溶性分散体，其制备方法及其组合物
公开(公告)号：US20130045241A1
公开(公告)日：2013-02-21
申请号：US13513084
申请日：2010-12-07
申请人： Raman Premachandran , Daniel H. Brown , Blanca Gomez , Karen Winkowski
发明人： Raman Premachandran , Daniel H. Brown , Blanca Gomez , Karen Winkowski
IPC分类号： A01N43/38 , A01P3/00 , A01N25/00
CPC分类号： A01N47/12 , A01N47/04 , A01N25/04 , A01N25/08 , A01N25/26 , A01N2300/00
摘要： An aqueous dispersion having a mixture of a hydrolysis-sensitive biocide, an iodo-derived hydrophobic biocide and an inert carrier dispersed in water. The iodo-derived hydrophobic biocide forms a complex with the inert carrier and the hydrolysis-sensitive biocide that is dispersible in water. The hydrophobic coating includes an inert carrier and the hydrolysis-sensitive biocide may be trihalogenomethylthio phthalimide or an analogue thereof and the iodo-derived hydrophobic biocide may be iodopropynyl butylcarbamate. The aqueous dispersion may also include a water-repelling layer coating the complex.
摘要翻译：具有水解敏感性杀生物剂，碘衍生的疏水性杀生物剂和分散在水中的惰性载体的混合物的水分散体。碘衍生的疏水性杀生物剂与惰性载体和可分散在水中的水解敏感性杀生物剂形成络合物。疏水性涂层包括惰性载体，水解敏感性杀生物剂可以是三卤甲基硫代邻苯二甲酰亚胺或其类似物，碘衍生的疏水性杀生物剂可以是碘代丙炔基丁基氨基甲酸酯。水分散体还可以包括涂覆复合物的防水层。

2. 发明申请

US20120171272A1 STABILIZED BIOCIDAL DISPERSION VIA SUB-MICRONIZED CARRIER PARTICLES, PROCESS FOR MAKING THE SAME AND COMPOSITION THEREOF 审中-公开
标题翻译：通过亚微米载体颗粒的稳定的生物分散体，其制备方法及其组合物
公开(公告)号：US20120171272A1
公开(公告)日：2012-07-05
申请号：US13378423
申请日：2010-06-09
申请人： Raman Premachandran , Kolazi S. Narayanan , Blanca Gomez , Karen Winkowski
发明人： Raman Premachandran , Kolazi S. Narayanan , Blanca Gomez , Karen Winkowski
IPC分类号： A01N25/26 , A01P15/00
CPC分类号： A01N25/04 , A01N43/40 , A01N43/653 , A01N43/80 , A01N47/12
摘要： A stabilized biocidal dispersion comprising a biocide coated or adsorbed onto stable sub-micron carrier particles and wherein sub-micronized particles are stabilized by additives having polar moieties, hydrophobic and hydrophilic segments. The sub-micron particles are selected from metal oxides like zinc oxide, titanium dioxide, cerium dioxide and silica, alumina, minerals, clays, stilbene and sub-micron carbons. Exemplary biocides include carbamates, isothiazolones, pyrithione chelates and/or trizoles. Also disclosed is a process for preparing stabilized sub-micronized carrier particles.
摘要翻译：一种稳定的杀生物分散体，其包含涂覆或吸附在稳定的亚微米载体颗粒上的杀生物剂，并且其中亚微粉化颗粒由具有极性部分，疏水和亲水链段的添加剂稳定。亚微米颗粒选自金属氧化物如氧化锌，二氧化钛，二氧化铈和二氧化硅，氧化铝，矿物质，粘土，二苯乙烯和亚微米级的碳。示例性杀生物剂包括氨基甲酸酯，异噻唑啉酮，吡啶硫酮螯合物和/或三唑。还公开了制备稳定的亚微粉化载体颗粒的方法。

3. 发明申请

US20100260691A1 Aqueous compositions containing a hydrophobic material 审中-公开
标题翻译：含有疏水性材料的水性组合物
公开(公告)号：US20100260691A1
公开(公告)日：2010-10-14
申请号：US11803108
申请日：2007-05-11
申请人： Kolazi S. Narayanan , Domingo Jon , Jayanti Patel , Karen Winkowski
发明人： Kolazi S. Narayanan , Domingo Jon , Jayanti Patel , Karen Winkowski
IPC分类号： A01N25/02 , A01N31/14 , A01N37/52 , A01N31/08 , A01N65/00
CPC分类号： A01N25/04 , A01N31/08 , A01N31/14 , A01N31/16 , A01N47/12 , A01N47/40 , A01N65/06
摘要： An aqueous composition containing a hydrophobic material, and, more particularly, a water soluble matrix of a water soluble polymer and a water soluble surfactant, in the form of a complex, for stabilizing the hydrophobic material, as a nanoparticulate dispersion or emulsion. A delivery system for delivering bioactive hydrophobic materials as an aqueous nanoparticle dispersion of a water soluble matrix of polymer and a surfactant.
摘要翻译：含有疏水性材料的水性组合物，更具体地说，为复合物形式的水溶性聚合物和水溶性表面活性剂的水溶性基质，用于稳定疏水性材料，作为纳米颗粒分散体或乳液。用于递送生物活性疏水材料作为聚合物和表面活性剂的水溶性基质的水性纳米颗粒分散体的递送系统。

4. 发明授权

US07105555B2 Stable, neutral pH VOC-free biocidal compositions of 1,2-benzisothiazolin-3-one 有权
标题翻译：稳定的中性pH无VOC的1,2-苯并异噻唑啉-3-酮的杀生物组合物
公开(公告)号：US07105555B2
公开(公告)日：2006-09-12
申请号：US10818890
申请日：2004-04-06
申请人： Xianbin Liu , Karen Winkowski
发明人： Xianbin Liu , Karen Winkowski
IPC分类号： A01N43/80 , C07D275/04 , C09K15/16
CPC分类号： A61K31/425 , A01N43/80 , A61K31/74 , A01N25/02 , A01N2300/00
摘要： What is described herein is a neutral pH, VOC-free biocidal composition of 1,2-benzisothiazolin-3-one which is stable at low temperatures for an extended period of time. The compositions are particularly advantageous in use in protecting latex, paint, coating, cosmetic and personal care formulations against microbiological spoilage.
摘要翻译：本文描述的是中性pH，无VOC的1,2-苯并异噻唑啉-3-酮的杀生物组合物，其在低温下长时间稳定。组合物在用于保护乳胶，油漆，涂料，化妆品和个人护理制剂中以防微生物腐败中是特别有利的。

5. 发明申请

US20060105007A1 Stable matrix emulsion concentrates and stable aqueous and/or organic solvent compositions containing biocides 有权
标题翻译：稳定的基质乳液浓缩物和含有杀生物剂的稳定的含水和/或有机溶剂组合物
公开(公告)号：US20060105007A1
公开(公告)日：2006-05-18
申请号：US10990995
申请日：2004-11-17
申请人： Kolazi Narayanan , Xianbin Liu , Karen Winkowski , Jayanti Patel
发明人： Kolazi Narayanan , Xianbin Liu , Karen Winkowski , Jayanti Patel
IPC分类号： A01N25/00
CPC分类号： A01N25/04 , A01N47/12 , A01N43/653 , A01N2300/00
摘要： A stable matrix emulsion concentrate of a biocide, e.g. 3-iodopropynyl-2-butyl carbamate (IPBC) and/or a triazole fungicide, and stable aqueous and/or organic solvent formulations thereof, i.e. dilutable in water and/or an organic solvent are provided, which are particularly useful for treating wood products to provide protection against microorganisms and insects.
摘要翻译：一种杀生物剂的稳定的基质乳液浓缩物，例如提供3-碘丙炔基-2-丁基氨基甲酸酯（IPBC）和/或三唑杀真菌剂，以及其稳定的水和/或有机溶剂制剂，即在水和/或有机溶剂中可稀释，其特别适用于处理木制品提供防止微生物和昆虫的保护。

6. 发明申请

US20150126479A1 AQUEOUS SOLUTIONS OF 1,2-BENZISOTHIAZOLIN-3-ONE 审中-公开
标题翻译： 1,2-BENZISOTHIAZOLIN-3-ONE的精华溶液
公开(公告)号：US20150126479A1
公开(公告)日：2015-05-07
申请号：US14117171
申请日：2012-05-09
申请人： Raman Premachandran , Karen Winkowski , Najeeb H. Hakimi
发明人： Raman Premachandran , Karen Winkowski , Najeeb H. Hakimi
IPC分类号： A01N43/80 , A01N39/00 , A01N31/02 , A01N31/06 , A01N35/04 , A01N33/12 , A01N47/44 , A01N25/02 , A01N37/10
CPC分类号： A01N43/80 , A01N25/02 , A01N31/02 , A01N31/06 , A01N33/12 , A01N35/04 , A01N37/10 , A01N39/00 , A01N47/44 , A01N31/14 , A01N31/16 , A01N35/02 , A01N35/08 , A01N37/40 , A01N2300/00
摘要： What is described herein is an environment-friendly, highly aqueous solution of 1,2-benzisothiazolin-3-one (BIT) which is free from volatile organic compounds (VOC's), glycols, derivatives of glycols, glycerols and/or derivatives of glycerols. The composition comprises: (i) about 0.1% to about 30% by wt. of BIT; (ii) about 5% to about 15% by wt. of neutralizing agent; (iii) about 50% to about 85% by wt. of water; and (iv) about 0.1% to about 5% by wt. of chelating agent. The aqueous solution of BIT may further comprise at least one water soluble form of a co-biocide. The composition is efficient in protecting aqueous media against microbial attack in various industrial applications.
摘要翻译：本文描述的是不含挥发性有机化合物（VOC），二醇，二醇，甘油和/或甘油衍生物的1,2-苯并异噻唑啉-3-酮（BIT）的环境友好的高水溶液。组合物包含：（i）约0.1重量％至约30重量％的BIT; （ii）约5重量％至约15重量％。的中和剂; （iii）约50％至约85％（重量）的水; 和（iv）约0.1重量％至约5重量％。的螯合剂。 BIT的水溶液可以进一步包含至少一种水溶性形式的辅助杀生物剂。该组合物在各种工业应用中有效地保护水性介质免受微生物侵袭。

7. 发明申请

US20130203825A1 PHOSPHATE-FREE HIGHLY CONCENTRATED AQUEOUS DISPERSION COMPOSITION OF BIOCIDES AND PROCESS FOR PREPARING THE SAME 审中-公开
标题翻译：无磷酸盐的高浓度水性分散体组合物及其制备方法
公开(公告)号：US20130203825A1
公开(公告)日：2013-08-08
申请号：US13700552
申请日：2011-05-26
申请人： Raman Premachandran , Karen Winkowski
发明人： Raman Premachandran , Karen Winkowski
IPC分类号： A01N25/04 , A01N47/12 , A01N43/80
CPC分类号： A01N25/04 , A01N25/30 , A01N43/80 , A01N47/12 , A01N43/40 , A01N59/16 , A01N2300/00
摘要： A phosphate-free, highly-concentrated aqueous dispersion composition comprising at least one biocide, sulfosuccinate based surfactant, block copolymer, suspending agent, and optionally an antifoaming agent and desired additives if any. The composition of the present application is significantly stable against heat, cold, transit, storage and dilution for at least 18 months. The preferred biocides of the dispersion composition are 2-meth-4-isothiazolin-3-one (MIT), 1,2-Benzisothiazolin-3-one (BIT), 5-Chloro-2-methyl-4-isothiazolin-3-one (CMIT), 2-Octyl-4-isothiazolin-3-one (Off) 3-Iodo-2-propynylbutyl carbamate (IPBC), oxyfluorfen, thiabendazole, terbutryn, zinc pyrithione (ZnPy), bronopol, folpet, diiiron, dehydroacetic acid (DHA), dazomet and carbendazim alone or in combination. Also disclosed is a process for preparing the dispersion composition and appropriate applications thereof.
摘要翻译：一种无磷酸盐，高浓度的水分散体组合物，其包含至少一种杀生物剂，磺基琥珀酸盐基表面活性剂，嵌段共聚物，悬浮剂和任选的消泡剂以及所需的添加剂（如果有的话）。本申请的组合物对于热，冷，运输，储存和稀释至少18个月是显着稳定的。分散体组合物的优选杀生物剂为2-甲基-4-异噻唑啉-3-酮（MIT），1,2-苯并异噻唑啉-3-酮（BIT），5-氯-2-甲基-4-异噻唑啉-3-酮（CMIT），2-辛基-4-异噻唑啉-3-酮（Off）3-碘-2-丙炔基丁基氨基甲酸酯（IPBC），氧氟芬，噻苯达唑，特丁苯醚，吡啶硫酮锌（ZnPy），布洛芬，叶酸，二酮，脱氢乙酸酸（DHA），dazomet和多菌灵单独或组合使用。还公开了制备分散体组合物的方法及其适用的应用。

8. 发明申请

US20120164203A1 PROCESS FOR PREPARATION OF STABLE, MICROENCAPSULATED AND SUSTAINED RELEASE BIOCIDAL ACTIVES AND COMPOSITION THEREOF 审中-公开
标题翻译：制备稳定，微晶和持续释放生物活性物质的方法及其组合物
公开(公告)号：US20120164203A1
公开(公告)日：2012-06-28
申请号：US13378397
申请日：2010-06-17
申请人： Raman Premachandran , Kolazi S. Narayanan , Blanca Gomez , Karen Winkowski , Daniel H. Brown
发明人： Raman Premachandran , Kolazi S. Narayanan , Blanca Gomez , Karen Winkowski , Daniel H. Brown
IPC分类号： A01N25/34 , B05D5/00
CPC分类号： A01N25/04 , A01N25/08 , A01N25/12 , A01N47/04 , A01N47/12 , A01N59/16 , C09D5/1612 , C09D5/1687 , A01N43/80 , A01N43/70 , A01N47/30 , A01N2300/00
摘要： Disclosed herein is a process for the preparation of a stable sustained-release biocidal composition containing microencapsulated biocide and wherein the process comprises the steps of: (i) adsorbing the biocide onto an inert carrier by grinding to attain the required particle size and wherein the ratio of biocide; inert carrier is in the range of about 1:99 to about 99:1 (ii) optionally coating with an appropriate amine or imine compound or a water resistant film forming polymer and dispersing the resultant biocide encapsulated inert carrier in an aqueous medium in the presence of suitable dispersing agent (iii) adding at least one thickening agent to re-disperse the encapsulated biocide containing partial amount of non-encapsulated biocide if any and (iv) preparing an aqueous or solvent based sustained release biocide dispersion. Also disclosed is a stable, sustained-release biocidal composition prepared by such process and uses thereof.
摘要翻译：本文公开了一种制备含有微囊化杀生物剂的稳定的缓释杀生物组合物的方法，其中该方法包括以下步骤：（i）通过研磨将杀生物剂吸附到惰性载体上以达到所需的粒度，的杀菌剂; 惰性载体在约1:99至约99:1的范围内（ii）任选用合适的胺或亚胺化合物或防水成膜聚合物涂覆，并将所得的杀生物剂包封的惰性载体在存在的水性介质中分散（iii）加入至少一种增稠剂以重新分散含有部分量的未包封的杀生物剂的包封的杀生物剂，如果有的话，以及（iv）制备基于水性或溶剂的缓释杀生物剂分散体。还公开了通过其方法和用途制备的稳定的缓释杀生物组合物。

9. 发明申请

US20080081059A1 Synergistic matrix composite for making stable microemulsions of active ingredients 有权
标题翻译：用于制备稳定的微乳液活性成分的协同基质复合材料
公开(公告)号：US20080081059A1
公开(公告)日：2008-04-03
申请号：US11540981
申请日：2006-09-28
申请人： Kolazi S. Narayanan , Domingo Jon , Jayanti Patel , Karen Winkowski , Andreas Mitschke , Otto W. Gordon
发明人： Kolazi S. Narayanan , Domingo Jon , Jayanti Patel , Karen Winkowski , Andreas Mitschke , Otto W. Gordon
IPC分类号： A01N25/00 , A61K8/37
CPC分类号： A01N25/04 , A61K8/068 , A61K8/922 , A61Q5/02 , C09D5/02 , C11D17/0021 , A01N27/00 , A01N31/08 , A01N53/00 , A01N65/06 , A01N65/36
摘要： What is described herein is a synergistic matrix composite for making a stable microemulsion in water of an active ingredient comprising a first matrix composition including by wt. (a) 5-30% of a C8-C18 N-alkyl pyrrolidone, (b) optionally, 5-60% of a water insoluble organic solvent soluble therein, (c) 30-70% of a non-ionic emulsifier, and (d) 1-15% of an EO/PO/EO copolymer, and, (e) optionally, 1-5% of a surface active buffering agent, e.g. a branched alkyl ethoxylated phosphate ester, a second matrix composition comprising a polar polymeric material, e.g. polyethylene glycol, and/or a neutralized derivatized vegetable oil, e.g. maleated linseed oil, which composite is capable of loading a higher amount of said active than either composition alone.
摘要翻译：本文描述的是用于在活性成分的水中制备稳定的微乳液的协同性基质复合物，其包含第一基质组合物，（a）5-30％的C 8 -C 18 N-烷基吡咯烷酮，（b）任选的5-60％可溶于其中的水不溶性有机溶剂，（c）30-70％的非离子乳化剂，和（d）1-15％的EO / PO / EO共聚物，和（e）任选地1-5％的表面活性缓冲剂，例如支链烷基乙氧基化磷酸酯，包含极性聚合物材料的第二基质组合物，例如。聚乙二醇和/或中和的衍生植物油，例如，马来酸亚麻子油，该复合材料能够单独加载比任一组合物更高量的所述活性物质。

10. 发明申请

US20070071778A1 Stable microemulsion concentrate for delivery of a bioactive biocide/disinfectant/fungicide/fragrance in an aqueous medium providing sustained release 审中-公开
标题翻译：稳定的微乳液浓缩物用于在提供持续释放的水性介质中递送生物活性杀生物剂/消毒剂/杀真菌剂/香料
公开(公告)号：US20070071778A1
公开(公告)日：2007-03-29
申请号：US11236888
申请日：2005-09-28
申请人： Kolazi Narayanan , Jayanti Patel , John Merianos , Susan Lindstrom , Karen Winkowski , Xianbin Liu , Donald Prettypaul
发明人： Kolazi Narayanan , Jayanti Patel , John Merianos , Susan Lindstrom , Karen Winkowski , Xianbin Liu , Donald Prettypaul
IPC分类号： A61K9/14 , A61K33/14 , A61K33/36 , A61K36/13
CPC分类号： A61K31/09 , A01N25/04 , A61K9/0014 , A61K9/1075 , A61K31/00 , A61K31/14 , A61K31/28 , A61K33/00 , A61K33/14 , A61K33/36 , A61K36/15 , A01N47/12 , A01N59/12 , A01N31/16 , A61K2300/00
摘要： What is described herein is a stable microemulsion concentrate and composition for delivery of an active biocide/disinfectant in an aqueous medium providing sustained release of the active. The composition is effective against both bacteria and fungi.
摘要翻译：本文所述的是稳定的微乳液浓缩物和用于在水性介质中递送活性杀生物剂/消毒剂的组合物，其提供活性物质的持续释放。该组合物对细菌和真菌均有效。

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