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1. 发明授权

US08586555B2 Immunomodulatory compositions, formulations, and methods for use thereof 有权
标题翻译：免疫调节组合物，制剂及其使用方法
公开(公告)号：US08586555B2
公开(公告)日：2013-11-19
申请号：US12396348
申请日：2009-03-02
申请人： Karen L. Fearon , Dino Dina
发明人： Karen L. Fearon , Dino Dina
IPC分类号： A61K48/00 , A61K45/00 , A61K47/00 , C07H21/02 , C07H21/04
CPC分类号： A61K9/167 , A61K9/1647 , A61K39/39 , A61K47/593 , A61K47/6927 , A61K2039/55555 , A61K2039/55561 , Y02A50/41 , Y02A50/412 , Y02A50/423
摘要： The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMO/MC) complexes comprising 3-6mer immunomodulatory oligonucleotides. The IMO/MC complexes may be covalently or non-covalently bound. Also provided are immunomodulatory compositions comprising a 3-6mer IMO encapsulated in an MC.
摘要翻译：本发明提供了用于个体免疫调节的新组合物和方法。通过施用包含3-6mer免疫调节寡核苷酸的免疫调节多核苷酸/微载体（IMO / MC）复合物来实现免疫调节。 IMO / MC复合物可能共价或非共价结合。还提供包含封装在MC中的3-6mer IMO的免疫调节组合物。

2. 发明授权

US08124590B2 Biodegradable immunomodulatory formulations and methods for use thereof 有权
标题翻译：可生物降解的免疫调节剂及其使用方法
公开(公告)号：US08124590B2
公开(公告)日：2012-02-28
申请号：US11820592
申请日：2007-06-19
申请人： Gary Van Nest , Stephen F. Tuck , Karen L. Fearon , Dino Dina
发明人： Gary Van Nest , Stephen F. Tuck , Karen L. Fearon , Dino Dina
IPC分类号： A61K39/00 , A61K48/00 , A61K47/00 , A61K38/00 , A61K39/38 , A61K45/00 , A61K9/127 , A61K39/385
CPC分类号： A61K9/1647 , A61K9/1075 , A61K9/1617 , A61K9/167 , A61K47/6925 , Y02A50/423 , Y10T428/2982
摘要： The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC) complexes. The IMP/MC complexes may be covalently or non-covalently bound, and feature a polynucleotide comprising at least one immunostimulatory sequence bound to a biodegradable microcarrier or nanocarrier.
摘要翻译：本发明提供了用于个体免疫调节的新组合物和方法。通过施用免疫调节多核苷酸/微载体（IMP / MC）复合物实现免疫调节。 IMP / MC复合物可以共价或非共价结合，并且特征在于包含至少一种结合生物可降解微载体或纳米载体的免疫刺激序列的多核苷酸。

3. 发明申请

US20100291218A1 IMMUNOMODULATORY COMPOSITIONS, FORMULATIONS, AND METHODS FOR USE THEREOF 有权
标题翻译：免疫组织化学，制剂及其使用方法
公开(公告)号：US20100291218A1
公开(公告)日：2010-11-18
申请号：US12396348
申请日：2009-03-02
申请人： Karen L. FEARON , Dino DINA
发明人： Karen L. FEARON , Dino DINA
IPC分类号： A61K9/14 , A61K39/00 , A61K39/12 , A61K39/02 , C07H21/00 , A61P31/12 , A61P35/04 , A61P31/04
CPC分类号： A61K9/167 , A61K9/1647 , A61K39/39 , A61K47/593 , A61K47/6927 , A61K2039/55555 , A61K2039/55561 , Y02A50/41 , Y02A50/412 , Y02A50/423
摘要： The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMO/MC) complexes comprising 3-6mer immunomodulatory oligonucleotides. The IMO/MC complexes may be covalently or non-covalently bound. Also provided are immunomodulatory compositions comprising a 3-6mer IMO encapsulated in an MC.
摘要翻译：本发明提供了用于个体免疫调节的新组合物和方法。通过施用包含3-6mer免疫调节寡核苷酸的免疫调节多核苷酸/微载体（IMO / MC）复合物来实现免疫调节。 IMO / MC复合物可能共价或非共价结合。还提供包含封装在MC中的3-6mer IMO的免疫调节组合物。

4. 发明授权

US5494793A Monomeric phthalocyanine reagents 失效
标题翻译：单体酞菁试剂
公开(公告)号：US5494793A
公开(公告)日：1996-02-27
申请号：US366971
申请日：1989-06-14
申请人： Deborah C. Schindele , Barry V. Pepich , George E. Renzoni , Karen L. Fearon , Niels H. Andersen , Thomas H. Stanton
发明人： Deborah C. Schindele , Barry V. Pepich , George E. Renzoni , Karen L. Fearon , Niels H. Andersen , Thomas H. Stanton
IPC分类号： A61K41/00 , C07H21/00 , C12Q1/68 , G01N33/533 , C07H21/04 , C12N9/00 , G01N33/53
CPC分类号： G01N33/533 , A61K41/0071 , C07H21/00 , C12Q1/6816 , C12Q1/6869
摘要： Fluorescent and/or chromogenic reagents in which a phthalocyanine derivative is monomerically conjugated with an antigen, antibody, oligonucleotide, or nucleic acid. Methods are presented in in which greater than 90% of the phthalocyanine dyes are monomeric when conjugated. This greatly enhances their performance as detectable markers in immunoassays, nucleic acid probe assays, immunoblotting, hybridization assays, microscopy, imaging, flow cytometry, DNA sequencing, and photodynamic therapy. For use as fluorophores, the free base phthalocyanine may or may not be metallated. Metals for fluorescent phthalocyanine include aluminum, silicon, phosphorus, gallium, germanium, cadmium, scandium, magnesium, tin, and zinc. For use as chromogens, the phthalocyanine may or may not be metallated. For use in aqueous solution, the phthalocyanine macrocycle should be derivatized with water-solubilizing substituents such as sulfonic acid, phosphate, phosphonate, hydroxy, phenoxy, amino, ammonium, or pyridinium groups. To promote disaggregation, metallation with an atom of +3 valence or higher is recommended, so that the monomer will take on an axial ligand in aqueous solution. For use in enzymatic immunoassays and enzymatically enhanced nucleic acid probe assays, the monomeric phthalocyanine derivative is conjugated via an enzyme-cleavable linkage with the antigen, antibody, oligonucleotide, or nucleic acid. Reversibly quenched embodiments are also provided in which a cleavable linkage joins a fluorescent phthalocyanine monomer with another phthalocyanine, a heavy metal, or a paramagnetic species.
摘要翻译：荧光和/或显色试剂，其中酞菁衍生物与抗原，抗体，寡核苷酸或核酸单体缀合。其中存在大于90％的酞菁染料当共轭时是单体的方法。这大大提高了其作为免疫测定中的可检测标记，核酸探针测定，免疫印迹，杂交测定，显微镜，成像，流式细胞术，DNA测序和光动力学治疗的性能。为了用作荧光团，游离碱酞菁可以是或可以不是金属化的。荧光酞菁的金属包括铝，硅，磷，镓，锗，镉，钪，镁，锡和锌。为了用作色素，酞菁可以是或可以不是金属化的。为了在水溶液中使用，酞菁大环化合物应当用水溶性取代基如磺酸，磷酸酯，膦酸酯，羟基，苯氧基，氨基，铵或吡啶鎓基衍生化。为了促进分解，推荐使用+3价以上的原子进行金属化，使单体在水溶液中呈轴向配体。为了用于酶免疫测定和酶促增强的核酸探针测定，单体酞菁衍生物通过酶切断连接与抗原，抗体，寡核苷酸或核酸缀合。还提供了可逆淬火的实施方案，其中可切割键连接荧光酞菁单体与另一种酞菁，重金属或顺磁性物质。

5. 发明授权

US5135717A Tetrabenztriazaporphyrin reagents and kits containing the same 失效
标题翻译：四氮唑嘌呤试剂和含有它的试剂盒
公开(公告)号：US5135717A
公开(公告)日：1992-08-04
申请号：US398433
申请日：1989-08-29
申请人： George E. Renzoni , Deborah C. Schindele , Louis J. Theodore , Clifford C. Leznoff , Karen L. Fearon , Barry V. Pepich
发明人： George E. Renzoni , Deborah C. Schindele , Louis J. Theodore , Clifford C. Leznoff , Karen L. Fearon , Barry V. Pepich
IPC分类号： A61K41/00 , C07H21/00 , C12Q1/68 , G01N33/533 , G01N33/58
CPC分类号： C07H21/00 , A61K41/0071 , G01N33/533 , C12Q1/6869 , Y10S435/81 , Y10S435/975 , Y10S436/808 , Y10T436/143333
摘要： Red-shifted, water-soluble, fluorescent, monomerically-tetherable derivatives having the formula: ##STR1## wherein, M represents either H.sub.2 or is selected from among the following metals: aluminum, silicon, phosphorus, gallium, germanium, cadmium, scandium, magnesium, tin, and zinc. Each R.sub.1 is independently selected from --XYW, --YW, and --W. X represents either a carbon, or heteroatom selected from among oxygen, nitrogen, sulfur, phosphorus, silicon, and selenium; Y represents a linking group; and W represents a water solubilizing group. The substituent R.sub.2 is selected from among --A, --Y'A, --XA, and --XY'A, where A denotes a biological entity such as an antibody, antibody fragment, nucleotide, nucleic acid probe, antigen, oligonucleotide, deoxynucleotide, dideoxynucleotide, avidin, streptavidin or membrane probe, or R.sub.2 is a reactive or activatable group suitable for conjugating to a biological entity. Y' is a linking group that tethers the biological entity to the phthalocyanine or tetrabenztriazaporphyrin macrocycle. Z is either a nitrogen atom or a carbon substituted with hydrogen, alkyl, aryl, or aralkyl groups. Z may also be attached to R.sub.2. Also disclosed are derivatives of the compounds of the above formula in which 1-4 of the benzo rings(s) contain 1 or 2 N atoms. Methods of sequencing DNA and detecting analytes, including cells, using these derivatives are disclosed, as are kits for carrying out assays for the analytes and flow cytometry. Methods of detecting DNA using cationic compounds of the above formula, wherein R.sub.2 =R.sub.1 and W=--N.sup.+ D.sub.1 D.sub.2 D.sub.3 are also disclosed. Further, compounds containing Tc, Gd, etc. as the metal in the above formula may be used for imaging or therapy.
摘要翻译：具有下式的红移，水溶性，荧光，单体 - 可连接的衍生物：其中，M表示H 2或选自下列金属：铝，硅，磷，镓，锗，镉，钪，镁，锡和锌。每个R1独立地选自-XYW，-YW和-W。 X表示选自氧，氮，硫，磷，硅和硒中的碳或杂原子; Y表示连接基团; W表示水溶性基团。取代基R2选自-A，-Y'A，-XA和-XY'A，其中A表示生物实体，例如抗体，抗体片段，核苷酸，核酸探针，抗原，寡核苷酸，脱氧核苷酸，双脱氧核苷酸，抗生物素蛋白，链霉抗生物素蛋白或膜探针，或R2是适于与生物实体缀合的反应性或活化性基团。 Y'是将生物体系到酞菁或四苯并三氮杂卟啉大环的连接基团。 Z是氮原子或被氢，烷基，芳基或芳烷基取代的碳。 Z也可以连接到R2。还公开了上式化合物的衍生物，其中1-4个苯并环含有1或2个N原子。公开了使用这些衍生物测序DNA和检测分析物（包括细胞）的方法，以及用于进行分析物和流式细胞术的测定的试剂盒。还公开了使用上式的阳离子化合物检测DNA的方法，其中R2 = R1和W = -N + D1D2D3。此外，可以使用含有上述式中的金属的Tc，Gd等的化合物进行成像或治疗。

6. 发明申请

US20130142814A1 IMMUNOSTIMULATORY SEQUENCE OLIGONUCLEOTIDES AND METHODS OF USING THE SAME 有权
公开(公告)号：US20130142814A1
公开(公告)日：2013-06-06
申请号：US13438757
申请日：2012-04-03
申请人： Dino Dina , Karen L. Fearon , Jason Marshall
发明人： Dino Dina , Karen L. Fearon , Jason Marshall
IPC分类号： C07H21/04
CPC分类号： C12N15/117 , A61K39/0011 , A61K45/06 , C07H21/00 , C07H21/02 , C07H21/04 , C12N2310/17 , C12N2310/315 , C12N2310/333 , C12N2310/335 , C12N2310/336
摘要： The invention provides immunomodulatory polynucleotides and methods for immunomodulation of individuals using the immunomodulatory polynucleotides.

7. 发明授权

US08372413B2 Immunomodulatory polynucleotides and methods of using the same 有权
公开(公告)号：US08372413B2
公开(公告)日：2013-02-12
申请号：US11963663
申请日：2007-12-21
申请人： Karen L. Fearon , Dino Dina
发明人： Karen L. Fearon , Dino Dina
IPC分类号： A61K45/00 , A61K47/00
CPC分类号： C12N15/117 , A61K2039/55561 , C12N2310/18 , C12N2310/315 , C12N2310/334 , Y02A50/41 , Y02A50/412
摘要： The invention provides immunomodulatory polynucleotides and methods for immunomodulation of individuals using the immunomodulatory polynucleotides.

8. 发明授权

US08114418B2 Chimeric immunomodulatory compounds and methods of using the same—IV 有权
标题翻译：嵌合免疫调节化合物及其使用方法IV
公开(公告)号：US08114418B2
公开(公告)日：2012-02-14
申请号：US11590150
申请日：2006-10-30
申请人： Karen L. Fearon , Dino Dina , Stephen F. Tuck
发明人： Karen L. Fearon , Dino Dina , Stephen F. Tuck
IPC分类号： A61K39/00 , A61K39/38 , A61K45/00 , A61K47/00
CPC分类号： A61K47/48023 , A61K39/12 , A61K39/292 , A61K47/54 , A61K47/549 , A61K2039/55561 , C07H15/18 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/332 , C12N2310/351 , C12N2310/3519 , C12N2310/52 , C12N2730/10134
摘要： The invention provides immunomodulatory compounds and methods for immunomodulation of individuals using the immunomodulatory compounds.
摘要翻译：本发明提供免疫调节化合物和使用免疫调节化合物免疫调节个体的方法。

9. 发明授权

US07745606B2 Immunostimulatory sequence oligonucleotides and methods of using the same 有权
标题翻译：免疫刺激序列寡核苷酸及其使用方法
公开(公告)号：US07745606B2
公开(公告)日：2010-06-29
申请号：US10741720
申请日：2003-12-18
申请人： Dino Dina , Karen L. Fearon , Jason Marshall
发明人： Dino Dina , Karen L. Fearon , Jason Marshall
IPC分类号： A61K45/00 , A61K47/00 , A61K31/70 , A01N43/04 , C07H21/04 , C07H21/02
CPC分类号： C12N15/117 , C07H21/00 , C07H21/02 , C07H21/04 , C12N2310/17 , C12N2310/315 , C12N2310/333 , C12N2310/336
摘要： The invention provides immunomodulatory polynucleotides and methods for immunomodulation of individuals using the immunomodulatory polynucleotides.
摘要翻译：本发明提供免疫调节多核苷酸和使用免疫调节多核苷酸免疫调节个体的方法。

10. 发明申请

US20080207550A1 IMMUNOMODULATORY POLYNUCLEOTIDES AND METHODS OF USING THE SAME 有权
标题翻译：免疫多聚核苷酸及其使用方法
公开(公告)号：US20080207550A1
公开(公告)日：2008-08-28
申请号：US11963663
申请日：2007-12-21
申请人： Karen L. Fearon , Dino Dina
发明人： Karen L. Fearon , Dino Dina
IPC分类号： A61K31/713 , A61P31/00
CPC分类号： C12N15/117 , A61K2039/55561 , C12N2310/18 , C12N2310/315 , C12N2310/334 , Y02A50/41 , Y02A50/412
摘要： The invention provides immunomodulatory polynucleotides and methods for immunomodulation of individuals using the immunomodulatory polynucleotides.
摘要翻译：本发明提供免疫调节多核苷酸和使用免疫调节多核苷酸免疫调节个体的方法。

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